서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

내시경역행성담췌관조영술 후 발생한 종격동기종, 피하공기증, 긴장성 기흉 1예

조용건,이현승,권균홍,김자영,김봉진,김지연,배용목,박선자 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

However, Endoscopic retrograde cholangiopancreatography (ERCP) is still helpful procedure for the diagonosis of the pancreatobiliary disease and treatment through endoscopic sphinterectomy (EST) is relatively safe, these have possiblity of complications such as hemorrhage, infection, panceatitis, and perforation. ERCP related perforation was rarely reported in 0.3 to 1.1% of previous study, but most serious complication. A report of Pneumomediastinum, Tension Pneumothorax complicating perforation after ERCP and EST is very uncommon. In our hospital, we experienced case of pneumomediastinum, subcutaneous emphysema, and tension pneumothorax after ERCP and EST, and the patient (a 58 years old female with suspicious common bile duct stone) was treated successfully with conservative treatment.

당뇨환자에서 발생한 두개저의 침습성 아스페르길루스증 1예

이지연,김성범,김용현,김정한,유상균,김희영,정영걸,박승철,정학현,최재걸,이진수,김민자 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

두개저의 침습성 아스페르길루스증은 매우 드물지만 치명적인 질환으로 침습성 아스페르길루스 부비동염에 합병될 수 있다. 침습성 아스페르길루스증의 치료 원칙은 병변의 외과적 적출술과 장기간의 항진균요법으로 되어 있으나, 적절한 치료 기간과 치료 반응의 경과 판정에 대한 지침은 없는 실정이다. 저자들은 부비동염 증상을 주소로 내원하여 아스페르길루스종을 진단받고 4개월 전에 수술받은 적이 있는 당뇨 환자에서 두 개저의 침습성 아스페르길루스증을 진단하였으며, 병소의 부분적인 수술적 제거와 5개월 이상의 전신적 항진균제 사용으로 환자의 임상 경과가 호전되었으며 치료전과 치료 과정에서 시행한 갈륨스캔에서 방서성동위원소의 섭취가 점차 감소하여 일치하는 소견을 관찰할 수 있었다. 이에 저자들은 당뇨를 포함한 면역저하자에서 발생하는 아스페르길루스 부비동염은 조직 침습 유무에 대한 정확한 진단이 매우 중요하며, 추후에도 침습성 아스페르길루스증으로 진행할 수 있음을 유의해야 할 것을 강조하며, 또한, 갈륨스캔이 그러한 감별과 치료 경과 판정에 유용함을 경험하여 보고하는 바이다. Invasive aspergillosis of skull base is a rare but potentially lethal disease which complicates fungal sinusitis and requires surgical debridement, and long term antifungal therapy. However, optimal duration of antifungal therapy and standard method to monitor of clinical response are not known. A 55-year-old diabetic female patient presented with headache and otatgia 4 months after surgery for non-invasive aspergilloma of sinus. Brain MRI findings revealed bone destructions at the skull base and mastoid process. Mastoidectomy and tympanoplasty were performed, and the resected specimen showed fungal hyphae invading the tissue. Amphotericin B was given for 9 weeks (a total dose of 3.3g) with oral itraconazole, followed by itraconazole (400 ㎎ daily) alone for another 12 weeks. Serial gallium scans, taken before treatment and at 8th and 16th weeks following therapy, showed gradual reduction in uptake of the lesions. We emphasize that non-invasive Aspergillus sinusitis may progress to invasive disease, and strong suspicion of invasiveness is mandatory, especially in immunocompromised patients including diabetes mellitus. Also, we suggest that gallium scan is useful for determining the presence and extent of the disease, and monitoring clinical response following therapy.

전자 서베잉을 이용한 서베이드 금관과 국소의치 프레임워크 디자인

홍용신,박은진,김성균,곽재영,허성주,박지만 大韓齒科保存學會 2011 Restorative Dentistry & Endodontics Vol.36 No.6

구강 스캐너와 CAD/CAM 기술로 인해 컴퓨터로 제작하는 방식이 활발히 보급된 고정식 보철 증례와는 달리, 의치를 디지털 방식으로 제작하는 데에는 아직 한계가 많다. 촉각을 느낄 수 있는 입력 장비와 전자 서베잉의 개념, 그리고 쾌속 조형법의 적용으로 인해 국소의치를 디지털로 제작할 수 있는 솔루션이 최근 소개되고 있다. 본 증례보고에서는 이러한 국소의치의 디지털 솔루션을 이용하여 총 다섯 명의 환자에서 서베이드 금관 및 국소의치를 제작하였다. 인상 과정상의 문제로 모형과 실제 치아 사이의 형태적 차이가 있었던 경우를 제외하고는 국소의치의 적합도는 우수했으며, 장착 후 안정성과 착탈 시의 유지력 또한 임상에서 적용하는 데에 문제가 없었다. There are still many limitations on fabricating dentures using digital method while computerized production of fixed prostheses utilizing intraoral scanner and CAD/CAM technology has propagated rapidly. Recently the digital solution of fabricating removable partial denture by applying haptic input device, electronic surveying, and rapid prototyping was introduced. In this case presentation, five patients were treated with surveyed crown and removable partial dentures by this digital solution. Fit of dentures was excellent except for one case which showed morphological difference between the actual teeth and that of master cast by the erroneous impression process. There also was not any problem of stability and retention after adaptation in the clinical setting.

