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      • KCI등재

        가미강활산(加味羌活散)이 집먼지 진드기 추출물로 유도된 NC/Nga mouse의 아토피 피부염에 미치는 영향

        김윤희,한재경,김윤희,Kim,,Yun-Hee,Han,,Jae-Kyung,Kim,,Yun-Hee 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.1

        Objectives The purpose of this study is to investigate the effect of KKHS on atopic dermatitis in an in-vivo experiment using an NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to this condition in humans. Methods To investigate the effect of KKHS on atopic dermatitis (AD), we evaluated atopic dermatitis-like skin lesions by clinical skin index and analyzed immunological parameters in peripheral blood mononuclear cells(PBMCs), splenocytes, draining lymph node(DLN) and performed skin histology in ears and dorsal skin of atopic dermatitis of NC/Nga mouse in vivo. Results In vivo, clinical skin severity score was significantly lower in the KKHS group than in the control group. IgE, IL-6, TNF-${\alpha}$, IgM, IgG2a and IgG2b levels in serum decreased remarkably in the KKHS group than in the control group, and the level of IFN-${\gamma}$ production which is secreted from Th1 cell was increased by KKHS. After this experiment we analyzed immunological cells ($CD3^+$, $CD19^+$, $CD4^+$, $CD8^+$, $CD3^+CD69^+$, $CD4^+CD25^+$ and $CD49b^+$) by flow cytometry. It results that the total absolute number of $CD3^+$, $CD19^+$, $CD4^+$ and $CD8^+$ cells were recovered as much as normal state, and the level of $CD3^+CD69^+$ in isolated DLN and PBMCs were significantly decreased, and total absolute number of $Gr-1^+$, $CD11b^+$ and $CD3^+$ in dorsal skin of NC/Nga mouse were decreased by KKHS. We analyzed ear, DLN, and neck-back skin after biopsy and dyeing by hematoxyline/eosin(H&E), toluidine staining (mast cells marker). KKHS were very effective to the histological symptoms which are in dermal and epidermal thickening, hyperkeratosis and inflammatory cell infiltration. Ear thickness was significantly decreased compared with the control group and the size of inflammatory lymphocytes cells (ILC) and plasma cells (PC) in DLN were also decreased. Conclusions KKHS on atopic dermatitis in an in-vivo experiment using an NC/Nga atopic dermatitis mouse was very effectiveness to the atopy dermatitis treatment.

      • KCI등재

        내방가사의 전승 과정을 통해 본 여성들의 기록과 소통 문화

        김윤희(金允姬) 한국국학진흥원 2019 국학연구 Vol.0 No.40

        This study focused on the openness and meaning of the communication structure of Naebang-gasa (“Women's lyric”) and analyzed several cases found in literary works. This can clarify the value and meaning of Naebang-gasa in terms of documentary and cultural heritage. As mentioned previously, the records of women's serious self-reflection found in Naebang-gasa of Gyeongbuk province are deemed as a highly significant documentary and cultural heritage in that, although women were in the position of socially underprivileged, they tried to communicate with themselves through words. The direction of such communication is also significant in that, while women were reading Naebang-gasa together and sympathizing, comforting, and solidifyingeach other, it provided a possibility for the direction of communication to spread to the outside world or to other people. Women shared the pain or joy of other people in the process of enjoying Naebang-gasa through which they expressed pain, frustration, and hope in their lives in their native language. Several materials confirmed that this process of emotional sympathy was an opportunity to promote a voluntary and sustainable documentary culture. Naebang-gasa of the late Joseon dynasty shows women's eagerness for recording their lives, their sincere mind to sympathize with the feelings of other people, and their efforts to express such mind aesthetically through words that they learned. In this sense, the Naebang-gasa of the late Joseon dynasty is deemed as a valuable cultural heritage in terms of women's culture and local culture. Therefore, it is necessary to further embody the universal value of Naebang-gasa that can be recognized as a world documentary and cultural heritage in order to solve the problems of the current discontinuity and the succession of the value.

