산모 및 제대 혈중 납농도에 관련된 행태학적 및 사회경제적 요인에 관한 조사

김주자,우극현,이임순 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

생활환경에 따라 산모 및 제대 혈중 납농도가 차이가 있을 것이며 그러한 납농도에 영향을 미칠수 있는 행태학적 및 사회경제적 수준의 영향이 어느정도일가 하는 문제를 알아보기 위하여, 연구대상 지역을 도시, 농촌, 공단 지역으로 구분하여 이들 각 지역에 거주하는 분만중의 산모를 대상으로 혈중 납농도 및 신생아의 제대 혈중 납농도를 조사하였으며 그에 관련된 여러 위험요인들에 대하여도 조사하였다. 도시지역으로는 서울에서 순천향 서울병원, 농촌지역으로는 음성에서 순천향 음성병원, 공단지역으로는 구미에서 순천향 구미병원을 선정하였다. 1993년 1월 부터 3월 사이의 기간동안 분만을 위하여 각 병원에 입원한 산모 306명에게서 일반 기초검사 및 혈중납 측정을 하였으며 분만시 신생아의 제대혈을 채취하였고 같은 기간동안 분만보조 간호사에 의하여 면접에 의한 설문작성을 하였으며 또한 의무기록도 조사하였다. 결과는 다음과 같다. 1. 조사대상자인 산모의 평균 연령은 27.5±5.3세, 임신기간은 39.4±3.1주로 모든 지역별 유의한 차이는 보이지 않았다. 산모 혈중 납농도는 4.73±1.49 ㎍/dl, 제대 혈중 납농도는 4.35±1.29 ㎍/dl이었으며 모두 지역별 유의한 차이는 보이지 않았다. 2. 산모의 생물학적 및 사회경제적 요인을 4분위로 나누어 각 등급정도에 따른 산모 및 제대 혈중 납농도의 변화경향을 조사한 결과 산모연령, 아기의 출생시 체중, 임신기간, 가정의 총 연수입등의 정도에 따라 일정한 변화경향을 보이지 않았다. 3. 산모 및 제대 혈중 납농도의 변화경향을 조사하기 위하여 산모 및 남편의 건강행태를 질문하여 전혀, 가끔, 자주, 매일의 4가지로 구분하여 그 정도에 따라 산모및 제대 혈중 납농도를 조사한 결과 임신중 산모의 철분복용, 비타민 복용, 화장품사용, 흡연, 음주, 커피음용에 있어서 일정한 경향을 보이지 않았으며 남편의 흡연, 음주, 커피음용의 정도에 있어서도 일정한 경향을 보이지 않았다. 4. 모든 조사대항 요인들과 산모 및 제대혈중 납농도와의 상관관계를 조사한 결과 산모 혈중 납농도와 제대 혈중 납농도와의 통계적으로 유의한 양의 상관관계를 보였으며 남편의 교육정도와는 산모 및 제대 혈중 납농도 모두에서 유의한 상관관계를 보였다. This study was performed to examine the effect of demographic and behavioral and socioeconomic factors on the maternal and cord blood lead level. Three Soon Chun Hyang University Hospitals (Seoul, Eumsung, Kumi) participated as of urban, rural, industrial areas, respectively. Blood sampling for lead and other routine tests and questionnaire were done on 306 pregnant women who were admitted to these hospitals to deliver the baby. Women who have history of disease, such as diabetes, hepatitis etc. were excluded from the analysis. The results were as follows; 1. Mean maternal age was 27.5±5.3, and mean gestational period was 39.4±3.1 weeks. Mean concentration was 4.73±1.49 ㎍/dl in maternal blood lead and 4.35±1.29 ㎍/dl in cord blood lead. there were no statistically significant differences between community areas. 2. Tendency of maternal and cord blood lead level by the degree of quartile of each demogrphic and socioeconomic variables showed no statistical significance in maternal age, baby birth weight, gestational period, family income. 3. Tendency of maternal and cord blood lead level by the degree (never, often, very often, everyday) of maternal and paternal health behavior showed no statistical significance in maternal iron supplement, vitamine intake, use of cosmetics, smoking, alcohol drinking, coffee drinking during pregnancy and paternal smoking, alcohol drinking, coffee drinking. 4. Correlation between demographic, health behavioral, socioeconomic variables and maternal and cord blood lead showed significant positive correlation between maternal and cord blood lead, and also correlation of paternal education to both maternal and cord blood lead.

