방사선 조사를 받은 두경부 병소의 재건을 위한 유리피판술

채수욱,고경석,김주봉,박상훈,한상훈,이택종,남순열,김상윤 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Radiation therapy is an effective cancer treatment modality as a primary treatment in early cancer and as an adjuvant treatment in advanced cancer, especially in head and neck lesions, but it also causes irreversible chronic damages to overlying normal tissues that may lead to wound complications. As well, at the microscopic level, radiation injury causes both stasis and occlusion of small vessels. Therefore, surgical reconstruction of previously-irradiated lesions in the head and neck poses a great problem. Fifth-six patients with head and neck lesions underwent 57 microsurgical reconstructions between 1990-1998. Thirteen patients were irradiated before surgery. The previous radiation dose was 30∼75.6 Gy. The free tissue transfer was successful in 52 of the 57 microsurgical reconstructions(91.2%). The success rate was 92.3%(12/13) in previously-irradiated patients and 90.9%(40/44) in nonirradiated patients. Postoperative complications, such as flap loss, fistula, and infection, developed in 4 irradiated patients and 8 nonirradiated patients. Overall complication rate was 30.8%(4/13) in previously-irradiated patients and 18.2%(8/44) in nonirradiated patients. Although the failure rate of previously-irradiated patients was higher than that of nonirradiated patients, there was no statistically significant difference between them. Thus, free tissue transfers in patients with previously-irradiated head and neck lesions are suitable for one-stage reconstruction.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

정신분열병 양성 및 음성증상과 혈소판 Monoamine Oxidase 활성도

윤성환,김영훈,진성태 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.1

The intention of this study to investigate the relationship between the activity of platelet MAO and positive and negative symptoms in the male chronic schizphrenics by DSM-III. The authors devided the male chronic schizophrenics into positive, mixed and negative subgroups by Andreasen & Olsen Criteria(1982), and also each patient was evaluated in relation with positive and negative symptom scales proposed by Lewin & Meltzer(1984). The authors assayed kinetic constants(Vmax and Km) for platelet MAO from 22 drug-free schizophrenics and 22 normal controls, radioenzymatically using 14C-benzylamine as a substrate. The results were as follows ; 1) Schizophrenic subjects had a lower mean Vmax Value(5.20±1.58 nmoles10(-6) platelets/hr) and Km value(38.92±19.28×10(-6)M) for poatelet MAO than normal controls(8.07±4.54, 49.56±18.48). Authough lower mean Vmax had a statistical significance, Km did not have. 2) In case of paranoid group(n = 6), there were no statistical differences in kinetic constants for platelet MAO compared with non-paranoid group(n = 16). 3) There were no significant differences in kinetic constants for platelet MAO between positive, mixed and negative symptom group. 4) The difference between kinetic constants for platelet MAO and positive symptom scale and negative symptom scale were not significant statistically. 5) Each scale item in the negative symptoms was not significantly different from platelet MAO activity. Finally, we confirmed that activity of platelet MAO was lowered in chronic schizophrenics, but we did not find any possible relationship between the negative symptom of schizophrenia and kinetic constants for platelet MAO.

머리염색이 인체에 미치는 영향

윤형식,황성호,이현륭,김수호,박연석,권낙현,정호진,김동훈,노현주,홍성호,박병찬,이관,정해관 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

