두개강내 혈종을 동반한 전이성 융모막암종 : 증례보고 Case Report

황수현,이현석,박용규,박인성,김은상,정진명,한종우 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.8

The authors report 2 cases of metastatic choriocarcinoma associated with intracranial hemorrhage One of them had intracranial hemorrhage on the right frontal lobe and the other one developed intracranial hemorrhage and enhancing mass on the parietal lobe revealed by admission brain CT They had rebled intracranially 2 and 3 times respectively. Even though the patients had recieved intracranial decompressive operations. they eventually died of intracranial rebleeding or hemothorax. respectively. These tumors generally occur in women of childbearing age and commonly produce signs and symptoms of subarachnoid hemorrhage, intracerebral hemorrhage or brain tumor Metastatic choriocarcinoma of the brain is a curable lesion. Cure is generally achieved by extirpation of the tumor chemotherapy. and irradiation of the site of the cerebral metastasis. The two cases in this report have been unsuccessful in their management.

통신프로토콜의 적합성시험열 생성을 위한 경로 탐색 방법

황익순,장민석,이상배,이재용 延世大學校 電波通信共同硏究所 1996 電波通信論文誌 Vol.2 No.1

본 논문에서는 적합성 시험에서 EFSM(Extend Finite State Machine) 모델에 대한 데이타부분 시험열을 효율적으로 생성시켜 주는 탐색 방법에 대해 제안하였다. 이 탐색 방법에서는 depth-first search와 같은 기존의 탐색 방법과는 달리 탐색 초기에 다양한 경로가 찾아진다. 이미 제안된 시험열 생성 방법인 데이타 값을 바탕으로 하여 시험열을 생성하는 방법에서 이 탐색 방법을 이용하였을 경우 기존의 탐색방법을 이용하는 것보다 효율적으로 시험열을 생성할 수 있다. 본 논문에서는 Inres 프로토콜에 이 탐색 방법과 기존의 탐색 방법인 depth-first search를 각각 적용하여 시험열을 생성, 비교하여 보았으며, 제안된 탐색 방법을 이용하면 같은 시험 범주를 가지면서도 짧은 길이를 갖는 시험열을 효율적으로 생성할 수 있음을 알 수 있다. In this paper we proposed a searching algorithm for generating test cases, which can test data part of EFSM model in conformance test. In a different way to existing algorithm like depth-first search algorithm, this one can find various paths in the early stage of searching. When it is used in readily proposed test case generation method which is based on the value of variables and parameters it can generate test cases efficiently than in the case of depth-first search algorithm being used. We generated test cases for Inres protocol using each of proposed and depth-first search algorithm, and compared these two methods. proposed algorithm can generate much shorter test sequences efficiently than existing one.

토끼에서 Etofenprox와 Spinosad 합제의 국소자극성 시험

황윤환,김명석,송인배,박병권,양승호,임용현,송치용,안성한,남현수,임정교,정상일,명노일,윤효인 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2008 動物醫科學硏究誌 Vol.15 No.1

This study was performed to evaluation the skin and eye irritation of etofenprox 8% and spinosad 4% combination in male New Zealand White rabbits. In skin irritation test, the combination of etofenprox and spinosad did not showed any change of body weight but caused slight skin irritation with the P.I.I. (primary irritation index) value 0.25. The etofenprox and spinosad combination showed severe eye irritation 1 h, 24 h, 48 h, and 72 h after ocular treatment, having the A.O.I. (acute ocular irritation) value of 37.3. Therefore, these result indicated that the combination of etofenprox and spinosad might be irritant formulation on eye and skin.

