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      • KCI등재SCOPUS

        국내 과학기술분야 회색문헌의 효율적 관리방안에 관한 연구

        이지연,이지연,Lee, Ji-Yeon,Lee, Jee-Yeon 한국과학기술정보연구원 과학기술정보센터 2007 Journal of Information Science Theory and Practice Vol.38 No.2

        회색문헌은 연구개발 활동에서 핵심적인 자료로 이용될 수 있는 가능성이 크지만 관리가 어려운 자료로 알려져 있다. 본 연구는 현재 회색문헌의 수집, 조직, 이용상의 문제점과 개선점을 파악함으로써 더 나은 회색문헌 관리방안을 모색하기 위한 근거자료를 마련하는 것을 목적으로 한다. 문헌 연구를 통해 회색문헌의 정의, 종류와 특징, 유용성에 대해 정리하고 해외의 주요 기관들에서 회색문헌을 관리하는 사례에 대해 분석하였으며 국내 과학기술분야의 정부산하연구소에서 회색문헌 관련 업무를 담당하고 있는 실무자와의 심층 면담을 통해 자료 유형별 관리방안을 제시하였다. Grey literature can be used as a substantial resource in Research & Development but it has trouble to manage. This study aimed at getting a better way to manage the grey literature by grasping the present problems in collecting, organizing and using the grey literature. This research studied the definition, type, and characteristics, usabilities of grey literature from the related materials and it performs the case study on how to manage the grey literature in major institutions. Finally, it suggested management method of various materials through the in-depth interview with the staffs in charge of managing grey literature in government institutes.

      • SCOPUSKCI등재

        소아 미소변화형 신증후군환아에서의 신간질 병변의 의의

        이지연,김정철,구자훈,정태호,곽정식,권순학 대한신장학회 1987 Kidney Research and Clinical Practice Vol.6 No.2

        Present study has been conducted to determine the significance of tubulo-interstitial change in children with MCNS (minimal change nephrotic syndrome). Study population consisted 47 children who had been admitted to the Pediatric department of Kyungpook University Hospital from 1976 to 1986,' and diagnosed pathologically as MCNS by tissue obtained from percutaneous renal biopsy, and the following results were obtained. Tubulo-interstitial change was present in 13 children (Q+ group) and absent in 34 children (Q group). 0+ group showed slightly lower hemoglobin and higher BUN and creatinine levels than Q group (p$lt;0.01). No difference was noted in ESR, serum protein, albumin and choles- terol between two groups. Urinary N-acetyl-glucosaminidase excretion (nM/ min/mg of creatinine) revealed that; 1. When urinary protein was negative, both groups and controls (taken from 8 healthy children) showed no difference, 2. When urinary protein was 1-2+ and 3-4+ range, both Q+ and Q groups showed significantly elevated values compared to the controls (p$lt;0.05), and though Q+ group showed somewhat higher level than Q group, there was no statistical difference. Response to the steorid therapy showed that initial partial response in Q+ group was seen in 46% compared to 15% in Q group (p$lt;0.05). However, subsequent steroid-dependency was much higher in Q group (74%) compared to Q+ group (31%) (p$lt;0.01). Cytotoxic therapy (cyclophosphamide or chlorambucil) was given in 22 children, and 13 out of 16 children (81%) from Q group showed no relapse within first 6 months or significantly reduced frequency of relapses following therapy, compared to 3 out of 6 children (50%) from Q+ group (p $lt; 0.05).

      • KCI등재

        A Putative APSES Transcription Factor Is Necessary for Normal Growth and Development of Aspergillus nidulans

        이지연,김이한,김하은,박재신,한갑훈,한동민 한국미생물학회 2013 The journal of microbiology Vol.51 No.6

        The nsdD gene encoding a GATA type transcription factor positively controls sexual development in Aspergillus nidulans. According to microarray data, 20 genes that were upregulated by deleting nsdD during various life cycle stages were randomly selected and deleted for functional analysis. None of the mutants showed apparent changes in growth or development compared with those of the wild-type except the AN3154 gene that encodes a putative APSES transcription factor and is an ortholog of Saccharomyces cerevisiae swi4. Deleting AN3154 resulted in retarded growth and development,and the gene was named rgdA (retared growth and development). The rgdA deletion mutant developed a reduced number of conidia even under favorable conditions for asexual development. The retarded growth and development was partially suppressed by the veA1 mutation. The conidial heads of the mutant aborted, showing reduced and irregular shaped phialides. Fruiting body development was delayed compared with that in the wild-type. The mutant did not respond to various nutritional or environmental factors that affected the development patterns. The rgdA gene was expressed at low levels throughout the life cycle and was not significantly affected by several regulators of sexual and asexual development such as nsdD, veA, stuA, or brlA. However, the rgdA gene affected brlA and abaA expression, which function as key regulators of asexual sporulation, suggesting that rgdA functions upstream of those genes.

