Effect of Ionizing Radiation on Rat Tissue: Proteomic and Biochemical Analysis

Park*, Eui‐,Chul,Yoon, Jong‐,Bok,Seong*, Jin‐,Sil,Choi, Kyoung‐,Soo,Kong, Eung‐,Sik,Kim, Yun‐,Jeong,Park, Young‐,Mee,Park, Eun‐,Mi Taylor Francis 2006 Preparative biochemistry & biotechnology Vol.36 No.1

<P>Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.</P>

청소년 도덕적 동기화 검사 도구 개정 연구(2차년도)

전종희 ( Jong Hee Jeon ),이인재 ( In Jae Lee ),김영한 ( Young Han Kim ),박균열 ( Gyun Yeol Park ),윤영돈 ( Young Don Yoon ),류숙희 ( Sook Hee Ryue ),홍성훈 ( Seong Hoon Hong ) 한국윤리교육학회 2013 윤리교육연구 Vol.0 No.29

본 연구는 J. Rest의 4구성요소 모형을 바탕으로 1차년도(2011년)에 개발된 도덕적 동기화 검사를 보다 신뢰롭고 타당한 도구로 개정하는 것이다. 따라서 선행연구를 보완하여 도덕 동기화의 구성 요소를 도덕지향성과 도덕적 정서귀인 등 두 항목으로 재설정하고, 스토리와 문항을 수정하였다. 개발된 세 개의 스토리(과제, 놀이공원, 작품) 별로 신뢰도를 분석한 결과, 전반적으로 .90 내외의 높고 수치를 보였다. 응답의 편포성을 완화하기 위해 2차년도에는 7점 척도를 사용하였다. 예비조사를 위해서는 전국 중학교 2학년생 409명을 대상으로 했고, 본조사를 위해서는 전국 6,216명의 중학교 2학년생을 대상으로 실시하였다. 개발된 검사도구의 신뢰도계수(문항 내적 일치도인 크론바흐 알파)는 .90이상으로 신뢰할만했다. 타당도를 검증하기 위하여 요인분석을 실시한 결과, 과제 스토리와 놀이공원 스토리의 일부 문항이 가정한 요인으로 잘 묶이지 않았는데 이 문항들을 제거하고 요인분석을 다시 실시해본 결과 기대하는 바를 충족했다. 그리하여 2차년도 연구를 통해 최종 스토리는 총 세 개(과제, 놀이공원, 작품)로 확정되었고, 각 스토리별 문항수는 과제 9개 문항, 놀이공원 9개 문항, 작품 10개 문항으로 총 28개 문항으로 확정되었다. 본 연구를 통해 수정 확정된 도덕적 동기화 검사도구는 상당히 안정적인 신뢰도와 타당도를 확보하였기에, 향후 우리나라 청소년의 도덕적 동기화 능력을 측정하기 위한 검사도구로 활용되기에 적절할 것으로 판단된다. The study aims to revise Moral Motivation Test I which was set for adolescents based on Rest`s four component model in 2011 and make standardized final morality test. In theory, this study is based on 4 components theory of James Rest who invented DIT (Defining Issues Test) to measure the moral judgment. The 4 components are composed of moral sensitivity, moral judgment, moral motivation, and moral character (or moral implementation, moral action). This study focused on moral motivation. This 2nd year study could get some significant outcomes. To make test form, 3 components relating teams have closely exchanged informations. Because teams have to share same real life stories as follows: “homework inspect”, “on going to park”, “broken art work”. The questionnaire used seven likert type to lessen the far epistemological tendency. To represent moral motivation, research team used moral orientation, moral emotion attributions. To get final form of morality test, this study was made two sequential steps. First one was pre-test which was for 409 respondents. Second main one was for 6,216 respondents. For moral motivation, the reliability was highly coefficient with Cronbach`s alpha(>.90). The validity was also much improved and stable. But just in the story “homework inspect”and “on going to park”, the factor analysis shows a little bit limitation result. Eliminated those questions, the result of factor analysis was more stable and reliable. Through these processes, to test moral motivation, this study shows 3 stories and 28 questions. And this recommends that just one simple story might be developed for one component(moral motivation).

