개에서 이중 결찰법을 통한 동맥관 개존증의 완치 예

윤헌영,정순욱,박희명,박철,정만복,김준영,한현정,황민,노병국,박상혁,장하영,박정윤 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.1

A ten months old, female Yorkshire terrier weighing 2.88 kg referred to veterinary teaching hospital of college of veterinary medicine, Konkuk University because of syncope, cough and dyspnea. First hematological and serum chemical test revealed thrombocytopenia, mild anemia, and increase of concentration of ALP (195 U/L). On 57 days later, second hematological and serum chemical test revealed polycythemia, increase of concentration of ALP (211 U/L), and Tchol (387 mg/dl). Right atrium enlargement, main pulmonary artery bulge and cardiomegaly (VHS = 11.5) were observed in radiographic findings. Ultrasonographic images showed both right and left ventricular dilation and turbulent flow between the descending aorta and the main pulmonary artery in color Doppler imaging. ECG showed left ventricular enlargement, SA block, and electrical alternant. Thoracotomy was performed through left fourth intercostal incision under isoflurane anesthesia. Patent ductus arteriosus was double ligated with 1-0 silk. Cough and dyspnea disappeared on 5 days after operation. Turbulent flow was not found in color doppler imaging of ultrasonography on 10 days after operation. Ten months later after the operation, syncope could not exist any more.

개 아토피성 피부염 장기치료 1례

박은정,윤기영,박정호,이왕희,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

A 7-year-old male castrated Shih-tzu dog was referred to the Veterinary Medical Teaching Hospital of Chungnam National University for severe pruritus. On physical examination were confirmed systemic erythema and alopecia, crust on the neck and flank region. Tape strip test identified numerous degenerative neutrophils and severe Malassezia infection. Treatment for severe pruritus was applied with systemic antihistamine therapy and topical therapy with antimicrobial shampoos. For the finding of appropriate treatment of atopic dermatitis, it was chosen six immune-related treatments. And clinical sign scores were evaluated by investigator with CADESI-03 after each application of six treatments. Application of human immunoglobulin G and leflunomide showed the remarkable regression of lesions.

Effect of Ionizing Radiation on Rat Tissue: Proteomic and Biochemical Analysis

Park*, Eui‐,Chul,Yoon, Jong‐,Bok,Seong*, Jin‐,Sil,Choi, Kyoung‐,Soo,Kong, Eung‐,Sik,Kim, Yun‐,Jeong,Park, Young‐,Mee,Park, Eun‐,Mi Taylor Francis 2006 Preparative biochemistry & biotechnology Vol.36 No.1

<P>Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.</P>

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

LC-ESI-MS/MS를 이용한 생체시료 중 브롬화피나베리움의 고감도 분석 및 이를 이용한 생체이용률 평가 : Applicability to Oral Bioavailability Determination

박석,이예리,김호현,이희주,김윤균,염정록,한상범 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

A sensitive method for quantification of pinaverium bromide in human plasma was established using liquid chromatography-electrospray ionization tandem mass spectrometrv(LC-ESI-MS/MS). Glimepiride was used as internal standard. Pinaverium bromide and internal standard in plasma sample were extracted using tert-but}lmethvlether(TBME). A centrifuged upper laver was then evaporated and reconstituted with mobile phase of acetonitrile-5 m1VI ammonium formate (8020. pH 3.0). The reconstituted samples were injected into a C_(18) reversed-phase column. Using MS/MS with multiple reaction monitoring (MRM) mode. pinaverium and glimepirde were detected without severe interference from human plasma matrix. Pinaverium produced a protonated precursor ion ([M+H]^(+)) at m/z 510.3 and a corresponding product ion at m/z 228.9. Internal standard produced a protonated precursor ion ([M+H] ^(+)) at m/z 491.5 and a corresponding product ion at m/z 352.0. Detection of pinaverium bromide in human plasma was accurate and precise. with limit of quantitation at 0.5 ng/ml. The method has been successfully applied to bioavailability study of pinaverium bromide tablet in Korean healthy male volunteers. Pharmacokinetic parameters such as AUCr. C_(max) T_(max). K_(el) and t_(l/2) were calculated.