전기 화상 환자의 수술 전 평가,고압손상과 저압손상 비교

황정원,이정기,전영태,강종만,오용석,노규정,김현철 대한정맥마취학회 2004 정맥마취 Vol.8 No.1

Polyozellus multiplex가 생산하는 지질과산화 저해물질

황지숙,송경식,김양섭,석순자,이태호,유익동 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.5

담자균류로부터 지질과산화 저해물질을 탐색하던 중 강원도 오대산 지역에 자생하는 버섯의 한 종류로 부터, Sparague-Dawley계 rat의 간 mirosome 분획의 지질과산화를 강하게 억제하는 물질이 있음을 발견하였다. 이 버섯의 미생물학적 특성을 관찰한 결과 민주름버섯목, 굴뚝버섯과에 속하는 까치버섯(Polyzellus multiplex)으로 동정하였으며 본 버섯의 자실체 methanol 추출물을 benzene, ethylacetate로 순차적으로 추출하고 각종 chromatography를 이용하여 활성물질을 정제한 결과, ethylacetate층으로 부터 황산화활성을 나타내는 PM1을 benzene층으로 부터 지방산 계열의 PM2와 PM3 화합물을 순수하게 분리 정제하였다. PM1은 정색반응 및 각종 기기분석 결과 thelephoric acid계의 화합물로 동정되었으며 PM2 및 PM3는 각각 linoleic acid와 oleic acid로 동정되었다. 지질과산화 활성물질로 분리정제한 PM1 화합물의 IC_50 값은 1.96 ppm이었으며 LD_50 값은 500 mg/Kg 이상이었다. In the course of screening lipid peroxidation inhibitor from basidiomycetes, a mushroom, which was collected at O-Dae mountain in Kangweon-Do, was found to have active compound. The mushroom was identified as Polyzellus multiplex, which belongs to Aphylloporalles Thelephoraceae, on the basis of macroscopic and microscopic characteristics of the fruiting body. The methanol extract of fruiting body was extracted with benzene and ethylacetate, sequentially. By using various kinds of chromatographies, PM1, and PM2 and PM3, were purified from the ethylacetate extract and the benzene extract, respectively. Color reaction and analyses of IR, UV, and NMR spectra indicated that PM1 was a derivative of thelephoric acid, and PM2 and PM3 were linoleic acid and oleic acid, respectively. IC_50 of PM1 for inhibition of lipid peroxidation was 1.96 ppm and LD_50 was 500 mg/kg.