Stage II B형 골육종에 대한 술전 항암화학요법 및 수술적 치료 결과

김정만,우영균,김형민,김훈교,이승구,강용구 가톨릭중앙의료원 가톨릭암센터 1997 암심포지움 Vol.- No.1

Recent advances in imaging techniques, surgery and combination anti-cancer chemotherapy have brought high survial rates in osteosarcoma. To investigate the survival rate, local recurrence and complications in treatment, we analysed 25 osteosarcoma cases who had been treated with preoperative neo-adjuvant chemotherapy, surgery and post operative chemotherapy at Department of Orthopedic Surgery, Catholic University. From May 1988 to April 1995, 42 cases of stage IIB osteosarcoma were admitted in Department of Orthopedic surgery. Among them, 17 cases who didn't follow our treatment guidance were excluded in this study. The average age were 19 years. There were 21 males and 4 females. The involved sites were 4 humerus, 10 femur, 10 tibia and 1 talus. Eleven cases had received intra-arterial cisplatin and intravenous adriamycin chemotherapy, and 7 T-10 protocol and 7 intravenous ifosfamide, ADR, methotrexate, cisplatin. Among twenty-three cases were treated with limb salvage surgery, and 2 amputation. The average follow-up was 35 months(3-82). There were 14 cases of continuous disease free, 9 cases of died of desease, 1 case of alive with disease, and 1 case of no evidence of disease at final follow-up. There were three cases of local recurrence at 6,8 and 12 months after operation. The Estimated kaplan-Meier's 5 year survival rates for all, ADR-cisloatin group, T-10 protocol group, and ifosfamide regimen group were 66%, 73%, 44% and 72%, respectively.

냉각유로를 가진 발열체주위에서의 열전달에 관한 연구

김동균,박용진,배석태,김시범 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.2

In this study was performed on the characteristics of heat transfer analysis by numerical method in a double horizontal channel with internal heat source, up and down side walls are adiabatic condition. Pseudo PCB(Printed Circuit Board) with cooling hole its located front of heat source. This channel have two heat sources that its condition is uniform heat flux maintenance 5W, upper channel and lower channel inlet valocity 0.3m/sec and outlet open condition. Parameter is cooling hole's size for three cases and increasing heat flux(10W, 15W) for one case.

Epidermal Growth Factor(EGF)가 개의 손상된 슬관절 전방십자인대의 치유에 미치는 영향

김용식,정도현,정진화,우영균,임영욱,이화성,권순용 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

폐결핵치료 중인 환자에서 Rifampicin에 의해 유발된 위막성 대장염 2예

김봉진,권균홍,임창섭,김자영,홍정범,옥미선,배용목,김지연 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Pseudomembranous colitis (PMC) is a disease caused by Clostridium difficile proliferation. The causative drugs are clindamycin, third-generation cephalosporins, flouroquinolone and so on. Rifampicin has been reported as a cause of PMC in the 1980s, and the frequency of PMC is increasing because rifampicin is a first line drug for anti-tuberculosis therapy. Two patients were recently admitted to our hospital due to watery diarrhea for 1 month and they were diagnosed with PMC by sigmoidoscopy. Their onset age were 74, 72 years old and latent period of symptoms were 60, 129 days, respectively. In one case, the patient displayed coexisting hypertension and diabetes. The clinical symptoms improved after discontinuing the rifampicin and then administering oral metronidazole. We report here on two cases presumed to be rifampicin-induced PMC.

口眼渦斜 患者의 Gadolinium-DPTA enhanced MRI 所見에 대한 臨床的 考察

김재수,최우석,김용석,고형균,강성길,김창환 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

This study is designed to evaluate the clinical implications of Gd-DPTA (Gadolinium-diethyl - enetriamine pentacetic acid) enhanced MRI(Magnetic resonance imaging) in Bell's palsy and find it's usefulness in Oriental Medicine In this study, 25 outpatients with Bell's palsy were studied that MRI was performed. To evaluate degree of facial palsy, H-B(House-Brackmann) Grade was used. In Oriental Medical therapy, Acupuncture and Herbal medicine were treated. Subjective causes was divided into exposure to chill, fatigue, stress, mixed cases. Enhanced site was compared with symptoms which were disorder of eye, hearing, taste, and facial muscle palsy. Also, Relation between time which was performed MRI and enhancement was analyzed. The enhanced lesion in MRI was divided into five segments; Internal auditory canal, Labyrinthine segment, Geniculate ganglion, Tympanic segment, Mastoid segment. In Bell's palsy, 20 of 25 patients(80%) had abnormal contrast enhancement of the facial nerve. The H-B grade and interval performed MRI from onset were directly proportionate to enhancement. That is to say, Severe facial palsy short interval show high possibility of enhancement. There was no relation between subjective causes and enhanced site of facial nerve in MRI. Also Clinical symptoms didn't coincide with MRI findings.

