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배추흰나비(Pieris rapae L.)의 혈림프내 β - N - acetylglucosaminidase 에 관하여
김학렬,윤치영 고려대학교 한국곤충연구소 1986 昆蟲硏究誌 Vol.12 No.1
전기영동 및 면역학적 방법을 이용하여 배추희나비(Pieris rapae L.)의 혈림프 β-N-acetylglucosaminidase의 몇가지 特性을 調査하였다. 1. Haemolymph β-N-acetylglucosaminidase는 2種의 구성소단위로 되어 있으며 분자량은 각각 7.8×104, 7.4×104 dalton이었다. 2. Haemolymph enzyme과 면역학적으로 동일한 효소가 moulting fluid 내에도 존재하였다. 3. 5齡 幼蟲에서 羽化 前까지 全時期에 걸쳐 혈림프에는 효소의 量的 변화는 없었으나, 효소활성은 前踊初에서 증가하여 化 直後 최대의 활성을 나타내었으며 그 이후 급격히 감소하였다. 4. 抗 haemolymph β-N-acetylglucosaminidase에 대하여 fat body, gut, testis 그리고 integument는 precpitin line을 형성하였으나 saliva는 형성하지 않았다. 즉 면역적으로 동일한 haemolymph enzyme은 fat body, gut, testis 및 integument에는 존재하였으나 saliva에서는 존재하지 않았다.
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대학교 신입생의 특성에 관한 실태조사(1) : 1994학년도 조선대 신입생 일부를 대상으로 1994 Chosun University Entrants
김학렬,조용래,박상학,김상훈,박근무,표경식 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2
The main purposes of this survey are to identify the characteristics of entrants and to provide some suggestions for both a policy planning for entrants and student guidance. For this, entrants(N=868) who were admitted to natural science, engineering, education. fine arts, and other colleges of Chosun University(CU) in 1994 were surveyed with the questionnaire developed by authors. The questionnaire dealt with 1) demographic characteristics. 2) life environment - family relationship, family circumstances, economic conditions, 3) life during high school, 4) attitudes toward both the university and one's subject of study - major sources of informations about the university and attitude toward the university. major sources of informations about one's subject of study and attitude toward one's subject of study, 5) the plan of the university life and course after graduation, 6) interpersonal relationship, and 7) self-perception. The characteristics of entrants were globally examined, and differences between the sexes and differences among colleges in the characteristics described above, if any, were also mentioned. Some suggestions based on the results of this survey were provided in terms of both a policy planning for entrants and student guidance, Finally, one limitation of this survey was discussed from the standpoint of the generalization of the results and some suggestions for future surveys were also discussed.
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NCl-H157 폐암 세포주에서 Caspase Cascade 활성을 통한 Arsenic Trioxide와 Sulindac 병합요법의 세포고사 효과
김학렬,양세훈,정은택 대한결핵및호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.56 No.4
Arsenic trioxide(As2O3) was introduced into the treatment of refractory or relapsed acute promyelocytic leukemia. Some investigators have reported that arsenic trioxide had induced apoptosis in a variety of solid human tumor cell lines, including non-small cell lung cancer. Non-steroidal anti-inflammatory drugs(NSAIDs) are powerful chemopreventive agents for gastrointestinal cancers and the growth of established tumors are reduced by inducing apoptosis. It's also reported that NSAIDs enhanced tumor response to chemotherapeutic drugs or radiation. In this study, we aimed to determine whether combination of arsenic trioxide with sulindac augmented its apoptotic potential in NCI-H157 human lung cancer cells. The human lung cancer cell line NCI-H157 was treated with arsenic trioxide and sulindac. Cell viability was measured by the MTT assay. Apoptosis was measured by nuclear staining and flow cytometric analysis. The catalytic activity of the caspase families were measured by the fluorogenic cleavage of biosubstrates. The western blotting were also performed to define the mechanical basis of apoptosis.Combination treatment of arsenic trioxide and sulindac decreased the viability of NCI-H157 human lung cancer cells in a dose-dependent manner. The catalytic activity of caspase-3, 8 and 9 proteases were increased after combination treatment. Consistently PARP was cleaved from 116kDa to 85kDa fragments, and the expression of ICAD was decreased by time-dependent manner. Also combination treatment increased the expression of Fas and Fas/L.Combination therapy of arsenic trioxide with sulindac augments cell death and induces apoptosis via the activation of caspase cascade in NCI-H157 human lung carcinoma cells.(Tuberculosis and Respiratory Diseases 2004, 56:381-392)
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