접적지역 복무 병사의 적응도 결정요인에 대한 연구

박상혁,윤여연 국제문화기술진흥원 2019 The Journal of the Convergence on Culture Technolo Vol.5 No.3

South Korea is in a dangerous situation where a war between the two Koreas could be triggered at any time based on the MDL (Military Demarcation Line) between the two Koreas due to the inter-Korean standoff over the armistice. Also, unlike the borders of other countries, the border between the two Koreas is the front-line area where people can feel the threat of life that could be triggered by war. Soldiers who work in special areas such as the contact area are not easily accessible due to local conditions, and are less likely to go out, stay out, stay out, or visit, and the working environment is overloaded with vast forests and silence at night, and feel anxious, lonely and insecure because they don't know when any situation will occur near the enemy. Therefore, a great deal of help will be needed to pay attention to soldiers who give up their lives here and perform their national defense duties, and to finish their barracks life safely and faithfully, and support for psychological adaptation of service members in the border areas. 우리나라는 정전으로 남북관계가 대치됨에 따라 남북의 MDL(군사분계선)을 기준으로 남북 간의 전쟁이 언제라도 촉발될 수 있는 위험한 상황에 처해 있다. 또한, 타 국가의 국경과는 달리 남북의 접경지역은 전쟁으로 촉발될 수 있는 생명의 위협을 느낄 수 있는 곳이 최전방 접적지역이다. 접적지역과 같은 특수한 지역에서 근무하는 병사들은 지역적 여건상 접근성이 용이하지 못하여 외출, 외박, 면회가 적은 실정이고, 근무 환경은 야밤에 넓은 숲과 적막함이 넘치고 적과 근접하여 언제 어떤 상황이 일어날지 모르기에 불안함과 외로움 그리고 불안함이 과중 되는 지역이다. 따라서 이곳에서 목숨을 내놓고 국방의 의무를 수행하는 병사들에게 관심을 갖고 병영생활을 안전하고 충실히 마칠 수 있도록 많은 도움이 필요할 것이며, 접적지역 복무병사들의 심리적 적응을 위한 지원이 필요하다.

공공부문의 e-비즈니스 성공요인에 관한 연구 : 한국자산관리공사의 온비드시스템과 조직관리변화를 중심으로

박상혁 진주산업대학교 산업과학기술연구소 2007 산업과학기술연구소보 Vol.- No.14

The purpose of this research is to seek the success factors of e-Business in the public sector. On-bid system is developed by KAMCO. This systems is a e-Marketplace on the assets trading (eg., disposition by public sale on the real estate). E-Marketplace on the real estate has some special characteristics. This paper 1) reviews the implementation pattern of e-Transformation on the public sector and 2) derives success factors of e-business on that area.

Two Cases of Myeloproliferative Neoplasm with a Concurrent JAK2V617F Mutation and BCR/ABL Translocation without Chronic Myelogenous Leukemia Phenotype Acquisition during Hydroxyurea Treatment

박상혁,지현숙,최영욱,장성수,박찬정,김대영,이제환,이규형 대한진단검사의학회 2013 Annals of Laboratory Medicine Vol.33 No.3

Rare Frameshift Mutation Cys475Tyrfs*11 in the BCR/ABL Kinase Domain Contributes to Imatinib Mesylate Resistance in 2 Korean Patients with Chronic Myelogenous Leukemia

