Ergotism associated with ketoconazole: A case report

권낙현,김덕경 대한내과학회 2009 대한내과학회 추계학술대회 Vol.2009 No.-

21세기를 향한 교육과정의 방향

권낙현 한국교육개발원 1986 한국교육 Vol.13 No.1

해외여행자의 Atovaquone-proguanil 순응도

권낙현,강효성,박태수,김성훈,황래석,노혜진,방지환,김재윤,신형식 대한감염학회 2008 Infection and Chemotherapy Vol.40 No.5

Background : Recently, many Korean people travel abroad where malaria is prevalent. However, in Korea, relatively little is known about compliance of chemoprophylaxis against malaria. This study was performed to determine the factors influencing compliance of chemoprophylaxis against malaria in Korean travelers. Materials and Methods : Face to face interview, telephone interview and e-mail correspondence were performed to 241 people who were prescribed with atovaquone-proguanil at the international travelers' clinic of National Medical Center between February 2007 and October 2007. Results : Total of 55 people out of 235 reported one or more events of adverse reactions after chemoprophylaxis (total 76 events). However, in 38 adverse events the link between chemoprophylaxis and adverse events were very weak. Compliance of malaria chemoprophylaxis with atovaquone-proguanil was 53.9% in the study group. The predictive factors for non-compliance were package tour, travel of business affair and young age group. Conclusions : Compliance of malaria chemoprophylaxis in Korea travelers was low compared with Dutch and French studies. More efforts to increase compliance are needed, especially in travelers on package tour, business travel and people under age 40. Background : Recently, many Korean people travel abroad where malaria is prevalent. However, in Korea, relatively little is known about compliance of chemoprophylaxis against malaria. This study was performed to determine the factors influencing compliance of chemoprophylaxis against malaria in Korean travelers. Materials and Methods : Face to face interview, telephone interview and e-mail correspondence were performed to 241 people who were prescribed with atovaquone-proguanil at the international travelers' clinic of National Medical Center between February 2007 and October 2007. Results : Total of 55 people out of 235 reported one or more events of adverse reactions after chemoprophylaxis (total 76 events). However, in 38 adverse events the link between chemoprophylaxis and adverse events were very weak. Compliance of malaria chemoprophylaxis with atovaquone-proguanil was 53.9% in the study group. The predictive factors for non-compliance were package tour, travel of business affair and young age group. Conclusions : Compliance of malaria chemoprophylaxis in Korea travelers was low compared with Dutch and French studies. More efforts to increase compliance are needed, especially in travelers on package tour, business travel and people under age 40.

Ergotism associated with ketoconazole: A case report (초)

권낙현,김덕경 대한내과학회 2009 대한내과학회지 Vol.77 No.4S

포스터 전시 발표 순서 : 소화기 ; 장기 이식과 무관한 거대세포바이러스 위장관 감염 8예의 임상 경과 (초)

권낙현,남승우,이성은,권혁춘 대한내과학회 2008 대한내과학회지 Vol.75 No.1S

해외여행자의 Atovaquone-proguanil 순응도

권낙현,박태수,강효성,김성훈,황래석,노혜진,방지환,김재윤,신형식 대한감염학회 2008 감염과 화학요법 Vol.40 No.5

Background : Recently many Korean people travel abroad where malaria is prevalent. However, in Korea relatively little is known about compliance of chemoprophylaxis against malaria. This study was performed to determine the factors influencing compliance of chemoprophylaxis against malaria in Korean travelers. Materials and Methods : Face to face interview, telephone interview and e-mail correspondence were performed to 241 people who were prescribed with atovaquone-proguanil at the international travelers' clinic of National Medical Center between February 2007 and October 2007. Results : Total of 55 people out of 235 reported one or more events of adverse reactions after chemoprophylaxis (total 76 events). However, in 38 adverse events the link between chemoprophylaxis and adverse events were very weak. Compliance of malaria chemoprophylaxis with atovaquone-proguanil was 53.9% in the study group. The predictive factors for non-compliance were package tour, travel of business affair and young age group. Conclusions : Compliance of malaria chemoprophylaxis in Korea travelers was low compared with Dutch and French studies. More efforts to increase compliance are needed, especially in travelers on package tour, business travel and people under age 40.

