과학교육 개선을 위한 실험모델 제작에 관한 연구(Ⅰ)

이기종,이광호,이종철,김자홍 全北大學校 基礎科學硏究所 1991 基礎科學 Vol.14 No.1

A curriculum for teaching materials in Science Education was studied as a model for modified xperiment on fundamental courses. Coscious effort can be made to desingn experiments that require minimum apparatus, that require low-cost equipment that can be made to from cheap locally available materials. Computer-aided instruction programs at high school, freshman course level have been developed. The software package was consist of five programs: The program contains explanation and problems for the calculation of resonance energy, molecular structure, mole concept, Rutherford's experiment, thermodynamic processes. Special course equipment package explanation mole concept, Rutheford's experiment, thermo dynamic processes. Special course were designed in Science Education with the understanding that to a certain extent science values would be covered in all of the modified experiments and program models.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Adamkiewicz 동맥의 폐색에 의한 척수경색 1례

이광훈,이종걸,이태연,신동익,이성현,이상수,한설희,차상훈 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

Southern Blot Hybridization법을 이용한 악성 림프종의 면역유전형에 관한 연구

전호종,기근홍,김윤신,이미숙,이미자,장원재,장숙진,박영진,정춘해,정종훈,양성훈,이광민 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Immunogenotyping using gene rearrangement analysis has emerged as a precise laboratory aid in the diagnosis and classification of malignant Iymphoid neoplasms. The lineage and clonality of the malignant Iymphoid neoplasms can be identified by the demonstration of rearrangements of antigen receptor genes of the immunoglobulin and T-cell receptor genes. The analysis of the gene rearrangements on the malignant Iymphoid neoplasms are also useful as a sensitive unique clonal markers to detect early recurrence in patients with malignant Iymphoid neoplasms after treatment. To analyze the sensitivity and specificity of gene rearrangements in the diagnosis of malignant Iymphoid neoplasms. 24 cases of malignat Iymphoma were examined by Southern blot hybridization using CTβ-T cell receptor β chain gene-DNA probe and JH-immunoglobulin heavy chain gene-DNA probe. The results of the immunogenotypings using Southern blot hybridization disclosed high correlation between the immunophenotyping using immunohistochemical stain with monoclonal antibodies (B-cell Iymphoma 84.2%. T-cell Iymphoma 75% ). The analysis of the gene rearrangement of the angioimmunoblastic lymphadenopathy(AILD) and unclassifiable Iymphoma using immunohistochemical stain could resolve the monoclonality and lineage . Rearranged bands to the CTβDNA probe were observed in one case out of 2 cases of AILD. One case of unclassifiable Iymphoma showed rearranged bands to the CTβ DNA probe. There were no rearrangements in reactive follicular Iymphoid hyperplasia and paracortical Iymphoid hyperplasia. In conclusion, DNA gene rearrangement study should be applied to differentiate the clonality and cell lineage in the malignant Iymphoma with indistinctive immunophenotype.

자기공명영상을 이용한 정신분열증 환자의 뇌량크기 측정

이종훈,이재광,나철 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

In order to evaluate the morphological change of corpus callosum which may play a major role in abnormal neural transfer of information between two cerebral hemisphres in schizophrenics, the authors measured the size of corpus callosum of the 25 schizophrenic patients who were diagnosed by DSM-Ⅲ-R(1987), visited at department of neuropsychiatry, Chun-Ang university hospital(Young San, Phildong) from October 1993 to March 1994, by using the midline saggital slice of MRI. These results were compared with the size of corpus callosum of 25 neurotic patients who had visited at Chung-Ang university hospital. The results were as follows : 1) Schizophrenic patients had larger total callosal area, genu area, splenium area than control group. 2) Female schizophrenic patients had significantly larger splenium area and higher ratio of splenium to total callosal area than the female control group. Male schizophrenic patients had significantly larger total callosal and genu area than the male control group. 3) Although male schizophrenic patients had simillar size of corpus callosum with female schizophrenics, the male control group had larger splenium, thicker anterior callosal width and higher ratio of splenium to total callosal area than the female control group.

