정신분열병과 Neurotensin 수용체 유전자 다형성의 연합 연구

이유상,김형배,한진희,채영규,이정식,이혜순,주연호,김형섭,최인근,양병환 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: Neurotensin(NT)은 NT수용체와 결합하여 그 효과를 나타내는 neuromodulator 혹은 neurotransmitter로서 대뇌에서 도파민의 분비를 조절하는데 중요한 역할을 한다. 근래의 연구에 의하면 NT와 그 수용체는 대뇌에서 항정신병 약물의 효과를 매개하는 것으로 생각되고 있으며 약물치료를 받지 않은 정신분열병 환자의 뇌척수액에서 NT의 양이 적으로 보고되고 있어 이들은 정신분열병과 깊은 관련을 가지고 있을 것으로 추정된다. 최근 NT수용체의 유전자의 3`인접영역에서 정보가치가 높은 4 염기반복 다형성이 발견되어 이를 유전 표지자로 하여 정신분열병과의 연합을 알아보았다. 방 법: 서로 혈연관계에 있지 않은 정신분열병 환자 120명(남자 91명, 여자 29명)과 정상 대조군 106명(남자 84명, 여자 22명)을 대상으로 하였다. PANSS를 사용하여 양성 및 음성을 알아보았다. 말초혈액에서 DNA를 분리한 후에 중합효소연쇄반응을 사용하여 3`인접영역에 있는 4 염기 반복 다형성을 증폭하였고 silver staining한 후에 유전자형을 관찰하였다. chi-square 검증과 Bonferroni`s correction을 사용하여 환자군과 정상 대조군간의 대립유전자 빈도의 차이를 알아보았다. 또한 양성 및 음성 환자군으로 나누어 차이를 알아보았다. 결 과: 총 23개의 대립유전자가 관찰되었으며, 399bp의 대립유전자(A10)의 빈도가 환자군보다 정상대조군에서 통계적으로 유의하게 높았다(χ²=16.49, df=1, p<0.001). 음성 정신분열병 환자군과 정상대조군 사이의 비교에서는 정상대조군의 A10의 빈도가 환자군보다 유의하게 높았다(χ²=21.33, df=1, p<0.001). 성별 비교에서 남자 정신분열병 환자군은 대조군에 비하여 A10의 분포가 유의하게 적었다. (χ²=13.71, df=1, p<0.001) 결 론: NT 수용체 유전자와 정신분열병사이에 음성연합이 관찰되었다. NT 수용체 유전자가 일부 정신분열병의 발병과정에서 확실하지는 않지만 어떤 종류의 보호기능을 할 수도 있다는 것을 암시한다. Objectives: Neurotensin(NT), of which functions are evoked by its interaction with neurotensin receptors(NTR), coexists with mesolimbic dopamine and regulates endogenous dopamine release. Recent studies have shown that NT with NTR exerts neuroleptic-like activity within the central nervous system and may play an important role in the pathogenesis and in the treatment of schizophrenia. We have examined the gentic association between schizophrenia and tetranucleotide repeat polymorphism in the 3-flanking region of the NTR gene to investigate the possible contribution of the NTR gene to the schizophrenia susceptibility. Methods: Among 23 alleles identified, the subjects were 120 patients(male 91, female 29)with schizophrenia and 106 normal healthy controls(male 84, female 22). They were unrelated native Korean. PANSS was used to determine positive or negative subgroup in the schizophrenic patients. Using polymerase chain reaction and polyacrylamide gel electrophoresis, tetranucleotide repeat polymorphism(CCTT and CTT) in the 3`-flanking region of NTR gene was observed. For a comparison of NTR gene`s allelic frequencies between patients with schizophrenia and normal healthy controls, chi-square test and Bonferroni`s correction was performed. Results: The frequency of A10 allele(base pair size=399)was significantly higher in normal healthy controls than schizophrenia(χ²=16.4902, df=1, p<.000). In the comparison between schizophrenic patients with negative symptoms and normal controls, the frequency of A10 allele was significantly higher in normal healthy control subjects than patients with schizophrenia(χ²=21.33, df=1, p<0.001). In the case of male, the frequency of A10 allele of schizophrenia was significantly higher than normal controls(χ²=13.71, df=1, p<0.001). Conclusions: NTR gene was negatively associated with schizophrenia. NTR gene`s tetranucleotide repeat polymorphism may provide some protective function against schizophrenia.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

온-라인 컴퓨터제어에 의한 메탄올로부터 균체의 생산

이형춘,이계호 서울保健大學 1989 論文集 Vol.9 No.1

포사맥스 정(알렌드론산나트륨 70mg)에 대한 대웅 알렌드로네이트 정 70mg의 생물학적 동등성

이예리,정선경,양승권,최기호,신용철,전형규,강승우,이희주 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.2

