서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

정상면역을 가진 성인에서 발생한 식도 방선균증

김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

Angiotensin Concerting Enzyme 유전자의 유전적 다형성(Genetic Polymorphism)이 관상동맥 질환 위험인자에 따른 혈중 Plasminogen Activator Inhibitor-1의 농도에 미치는 영향

김덕경,김종원,권현절,류재춘,박승우,김준수,이상훈,홍경표,박정의,이원로 대한고혈압학회 1996 대한고혈압학회지 Vol.2 No.2

부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

TEOS 솔 침전공정에서 SiO2 과포화 농도 및 입자 크기에 미치는 반응조건 영향

김경수,김선근,김우식,김성수,김준경 한국화학공학회 2000 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.38 No.6

본 연구에서는 솔 침전공정에서 TEOS(Tetraethylorthosilicate) 반응물을 이용하여 실리카 분말 합성시에 TEOS 농도, 물농도, 반응물 주입속도, 교반속도 등의 반응조건이 실리카 과포화 농도 및 입자크기에 미치는 영향에 대해 연구하였다. TEOS 반응물과 물 농도가 증가할수록 입자유도시간은 짧아졌으며 입자유도시점에서의 과포화 농도는 감소하였다. 그러나, 반응물 주입속도가 입자유도시간과 입자유도시점에서의 과포화 농도에 미치는 영향은 서로 상반되었다. 즉, 반응물 주입속도의 증가에 따라 입자유도시간은 감소하였으나 입자유도시점에서의 과포화 농도는 증가하였다. 반응조건에 따라 서로 다른 과포화 농도에서 입자가 유도되는 것은 입자의 형성에 있어서 과포화도 이외의 용액의 조건에도 영향을 준다는 것을 의미하는 것이다. 한편, 교반속도는 입자유도시간과 유도시점에서의 과포화 농도는 거의 영향을 주지 않았다. 이것은 솔 침전공정에서 반응물 혼합시간이 충분히 짧아 실리카 생성에 있어서 반응속도가 입자유도 및 과포화 농도 결정에 가장 크게 영향을 미쳤기 때문이다. 반응조건에 따른 가수분해 및 축합 반응속도를 Kim등[15]이 제시한 식을 이용하여 예측하였으며 이 결과는 본 실험에서 측정한 입자유도시간의 함수로도 매우 잘 묘사될 수 있었다. 또한, 반응조건에 따라 합성된 최종입자의 크기 변화도 입자유도시간의 함수로 훌륭히 묘사될 수 있음을 보여 주었다. In a single feed semi batch reactor effects of reaction conditions, such as TEOS and water concentrations, react feed flow rate and agitation speed, on the silica supersaturation and particle size synthesized in sol precipitation were investigated. As the TEOS and water concentrations increased, the particle induction time and the supersaturation at the particle induction point were reduced. However, the dependencies of the particle induction time and supersaturation at the particle induction point on the reactant flow rate were opposite to each other. That was, the particle induction tune decreased with increase in the reactant flow rate but the supersaturation at the particle induction point increased. The fact that the supersaturation level to induce the particle was varied with the reaction condition implied that the solution condition determined by the reaction condition as well as the supersaturation level was important to the particle induction. Meanwhile, the particle induction time and supersaturation at the particle induction point were little influenced by the agitation speed in the reactor. This result was due to the micromixing time being short enough in comparison to the reaction time of TEOS. Thus, the particle induction time and supersaturation at the particle induction point was predominantly determined by the reaction time rather than the micromixing time of TEOS. The reaction rate constants of TEOS hydroysis and condensation, which was predicted with Kim et al.'s equations [15] at the reaction conditions was described as a function of the particle induction time. In addition, the particle size synthesized at the reaction conditions was able to be well fitted as a function of the particle induction time.