장기 이식과 무관한 거대세포바이러스 위장관 감염 8예의 임상 경과

권낙현,남승우,이성은,권혁춘 대한내과학회 2008 대한내과학회 추계학술대회 Vol.2008 No.-

대사증후군 위험인자 집적도, hs-CRP, 죽상동맥 경화증의연관성 고찰

노혜진,권낙현,주신배 대한심장학회 2006 Korean Circulation Journal Vol.36 No.12

Background and Objectives:Metabolic syndrome and high sensitivity C-reactive protein (hs-CRP) are known tobe strong predictors of coronary atherosclerosis. Even though there have been many observations and much researchconcerning the association of coronary atherosclerosis with CRP and metabolic syndrome, certain problems stillneed to be resolved in order to produce clear mechanistic illustrations. Therefore, the correlations of metabolicsyndrome, hs-CRP and the severity of coronary atherosclerosis were evaluated herein. Subjects and Methods:271 patients, aged between 29 and 87, who had undergone diagnostic coronary angiograms at the National MedicalCenter, between January, 2004 and June, 2006 were evaluated. Coronary angiograms were performed in patientswho complained of typical chest pain and had risk factors associated with coronary atherosclerosis. The correlationsof metabolic syndrome, hs-CRP and coronary atherosclerosis were analyzed in these patients. Results:Positiverelationships were found between the metabolic syndrome risk factor clustering and an increased level of hs-CRP(p<0.01). The severity of coronary atherosclerosis increased with the increasing number of metabolic syndrome riskfactors. As metabolic syndrome risk factor clustering increased, the quantity of 1, 2 and 3 vessel diseases also increased(Odd ratios 1.61, 1.83 and 2.50; p=0.001, <0.001 and <0.001, respectively). In contrast to metabolic syndromerisk factor clustering, no definite relationship between the hs-CRP level and the severity of coronary atherosclerosiswas observed. Conclusion:The more metabolic syndrome risk factors clustered, the greater the severityof coronary atherosclerosis. The extension of coronary atherosclerosis maybe predicted using evaluation of metabolicsyndrome risk factor clustering in patients with angina. (Korean Circulation J 2006;36:802-808) 배경 및 목적:아직까지 그 인과 관계가 명확히 밝혀져 있지는 않지만 대사증후군을 구성하는 위험인자가 많은 환자 군에서 hs-CRP수치가 증가되어 있다는 연구결과들이 많이 발표되어 왔으며대사증후군 및 hs-CRP는 관동맥 죽상경화증의 강력한 예측인자로서 널리 알려져 있다. 이러한 연구결과들은 염증반응이 관동맥 죽상경화증의 발생과 경과에 중심적 역할을 하는것과 연관되어 있을 것이다. 이 연구의 목표는 대사증후군위험인자 집적도, hs-CRP 및 관동맥 죽상경화증 중증도와의 연관성을 고찰함으로써 관동맥 죽상경화증과 대사증후군위험인자 및 염증반응의 상관관계를 알아보고자 한다.방 법:2004년 1월부터 2006년 6월까지 국립의료원에서 관상동맥조영술을 시행한 29세에서 87세 환자 271명을 대상으로 연구하였다. 관상동맥 조영술은 전형적인 흉통을 호소하면서 관동맥 죽상경화증의 위험도가 높은 환자를 대상으로 시행되었다. 5개의 대사증후군 위험인자와 hs-CRP 및 관상동맥 조영술 결과의 상관관계를 비모수(Nonparametric) 통계 방법중 하나인 Spearman ’s correlation, 다중 회귀분석(Multipleregression) 및 다항 로지스틱 회귀분석(Multinomial logisticregression)을 통하여 연구하였다. 결 과: Spearman ’s correlation 분석 결과, 대사증후군과 hs-CRP 및 관동맥 죽상경화증은 각각 양의 상관관계를 나타냈다(Table 4) (p<0.01). 다중 회귀분석 결과, 관동맥 죽상경화증과 그 위험 인자로 잘 알려진 대사증후군, hs-CRP, 연령이 상관관계를 나타냈으며 그 중 대사증후군의 집적도가 가장 밀접한 관계를 나타냈다. 그러나 저밀도 지단백 콜레스테롤은 관동맥 죽상경 화증과 상관관계가 없는 것으로 나타났다(R-squre=0.2461, p=0.0003, p<0.0001, p=0.0553, p=0.5452)(Table 5). 다 항 로지스틱 회귀분석(Multinomial logistic regression) 결 과, 대사증후군 점수가 올라갈수록 한 혈관 질환은 1.61배, 두 혈관 질환은 1.83배, 삼 혈관 질환은 2.50배로 관동맥 죽상경화증 중증도의 비교위험도가 증가하는 것을 알 수 있 었다(p=0.001, p<0.001, p<0.001)(Table 6). 그러나 hs- CRP와 관동맥 죽상경화증의 상관관계는 통계적으로 유의하 지 못하였다. 808·Korean Circulation J 2006;36:802-808 결 론: 대사증후군의 위험인자 집적도가 증가할수록 hs-CRP 및 관동맥 죽상경화증 중증도가 증가하였다. hs-CRP가 증가한 것은 대사증후군의 위험요소 증가에 의한 염증의 증가 정도를 반영하는 것 일 수 있으며 염증반응이 증가함으로써 관동맥 죽상경화증이 증가할 수 있음을 추측할 수 있었다. 그러나 hs- CRP와 관동맥 죽상경화증의 관계는, 단변수분석과 다변수 분석결과가 상이하여, 관동맥 죽상경화증 중증도에 대한 hs-CRP의 역할을 정확히 검증하지 못하였다.