일상생활에서 모발염색은 흔히 접할 수 있는 미용의 한 종류로 특히 젊은층을 중심으로 폭발적으로 유행하고 있다. 염색을 위항 사용하는 약제는 표백제와 발색제 등 각종 화학약품이 사용되고 있으나 이로 인한 건강장해에 대한 연구는 그리 많지 않다. 저자들은 염색이 인체의 모발건강에 미치는 영향을 파악하기 위하여 염색과 관련된 주관적 증상과 모발의 변화에 대한 실험적 연구를 시행하였다. 동국대학교 경주 캠퍼스 재학생 80명을 대상으로 설문조사를 시행하여 염색 유 ·무 및 염색 후에 경험한 증상에 대해 설문 조사하였고, 의과대학 재학생 46명을 대상으로 피부 반응 테스트를 실시하였다. 또한 염색 전후의 모발 탄성도를 측정하였고 모발의 상태를 파악하기 위해 전자 현미경검사를 실시하였다. 설문조사 결과 염색 전에 비하여 염색 후 안구혼탁, 안구건조, 시력저하, 발진 및 접촉성 피부염, 모발손상, 모근손상 등의 증상을 더 많이 경험한다고 호소하였다(p<0.05). 모발손상과 모근손상은 헤어드라이어 사용 빈도에 따라 증가하는 것으로 조사되었다(p<0.05). 피부반응검사에서 가려움증이 가장 많은 증상이었으며 이는 여성보다는 남성에서 높은 것으로 조사되었다. 염색 전후의 모발장력은 염색 전 134.5±10.37g, 염색 128.0±30.69g, 염색 이틀 후 112.5±19.69g으로 나타났다. 염색 전후의 모발의 전자현미경 케라틴 층이 현저히 감소하고 모발이 가늘어지는 차이를 보였다. 염색은 모발손상, 모발 케라틴 손상 및 모근 손상, 발진 및 접촉성 피부반응, 안구혼탁, 안구건조, 시력 저하를 유발한다. 따라서 염색약으로 인한 손상에 대한 주의와 예방이 필요하다고 생각한다. 예방대책으로 염색 전 피부테스트를 통한 적합성 여부를 판단하는 것이 필요하며 가급적 염색을 피하는 것이 좋을 것이다. 염색약에 발암물질이 포함되어있다는 보고도 있어 염색 제조사의 철저한 실험과 염색 물질의 선별이 염색으로 인한 부작용을 최소화하는데 중요한 역할을 할 것이다. Hair coloring has became one of the most popular cosmetic activities to younger generations during last decade. However, there are few studies on the health effect of widespread use of chemical dyes. This study was conducted to study the effects of hair coloring dye on hair and other systems. We conducted a questionnaire survey of 80 persons in Kyongju campus, Dongguk University. We have done open patch skin test on 46 medical students. We also conducted scanning electron microscopy to examine the hair strength and structure before and after hair coloring process. Injury of hair and hair bulb, contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity were the main symptoms complained after hair coloring (p<0.05). Injury of hair and hair bulb were increased by frequency of hair-dryer use(p<0.05). In open patch test, pruritus was complanined by more than half of the subjects. Mean strength of hairs before and after hair coloring was as follows; 134.5 (SD 10.37)g before hair coloring, 128.0 (SD 30.69)g immediately after hair coloring, and 112.5 (SD 19.69)g after two days. The scanning electron microscopic findings of hair surface before and after hair coloring showed decreased keratin layer and thinning of the hair. Hair coloring induces injury to hair, its keratin layer, and hair bulb as well as contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity. Therefore, we think that precaution is needed in use of hair coloring dye. To prevent complications induced by hair coloring dye, it is necessary, especially to those with allergy or skin disorders, to perform skin test before action and avoid hair coloring whenever possible. Longterm health effects of hairdye should be studied and manufacturing companies should try to minimize complications induced by hair coloring dye.

남중 육상경기 선수의 Foot Ratio와 체력과의 상관

윤길환,서국웅,이훈식,정미라,윤양진,박승범 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-

Foot ratio and physical fitness were measured and multiple-compared in the level of P<.05 on the subject of 28 prize winners from Men's part of middle school in the field and track events of the "P" youth athletic tournament in 1998 and 7 general students adopted by random sampling. These are conclusions from the result of relative analysis of foot length measured by X-ray, Medial longitudinal arch's height, foot ratio and physical fitness in the level of P<.05. 1. No significance was discovered in FR but throwing group is better than medium and long distance group. 2. Flexibility and endurance have meaning in physical fitness. The short distance group has better flexibility than the medium and long, throwing and general one. And medium and long distance/ throwing group have better endurance than general one. 3. FR and physical fitness show a negative correlation in the muscular strength of throwing group.

이중 산화구 시스템에서 HRT에 따른 유기물 및 영양염류의 처리성 평가

윤조희,김승현,이상훈,정기홍 경남대학교 환경문제연구소 1999 환경연구 Vol.22 No.-

This study was conducted to estimate treatability of organics and nutrients at new developed double oxidation ditch system when the ratio of anoxic/oxic basin volume was 1. An internal recycle pump did not need because of using with port and baffle in this system. The results obtained from this study were as follows. The removal efficiency for TOC was over 93%, and the removal rate was 1215.3 g/㎥/day when the HRT was over 8hr. The removal efficiency for TIN was over 85%, and the maximum removal rate was 110.6 g/㎥/day when the HRT was over 16hr. The removal efficiency for PO₄^(3-)-P was 83%, and the maximum removal rate was 25.4 g/㎥/day when the HRT was 16hr.

콩에서 발생하는 강낭콩일반모자이크바이러스(BCMV)와 땅콩위축바이러스(PSV)의 저항성 평가

이영훈, 윤영남, 강범규, 김현영, 최만수, 구성철, 김현태, 윤홍태, 이수헌, 백인열 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

It has been reported several viral diseases in soybean. The occurrence of Bean common mosaic virus and Peanut stunt virus are able to induce severe problem because the main breeding target for viral disease was focused on Soybean mosaic virus. BCMV is a spcies of the genus Potyvirus of the family Potyviridae. BCMV reduces yield by as much as 80% and also adversely affects seed quality in common bean. BCMV has a worldwide distribution because of its high rates 35% of transmission via seeds produced by plants systemically infected prior to bloom. PSV is a species of the genus Cucumovirus of the family Bromoviridae. PSV has been reported to be economically damaging on beans worldwide. Although the virus is reportedly seed transmissible at very low rates, infected plants rarely produce pods with normal viable seeds. The most satisfactory management method of viral diseases such as BCMV and PSV is the use of resistant cultivars and healthy seed. For the overcome of genetic resistance by new virus such as BCMV and PSV, virus diseases monitoring and researches need to study deeply and continually. In this study, we conducted the resistance screen on BCMV and PSV for selection of resistance cultivars. We inoculated on 128 cultivars with PSV and BCMV respectively. These cultivars were classified through pathogenic response such as resistance, necrosis and susceptibility. In addition, 99 and 66 resistant cultivars were confirmed against PSV and BCMV respectively.