위암의 병기결정에 있어서 이중시기 나선식 CT의 유용성

최교창 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: To evaluate the usefulness of two-phase spiral CT in the staging of gastric carcinoma. Materials and Methods: The author preformed two-phase spiral CT in 49 patients with gastric carcinomas surgically and pathologically proven after endoscopic biopsy. CT scans were obtained after ingestion of 800-1000mL of water. In all 49 patients, two-phase spiral CT findings of gastric carcinoma were retrospectively evaluated and correlated with surgical and pathological findings. Results: The author correctly detected 15(83.3%) of 18 early gastric carcinomas and 31(100%) of 31 advanced gastric carcinomas by two-phase spiral CT. The overall detection rate of gastric carcinomas was 93.9%(46 of 49 cases). The detection rate of early gastric carcinoma was 100%(5 of 5 cases) among elevated lesions and 76.9%(10 of 13 cases) among flat or depressed lesions. With regard to the depth of tumor invasion, there was good correlation between CT findings and pathologic findings in 28 of 49 cases(57.1%). Overstaging occurred in 24.5%(12 of 49 cases) and understaging in 18.4%(9 of 49 cases). In lymph node staging, good correlation between CT findings and pathologic findings was noted in 33 of 49 cases(67.3%). Understaging occurred in18.4%(9 of 49 cases) and overstaging in 14.3%(7 of 49 cases). All of liver metastases(3 cases) and peritoneal carcinomatosis(1 case) were correctly diagnosed by two-phase spiral CT. Conclusion: In the staging of gastric carcinoma, two-phase spiral CT is useful in the deterction of early gastric carcinoma and distant metastasis. However, for determining the depth of tumor invasion and for the evaluation of metastasis to lymph node its usefulness is limited. Further research using various analytic approaches will therefore be necessary.

결핵균 감염에 의한 대식세포에서의 TNFα 유전자 발현 증가

송호연 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Mycobactetium tuberculosis is capable of growing and survival dormant for a long time within macrophages. This might be due to a balance between antimicrobial activity of host cell and pathogencity of M. tuberculosis. This study examined gene regulation in human monocyte derived THP-1 cell infected with mycobacteria. Gene expression was evaluated by differential display RT-PCR and was compared to uninfected cells. Results were confirmed by real time quantitative RT-PCR(TaqMan). Among many up or down-regulated clones, 25 colnes were sequenced and compared with known genes on GenBank. One of over-expressed clones from THP-1 cells infected with mycobacteria was identical to human tumor necrosis factorα(TNFα). In particular, the expression of TNFα was highly over-expressed in THP-1 cells infected with M. tuberculosis H_(37)Ra(avirulent) than H_(37)Rv(virulent). This may in fact be a mycobactetial virulence tactic.

급성 위장관염에 동반된 양성 경련 1예

서원석 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Rotavirus is an important pathogen of acute gastroenteritis as well as is suspected of being one of the causative agents of benign convulsion. The development of sensitive new molecular genetic techniques has led to the detection of rotavirus in cerebrospinal fluid, stools and throat swabs from patients with gastroenteritis with accompanying clinical symptoms similar to infantile benign convulsions. However, the mechanism by which these viral infection induce benign convulsions remains to be elucidated. The occurrence of afebrile seizures in association with viral gastroenteritis, without dehydration or electrolyte imbalance, is virtually unknown. I report a case of afebrile benign convulsion in association with viral gastroenteritis.

