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Experimental sinusitis in Rabbits (I)
정학현,황찬승,최종욱,이준희,남순열,박재훈 대한비과학회 1994 Journal of rhinology Vol.1 No.1
Several investigators have tried to make the experimental sinusitis in rabbits, but it is still unclear which method is the best and ideal. The purpose of this study was to investigate the effects of obstrution of maxillary sinusostium or streptococcus pneumoniae infection on the maxillary sinuses of normal rabbits. Unilateral sinus ostia of 12 rabbits were completely occluded by inserion of merocel to middle meatus and bilateral maxillary sunuses of 12 rabbits were infected by unjection of strepto-coccus pneumoniae(170-9/ml). The animals were sacrified at first, third, sixth and twelveth week with culture of purulent secretion in the maxillary sinus and then pathology of maxillary sinuses were observed by the light microscopy. As results, maxillary sinusitis with pus was developed in 10 animals of 12 occluded middle meatus, but pus was collected in only 6 sinuses and mucopurulent discharge in 10 sinuses among 24 streptococcus pneumoniae injected sinuses. Therefore, complete obstruction of sinusostium by merocel was effective to induce the experimental sinusitis in rabbits, but streptococcus pneumoniae may induec the chronic sinusitis in some experimental animals.