박상혁,지현숙,권미량,조영욱,장성수,박찬정 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.6

Mutations in the BCR/ABL kinase domain contribute to resistance to imatinib, which has driven the choice of second-line tyrosine kinase inhibitors, such as dasatinib or nilotinib, in CML patients. Thus far, more than 90 different mutations have been reported in previous reports [1, 2]. The majority of known mutations are missense mutations. In contrast, insertion or deletion mutations are very rare, and only 3 such mutations have been reported [3, 4]. Here, we describe the insertions of 35 nucleotides resulting from frameshift mutation (p.Cys475Tyrfs*11) in the BCR/ABL kinase domain, which contributed to imatinib resistance, in 2 Korean patients with CML. Case 1 was a 20-yr-old woman who was diagnosed with CML in the chronic phase 2 yr before. She had a major BCR/ABL rearrangement (b3a2) at diagnosis with a BCR/ABL fusion transcript/ GAPDH ratio of 0.024 in peripheral blood (PB). She was treated with imatinib. The response was successful during the follow-up period, and the ratio was maintained between 0.0002 and 0.0003 in PB. After 15 months of imatinib treatment, her BCR/ABL quantification ratio increased to 0.05 in PB, which suggested molecular relapse. The therapeutic regimen was changed to dasatinib immediately, and her follow-up BCR/ABL quantification results 3 weeks after the change of treatment regimen showed marked reduction (from 0.05 to 0.00014) in PB. She was in a complete hematologic response state at a followup bone marrow examination that was performed 4 months after the treatment change from imatinib to dasatinib. Case 2 was a 38-yr-old man who was treated with imatinib for 5 yr but who suffered from relapse with a lymphoblastic crisis of CML 4 yr before. After the relapse, he immediately underwent allogeneic bone marrow transplantation (BMT), and his BCR/ ABL quantification results in PB changed from 0.25 at relapse to negative after the BMT. Five months after the BMT, his followup BCR/ABL quantification results in PB increased to 0.52, which suggested molecular relapse, but the treatment regimen was not changed. Finally, he expired due to sepsis 1 month after molecular relapse. To confirm the diagnosis of imatinib resistance, BCR/ABL kinase domain mutation analyses that were based on reverse transcriptase PCR-direct sequencing were performed retrospectively using stored RNA at the time of molecular relapse for both patients. cDNA was synthesized from stored RNA by reverse transcriptase PCR methods. Three sets of forward and reverse primers were used for amplification of the BCR/ABL kinase domain, and the sequences of each primer were as follows: ABL-A(forward: 5’-CAT CAT TCA ACG GTG GCC GAC GG-3’, reverse:5’-GTT GCA CTC CCT CAG GTA GTC-3’), ABL-B (forward: 5’-GAA GAA ATA CAG CCT GAC GGT G-3’, reverse: 5’-CGT CGG ACT TGA TGG AGA A-3’), and ABL-C (forward: 5’-TGA CAG GGG ACA CCT ACA CA-3’, reverse: 5’-ATC TCA GGC ACG TCA GTG GT-3’). The amplification protocol consisted of an initial denaturation at 95°C for 5 min, which was followed by 32 cycles of denaturation at 95°C for 30 sec, annealing at 60°C for 30 sec, and extension at 68°C for 3 min, and a final extension at 72°C for 7 min. After confirmation of the single bands that were sized 393, 482, and 487 bp by electrophoresis for ABL-A, -B, and -C, respectively, direct sequencing was performed using the BigDye Terminator Cycle Sequencing Ready Reaction kit on the ABI 3130 genetic analyzer (Applied Biosystems, Foster City, CA, USA) according to the manufacturer’s protocol. The Sequencher program (GeneCodes Corp., Ann Arbor, MI, USA) was used for alignment with the reference sequence (Genbank accession no. X16416.1). The identified mutation was described according to the Human Gene Variation Society guidelines (http://www.hgvs.org/). The direct sequencing results for both patients showed the same heterozygous frameshift mutation, which was an insertion of 35 nucleotides between the 1,423rd and 1,424th nucleotide(c.1423_1424ins35...

SBD(Self Bag Drop) 시스템 기술 분석

박상혁,지민석,이강석 한국항공경영학회 2014 한국항공경영학회 추계학술대회 Vol.2014 No.-

Self Bag Drop 시스템은 수하물처리시스템(Baggage Handling System) 중 셀프서비스의 대표적인 기술로 해외 허브공항에 이용 중이며 체크인에 필요한 시간을 줄이고 서비스의 수준을 높이면서 승객에게 편의를 제공한다. SBD 시스템은 공항을 이용하는 승객들이 기내에 휴대하지 않고 위탁하는 수하물을 승객 스스로 Kiosk 또는 통합된 자체 SBD에서 Bag Tag를 인쇄하고 가방에 부착하여 대기시간을 감소시킬 수 있는 장비이다. 대부분의 해외 허브공항에서 SBD 시스템을 도입하여 첨단 공항으로 변화하고 있으나, 국내에서는 인천국제공항을 포함하여 어느 공항도 SBD 시스템이 도입되어 있지 않다. 공항의 진정한 여객처리 간소화를 위해서는 Self Check-in 시스템과 더불어 여객수하물의 자동위탁처리를 위한 SBD 시스템 구축이 필요하다. 국내 무인자동화시스템, 생산자동화 시스템에 대한 개발과 제조능력은 세계 수준이므로 SBD의 국산화를 통해 해외제품과의 경쟁이 충분히 가능하다고 본다. 본 연구에서는 SBD 시스템의 기술 분석을 통해 국산화 도입 및 발전방안을 제시한다.