      • KCI등재

        Molecular marker analysis of Cynanchum wilfordii and C. auriculatum using the simple ARMS-PCR method with mismatched primers

        김윤희,이신우,김만배,신용욱,김윤희,이수진 한국식물생명공학회 2017 Plant biotechnology reports Vol.11 No.2

        SNPs can be used to discriminate allele-specific genotypes based on the 30-terminal nucleotide of a primer corresponding to a specific SNP site. However, reliable discrimination between alleles in closely related species is not sufficient for molecular genetic identification. To overcome this problem, the present study evaluated the amplification refractory mutation system (ARMS)-PCR analysis method to discriminate closely related species, which utilizes specific primers that have a base pair change within three bases closest to the SNP site. The aim of this study was to develop a simple and precise DNA-based method for molecular authentication of C. wilfordii when compared with the highly similar species C. auriculatum. Molecular authentication of C. wilfordii and C. auriculatum was achieved using specific modified primers for DNA sequences of chloroplast TrnL-F and nuclear internal transcribed spacer (ITS) regions. A species-specific SNP was detected for each of the two species, and mismatched ARMS-PCR was conducted to specifically identify the SNP site. Plant samples collected from different locations were used to validate the selectively modified SNP markers, and the established method was determined to be effective. Therefore, this study provides a rapid and reliable method for specific identification of the medicinal plants, C. wilfordii and C. auriculatum.

      • KCI등재

        클래스카드를 활용한 일본어 교육의 사례 고찰 - 코로나19 시대에 진행한 관광일본어 온라인수업을 중심으로 -

        김윤희(金允喜) 동북아시아문화학회 2021 동북아 문화연구 Vol.1 No.66

        In the era of COVID-19, universities have postponed opening of classes and decided to provide online classes instead of face-to-face classes to prevent the spread of COVID-19. In order to enhance efficiency in the entire online class going on due to COVID-19, the class was designed in a hybrid type. Online class production through video shooting, class card production for self-directed learning, Kakao Talk"s talk board to check review studies, and 1:1 Google Meet have been in place to secure individual question and answer time for learners. For class design to complement the downside of unidirectional online classes, we approached learners as both instructors and managers. The survey results are as follows. First, When looking at the status of Hiragana learning in the class card, it was confirmed that learners with intermediate level of understanding in hiragana improve their basic learning ability by using the class card. Second, It was found that 14(87.5%) out of 16 learners who achieved 100% of the class cards had excellent grades. It was also found that 11(91.7%) out of 12 students with perfect grades achieved 100% of the class card. Third, The results showed the cases of affirming the improvement of skill through the class card among those who had perfect grades in Group B and Group C. Fourth, As a result of conducting an end-of-course questionnaire for learners, it was found that the class card seemed to have had a high effect in ‘learning', ‘reviewing', and ‘a sense of achievement.' This research has significance in that the findings can be used as a basic reference regarding the design and practice of online Japanese classes.