데칼 공정을 적용한 고성능 MEA 개발

이기섭,이재승,권낙현,황인철 한국수소및신에너지학회 2011 한국수소 및 신에너지학회논문집 Vol.22 No.5

This study has focused on the development of high performance membrane-electrode assemblies (MEAs)fabricated by decal method for proton exchange membrane fuel cell (PEMFC). To study the effect of ionomer contents on performance, we fabricated MEAs with several electrodes which were prepared by varying the quantity of ionomer from 20 wt.% to 45 wt.% in catalyst layer. The MEA performance was obtained through single cell test. The MEA prepared from electrode with 25wt.% of ionomer showed the best performance. We evaluated the surface area and pore volume of electrode with BET. We found that the surface area and pore volume in electrode decreased rapidly at the electrode with 40wt.% of ionomer in catalyst layer. MEA was fabricated by roll laminator machine and the roll laminating conditions for the preparation of MEA, such as laminating press, temperature and speed, were optimized. The MEA performance is not affected by laminating temperature and speed, but roll laminating press have a great effect on MEA performance.

P-44Mismatched DNA 검출을 위한 단백질 고정화 기술의 개발

김기범,정우석,권낙현,박덕수,심윤보,반창일 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.2

본 연구는 mismatched DNA을 감지하기 위한 SH-SAW(Shear Horizontal Surface Acoustic Wave) 센서를 개발하기 위하여 mismatched DNA를 감지하기 위한 액상의 단백질을 Au이 증착되어 있는 QCM(Quartz Crystal Microbalance) 전극에 고정화하는 방법에 대하여 연구하였다. Au이 증착되어 있는 QCM전극 표면 위에 NTA 용액을 SAM(self assembled monolayer)을 형성시켰으며 MutS 단백질을 고정하기 위하여 NTA 단분자 표면에 촉매 역활을 하는 EDC를 고정한 후 mismatched DNA을 감지할 수 있는 MutS 단백질을 고정하였다. MutS 단백질의 고정화 정도를 측정하기 위하여 QCM을 사용하여 공진 주파수의 변화를 측정하여 고정화되는 단백질의 질량변화를 측정하였다. 실험결과 시간의 변화에 따라 진동 주파수는 감소하는 경향을 보이고 있으며 MutS 단백질의 질량변화는 증가하는 경향임을 확인할 수 있다. 그러므로 MutS 단백질이 NTA 표면에 효과적으로 화학결합을 하여 질량의 변화가 증가하기 때문이다. 이와 같은 실험결과를 통하여 Au표면에 NTA-MutS 단백질을 고정함으로 MutS 단백질이mismatched DNA을 감지할 수 있을 것이라 판단된다.