Yamaguchi index에 의한 파라쿼트 중독 환자의 예후 결정

김인병,최성욱,김성중,김경수,이영수 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

Study objective: To evaluate the significance of Yamaguchi index as a predictor of outcome in patients with acute paraquat poisoning Design: Retrospective chart review Setting: Two university Hospital EDs Methods: We reviewed the medical records of 47 patients with acute paraquat poisoning(18 survived and 29 died). The Eq1 was defined as : Eq1=[K+] x [HCO₃] / 0.088[Cre] mEq L¹ The patient's data were plotted as calculated Eq1 values(y-axis) against interval of time from ingestion to admission (T) (x-axis). The study patients were divided into three groups. Group A consisted of patients with Eq1> 1500-399LogT; Group B consisted of patients with Eq1: 930-399LogT < Eq1 ≤ 1500-399LogT; Group C consisted of patients with Eq1 ≤ 930-399LogT. Results: There was a significant difference among three groups (A, B and C) as far as prognosis was concerned(P<0.01). In group A, all patients survived(survival rate 100%). In group B, six of 13 patients survived(survival rate 46%). In group C, none of patients survived Isurvival rate 0%). Conclusion: Yamaguchi index is a significant predictor of outcome in patients with acute paraquat poisoning

제한된 적응증의 대퇴골 간부 골절에 사용된 역행적 골수정 삽입술

김성중,오창욱,인주철,김희수,전인호,경희수,박일형,김경훈 대한골절학회 2003 대한골절학회지 Vol.16 No.1

목 적 : 전향적 골수강내 고정술로는 치료가 힘들었던 대퇴골 간부 골절에 대해 역행적 골수강내 고정술을 시행한 후 그 결과를 분석하였다. 연구 대상 및 방법 : 대퇴골 간부 골절로 진단 후 슬관절에서 역행적으로 비확공성 골수강내 금속정(Unreamed femoral nail, Synthes R)으로 치료한 환자 중 최소 1년 이상 추시(평균; 21개월, 범위; 13개월-28개월)가 가능하였던 21명 24례의 환자를 대상으로 임상적, 방사선학적 평가를 시행하였다. 남자가 16명, 여자가 5명이었으며, 수술시 평균 연령은 41세(18-76세)이었다. Winquist-Hansen의 분류상 제1형이 10례, 제2형이 5례, 제3형이 3례, 제4행이 6례 이었으며, 전 례에서 동반된 골절 손상이 있었으며, 적용된 적응층에 따르면 동측 경골 골절이 8명, 동측 근위 대퇴골 골절)경부 및 전자부 골절) 5명, 동측 골반부 및 비구 골절 4명, 양측 대퇴골 골절 3명, 동측 슬관절 손상이 1명이었다. 방사선 소견상 골유합 시기 및 불유합, 부정유합 등을 평가하였고, 임상적 평가는 슬관절의 동통을 포함한 Neer 등에 의한 방법을 이용하였다. 결 과 : 대부분(87.5%)에서 일차적인 골유합을 얻을 수 있었으며, 평균 골유합 기간은 15.8주(범위; 12-20주)이었다. 추가적인 술식이 요구된 지연유합 또는 불유합은 3례가 있었으며, 그 외 ㎝ 이상의 단축이나 10도 이상의 부정유합 술 후 슬관절 감염 또는 불안정성이 발생한 경우는 없었다. 슬관절의 운동 평가에서 Neer score는 평균 86.9점으로, 모든 례에서 양호한 결과를 나타내었다. 평균 슬관절 운동영역은 120.2도 이었고, 3례에서 경미한 슬관절 동통을 나타냈다. 결 론 : 역행성 골수정은 동측 하지의 동반된 골절이나 다발성 골절이 있는 환자에서 대퇴골 간부 골절에 대하여 제한적으로 이용될 수 있는 유용한 방법으로 사료된다. Purpose : This is a retrospective study to analyze the results after retrograde intramedullary(IM) nailing in femoral shaft fractures with limited indications. Materials and Methods : Twenty-four femoral shaft fractures(21 patients) were operated with unreamed IM nail(Unreamed femoral nail, SynthesR) in a retrograde method and were followed for more than 1 years. There were 16 men and 5 women, and the mean age at index operation was 41 years (range 18-76 years). In Winquist-Hansen classifications, there were 10 of type Ⅰ, five of type Ⅱ, three of type Ⅲ, and ix of type Ⅳ. All the patients had associated fractures or injuries, and there were eight ipsilateral tibia fractures, five ipsilateral proximal femoral fractures(including neck and trochanter), four ipsilateral pelvic or acetabular fracture, three bilateral femoral fractures, and one ipsilateral knee injury according to the used indication, and clinical evaluation with Neer's criteria was done. Results : Most fracture(87.5%) were primarily united cases, and the mean time for union was 15.8% weeks(range 12-20 weeks). Three cases of delayed union or nonunion were developed, but a shortening over 1㎝ or malunion over 10 degrees angular deformity were not found. Evaluating the knee functions, the Neer score wes 86.9 in average and all the cases were above satisfactory grade. The average range of knee motion was 120.2 degrees, and the mild knee pain was developed in three cases. Conclusion : The retrograde IM nailing can be a useful option for femoral shaft fracture with limited indications, including ipsilateral fractures of other areas or multiple fractures.

