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Neurophyisological and Neurocognitive Endophenotypes for Schizophrenia Genetics Research
주연호 대한신경정신의학회 2008 PSYCHIATRY INVESTIGATION Vol.5 No.4
There is growing interest in the genetic analysis of schizophrenia using endophenotypes rather than clinical diagnosis or symptom dimensions. Endophenotypes could be alternative phenotypes for the clinical phenotypes. With their intermedicate and quantitative characteristics, endophenotypes could be functionally important links in the pathways between the genetic variation and clinical expression of the disorder. In this regard, the neurophysiological and neurocognitive endophenotypes used in the genetic analysis of schizophrenia have been reviewed.
주연호,안지영,김종훈,김용식 대한신경정신의학회 2003 신경정신의학 Vol.42 No.3
Objectives:To explore the possibilities of finding a heritable phenotype(s) in patients with psychosis, we examined the similarities of clinical variables between psychotic sibling patients who share the half of genetic information. Methods:We recruited a group of sibling patients, whose diagnoses were schizophrenia, schizoaffective disorder and bipolar disorder and confirmed the diagnosis using SCID-RV(Structured Clinical Interview for DSM-IV, Research Version). Using 30 sets of sibling patients, we examined concordances or similarities of diagnosis, diagnostic subtypes, clinical symptoms, and longitudinal outcomes. Results:There were significant concordances in terms of age of onset, auditory hallucination persisted for more than 7 years, general level of functioning. No significant similarities or concordances were found in diagnosis, diagnostic subtypes, delusion, negative symptom, and thought disorder between sibling patients. Conclusion:Above mentioned similarities have the possibilities of genetically determined phenotypes that could be used in the future genetic studies. Concordance of hallucination persisted for more than 7 years, not the presence or absence of auditory hallucination between sibling patients suggests that it is more important to examine longitudinal patterns of symptoms than to merely examine the presence of symptoms at specific cross-sectional time points in terms of genetic studies
춘계학술대회 : 포스터전시 ; 원발성 간 MALT 임파종 1예
주연호,장성훈,하동호,이윤복,이재화,허주령 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3(S)
서론: 원발성 간 임파종은 매우 드물어 extranodal 임파종의 0.4% 미만을 차지하며 이의 대부분은 large B cell type이다. 원발성 간 MALT 임파종은 더욱 드물어 영문으로 10여 개의 증례가 보고되어 있다. 저자들은 상기 희귀한 증례를 경험하였기에 문헌 고찰과 더불어 보고한다. 증례: 63세 여자 환자가 1주일 전부터 시작된 우상복부 통증을 주소로 일차의료기관에서 복부 초음파 검사를 받고 간 좌엽에 종양이 발견되어 내원하였다. 과