      • KCI등재

        PARAMETER CHANGE TEST FOR NONLINEAR TIME SERIES MODELS WITH GARCH TYPE ERRORS

        이지연,이상열 대한수학회 2015 대한수학회지 Vol.52 No.3

        In this paper, we consider the problem of testing for a param- eter change in nonlinear time series models with GARCH type errors. We introduce two types of cumulative sum (CUSUM) tests: estimates-based and residual-based tests. It is shown that under regularity conditions, their limiting null distributions are the sup of independent Brownian bridges. A simulation study is conducted for illustration.

      • KCI등재

        Association between Chemotherapy-Response Assays and Subsets of Tumor-Infiltrating Lymphocytes in Gastric Cancer: A Pilot Study

        이지연,손태일,정재호,형우진,노성훈,김충배,박정규,김형일 대한위암학회 2015 Journal of gastric cancer Vol.15 No.4

        Purpose: The purpose of this pilot study was to evaluate the association between adenosine triphosphate-based chemotherapy response assays (ATP-CRAs) and subsets of tumor infiltrating lymphocytes (TILs) in gastric cancer. Materials and Methods: In total, 15 gastric cancer tissue samples were obtained from gastrectomies performed between February 2007 and January 2011. Chemotherapy response assays were performed on tumor cells from these samples using 11 chemotherapeutic agents, including etoposide, doxorubicin, epirubicin, mitomycin, 5-fluorouracil (5-FU), oxaliplatin, irinotecan, docetaxel, paclitaxel, methotrexate, and cisplatin. TILs in the tissue samples were evaluated using antibodies specific for CD3, CD4, CD8, Foxp3, and Granzyme B. Results: The highest cancer cell death rates were induced by etoposide (44.8%), 5-FU (43.1%), and mitomycin (39.9%). Samples from 10 patients who were treated with 5-FU were divided into 5-FU-sensitive and -insensitive groups according to median cell death rate. No difference was observed in survival between the two groups (P=0.216). Only two patients were treated with a chemotherapeutic agent determined by an ATP-CRA and there was no significant difference in overall survival compared with that of patients treated with their physician’s choice of chemotherapeutic agent (P=0.105). However, a high number of CD3 TILs was a favorable prognostic factor (P=0.008). Pearson’s correlation analyses showed no association between cancer cell death rates in response to chemotherapeutic agents and subsets of TILs. Conclusions: Cancer cell death rates in response to specific chemotherapeutic agents were not significantly associated with the distribution of TIL subsets.