하악골 후퇴 수술 환자의 연조직 측모 예측의 정확성 : Quick Ceph Image Pro™(ver 3.0)와 V-Ceph™(ver 3.5)의 비교 a comparison of Quick Cept Image Pro™(ver 3.0) and V-Ceph™(ver 3.5)

김명규,최용성,정송우,전영미,김정기 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.3

본 연구는 Quick Ceph Image Pro^(™)(ver 3.0)와 국내에서 개발되어 사용 중인 V-Ceph (ver. 3.5) 2 종의 비디오 이미지 예측 프로그램의 수술 후 연조직 측모의 정확성과 신뢰성에 대해서 알아보고자 시행되었다. 골격성 Ⅲ급 부정교합으로 진단되어 수술 전 교정 치료를 받고, 하악골 후퇴 수술(body osteotomy 또는 SSRO)을 시행한 남녀 환자 각각 20명을 대상으로 하였다. 나이는 평균 21.4 ± 4세이고, 수술 전 측모두부방사선계측사진은 수술 전 평균 21.1일에, 수술 후 측모두부방사선계측사진은 수술 후 평균 335.7일에 촬영되었으며, 예측치와 실측치 차이를 비교하였다. 연구결과 Quick Ceph과 V-Ceph 모두 예측치와 실측치 사이에 크기와 방향에 있어서 오차가 관찰되었으며 이러한 오차는 상순과 하순, 턱과 연관된 항목에서 크게 나타났다 (p〈0.05). Quick Ceph은 A', Ls, Li의 수평적 위치 및 각 부분에서의 연조직 두께(Ul-Ls, L1-Li, Pog-Pog')의 수평거리 예측에서,Y-Ceph은 하순의 수직적 위치 예측에서 오차가 컸다 (p〈0.05) V-Ceph의 경우 하악골의 이동양이 증가할 때 Sn의 수직적 위치, Ls의 수평적 위치, 상순의 연조직 두께(U1 -Ls)처럼 상순과 연관된 계측치에서 예측오차가 컸으며, Quick Ceph의 경우 하악골의 이동양이 증가할 때 하순의 수평위치 및 하순의 두께에서의 예측오차가 작았다 (p〈0.05). 또한, 연조직의 두께에 따른 오차를 평가한 결과, Quick Ceph의 경우 상순과 하순의 두께가 두꺼울수록 각각에 관련된 연조직 예측의 오차가 컸으며 (p〈0.05), Y-Ceph의 경우 하순과 턱의 연조직 두께가 두꺼울수록 턱의 연조직 예측의 오차가 크게 관찰되었다 (p〈0.05). 그러나, 본 연구에서의 모든 예측오차값은 3 mm 이내로 계측되었으며 이러한 오차 범주는 임상적으로 허용 가능한 수준인 것으로 생각된다. The purpose of this study was to test and compare the accuracy and reliability of soft tissue profile predictions generated from two computer software programs (Quick Ceph Image Pro^(™) (ver 3.0) and V-Ceph^(™) (ver 3.5)) for mandibular set-back surgery. The presurgical and postsurgical lateral cephalograms of 40 patients (20 males and 20 females) were traced on the same acetate paper with the reference taken as the cranial base outline. The presurgical skeletal outlines were digitized onto each computer program and the mandible was moved to mimic the expected surgical procedure with reference to the mandibular anterior border and lower incisor position of the actual postsurgical skeletal outline. The soft tissue profile was generated and the amount and direction of skeletal movement was calculated with each software. The predicted soft tissue profile was compared to the actual postsurgical soft tissue profile. There were differences between the actual and the predicted surgical soft tissue profile changes in the magnitude and direction, especially the upper lip, lower lip and the soft tissue chin (p〈0.05). Quick Ceph had more horizontal measurement errors and thickness errors for the upper lip and lower lip, but V-Ceph had more vertical measurement errors of the lower lip (p〈0.05). There was a positive correlation between the prediction errors and the amount of mandibular movements in the vertical position of Sn, the horizontal position of Ls and the upper lip thickness for V-Ceph, and there was a negative correlation in the horizontal position and the thickness of the lower lip for Quick Ceph (p〈0.05). However, all of the prediction errors of both imaging softwares were ranged within 3 mm, and this was considered to be allowable clinically.