      • KCI등재SCOPUS

        원내검사 및 원외검사 결정을 위한 손익분기점 분석 경험

        김윤희 대한진단검사의학회 2006 Annals of Laboratory Medicine Vol.26 No.6

        배경 : 심화된 경쟁구도 의료시장에서는 의료서비스의 지속적품질개선을 통한 원가절감이 요구된다. 검사실에서는 정기적으로원내 또는 원외검사(make-or-buy) 결정을 위한 자료들을 검토하는 것이 요구되는 데, 이때 유용한 도구가 손익분기점(break-even point, BEP) 분석이다. 본 연구에서는 최근 본원 검사실에서 의뢰건수의 증가추세를 보인 면역측정 외부위탁검사들을 검사실 내부에서 시행(make)할 경우의 원가계산을 하여, BEP 분석을 시행하였다. 대 상 및 방 법 : AFP, CEA, PSA, ferritin, fT4, T3, TSH,CA 125, CA 19-9 및 HBeAb 의 10가지 검사를 Abbott Ax-SYM 장비로 검사실 내부에서 자체 시행할 경우의 고정비 및 변동비를 계산하였다. 손익분기건수(break-even volume)는 연간고정비를 단위당 외부위탁구매가와 단위당 변동비의 차로 나누어서, BEP 비율은 손익분기건수에서의 총 구매가를 현재의 연 검사건수에서의 총 구매가로 나누어서 구하였다.\\Test volumeLoss\6,149,000 \18,447,000 \30,745,000ProfitTotal purchasing costsTotal purchasing costsContribution margin rateBreak-even pointTotal costsBreak-even pointBreak-evenvolume: 155930,000,00025,000,00020,000,00015,000,00010,000,0005,000,000012,000,00010,000,0008,000,0006,000,0004,000,0002,000,0000-2,000,000-4,000,000-6,000,000-8,000,000-10,000,0000 500 1,000 1,500 2,000 2,500 3,000A B464 김윤희결과 : AFP, CEA, PSA, ferritin, fT4, T3, TSH, CA125,CA19-9 및 HBeAb의 연 고정비는 평균 8,279,187원, 단위 당 변동비는 평균 3,786원이었다. 손익분기건수는 평균 1,599건, BEP비율은 평균 852%이었다. 고정비에 질 관리 비용을 포함하지 않은 경우의 BEP 비율은 평균 74%이었다.