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

흡연에 의한 급성 호산구성 폐렴 2예

박종빈,김학렬,주현준,유태양,신성남,신정현,송정섭,황기은,김소영,양세훈,정은택 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

최근 흡연을 시작한 젊은 성언에서 급성 호산구성 폐렴의 발생에 대한 증례가 보고되고 있다. 급성 호산구성 폐렴은 대개 발열을 동반하기 때문에 초기에는 감염성 폐렴으로 잘못 진단, 치료되는 경우가 많다. 아직 정확한 병태 생리 및 조직학적 소견은 밝혀져 있지 않지만 병력 청취 및 임상 양상, 방사선 소견의 관찰을 통해 급성 호산구성 폐렴을 의심하고, 진단을 위해 기관지 폐포 세척액 검사를 시행한다면 좀 더 쉽게 진단 내릴 수 있을 것이다. 본 저자들은 최근 처음 시작한 흡연에 의해 발생한 급성 호산구성 폐렴을 진단하고, 스테로이드를 투여하여 성공적으로 치료한 환자 2예를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Acute eosinophilic pneumonia(AEP) is characterized by acute febrile respiratory illness associated with diffuse pulmonary infiltration and pulmonary eosinophilia. The specific etiology for acute eosinophilic pneumonia is elusive. By some investigators, cigarette smoking is suggested as a causative substance which can cause AEP. In recent, the authors experienced two cases of AEP following cigarette smoking. Both cases had characteristic features including age around 20 years, new onset smoking before occurance of AEP, diffuse infiltration on chest radiography, pulmonary eosinophilia based on bronchoalveolar lavage and acute improvement after steroid therapy. These clinical features are resemble with previous smoking induced AEP case reports. Base on these clinical features, cigarette smoking associated AEP could be diagnosed more easily.

이산경험의 문학적 형상화 : 인도계 출신작가 나이폴과 루시디의 경우

박종성 충남대학교 아시아지역연구소 2004 아시아지역연구 Vol.6 No.-

This paper explores how V.S. Naipaul(1932 - ) and Rushdie(1947 - ), writers of Indian origin, construct diasporic narratives in the postcolonial era, focusing on their hybrid identities, nomadic sensibility, and a dual vision. Diaspora is a very important historical and political issue in the sense that colonialism is to blame for scattering and dispersing dispossessed peoples all over the world. The gist of my argument is that Naipaul and Rushdie not only challenge the validity of a monolithic British view from the perspective of the outsider but also create such uprooted characters as immigrants, refugees, and exiles. What is so distinctive to both writers is that they register the lives and voices of the displaced people. In this paper, I draw attention to the importance of writing diasporic narratives which has been wrongly belittled by either a nationalist discourse or a monolithic vision. Naipual's novels under discussion are The Mimic Men(1967), A Bend in the River(1979), The Enigma of Arrival(1987); Rushdie's are The Midnight Children(1980) and The Satanic verses(1989). I demonstrate that nomadic writers (or characters) are equipped with a dual vision as well as hybrid identities. I argue that their identities, perceptions, and strategies deserve our attention in a multicultural present time.

직장 구조조정과 파업에 의한 근로자의 사회심리적 스트레스의 변화

박봉진,이종태,손혜숙,김성준 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : This study was conducted to evaluate the insecurity of employment and anxiety by downsizing and strikes affected job characteristics and psychosocial distress of workers. Methods and Material : This is a longitudinal study of the container terminal workers in Pusan. The company operated downsizing from October to December in 1999 by economic depression. In the result of that, the number of workers decreased into 627 from 662. During that period, a new union was built and it made conflict between employers and employees, so the conflict caused the strikes from February to April in 2000. The first cross-sectional study was performed in February, 2000 and the oneyear follow-up cross-sectional study was performed in February, 2001. Socio-demo graphic characteristics, stress-related behavior, job characteristics and psychosocial distress were assessed with job content questionnaire(JCQ) and Psychosocial well-being Index(PWI) in 200 workers(white-collar: 100 men, blue collar: 100 men) from 662 men in total. Results : In the first study, job strain was high in the whole, but there was no difference between white and blue-collar workers. The level of PWI was very high at 86.67 points and the level of blue-collar workers was higher than that of white-collar workers(p=0.013). In the results of follow-up study, the rate of drinking and smoking decreased as the change of stress-related behaviors. In the job characteristics change, decision authority and physical exertion of the white-collar workers got lower(p<0.05), but social support and job strain didn't have no difference. In the PWI level change, stress level got rather higher(p<0.01), especially, increase of the white-collar workers' stress was big difference from that of the blue-collar workers'. Conclusion : Job stress management programs should be made to reduce stress. And in approaches to management and prevention, excessive physical exertion, shift work and irregular meals and breaks should be considered. Especially, this stress control program should be begun with recognition on conflicts between employers and employees and between employees and employees by downsizing and strikes. And also efforts to reinforce social support should be needed.

