시간의 흐름에 따른 핸드폰의 품질동태성에 관한 연구

윤성필(Sung-Pil Yoon),임성욱(Sung-Uk Lim),박만희(Man-Hee Park),조인희(In-Hee Cho) 한국엔터테인먼트산업학회 2010 한국엔터테인먼트산업학회논문지 Vol.4 No.3

본 연구는 선행연구에서 조사된 핸드폰의 고객요구속성을 Kano 모델의 품질특성에 적용하여 시간의 흐름에 따라 어떤 변화가 있는지를 살펴보고자 한다. 또한 고객들의 새로운 요구속성이 나타났는지도 함께 살펴보고자 한다. 많은 문헌과 선행연구에서 나타나고 있는 시간에 따른 품질특성의 이동이 매력적 품질에서 일원적 품질로 일원적 품질에서 당연적 품질로 변화하는 진부화(陳腐化)현상이 나타나는지도 함께 살펴보고자 한다. In this study, previous research (Sung-Uk Lim, 2004) surveyed in customer demand for mobile phones the quality characteristics of properties applied to the Kano model, the flow of time, depending on whether any changes will be discussed. In addition, our customers" new requirements will be examined along with the property map appeared. The movement of time-dependent quality characteristics appeared in many previous studies Obsolescence Phenomenon - from Attactive Quality Element to One-Dimensional Quality Element, from One-Dimensional Quality Element to Must-Be Quality Element - may appear be examined together.

Efficient Interleukin-21 Production by Optimization of Codon and Signal Peptide in Chinese Hamster Ovarian Cells

( Hee Jun Cho ),( Byung Moo Oh ),( Jong-tae Kim ),( Jeewon Lim ),( Sang Yoon Park ),( Yo Sep Hwang ),( Kyoung Eun Baek ),( Bo-yeon Kim ),( Inpyo Choi ),( Hee Gu Lee ) 한국미생물 · 생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.2

Interleukin-21 is a common γ-chain cytokine that controls the immune responses of B cells, T cells, and natural killer cells. Targeting IL-21 to strengthen the immune system is promising for the development of vaccines as well as anti-infection and anti-tumor therapies. However, the practical application of IL-21 is limited by the high production cost. In this study, we improved IL-21 production by codon optimization and selection of appropriate signal peptide in CHO-K1 cells. Codon-optimized or non-optimized human IL-21 was stably transfected into CHO-K1 cells. IL-21 expression was 10-fold higher for codon-optimized than non-optimized IL-21. We fused five different signal peptides to codon-optimized mature IL-21 and evaluated their effect on IL-21 production. The best result (a 3-fold increase) was obtained using a signal peptide derived from human azurocidin. Furthermore, codon-optimized IL-21 containing the azurocidin signal peptide promoted IFN-γ secretion and STAT3 phosphorylation in NK-92 cells similar to codon-optimized IL-21 containing original signal peptide. Collectively, these results indicate that codon optimization and azurocidin signal peptides provide an efficient approach for the high-level production of IL-21 as a biopharmaceutical.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

음향방출법에 의한 탄소섬유강화 플라스틱의 파괴특성에 관한 연구 (2)

윤종희,이장규,박성완,우창기,김봉각,조진호 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

This study is to investigate a fracture characteristics of carbon fiber reinforced plastics (CFRP) under the tensile loading as a function of acoustic emission (AE) according to the frequency analysis (transient mode) and AE source location (location mode). It was found that the fracture mechanism of AE frequency analysis was a useful tool for the estimation of different type of fracture in CFRP, i.e., matrix(epoxy resin) cracking, delamination and fiber breakage same as AE amplitude distribution.

제조업 근로자에서 직무 스트레스가 자율 신경계 활성도에 미치는 영향

윤기정,하미나,김재용,이상윤,임형준,신애선,황승식,김정수,강대희,조수헌 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.3

