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조성우,지현근,안현성,홍기우,박혜림 대한흉부심장혈관외과학회 2001 Journal of Chest Surgery (J Chest Surg) Vol.34 No.1
성인의 선천성 식도 기관지루는 드문 질환이고 그 중 Braimbridge 제III형은 매우 드물다. 본 교실은 폐내형 기관지성 낭종을 동반한 선천성 식도 기관지루(제III형) 1례를 경험하였다. 환자는 38세 남자로 내원 3일전부터 시작된 기침과 복통을 주소로 내원하였다. 식도조영술상 식도와 우폐하엽의 낭성 병변사이에 누관이 발견되었다. 누공절제술과 우폐하엽과 우폐중엽 절제술을 시행하였고 수술후 경과는 별 문제가 없었다.
조성우,Hoang Thi Huong,이시윤,안병현,임권택 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
The pH-/thermal-responsive hydrogels for colon-targeted drug delivery applications were prepared based on ionic cross-linked of Polyacrylic acid (PAA), Norbornene-modified Chitosan (CsNb) then chemically crosslinked with bis Tetrazine-Poly(N-isopropyl acrylamide) (bis Tz-PNIPAM). PAA provided the system’s pH-responsiveness property with least swelling and drug release at acidic, meanwhile strong swelling and release in alkaline environment. Bis Tz-PNIPAM crosslinker led to increasing of drug loading content because of more porosity structure, and controlled the release based on shrinkage mechanism. Hydrogels provided highly drug loading content, performed the least swelling, least drug release fraction at pH 2.2 (8.5%), rapidly swelling and enhanced release at pH 7.4 (95%). These above features made hydrogels the suitable carrier for colon targeted drug delivery.
조성우,정혜원,정나슬,정재현 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
This study aims to create a novel functional poly(amino acid)s with multivalent reactive groups by top-down synthesis and exploits those conductive moieties to stimulate electrically. It is the hypothesis that the incorporation of this functional polymer into the hydrogel surface via micro-contacting printing (μCP) method would induce the electrically conductive hydrogel which is locally and selectively stimulated. This hypothesis was examined by in situ polymerization of pyrrole molecules with varying degrees of substitution (DS) to control the electrical conductivity. This approach allowed the surface density of the pyrrole to be adjusted without changing the concentration of the pyrrole monomer in the hydrogel. Hence, this new strategy to prepare the electrically conductive hydrogel using the functionalized poly (amino acid)s would be actively applied to biomedical applications such as neuron-muscle tissue engineering, bioactuators, and Bio-MEMS.
조성우,지현근,이재진,신윤철,남은숙 대한흉부심장혈관외과학회 2000 Journal of Chest Surgery (J Chest Surg) Vol.33 No.6
Epithelial-myoepithelial carcinoma is a rate low-grade malignant salivary neoplasm that usually occurs in the parotid gland but can also arise in minor salivary glands. We report a case of a primary epithelial-myoepithelial carcinoma of the lung neoplasm. The patient was 48-year-old women who presented with dry cough of 1 month duration. A right middle lobe endobronchial lesion was identified bronchoscopically. The bilobectomy of RML & RLL was performed, the pathologic result was epithelial-myoepithelial carcinoma.
조성우,김형규,성지희,김예슬,김재호,한진 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.5
Simultaneous myofibril and mitochondrial development is crucial for the cardiac differentiation of pluripotent stem cells (PSCs). Specifically, mitochondrial energy metabolism (MEM) development in cardiomyocytes is essential for the beating function. Although previous studies have reported that MEM is correlated with cardiac differentiation, the process and timing of MEM regulation for cardiac differentiation remain poorly understood. Here, we performed transcriptome analysis of cells at specific stages of cardiac differentiation from mouse embryonic stem cells (mESCs) and human induced PSCs (hiPSCs). We selected MEM genes strongly upregulated at cardiac lineage commitment and in a time-dependent manner during cardiac maturation and identified the protein-protein interaction networks. Notably, MEM proteins were found to interact closely with cardiac maturation-related proteins rather than with cardiac lineage commitment-related proteins. Furthermore, MEM proteins were found to primarily interact with cardiac muscle contractile proteins rather than with cardiac transcription factors. We identified several candidate MEM regulatory genes involved in cardiac lineage commitment (Cck, Bdnf, Fabp4, Cebpα, and Cdkn2a in mESC-derived cells, and CCK and NOS3 in hiPSC-derived cells) and cardiac maturation (Ppargc1α, Pgam2, Cox6a2, and Fabp3 in mESC-derived cells, and PGAM2 and SLC25A4 in hiPSC-derived cells). Therefore, our findings show the importance of MEM in cardiac maturation.