大明律直解의 韓國漢字語 一考察

朴盛鐘 영남대학교 2003 민족문화논총 Vol.28 No.-

Daemyeongryuljikhae(大明律直解) is the Korean translation of the Ming(明) penal code, Ta Ming Lu¨(大明律). That book is one of the extensive idu(吏讀) texts to be transmitted in the Yi dynasty, and contains so many Chinese words. These Chinese words are as a matter of course written in Chinese characters, but are composed of two groups of words. One group of these words belongs to Chinese, but the other group to Korean. This group is called Korean-Chinese in this paper, and that group is called Sino-Korean. On the whole Sino-Korean words dated back from the old classical texts of China. And Korean-Chinese words have been made by Koreans with the medium of Chinese characters from the early period. In Daemyeongryuljikhae the arrangement of each item of the Mling(明) penal code is usually as follows : ① the original text of written law for Ming - ② jikhae(直解) - ③ the notes of the original text - ④ jikhae. ① and ③ are written in Chinese sentences, while on the other ② and ④, namely jikhae(直解), in Korean idu sentences. Jikhae contains not only Sino-Korean but also Korean-Chinese. The Korean-Chinese words in jikhae are the Chinese counterparts, but both are not alike. Some Korean-Chinese words correspond to each one character in Chinese sentences. We can show '趣便'( ← 擅) as an example. The other some Korean-Chinese words are also composed of two Chinese characters, one of which has similarity in its meaning with one of the counterparts of Chinese sentences. '邊利'( ← 花利) is an example in this case. And another some Korean-Chinese words are also similar with but not much the same as the counterparts of Chinese sentences. One of these words is '門直人'(← 守門人), the word-order of which agrees with that of Korean. We can find many Chinese words included in Iduyakhae(吏讀略解) of Gyojeong Daemyeongryuljikhae(校訂 大明律直解) published in 1936. Those words which are marked with an asterisk(*) in it are distinguished from the idu words. We need to pick out the Korean-Chinese words from those Chinese words in Iduyakhae(吏讀略解) and make a classification of those words.

경피적 승모판막 성형술 전후 측정방법에 따른 승모판구 면적

성인환,이종구,박종훈 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

To assess mitral valve area(MVA) before and after percutaneous mitral ballon valvuloplasty (PMV), MVA was calculated by 2-D and Doppler (pressure half time) echocardiography before and 1 day after PMV. Also the catheterization derived MVA was calculated by modified Gorlin's fomula before and immediately after PMV. Among a total of 63 patients performed successful PMV, 29 patients were female and 24 patients were male. The age of the patients were between 21 and 68 years with the mean age of 42±12 years. On the EKG 34 patients showed a sinus rhythm 29 patients showed an atrial fibrillation. PMV was performed using Inoue balloon in 31 patients and double balloon in 32 patients with mitral stenosis. After PMV MVA by Gorlins formula, 2-D and Doppler echocardiography was increased from 0.84±0.22㎠ to 1.86±0.47, 1.86±0.31 and 1.76±0.34㎠, respectively (p<0.01). Before PMV MVA determined by the Gorlin's formula correlated closely with MVA by 2D and Doppler echocardiography (r=0.66 and r=0.69 respectively). However, after PMV MVA determined by the Gorlin's formula did not correlate well with MVA by 2-D and Dopper echocardiography (r=0.32 and r=0.41) However, after PMV MVA determined by the Gorlin's formula did not correlate well with MVA by 2-D and Doppler echocardiography (r=0.32 and r=0.41 respectively). Then Correlation between the 2-D planimeteral MVA and doppler derived MVA was good (r=0.82) After PMV the discrepancy of correlation may be bue to lack of simultaneous meusurements of MVA by echocardiogrphy and catheterization. Immediately after PMV the dramatic hemodynamic changes by have a disturbing effect of MVA measurement by Gorlin's formula. In conclusion, 2-D and Doppler echocardiography was non-invasive and effective method for assessment of MVA before and after PMV.