일개 대학병원에서 항생제 사용량과 분리 균주의 항생제 내성률에 관한 시계열 분석

윤영경,김민자,손장욱,박대원,김정연,천병철 대한감염학회 2008 감염과 화학요법 Vol.40 No.2

배경 :항생제 사용이 내성 균주를 유발하는 것으로 알려져 있다. 그러나, 항생제 사용량과 분리 균주들의 항생제 내성률의 관련성에 관한 연구는 매우 드물다. 본 연구는 일정 기간 동안의 항생제 사용량과 분리 균주의 항생제 내성률의 추이를 확인하고, 시계열 분석을 통해 사용된 항생제 양에 따른 내성률의 정도를 예측할 수 있는 모델링 방법을 확인하고자 하였다. 방법 : 전산화 항생제 처방 시스템이 갖춰진 750 병상의 대학 병원에서 2004년 1월부터 2007년 3월까지 분리된 전체 임상 분리 균주를 대상으로 항생제 내성률을 조사하였다. 항생제 사용량은 12가지 계열별로 분류하여 월별 항생제 사용 밀도(antimicrobial use density; AUD={총량 /(DDDX연환자수)}x1,000)를 구하였다. 선택된 항생제들의 월별 사용량과 특정 분리 균주들의 항생제 내성률의 변동과의 연관성을 SAS/ETS를 이용하여 상관 분석과 시계열 분석을 실시하였다. 결과 : 39개월의 연구 기간 동안 총 15,522개의 균주가 분리되었고, 항생제 사용량은 총 1,926.07 DDD/1,000명/일 이었다. 계열별 항생제의 월별 총 사용량은 연구 기간 중 큰 변화가 없었다. 항생제 내성률은 ciprofloxacin 내성 Escherichia coli는 32.46%±14.0, imipenem 내성 Pseudomonas aureginosa는 11.44%±8.1, methicillin 내성 Staphylococcaus aureus (MRSA)는 78.60%±6.9였으며, van-comycin 내성 Enterococcus faecium은 7.43%±4.5 이었다. 12개의 항생제 계열 중 월별 AUD의 평균은 aminoglycosides는 156.16±6.49, 3세대 cephalosporins은 145.67±5.95, 2세대 cephasporins은 90.95±7.47의 순서로 확인되었다. 시계열 분석에서, E. coli ciprofloxacin 내성률은 2개월 전의 E. coli CFX 내성률과 2개월 전의 ciprofloxacin 사용량(52.98±2.12)과 유의한 연관성이 있음을 확인하였다. 또한, MRSA 비율은 2개월과 4개월 전의 MRSA 비율과 3개월 전의 oxacillin 사용량(4.69±0.67)과 유의한 연관성이 있음을 확인하였다. 결론 : 연구 기간 동안의 항생제 사용량과 분리 균주의 항생제 내성률의 안정적 추이를 확인하였다. 또한 항생제 사용과 항생제 내성 사이의 일시적 관계를 나타내는 데에 시계열 분석의 유용함을 확인하였고, 이를 통하여 특정 항생제의 사용량과 관련된 항생제 내성률을 예측할 수 있었다. Background : The purpose of this study was to investigate the relationship between antimicrobial consumption and antimicrobial resistance and to predict for the level of antimicrobial resistance by a time series analysis. Materials and Methods : In a 750-bed medical center, antimicrobial consumption data of 12 classes of antimicrobials and surveillance of resistant profiles from all microbial isolates were collected from 1/2004 through 3/2007 by database from the hospital's computerized order system. World Health Organization 2004 definition of defined daily doses per 1,000 patient days were used to express the antimicrobial use density (AUD). The monthly proportion of resistant isolates (PR) of selected pathogens and monthly AUD were analyzed by time series analysis with transfer function model by using the SAS/ETS software. Results : The microbial surveillance data covered 15,522 isolates. PR of ciprofloxacin-resistant E.coli (EC-CFX), imipenem-resistant P. aureginosa, and methicillin-resistant S. aureus (MRSA) were 32.5%±14.0 11.4%±8.1, and 78.6%±6.9. The two highest monthly AUD of 12 class antimicrobials were 156.2±6.5 AUD for aminoglycosides and 145.7±6.0 AUD for 3rd-generation cephalosporins. By using time series analysis, we verified a significant correlation between the monthly CFX use and the PR of EC-CFX, and between the monthly penicillin use and the PR of MRSA. Conclusion : Antibiotic consumption and PR of antimicrobial resistant pathogens remained stable over the period of study. Furthermore, we could confirm the usefulness of a time series analysis to demonstrate a temporal relationship between antimicrobial use and resistance, to predict the effect of antibiotics use on antimicrobial resistance.

당뇨병성 족부병변의 관리

박윤정,윤소영 한국전문물리치료학회 1998 한국전문물리치료학회지 Vol.5 No.2

영적 간호중재가 호스피스 환자의 불안과 우울에 미치는 효과

윤매옥,박정숙 성인간호학회 2002 성인간호학회지 Vol.14 No.3

Purpose: The purpose of this study was to elucidate the effects of spiritual nursing intervention on anxiety and depression of the hospice patients. Method: It was devised with a quasi-experimental design using non-equivalent control group pre-post design. The data was from July 10 to September 25 in 2000 at the general hospital in CheonJu city. Subjects were 37 members of the experimental group and 30 members of the control. The tools were used Spielberger's State Anxiety Scale and Zung's Depression Inventory. The spiritual nursing intervention was carried out through Hymn, Scripture, Prayer, the therapeutic ues of self. Data were analyzed by mean, standard deviation, x^2-test, t-test. Result: 1. After the spiritual nursing intervention, state anxiety of the experimental group was lower than those of the control (t=-5.987, p=0.000). 2. After the spiritual nursing intervention, depression of the experimental group were lower than those of the control (t=-9.128, p=0.000). Conclusion: The hospital patients who were offered spiritual nursing intervention had lower anxiety & depression than not offered it. According to these results, it can be regarded as an effective on that relieved anxiety and depression of the hospice patients.

어린이 공공전문진료센터의 진료 역량: 상급종합병원과의 비교를 중심으로

오정윤,조수진,정진선,조진숙,박춘선 건강보험심사평가원 2022 HIRA RESEARCH Vol.2 No.2