압연공정에서의 피드포워드 제어기 성능 개선에 관한 연구

박상혁,이혜영,이달해 한국지능시스템학회 1996 한국지능시스템학회 학술발표 논문집 Vol.6 No.2

A Case of Residual Non-Small Cell Lung Cancer Cells Coexisting With Newly Developed Small Cell Lung Cancer Cells in Ascitic Fluid after Chemotherapy for Non-Small Cell Lung Cancer

박상혁,최현숙,김영진,조영욱,장승수,박찬정,김상위 대한진단검사의학회 2014 Annals of Laboratory Medicine Vol.34 No.2

Dear editor, Synchronous primary lung cancer occurs in only 0.5% of pa- tients with lung cancer, and coexistence of non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) has been reported in a very small fraction of lung cancer cases [1, 2]. In NSCLC, malignant cells are generally arranged in three-dimen- sional clusters and have eccentrically placed round to oval nu- clei with prominent nucleoli. The cytoplasm may contain single to many vacuoles with diffuse and strong positivity on periodic acid-Schiff (PAS) cytochemical staining. Most NSCLC cells show positive cytoplasmic immunoreactivity for cytokeratin (CK) 7 but negative immunoreactivity for CK20. In SCLC, the small tumor cells have an extremely high nuclear to cytoplasmic ratio and show nuclear molding with positive immunocytochemical stain- ing for CD56. The nuclear contours are often “squeezed” in ap- pearance in order to accommodate the contours of the adjacent nuclei (a back-to-back appearance) [3]. To the best of our knowledge, coexistence of residual NSCLC cells and newly de- veloped SCLC cells in ascitic fluid after chemotherapy for previ-ously diagnosed NSCLC has not been reported. Here, we report a case of residual NSCLC cells coexisting with newly developed SCLC cells in the ascitic fluid of a patient who had received che- motherapy for previously diagnosed NSCLC.

진화구조의 위상변환에 의한 디지털 공간에서의 주거 진화 모델링

박상혁 경기대학교 건축전문대학원 2005 경기대학교 건축대학원 논문집 Vol.9 No.-

건축에 있어서 다른 건축물과 달리 주거는 인간의 본질적 삶의 공간으로서 역할을 한다. 그러므로 주거는 인간에게 있어서 생존의 역사이며 삶의 역사이며 진화의 역사이다. 주거공간은 인간의 본능에서 충동되어 표출되어진 생존과 번식을 위한 절대적인 공간의 의미를 갖으며 그 공간을 통해 인간의 존재를 인식시켜 준다. 주거공간에는 단순히 물리적 공간으로서의 의미만이 존재하는 것이 아니라 인간의 본능적 생득적 핵을 담고 있으며 이는 인간의 행동과 삶 그리고 정신적 진화의 응집된 결과물로서의 공간이라고 할 수 있다. 본 연구는 인간에게 있어서 절대적 공간인 주거가 단순히 경제적 가치로서의 논리와 인간에게 있어서 본질적 공간으로서의 의미를 도외시한 결과물로서의 주거로부터의 반성에서 출발한다. 위의 부산물로 쏟아지는 주거공간들은 인간의 삶을 황폐화 시키고 있다. 여기서 우리는 주거를 단순히 물리적 공간으로서의 의미로 혹은 주어지는 삶의 은둔처가 아닌 인간의 삶의 풍요롭게 해줄 수 있는 생존의 삶의 공간으로서 재해석함이 필요하다. 이는 곧 인간의 역사와 함께 해온 주거의 진화를 통해서 재고하고 새롭게 적용될 수 있는 주거의 패러다임을 모색하고 제시함이 필요하다고 생각한다. 이 논문에서 주거공간을 해석함에 있어 물리적 공간으로서 한계 짓는 기존의 기준을 폐기하고 인간의 생존과 번식 그리고 인간의 심리와 행동을 담기 위한 본질적 공간으로의 확장을 통해 새로운 주거공간의 의미를 찾고 그것을 통해 디지털 공간 속에 진화의 알고리즘을 통한 주거 진화 모델링을 시도하고자 한다. Unlike a building different in the architecture the residence plays the role as the space of the human of essential life. Therefore it is the history of the survival and it is the history of the life and it is the history of the evolution. The residing space means the absolute space for the survival and propagation which is instigated and expressed in the instinct of the human and by which we are able to recognize the existence of the human being. There is not only a constructing building space but the space that is included the kernel of the instinct for survival and the sensibility in the residing space. So the residing space is the result to be cohered the action, the life and the sprit of human that has evolved. This study is the starting point of reflect that we have evaluated the residence as only the economic value and the result that is neglected the essential space to human. Like the copies of the documents the existing residence devastate and standardize our life. Therefore it is necessary to try to reinterpret the existing residing space as the essential space that makes the monotonous life to the bountiful life. In this study I try to find a solution to the problem by groping the new paradigm for a residing evolution included the human life. In interpreting the residing space I suggest the new method to extend the essential space that is included the survival of human, the propagation of human, the mind of human and the action of human after I abolish the standards to defining the boundary of the existing residence. By that I try to make a residing evolution modelling in digital spae.