전국 형광등 제조 사업장의 수은 오염원에 대한 조사연구

이창주,김광종,차철환 大韓産業醫學會 1990 대한직업환경의학회지 Vol.2 No.1

This research was conducted to study the correlations between the airbone mercury concentration and each independent variable to detect the source of mercury contamination in a total of 11 fluorescent lamp manufacturing factories. The mercury concentration in air was measured and informations about production management (operation hour, overtime, vacuum exhaustion system, number of droppers, number of vacuum exhaustion pumps, frequency of mercury infusion, mercury consumption per lamp, number of lamps producted, number of inferior lamps producted, number of breakage lamps, local exhaust ventilation system) were collected from January 1988 to March 1989. The results were as follows: 1. Among the airborne mercury concentrations according to the sampling point the highest mean concentration was 0.162mg/㎥(0.016-0.635mg/㎥) at the workeplace floor, and 0.074mg/㎥ at the vaccum exhaustion pump site, and 0.66mg/㎥ at the breathing zone in order. 2. The correlation between airborne mercury concentration and each independent variable was significant in a following order : the number of inferior lamps producted(0.485), vacuum exhaustion system(-0.405), number of breakage lamps (0.344), operation hour (0.341), number of vacuum exhaustion pumps(0.337) and local exhaust ventilation system(0.331). 3. The result of stepwise multiple regression analysis that the airborne mercury consumption was affected by number of inferior lamps producted, frequency of mercury infusion, overtime, ventilator, mercury consumption amounts per lamp, local exhaust ventilation system in order. And these six variables explained 36.7% of the variance of airborne mercury concentration.

대학·실업 아이스하키 선수들의 정신력 조사분석

이종희,한광령,김창범 경희대학교 체육과학연구소 2004 體育學論文集 Vol.32 No.-

This study intended to study for comparison and analysis the mental strength of the ice hockey players in the college and professional teams, and the conclusions and suggestions on the mental strength of 111 players in five college teams and 38 players in two professional teams, that were registered at Korea Ice Hockey Association in 2003, are as follows. 1) In the factor of the self-confidence, there was a significant difference(P<.005)among the professional and college teams, with the highest level of 12.07 for HR professional team and the lowest level of 7.74 for KR college team players. 2) In the factor of the anxiety, there was not a significant difference(P>.005)among the professional and college teams, with the highest level of 9.00 for KW college team and the lowest level of 5.26 for KR college team players. 3) In the factor of the concentration of attention, there was a significant difference(P<.005) among the professional and college teams, with the highest level of 8.5 for HR professional team and the lowest level of 6.20 for KW college team players. 4) In the factor of the awareness of challenge, there was not a significant difference(P>.005) among the professional and college teams, with the highest level of 13.20 for KW college team and the lowest level of 10.87 for KH college team players. 5) In the factor of the crisis management, there was a significant difference(P<.005)among the professional and college teams, with the highest level of 14.95 for YS college team and the lowest level of 19.58 for KR college team players. 6) In the factor of the awareness of goal, there was not a significant difference(P>.005) among the professional and college teams, with the highest level of 13.14 for HR professional team and the lowest level of 10.74 for KR college team players. 7) confidence in coaches In the factor of the confidence in coaches, there was not a significant difference(P>.005)among the professional and college teams, with the highest level of 12.30 for YS college team and the lowest level of 10.47 for KR college team players. As a result, the low level of such mental strength factors as self-confidence, anxiety, concentration of attention awareness of challenge, crisis management, awareness of goal, and confidence in coaches, which may affect directly or indirectly the performances in the actual situations of competition, is considered to affect unfavorably the improvement in competitiveness. Thus, while training the players for the improvement of in competitiveness, the coaching staff on the spot may be advised to apply the programs designed to improve the mental or psychological strength, along with the repetition of physical training. In this study, the subjects of analysis were limited to the players in the college and professional teams. In the future studies, the further expansion and subdivision of the subjects in terms of academic career and sex are considered necessary in order to present ideal models to the players. In addition, it is hoped that the subdivision be made by the game for the systematic study intended to develop the mental strength test forms and present the profile, ideal and suitable for the individual games and eventually for the improvement in competitiveness.

儒學思想의 行政倫理的 價値

李光鍾,韓石泰 청주대학교 교육문제연구소 1988 교육과학연구 Vol.2 No.1

The contents of this paper can be divided into three main parts. In the first part, we emphasize the necessity of philosophical viewpoint in the study of public administration and further investigate sub-disciplines of administrative philosophy. They are administrative ontology, epistemology and axiology. We focus our discussion an the ethical value which is one of value type treated in adminisrrative axiology. In the second part, some principal virtues of Confucianism, which can be applied to the behavioral norms of contemporary administrators, are investigated. In the last part, we discuss the dysfunctional elements of Confucian values in comparison with value elements of "development".