요골동맥을 이용한 관동맥 조영술의 유용성

윤정한,이승환,이한요,김장영,김일회,최윤종,이형준,이명옥,김승년,황성오,홍인수,최경훈 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.10

악골 외상성 골 낭의 임상 및 병리조직학적 분석

윤정훈,김도경,안상건,김수관 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1

We reviewed a series of 22 traumatic bone cysts of the jaws experienced during the 21-year period between 1982 and 2002 at the Chosum University Dental Hospital. The study group consisted of 13 females (59.1%) and 9 males (40.9%). The patient's mean age was 25.2 years, with peak incidence occuring in the first and second decade. Most traumatic bone cyst was located in the posterior mandible. Radiographically, well-defined round radiolucent (9 cases) or scalloped appearance (8 cases) were the predominant type, whereas 2 cases were ill-defined. A provisional clinical diagnosis was varied, only 9 of which were correct. Histopathologically, all the biopsy specimen composed of loose fibrous connective tissue accompanied by inflammatory reaction (13 cases), giant cells (9 cases). In addition, calcifications (6 cases) and new bone formation (5 cases) in the cyst wall were also observed. Taken together, correlative analysis of histopathologic and clinico-radiographic features is essential for definitive diagnosis and management.

緯度와 地形에 따른 溫帶中部 溪谷植生의 種多樣性 및 群集構造에 關한 硏究

尹相旭,辛壽哲,郭東勳,金昌浩 동국대학교 농림과학연구소 1994 農林科學 論文集 Vol.18 No.-

This study was Carried out to analyse species composition, species diversity and structure and variation trends of vegetation, of Mt. Odae, Mt. Sobaek, and Mt. Juwang following various latitudes and topographies which were in middle temperate zone in Korea. Obtained results are as follows : 1. As a result of the simple discriminant analysis, soil texture Showed the highest high percent contribution of each environmental factor to the discriminant of Studred area. And Mt. Odae showed high content of sand while Mt. Juwang Showed silt. 2. Mean stem density showed highest value in Mt. Juwang and mean D. B. H. was Mt. Odae, and on phisiographic locations showd high values of stem density and mean D. B. H in slow slope area, nothern aspect area, and high elevation area, in order. 3. Species that showed the highest importance value in each canopy-subtree-shrub layer in study area were Quercus mongolica-Acer pseudo-sieboldianum-Lindera obtusiloba were in Mt. Odae, Betula platyphylla var. japonica-Styrax obassia-Deutzia parviflora were in Mt. Sobaek, and Pinus densiflora-Acer pseudo-sieboldianum-Lindera obrusiloba were in Mt. Juwang. 4. Species that showed the highest importance value in each canopy-subtree-shrub layer on the physiographic location were Quercus mongolica-Acer pseudo-sieboldianum-Lindera obtusiloba in high elevation and southern aspect, Carpinus laxiflora-Acer pseudo-sieboldianum-Lindera obtusiloba in high elevation and southern aspect, Carpinus laxiflora-Acer pseudo-sieboldianum-Lindera obtusiloba in nothern slope, Carpinus laxiflora-Styrax obassia-Lindera obtusiloba in low elevation, and Betula platyphylla var. japonica-Styrax obassia-Deutzia parviflora in high elevation. 5. According to decrease of latitudes with going down from Mt. Odae to Mt. Juwang, the more Number of species and individuals were increased, and the deversity index was the highest value in Mt. Sobaek, the evenness was in southern aspect, and the dominance was in high elevation. 6. As a result of Cluster analysis, the study area were divided into 4 groups, Carpinus laxiflora community, Styurax obassia community, Deutzia parviflora community, and Quercus mongolica community. 7. As a result of COA analysis, communities of the study area were divided into Betula platyphylla var. japonica community, Deutzia parviflora community, Quercus mongolica-Acer pseudo-sieboldianum community, and species were divided into 4 groups as the major, the disturbed, the waterside, and the fertile. 8. As results of the simple discriminant analysis and the linear regression, sand and silt content, slope aspect, total nitrogen content, and elevation among environmental factors had high percent contribution to classification and ordination of vegetation communities of the study area. 9. Major tree species had the unstable layer structure due to lower importance values of canopies and subtrees than those of shrubs, and Pinus laxiflora and Betula platyphylla var. japonica were on the decline phase due to very low dominance and absence of next generation. while, Styrax obassia and Acer pseudo-sieboldianum were sustanable layer structure as being distributed on all the crown layer.