화성시 무인도서 조간대의 저서무척추동물상

박상혁,김세훈,정연우,손대선,마채우 순천향대학교 기초과학연구소 2020 순천향자연과학연구 논문집 Vol.26 No.1

Macrobentic invertebrates on intertidal zone in 14 desert islands of Hwaseong-si investigated from May to December 2008. A total of 48 species was found with mollusca 32, arthropoda 13, annelida, cnidaria and brachiopoda 1. The species diversity was highest in Maebakseom (18 species) and it was lowest in Jebudo, Jageunkkachiseom and Angoryeomseom (10 species). The dominance species was Fistulobalanus albicostatus. The species diversity of the study area was lower than southern coast of Korea. In addition Austruca lactea was an important species in Oenongdo.

창업대학원과 대학생을 연계한 창업컨설팅 사례연구: 액션러닝을 활용한 창업교육 및 컨설팅 프로그램

박상혁,설병문,Park, Sang Hyeok,Seol, Byung Moon 한국벤처창업학회 2014 벤처창업연구 Vol.9 No.1

경영혁신도구로 액션러닝 활용비중은 점차 높아지고 있으나, 5인 이하 규모의 창업인의 경우에는 활용에 어려움이 있다. 본 연구에서는 이러한 문제를 해결할 수 있는 사례로 경남과학기술대학교 창업대학원에서 운영하고 있는 '창업교육 및 컨설팅 융합프로그램'을 살펴보았다. 본 프로그램은 교수가 퍼실리테이터로 참가하고 대학생으로 구성된 팀이 창업대학원생 창업과제를 해결하는 프로그램이다. 본 프로그램의 운영사례는 다음과 같은 의미를 가진다. 첫째, 학부생이 창업과정에 직접 참여함으로써 대학생에게 창업경험을 제공하고 창업마인드 고취 및 역량강화 효과를 기대할 수 있다. 둘째, 창업자의 입장에서는 잠재적 수요자에게 아이템을 직접 검증받는 기회를 갖는다. 검증은 팀활동을 통한 집단지성의 활용과정에서 이루어진다. 이 과정에서 만들어지는 아이디어는 창업자에게 창업과정에서 발생하는 구체적이고 현실적 현안들을 제공한다. 셋째, 참여교수의 퍼실리테이터 기능을 대학원생과 학부생이 학습하는 기회를 가진다. 본 연구결과는 지역의 창업기반과 교육기관을 연계하여 대학내 교육 프로그램을 지역사회에 확산하는 기반을 효과적으로 마련 할 수 있을것이다. 교육과정에서 대학원생과 대학생은 퍼실리테이터로 프로그램 확산에 참여하는 효과가 기대된다. Action learning takes advantage of innovative management tool but not more to small business than five employees. It is difficult to utilize to them. As a case to solve this problem, this study investigates GNTECH(Gyeongnam National University of Science and Technology)'entrepreneurship training and consulting convergence program. This program is applied to the development and operation of the start-up entrepreneur. Project participants are three groups those are graduate students, undergraduate students and professor. Professor has a role as facilitater. This case has the following meanings. First, by participating in entrepreneurship courses, undergraduate students experience entrepreneurship and mindset can be expected. Second, the start-up entrepreneur has the opportunity to directly verify the item. The consumer's perspective is the use of collective intelligence through team activities carried out in the process. Third, students of graduate and undergraduate has a chance learning facilitator function from professor. The results of this study provide conjunction between university educational programs based on entrepreneurship.