나프탈렌기를 갖는 새로운 액정폴리우레탄의 합성 및 특성

이종백,이광현 한국고무학회 2005 엘라스토머 및 콤포지트 Vol.40 No.1

새로운 형태의 액정성 폴리우레탄을 2,6-bis(ω-hydroxyalkoxy)naphthalene (BHNm; m= 5, 6, 8, 11)과 2,5-tolylene diisocyanate 또는 1,4-phenylene diisocyanate의 중부가 반응에 의해 합성하였다. 폴리우레탄의 고유 점성도는 0.28-0.43 dL/g 였다. 열적 성질은 DSC 및 편광현미경에 의해 측정되었다. 단량체 BHNm과 메틸치환기를 가진 2,5-tolylene diisocyanate에 의해 합성된 폴리우레탄은 모두 단방성 액정성을 나타내었다. 그러나 BHNm와 1,4-phenylene diisocyanate를 합성한 폴리우레탄에서는 DSC와 편광현미경으로 조사 결과 전혀 액정성을 나타내지 않았다. Novel polyurethanes containing no mesogenic unit were synthesized by the polyaddition reaction of para-type diisocyanates such as 2,5-tolylene diisocyanate (2,5-TDI) or 1,4-phenylene diisocyanate (1,4-PDI) with 2,6-bis(ω-hydroxyalkoxy)naphthalene (BHNm; m= 5, 6, 8, 11). Intrinsic viscosities of the polymers were in the range of 0.28-0.43 dL/g. The thermal properties of these polymers were studied by differential scanning calorimetry and polarizing microscopy. Polyurethanes prepared from BHNm and 2,5-TDI having methyl sub stituent on the phenylene unit exhibited monotropic liquid crystallinity. However, in the series of polyurethanes prepared from 1,4-PDI and BHNm, no explicit mesomorphic behavior was observed by differential scanning calorimetry and polarizing microscopy.

취학전 어린이의 상악 유전치 우식증과 관련 요인

정승열,이광희,라지영,이동진,안소연,김지영,송지현,김윤희 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

연구 목적은 상악 유전치 우식증의 발생 요인을 규명하기 위함이었다. 연구대상은 익산시 어린이집 중에서 무작위로 추출 한 7개 어린이집의 36개월 이상 71개월 미만의 남아 214명, 여아 187명, 모두 401명이었다. 연구방법은 상악 유전치 우식 증의 유병률을 조사하고, 성별, 연령, 모유 수유 또는 인공 수유, 수유 기간, 감미 간식 섭취 빈도, 칫솔질 시작 시기, 1일 칫솔질 횟수 등을 조사하여 상악 유전치 우식증과의 연관성을 분석하였다. 연구결과를 보면, 상악 유전치 우식증의 유병률은 남아에서 43.0%, 여아에서 26.7%로서 남아가 여아보다 유의하게 높았고(P<0.01), 수유 기간 2년 이하 군에서 31.0%. 2-3 년 군에서 43.2%, 3년 이상 군에서 63.2%로서 수유 기간이 길어질수록 유의하게 증가하는 경향을 나타내었으며(P<0.01), 감미 간식을 매일 섭취하는 군에서 44.2%,2-3일에 한 번 섭취하는 군에서 31.47%, 자주 섭취하지 않는 군에서 32.4%로서, 매일 섭취하는 경우에 상악 유전치 우식증과의 유의한 연관성이 있었다(P<0.05). 연령, 모유 수유 또는 인공 수유, 칫솔질 시작 시기, 1일 칫솔질 횟수에서는 상악 유전치 우식증과 유의한 연관성이 나타나지 않았다(P>0.05). The purpose of study was to investigate the etiologic factors of maxillary primary anterior caries. The subjects of study were 401 preschool children, 214 boys and 187 girls, from 36 to 71 months old of randomly selected seven nurseries in Iksan city. The prevalence of maxillary primary anterior teeth was cross-analyzed with gender, age, breast feeding or bottle feeding, length of feeding, sweet snack intake frequency, beginning of tooth-brushing, and toothbrushing frequency per day. The prevalence was 43.0% in boys and 26.7% in girls, and there was significant association between the prevalence and gender in cross analysis(P<0.01). The prevalences of the shorter than 2 years of feeding group, the from 2 to 3 years group, and the longer than 3 years group were 31.0%, 43.2%, and 63,2%, respectively, and there was significant association between the prevalence and the length of feeding (P<0.01). Daily intake of sweet snacks had a significant association with the prevalence(P<0.05) There was no significant association between the prevalence and the variables of age, breast feeding or bottle feeding, beginning of toothbrushing, and toothbrushing frequency per day(P>0.05).