우리나라 남해안과 제주 근해에서 자생하는 해조류 추출물의 Melanogenesis에 대한 억제 효과

송무현,황규왕 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Backgroung: Many people have a great interest on skin pigmentation due to melnin production which is caused by UV exposure, hormone, physical and chemical injury from the cosmetic viewpoint. Therefore, need of new depigmenting agent which has safety and potency has been recently increasing. Traditionally, sea weeds have been considered as whitening agents in Korea. We screened sea weeds which was grown in southern parts of Korean sea whether they had tyrosinase inhibition activities by mushroom tyrosinase inhibition assay. Objective:Our purpose was to examine the inhibitory effects of Seaweed extracts on tyrosinase activity and melanin synthesis and compating with other depigmenting agents such as kojic acis, arbutin, licorice extract. Methods: Tyrosinase activity was determined by spectrophotometry, the effects of whitening agents(Kojic acid, arbutin, licorice extracts, Seaweed extracts) on mushroom tyrosinase was compared by measuring the IC_(50), the concentration of the compound at which half of the original tyrosinase activity was inhibited. B-16 melanoma cells were cultured in a pair of 6-well plate 37℃, 5% CO_(2), with DMEM plus 10% FCS contaning of various concentrations of Seaweed extracts. After 24 hours B-16 cells were harvested with trypsinization. B-16 cell pellets were used for measurement of mRNA expression for tyrosinase, TRP-1 and TRP-2 by RT-PCR. Results: 1. Seaweed extracts has relatively strong inhibitory effect on tyrosinase according to increment of concentration. 2. Seaweed extracts has relatively strong inhibitory effect on tyrosinase as compared with kojic acid, arbutin, licorice extract. 3. Seaweed extracts showed inhibitory effect on Tyrosinase and TRP-2 gene transcription but didn't showed inhibitory effect on TRP-1 gene transcription. Conclusion This study provided that Seaweed extracts has strong inhibitory effects aganise melanogenesis. The results suggest that Seaweed extracts will be able to use as a new whitening agent.

허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

외상후 발작의 위험인자에 대한 조사

이재학,배학근,윤석만,도재원,이경석,윤일규,최순관,변박장 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Risk Factors for Posttraumatic Seizure The authors evaluate the risk factors for posttraumatic seizures. this prospective study was performed in a series of 470 head injured patient from January 1996 to Decomber 1998. The patients who were dead within 1 week of injury or children from 3 years old and under were excluded. There were 358 male and 112 female with a mean age of 35.2±22.8 years (range, 4-88 years). The results were as follows : 1). Of the 470 patients, pasttraumatic seizure occurred in 48 patients(10.2%): early seizure in 28(6%) and late seizure in 20 patients(4.2%). 2). The clinical risk factors for posttraumatic seizure were poor consciousness at admission, presence of brainstem herniation signs, poor GCS score, and posttraumatic amnesia more than 24 hours after trauma(p<0.001). 3). The radiological risk factors for posttraumatic seizure were subdural hematoma(p<0.001), intracerebral hematoma (p<0.02), mutiple intracranial CT lesions(p<0.001), or delayed lesions on follow-up CT scans(p<0.001). the incidence of seizure increased according to the severity of diffuse brain lesion(p<0.001), and the seizure rate in mass lesion was higher than that in diffuse lesion(p<0.001). 5). Hypoxia and coagulopathy had a statistically significant influence on posttraumatic seizure(p<0.05). Hypoxia had a infuence on occurrence of late seizure(p<0.05). 6). The incidence of posttraumatic seizure signiticantly increased in surgical group compared with coservative group(p<0.001) and significantly increased in patient who underwent decompressive craniectomy compared with those who underwent craniotomy(p<0.001) 7). Preventive administration of antiepileptic drugs decreased the incidence of early seizure, but did not affect on the reduction of late seizure. 8). Multivariate logistic regression analysis showed the subdural hematoma, GCS score, delayed lesion, and intracerebral hematoma in order of importance for seizure risk. in conclusion, the risk factors affecting on the occurrence of seizure were clinical status at admission, CT lesions, and severity of diffuse brain inJury. Considering that hypoxia affected on the late seizure, it is necessary to detect and treat it immediately after trauma. In addition, the patients who underwent decompressive craniectomy should be carefully followed to evaluate the risk of late seizure. Even though preventive administration of antiepileptic drugs had a tendency to decrease the incidence of early seizure, it is unclear whether administration of antiepileptic drugs can reduce the incidence of posttraumatic seizures. Prospective study will be needed in the selected patients.

B-Carotene이 혈중 효소활성도에 미치는 영향

김현철,이상한,김창세,우기민,장예진,조만희 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

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초음파를 이용한 한국성인의 갑상선 질환의 발생빈도

박병문,박재성,김대호,최득린,김기정,안재억 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

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선천형 골형성 부전증(증례 보고 2례)

임수재,문웅,임한혁,윤승렬,정석영,나수균,최창욱 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

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