CaBaLaCu₃Oy의 초전도 특성과 고온 비저항 거동

이호섭,이형철 國立昌原大學校 基礎科學硏究所 1990 基礎科學硏究所論文集 Vol.2 No.-

The superconducting properties of CaBaLaCu₃Oy with Tc = 76K were reported. The X-ray diffraction pattern analysis shows that CaBaLaCu₃0y compound has tetragonal structure at room temperature. The superconductivity of this compound was confirmed from the temperature dependence of electrical resistivity and self-inductance between 300 K and 20 K. We also examined the temperature dependence of the electrical resistivity p(T) in the range of 300 K and 900 K. From the linear behavior of p(T), the strength of electron-phonon coupling constant λ and the electron mean free pathℓ are obtained from the standard electron-phonon dissipation mechanism. Our estimated value of ?????? implies that the superconductivity of CaBaLaCu??0y may not to be interpreted only in terms of the photon-mediated electron-electron interaction.

전기침이 구강동통에 미치는 영향에 관한 연구

이창섭,송형근,이상호,최용성 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.3

The effects of electro-acupuncture on the pain threshold and the amplitude of dEMG(digastric EMG) evoked by the noxious electric stimulation on teeth and gingiva in dogs were studied. Experiments were carried out with 10 dogs weighing 5-8kg. Each animal was anestheticed with Entobar given intraperitoneally in an initial dose of 30㎎/㎏. Maintenance dose of 5㎎/㎏/hr was given through a cannula, in the femoral vein, as required to keep up light anesthesia. Bipolar stimulating wire electrodes, 0.1mm in diameter, insulated except for tips, were inserted into the upper canine and palatal gingiva. Rectangular aluminium plate electrodes (15×5mm) were placed on acupuncture points, called Yin-Hsiang, located at both sides of the upper jaw. Rectangular biphasic current pulses of 2Hz, with a 250μsec duration,were delivered for 15 minutes. The dEMG activities were recorded from the anterior belly of the digastric muscle(one of the jaw opening muscles) using bipolar wire electrodes. The magnitude of the jaw opening reflex at different intensties of electro-acupuncture(1volt 4volt and 10volt) was estimated by averaging the 30 superimposed dEMGs recorded on an oscilloscope and audiomonitor. Data were analysed statistically with ANOVA and paired t-test. The obtained results were as follows : 1. Pain thresholds were increased 7.7%, 15.4%, 17.3% in the teeth and 11.1%, 19.0%, 25.4% in the gingiva as the intensities of electro-acupuncture increased incrementally. 2. Amplitudes of dEMG were decreaed 8.3%, 22.4%, 27.4% in the teeth and 9.8%, 36.5%, 42.2% in the gingiva as the intensities of electro-acupuncture increased incrementally. 3. Inhibition of pain responses by the electroacupuncture was more effective in the gingiva than in the teeth.

초고속 국가망의 가입자망 유형별 정보보호 대응방안

이형옥,조정호,한치문 한국정보사회진흥원 2003 정보화정책 Vol.10 No.1

본 논문에서는 초고속국가망의 가입자별 망구조와 초고속 국가망을 이용하는 기능에 따른 가입자망의 유형을 분석하고, 이를 토대로 초고속국가망에서 가입자망의 정보보호를 위한 보안모델을 제시한다. 이를 위해 가입자망 구조를 FR망 가입자, ATM망 가입자 및 라우터망 가입자로 구분하고, 가입자망의 기능을 인터넷 백본 모델, ATM종단간 전용선 기능인 가상 터널링 모델, VPN모델로 분류한 다음, 각 모델별 가입자 정보보안을 위한 대응 방안을 분석한다. In this paper, subscriber network types in KII(Korea Infornation Infrastructure) accofding to subscriber network structures and the application types of subscriber are analyzed, and the protction models for the user data of subscriber networks on KII are proposed. The subscriber network structures such as FR(Frame Relay) network, ATM network and router network are defined, and the service application model in KII are classified. As a results, user data protection methods suitable for each model are analyzed.

수냉쿨러의 냉각 효율 향상을 위한 플레이트 부품의 형상에 관한 연구

성윤호,김형찬,김선민,윤석영,이영웅,이상욱 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

This study investigates changes in cooling efficiency for heat sink plate width, perforated width, and chamfer angle as part of a parameter study to maximize cooling efficiency of heat sink by setting various variables on plates. The width of the plate is set to 16, 20, 24, 28 mm, perforated width 1.5, 2.0, 2.5 mm, chamfer angles 5, 10, 15 and 20°. By conducting a computational study with Ansys Fluent, the sink plate with plate width of 16mm, perforated width of 3mm and chamfer angle of 10° is shown to be the best cooling efficiency.