목적 : 자율신경계 활성도와 직무 스트레스와의 연관성을 구명하기 위해 본 연구를 수행하였다. 직무 스트레스에 의한 심혈관계 질환 발생의 주요 기전으로 자율 신경계 활성도, 특히 교감신경계의 활성화가 기존의 연구에서 제시되고 이는 바, 이러한 자율신경계 활성도를 생리학적 지표(심박수 변동성; Heart rate variability, HRV) 및 생체시료(요중 카테콜아민)를 이용하여 정량적으로 평가하고 이들의 수준과 직무 스트레스와의 연관성을 구명하는 것을 목적으로 한다. 방법 : 천안시 소재 제조업체의 생산직 남성 근로자 145명을 대상으로 하여 단면연구를 실시하였다. 연구 대상자들은 동일한 근무조건(4조 3교대)로 한정하였다. 직무스트레스는 '직무 만족도 설문조사(Karasek's Job Conten Questionnaire, JCQ)'를 이용하여 평가하였고, 자율신경계 기능은 심박수 변동성과 요중 카테콜아민(에피네프린, 노에피네프린, 도파민)을로 평가하였다. 시료 수집 및 심박수 변동성 측정은 자율신경계의 일주기 리듬을 고려하여 각 연구 대상자들에게 각 교대근무대별로 각각 3회 반복 측정하였다. 직무 만족도 설문조사(49문항)와 함께 인구학적 사항, 직업력, 과거병력, 흡연, 음주력 등에 대한 자기 기입식 설문조사를 시행하였다. 결과 : 직무 만족도 설문조사에 의해 평가된 직무 스트레스 수준을 직무긴장모형(job strain model)에 의한 4개 집단으로 나누었을 때 연구 대상자들은 저긴장 집단(low strain) 24명, 고긴장 집단(high strain) 32명, 수동적 집단 65명, 능동적 집단 20명으로 분포하였다. 직무긴장모형 4개 집단간의 심박수 변동성 및 요중 카테콜아민의 유의한 차이는 없었으며, 심박수 변동성중 특히 심혈관계 질환의 주요 기전으로 제시되는 교감신경계의 활성을 나타내는 저주파 변동성도 4개 집단간에 유의한 차이는 없었다(p-value=0.71). 하지만, 직무기간을 사분위수로 나눈 후 직무 기간이 가장 짧은 군(직무기간<48.5개월, N=28)을 대상으로, 직무긴장모형의 4개 집단간의 저주파 변동성(교감신경 활성도 지시) 차이 비교를 위해 일원분산분석을 시행한 결과 집단-간(between group) 동질성검정이 p-값 0.092의 유의확률을 나타내었다. 결론 : 자율신경계 활성도, 특히 심박수 변동성을 이용한 정량적 평가를 통해 직무 스트레스와의 연관성을 평가한 연구라는 점에서 의의를 지닌다. 제한적이긴 하지만, 근무기간이 짧은 군에서 저긴장 집단과 고긴장 집단간의 저주파 변동성의 차이를 보여 심박수 변동성이 잠재적인 생리적 지표가 될 수 있음을 시사한다. Objective: A cross-sectional study was conducted to evaluate the relationships between autonomic nerve activity (i.e., heart rate variability and urinary catecholamines) and job stress. Methods: The study was conducted on 134 workers from a company producing consumer goods (i.e., diaper, paper towel) located in Cheonan, Korea. Job stress was assessed by Karasek's Job Content Questionnaire (JCQ), Autonomic function was assessed by heart rate variability (HRV) and urinary catecholamines (eponephrine, norepinephrine, and dopamine). Urine samplings, and measurings of HRV, were repeated three times for each shift. Information on demographic characteristics, previous job histories, past medical history, smoking and drinking were also collected. Results: No statistically significant differences were observed in ant HRV and urinary catecholamines among the four groups, which were categorized by the Job Strain Model. When data were stratified by work duration, low field HRV was borderline sigificantly higher in the high strain group in individuals with a sgorter work duration (<48.5 months, N=28, p-value of 0.92 by analysis of variance). Conclusions: Neither HRV nor urinary catecholamines are significantly associated with job stress, as assessed by the Karasek's JCQ. However, HRV seems to be a potential physiological incicator of jov stress only in the workers with a shorter work duration.

유아기의 신체활동과 발육ㆍ발달에 관한 연구

조성호,윤해철,권기욱 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

This study was conducted for 216 infants (64 two-year-old males and 64 three-year-old males and 44 females) on the infant physical aptitude test, the infant educational program of the "H" sport center located in Kangdong-ku, Seoul. Both the physical fitness test and the exercise ability test were conducted for the two-year-old infants having 1-month exercise period and the three-year-old infants having a 18-month exercise period. As a consequence of inquiring into them by gender and y exercise period and of analyzing the relationship between physical fitness and exercise period, the following conclusion was obtained. 1. It could not be found that male infants' physical fitness varied significantly according to exercise period and that female infants' standing height and body weight varied significantly according to exercise period(p<.05). 2. It was shown that flexibility-sit and reach test of infants' exercise ability had a very significant difference according to exercise period for both male and female infants(p<.05). 3. It was found that foot and toe balance of infants' exercise ability showed a significant difference according to exercise period and that female infants showed a very significant difference(p<.05). 4. It was shown that in measuring power of infants' according to exercise period and it varied significantly for female infants(p<.05). 5. It was shown that in measuring muscular endurance, of infant's exercise ability, and sit-up infant's exercise ability had a very signigicant difference for both males and females according to exercise period(p<.05). And it was shown that V-form sit varied very significantly for both male and female infants(p<.05). 6. It was shown that as result of measuring agility of infant's exercise ability 25M-run varied very significantly for both male and female infants but that it varied more significantly for female infantstha for male infants(p<.05).

흉부 둔상 후 전종격동 출혈에 의한 종격동 압전 1예

윤상규,박종석,조준필 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Sternal fractures are most common in drivers of motor vehicles whose anterior chest hits the steering wheel during sudden deceleration. Sternal fractures may result in mediastinal hematoma secondary to bone marrow oozing. The hematoma usually resolves itself without complications, so an anterior mediastinal hematoma causing tamponade is rarely reported. We describe a case of blunt chest trauma resulting in a sternal fracture with a resultant anterior mediastinal hematoma and mediastinal tamponade.

STI571 (Glivec^(�))에 의하여 빠른 치료 반응을 보인 불응성 Gastrointestinal stromal tumor

윤경원,이제중,김여경,황호인,이병환,조상희,정익주,김형준 全南大醫大 2001 전남의대학술지 Vol.37 No.4

황토 벽돌벽 주택의 실내공기질에 관한 연구

조성우,이재윤 三陟大學校 産業科學技術硏究所 2003 産業科學技術硏究論文集 Vol.8 No.1

The purpose of this study was to evaluate air quality in the earth brick wall house by measuring. The concentration of CO. CO₂, NO₂, SO₂ was measured using Indoor Air Quality Monitor(BABUC-A) and Radon was measured by Gas Monitor(RAD-7). 1) The concentration of CO and CO₂ were l..65ppm and 427ppm as average value. 2) The average concentration of SO₂ was 0.45ppm in the reference house. 3) The average radon concentration was 0.903 pCi/L and the maximum value was 2.134 pCi/L. The air pollution concentration of the reference house was showed under the criterion of air pollution was published by the Building standards Act in Korea.