Callus distraction method를 이용한 하악골 신장술 : 계단골절단술식의 적용

김명진,윤필영,신동준,김수경,김종원,김규식 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.2

Since callus distraction technique was applied clinically for the correction of dentofacial deformity to the patients with hemifacial dysplasia by McCarthy in 1992, many surgeons have tried to apply this method to the maxillofacial region. But this technique has some drawbacks. One of the disadvantages of this technique is extensive scar formation in the facial area, which is a sequelae of extraoral approach for supraperiosteal dissection of the periosteum overlying the mandible. Recently, we have made an effort to perform this technique through intraoral approaches to prevent scar formation on the submandibular area and modified the design of the osteotomy, that is step osteotomy technique, to increase the raw bone surface on both osteotomized segments. The rationale for the application of this step osteotomy technique is to increase the amount of regeneracted bone and the length of distraction, to avoid damage of inferior alveolar neurovascular bundle, and to increase initial stability of the splitted segments. Step osteotomy procedure can be done with fine micro-osteotomy saw through subperiosteal tunneling. Extraoral pins should be inserted before making the osteotomy. Since 1974 we have applied this technique at 8 sites In 5 patients with mandibular deficiencies: 2 cases of hemifacial microsomia, 1 case of developmental facial asymmetry and 2 cases of mandibular bony defect. Mandibular elongation have been achieved from 12 to 20mm in length. 1 out of 8 site, we experienced non-union in the case of mandibular body defect. Some skeletal relapse and growth retardation phenomenon have been observed in some cases with the longest follow-up of 48 months.

소모성 질환에 이환된 이유자돈에 대해 Porcine cytomegalovirus DNA Polymerase 유전자 검출과 분석

김지언,김지영,楚佳奇,채미경,장경수,김명철,박창식,전무형 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Porcine cytomegalovirus (PCMV) causes piglet deaths, runting, inclusion body rhinitis, respiratory and reproductive disorders in swine herd, resulting in the significant economic losses in the swine industry. Recently, in the field of pig-to-human xenotransplantation, PCMV has been indicated as a potential xenogeneic pathogen with the risk for infection transmitted from the xenograft donor to the recipient. In this study, PCMV DNA polymerase gene was detected in the sera and nasal swabs from 30 heads of the weaned piglets affected with various wasting diseases and 10 heads of normal healthy piglets using polymerase chain reaction (PCR), and the diagnostic efficacy of PCR was evaluated. The prevalence of the PCR-positive by specimens from the diseased piglets were 83.3% in sera and 33.3% in nasal swabs. In the normal healthy group, the PCR-positive rates of sera and nasal swabs were 40% and 30%, respectively. Ten piglets (25.0%) out of 40 showed the simultaneously positive results in both of sera and nasal swabs. According to this result, it was found that the serum specimen was the most appropriate sample for detection of PCMV by PCR. The nucleotide sequence homology of DNA polymerase gene of PCMV KS1 as compared with the reference strain of PCMV (GenBank accesson no.AF027217) was 99.0%.