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유도항암요법에 반응치 않는 환자와 재발한 두경부암환자에서 Cisplatin과 방사선 동시치료
김훈교,강진형,이경식,김동집,장홍석,윤세철,조승호,서병도,Kim Hoon-Kyo,Kang Jin-Hyoung,Lee Kyung-Sik,Kim Dong-Jip,Chang Hong-Suk,Yoon Sei-Chul,Cho Seung-Ho,Sub Byung-Do 대한두경부종양학회 1992 대한두경부 종양학회지 Vol.8 No.1
In patients with locally advanced head and neck cancers who do not respond to induction chemotherapy and who have locoregional recurrence after local treatment subsequent radiotherapy alone does not have any additative effect. The theoretical rationale and promising clinical response of concurrent chemoradiotherapy in patients with the head and neck cancers have been recently conducted Ten patients(9 stage IV, q stage III) were treated with concurrent chemoradiotherapy(radiotherapy start from day 1 of chemotherapy; cisplatin $100mg/m^2$ intravenously every 3 weeks for $3{\sim}4$ cycles on day 1.22 and 43..). Four patients achieved complete response(CR) and overall response rate was 80% (8/10). The major toxicities we re leukopenia (90%), nausea/vomiting(80%), stomatitis(80%) and peripheral neuropathy(30%). Most of these side effects were mild to moderate and reversible.
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