      • KCI등재

        율무 새싹 추출물의 Riboflavin과 Coixol의 동시 분석법 검증 및 항산화 활성

        이지연,박정용,박춘근,김동휘,지윤정,최수지,오명원,황호섭,이윤지,정진태,이정훈,서경혜 한국작물학회 2019 한국작물학회지 Vol.64 No.4

        Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf (CL), which contains riboflavin and coixol, has traditionallybeen used to treat cancer and arthritis. However, no method for the simultaneous determination of riboflavin and coixol in CLsprouts has been established. In this study, we established and validated a high-performance liquid chromatography–diode arraydetection (HPLC-DAD) method for the identification and quantification of two reference markers, riboflavin and coixol, in CLsprout extracts. CL sprouts (whole sprouts and leaves) were subjected to extraction with 70% ethanol at room temperature and at80 °C under reflux conditions. The two extractions were validated with respect to specificity, accuracy, precision, and linearity. The content of the two reference markers was highest in leaves extracted under reflux conditions (riboflavin, 8.23 ± 0.32 mg/g;coixol, 5.95 ± 0.04 mg/g). We also investigated the antioxidant activity of the extracts via 2,2-diphenyl-1-picrylhydrazyl (DPPH)and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+) scavenging assays. The results indicated that extractsobtained from sprouts under reflux conditions had the strongest antioxidative effects (DPPH half maximal inhibitoryconcentration [IC50], 68.9 ± 4.1 g/mL; and ABTS, IC50, 34.9 ± 0.1 g/mL). These results can serve as baseline data for thesimultaneous determination of the two reference marker compounds, riboflavin and coixol, and development of functional foodmaterials using CL sprouts. 율무 새싹 추출물의 riboflavin과 coixol의 원료표준화를위한 동시분석 조건을 검증하고, 율무 새싹의 전초와 잎 추출물의 항산화 활성과 함량의 상관관계에 대해 조사하였다. 1. HPLC 분석을 위한 riboflavin과 coixol의 피크가 각각분리되어 특이성을 확인하였고, 일내 및 일간 정확성은모두 회수율이 100.28%에서 103.98% 사이이며 정밀성은 모두 1.93%이하를 나타내므로 본 실험의 분석조건은높은 정확성과 정밀성을 가지고 있다. 2. Riboflavin과 coixol의 동시분석 조건의 검출한계(LOD)및 정량한계(LOQ)를 조사한 결과 검출한계는 0.71 및 0.31μg/mL, 정량한계는 2.71 및 0.94 μg/mL이므로 확립된HPLC 분석조건은 riboflavin과 coixol의 동시분석하기에무리가 없는 분석법으로 조사되었다. 3. 율무 새싹의 전초와 잎의 riboflavin과 coixol의 함량을본 연구에서 얻어진 동시분석법을 적용하여 잎의 환류추출물에서 가장 높은 함량이 나타났다. 4. 항산화 활성 측정 시, DPPH와 ABTS+ 소거능에서 모두율무 새싹의 전초보다 잎에서, 상온 추출보다 환류 추출이 더 낮은 IC50값을 나타내었다. 율무 새싹 추출물의riboflavin과 coixol 및 항산화 활성과의 상관관계를 실시한 결과, coixol이 증가할수록 DPPH와 ABTS+ 소거능의IC50값이 유의적으로 감소하는 경향이 나타나므로 원료표준화 지표뿐만 아니라 기능성 지표로 활용이 가능할것으로 판단되었다.

      • KCI등재

        무통분만의 임상 경과

        이지연,김현주,황혜란,김경미,조지영 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.8

        1997년 6월 1일부터 1997년 11월 30일까지 일신기독병원 산부인과에 입원한 산모 중 경막외 마취를 시행한 산모 170명(초산모 100예, 경산모 70예)과 경막외 마취를 시행하지 않은 산모 170명(초산모 100예, 경산모 70예)을 비교분석하여 다음과 같은 결론을 얻었다. 1. 분만시 oxytocin 정맥 점적 투여는 초산모와 경산모 모두 경막외 마취군에서 유의하게 높았다(p<0.05). 2. 분만 제 1기, 제 2기의 시간은 초산모와 경산모 모 두 유의하게 길어지는 소견을 보였다(p<0.05). 3. 기계 분만은 초산모에서 경막외 마취를 시행한 군 이 2예 있었고, 나머지 군에서는 없었다. 제왕절개술의 빈도는 초산모와 경산모 모두 유의한 차이는 없었으며, 태아 곤란증이나 난산으로 인한 제왕절개술도 두 군사 이에 유의한 차이는 없었다. 4. 양수내 태변의 착색과 신생아 Apgar 점수, 체중은 유의한 차이가 없었다. 5. 분만시 총 실혈량에서는 유의한 차이는 없었다. The aim of this study was to evaluate the effect of epidural analgesia on labor progress. We studied 340 women at term, with singleton fetus in vertex presentation and with spontaneous onset of labor at the Department of Obstetrics and Gynecology, Il Shin Christian Hospital during 6 months from June 1, 1997 to November 30, 1997. Comparison of 170 women (100 cases of primiparous women, 70 cases of multiparous women) who received epidural analgesia in labor with 170 women (100 cases of primiparous women, 70 cases of multiparous women) who did not receive epidural analgesia was performed. The results were as follows: 1. The frequency of oxytocin augmentation was significantly greater in the primiparous and multiparous epidural group than in the primiparous and multiparous control group (p<0.05). 2. The duration of the first stage and second stage of labor was significantly delayed in the primiparous and multiparous epidural group than in the primiparous and multiparous control group (p<0.05). 3. The mode of delivery showed no significant difference between epidural group and control group. 4. The meconium-stained amnionic fluid, Apgar score and birth weight were similar in both groups. 5. The maternal blood loss was similar in both groups.

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