      • 크리스타 볼프의 "메데아"에 나타난 현실인식

        김윤희 전주대학교 인문과학종합연구소 2001 인문과학연구 Vol.- No.6

        Nachdem Christa Wolf in ihren drei letzten Prosatexten das Alltagsleben in der unmittelbaren Vergangenheit a¨sthetisch bearbeitet hat, wendet sie sich in ihrem ju¨ungsten Roman "Medea. Stimmen" wieder der mythischen Vergangenheit zu. Der Roman ist nach einem la¨ngerem Schweigen der Autorin als Erza¨hlerin erschienen. Der Grund ist bekannt: vor der Wende hat man Christa Wolf als Nobelpreiskandidatin gepriesen, dann - als die DDR als ein Irrtum der Geschichte bezeichnet wurde - hat man sie im Westen als Staatsdichterin verho¨hnt. 1996 vero¨ffentlicht Christa wolf mit Medea ihren ersten Roman nach der Widervereinigung. Mit dem Werk Was bleibt (1990) hatte sie eine heftige Debatte u¨ber die ehemalige DDR Literatur entfacht und wurde wegen des Verdachts ihrer Stasi-Mitarbeit nochmals in den Mittelpunkt der Diskussion geru¨ckt. Medea erinnert uns zuna¨chst wegen der Mythenbearbeitung an die fru¨here Erza¨hlung "Kassandra(1983)". Diese Arbeit bescha¨ftigt sich mit den folgenden Fragen : Wie ist, in einer zeit, in der eine Utopie unmo¨glich erscheint, Christas Wolfs heutige Position von Schreiben? Warum und wie rekurriert wolf wiederum auf die Zeit der griechischen Mythen zur palimpsestartigen Darstellung gegenwa¨rtiger Probleme? Welche neuen, u¨ber Kassandra hinausgehenden Aspekte zeigt Wolfs Behandlung des Medea-Stoffes hinsichtlich des zeitgeno¨ssischen Prozesses der Zivilisation sowie seiner Wurzeln? Wolfs Schreiben kann ohne eine Utopie nicht gedacht werden. Wolfs Literatur selbst ist gerade der Raum, in dem der Versuch einer Utopie stattfindet. Die Autorin sucht schreibend und erkennt die Welt neu und vera¨ndert sie. La¨ßt sich die weitverbreitete apokalyptische Gemu¨tslage der fru¨hen 80er Jahre sehr gut als Druck verstehen, der die Wa¨nde zwischen der Zeit des troianischen Krieges und des Kalten Krieges wegschmolz, so stellt sich dreizehn Jahre spa¨ter, nach dem Ende des Kalten Krieges und nach der Auflo¨sung des sozialistischen Ostblocks, die Frage, worin jetzt der Druck besteht. Hinsichtlich des Modus der Darstellung fa¨llt als erstes die Differenz der narratologischen Struktur von Kassandra und Medea ins Auge. War Kassandra in der Form eines inneren Monologes der Heldin gestaltet, die unmittelbar vor ihrem Tode in Mykene ihr Leben rekapituliert, wobei zu anfang und Ende der Erza¨hlung der Blick einer modernen Erza¨hlerin mit dem der mythischen Ich-Erza¨hlerin zusammenfa¨llt, so ist Medea, so scheint es, dem bachtinschen Modell der Polyphonie verpflichtet. Nach der oben diskutierten erza¨hlerischen Einleitung folgen elf numerierte, jeweils mit Motti und Namen versehene Erza¨hlblo¨cke, in denen sechs verschiedene Ich-Erza¨hler - die "Stimmen" des Romanuntertitels - Medeas Geschichte erza¨hlen. So wie in Kassandra die Troianer und die bereits in ihrem geographischen Verha¨ltnis zueinander den modernen Ost-West-Konflikt evozieren, tun es auch Medeas o¨stlicher Herkunftsort Kolchis und ihr gegenwa¨rtiger westlicher Aufenhaltsort Korinth. Doch wa¨hrend in Kassandra der Schwerpunkt der Erza¨hlung auf Kassandras Analyse des o¨stlichen Staates und der Verstrickung ihrer identita¨t mit ihm liegt, steht in Medea die Analyse des westlichen Staates, dem die Exilantin Medea sich emotional nicht verbunden fu¨hlt, im Mittelpunkt. Von politisch entgegengesetztyen Erza¨hlstimmen wird das westliche Korinth in Medea u¨bereinstimmend als selbstgerecht identifiziert. Die wiederholt behauptete Offenbarkeit und die U¨bereinstimmung der Erkenntnisse u¨ber das westliche Korinth deuten darauf hin, daß die Motivation, das Selbsbild des modernen westlichen Staates als falsch, ja gefa¨hrlich falsch zu entlarven, gerade nachdem der Sozialismus aufgeho¨rt hat, als Alternative zu fungieren, wohl dazu beigetragen hat, den starken Druck zu erzeugen, unter dem Jahrtausende schmelzen. Medeas konfliktfreie Reinheit, auch ihre Unberu¨hrtheit von der Macht ist im Roman die Voraussetzung dafu¨r, in Korinth "die verschu¨ttete Wahrheit aufzudecken, die unser Zusammenleben bestimmt". Medea entdeckt, daß Korinth auf ein Verbrechen gegru¨undet ist, und zwar auf das gleiche Verbrechen, um dessenwillen sie Kolchis verließ. Sowohl in Kolchis als auch in Korinth wurden Menschen von den Regierenden geopfert, um ihre eigene Macht zu erhalten, In Korinth wird Medea schließlich zu einer bo¨sen Su¨nderin abgestempelt. Was ihr bleibt, ist der Fluch u¨ber die auf ein Verbrechen gegru¨undete Gesellschaft. Eine Verso¨hnung scheint nicht mehr mo¨glich zu sein. Wolfs Schreiben fragt nach den dunklen Seitein des Lebens und kritisiert die Blindheit aller Versuche. In ihrer Kritik an der heutigen Realita¨t steckt ein Hoffnungsschimmer, den herauszufinden dem Leser bleibt. Der Roman gibt keine Antworten mehr und endet mit einer Frage.

      • KCI등재
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