폐굴껍질의 정석반응을 이용한 수중 인제거 특성

이호수,정유진,김은호,성낙창,이영형 동아대학교 환경문제연구소 1998 硏究報告 Vol.21 No.2

The technology of removing phosphorous, considered as one of the most important control nutrients causing eutrophication in various water bodies, have been investigated by many researchers. Recently, phosphorous crystallization process is emerging as a new technology for phosphorous removal. In this study, waste oyster shells which can be easily obtained from the ocean, were used as a seed crystal, and their effects of several physical/chemical factors on the phosphorous removal efficiencies were examined by batch tests. Ca^(2+) and pH affected phosphorous crystallization process using waste oyster shells. As alkalinity of wastewater increased, phosphorous removal efficiencies gradually decreased. Phosphorous removal efficiencies were increased, as specific area and contact efficiency per unit area of waste oyster shells were increased. In case of high temperature, phosphorous crystallization process was rapidly advanced and phosphorous removal efficiencies were increased. Depending on X-ray diffraction analysis, it was showed that generation materials extracted from the surface of waste oyster shells with short reaction time were dominated by CaHPO₄ ·2H₂O, but progressed to Ca_(5)(OH)(PO₄)₃.

배추 Plug育苗條件이 苗素質에 미치는 影響

李喆浩,崔周鎬,朴重春,孫嶺杰,朴鳳植,李炯貞 진주산업대학교 농업기술연구소 1999 農業技術硏究所報 Vol.12 No.-

배추 plug육묘 조건을 알아보기 위하여 상토 종류, 질소시비수준, plug트레이 배수공수준을 달리하여 실험한 결과를 요약하면 다음과 같다. 1. 유묘출현율은 A상토<B상토<C상토의 順으로 높았고, 질소시비수준은 무비구에서 높고, 시비구에서는 90∼90ppm수준에서 높은 편이었으며 배수공수에 따라서는 배수공이 적은 128공구가 출현율이 높았다. 2. 幼苗의 葉발생도 A상토<B상토<C상토 순으로 높았고, 질소시비수준은 다비구(150ppm구)에서 엽수 5배로 최대엽수를 나타내었고, 배수공수에 따라서는 배수공이 적은 128공구가 높았다. 3. 엽장의 길이는 A상토구는 128공구에서 질소시비수준 120ppm에서 6.98cm로 가장 길었으며, B상토구에서 128배수공구의 시비수준 150ppm에서 12.41cm로 가장 길었고, C상토구에서도 128배수공구의 시비수준 150ppm에서 12.88cm, 200배수공구에서도 9.29cm로 가장 길었고 무비구에서는 공히 가장 짧았다. 4. 葉幅도 엽수와 엽장과 비슷한 경향으로 기비로 사용된 질소의 시비수준이 증가할수록 엽장이나 엽폭이 증가하여 B상토구의 150ppm 시비구에서 4.80cm로 최대치를 나타냈으며 시비량이 감소할수록 엽폭도 줄어드는 경향이였다. 5. 뿌리의 신장은 A상토구의 128배수공구에서 질소질 함량이 90∼120ppm수준의 범위내에서 신장이 양호하였으나 150ppm시비구에서는 불량한 반면, B와 C상토구에서는 90∼150ppm 모두에서 양호하였다. 6. 생체중과 건물중도 상토조성, 질소질비료 및 트레이 크기에 따라 모두 크게 영향을 받는 것으로 나타났으며 C상토구의 150ppm시비구에서 주당 3.0g의 생체중에서 최대치를 보였고 건물중 역시 C상토구의 150ppm시비구에서 4주에 600mg의 생체중의 증가를 보여 최대의 기록을 나타냈고 질소질의 농도 150ppm이 생체중 및 건물중 증가에 가장 효과적인 것으로 나타났다. The experiments were conducted to develop ideal substrates for the production of good quality in cabbage plug and also to improve the media with low or non environmental pollution by blending and mixing artificial substrate including peat moss, coir, perlite, vermiculite, carbonized rice hull and zeolite. In effects of soil substrate combination, nitrogen concentration and tray cell size on growing of 'Baekro', chinese cabbage, the ratio of seedling emergency in all fertilizer block was higher than non-fertilizer of nitrogen by 80%. The number of leaves were most increased in the 150ppm nitrogen solution of B block(coir 50%, vermiculite 10% and perlite+carbonized rice hull-zeolite 40%) and C block(coir 40%, vermiculite 20% and perlite+carbonized rice hull+zeolite 40%). The leaf length and leaf width were similar with that result in the number of leaves. Rooting condition was the best in the 90∼120ppm nitrogen solution of A block(TOSILI No1, SHINAN-JEONGMIL(Co)) in 128 tray cell size. The fresh weight and dry weight were increased as the order A<B<C in soil combination, were increased in the fertilizer which has more nitrogen concentration and were increased higher in 128 than 200 tray cell size, and chlorophyll concentration was the highest in the 150ppm nitrogen solution of A and B soil combination.