직업적 연폭로에서 혈중 연량 수준에 따른 선별검사로서의 혈중 ZPP 검사의 타당도

한구석,안현철,김용배,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

In order to evaluate the validity of current screening criteria of lead exposure and to provide effective information for the better health management of lead workers, author investigated the interrelationship between blood lead and blood zinc protoporphyrin(ZPP) and evaluate the validity of blood zinc protoporphyrin as the screening test and blood lead as gold standard of diagnostic test. The total of 2245 lead workers (male workers: 1982, female workers : 263) from 12 lead using industries were studied. Blood lead, ZPP, hemoglobin and hematocrit were selected as lead exposure variables. Personal information on sex, age and work duration were also checked. Blood lead was measured with flameless atomic absorption spectrometry (model: Hitachi 8100) using standard addition method. Blood ZPP was measured with portable hematoflurometer (model: Aviv 206). The results obtained were as follows: 1. The mean blood lead of all lead workers were 0.7±14.3㎍/㎗(Male: 31.0±14.4㎍/㎗, Female: 28.2±12.9㎍/㎗), whereas the mean blood ZPP of those were 68.1±47.5㎍/㎗(Male: 63.9±43.7㎍/㎗, Female: 100.1±61.0㎍/㎗). The mean value of hemoglobin and hematocrit of all lead workers were 14.5±1.5g/㎗(Male: 14.7±1.3g/㎗, Female: 12.3±1.2g/㎗) and 45.4±3.6(Male: 46.2±2.8, Female: 39.5±3.1) respectively. 2. Validity of test using blood zinc protoporphyrin as screening test for blood lead levels of 30㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 50 and 90 ㎍/㎗ of ZPP respectively, showing 50 and 60 ㎍/㎗ of ZPP for all lead workers. While those test for blood lead levels of 40㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 and 90 ㎍/㎗ of ZPP respectively, showing 60 ㎍/㎗ of ZPP for all lead workers, those test for blood lead levels of 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 or 70 and 100 ㎍/㎗ ZPP respectively, showing 60and 70 or 80 ㎍/㎗ of ZPP for all lead workers. 3. Predictive value of test using blood zinc protoporphyrin as the screening test for different blood lead levels of 30, 40, 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that positive predictive value of screening test were decreased by the increase of blood lead level regardless of csreening criteria value ZPP and negative predictive value of screening test were increased accordingly regardless of screening criteria value of ZPP. On the other hand, within same blood lead level as a gold standard positive predictive values were inceased by the increase of screening criteria value of ZPP, whereas the negative predictive value were decreased accordingly by the the increase of screening criteria value of ZPP. 4. The correlation analysis of all lead workers among study variables revealed that CPbB and natural log transformation ZPP(LZPP) were better correlated with other variables and found to be better estimate than PbB and ZPP themselves. The age was correlated with all other variables, but the work duration was not. The correlation analysis of male and female workers among study variables revealed the same results with all lead workers. 5. The slope of simple linear regression of CPbB (independent variable) with ZPP in female workers(3.223)was steeper than in male workers(2.144). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But there was no slope difference between two groups divided by their work duration of 2 years less and more. The slope of simple linear regression of CPbB lead (independent variable)with ZPP in lead workers whose blood lead were higher than 30㎍/㎗and 40㎍/㎗ were steeper than those whose blood lead were less than 30㎍/㎗ and 40㎍/㎗. 6. The slope of simple linear regression of CPbB (independent variable) with ZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead. 7. The slope of simple linear regression of CPbB (independent variable) with LZPP in female workers(0.0308was steeper than in male workers(0.0253). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But where was no slope difference between two groups divided by their work duration of 2 years less and more. While the slope of simple linear regression of CPbB lead (independent variable) with LZPP in lead workers whose blood lead were hogher than 30㎍/㎗ was not steeper than those whose blood lead were less than 30㎍/㎗, there was no slope difference between two groups whose blood lead were less than 40㎍/㎗ and more than 40㎍/㎗. 8. The slope of simple linear regression of CPbB (independent variable) with LZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead, but the difference was not significant then that of CPbB and ZPP. With above results, it is recommended that the screening criteria value of ZPP should be down to 60-70㎍/㎗ from 100㎍/㎗ for male lead workers and screening criteria of ZPP for female lead workers was all right with current value of 100㎍/㎗. So it is recommended to make different screening criteria of ZPP for male and female workers like the hemoglobin and hematocrit screening criteria. It is also preferable to use CPbB and LZPP rather than uncorrected PbB and ZPP in the evaluation of lead exposure for lead workers.

Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

조건단일화를 이용한 한국어 구문 분석

이용석,황이규,양승원 全北大學校 1995 論文集 Vol.39 No.-

Korean, which is classified as a non-structural language, has a simple grammar structure but it has a lot of structural ambiguities in its grammar itself. As the role of extra-grammatical information is much more important than that of grammar rules in the syntactic analysis of Korean, an analysis mechanism is required to check dynamically the grammatical relationship between each of constituents. In this paper, we define the conditional unification the method that selectively performs unifications which are satisfied with some conditions in the unification-based analysis. In order to support this kind of analysis method, we extend the PATRⅡ by adding the various condition check devices. We adopt the tree unification to solve the problem of the DAG unification when we implement the conditional unification. In order to show that our presented method is suitable for Korean analysis, we explain that it can solve difficult problems easily, such as ellipsis and inversion. In addition, we show that it is possible to process the coordinate clause that the predicate of the first clause is omitted in the presented method.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

e-Business를 위한 정보기술 평가모델에 관한 연구

서창갑,황종호,정기호,이석용 동명정보대학교 2002 사이버 비지니스 Vol.1 No.-

최근 몇 년 사이에 인터넷(Internet) 공간상에서 거래되는 선박 매매 사이트의 출현으로 인하여 사이버해운거래 시장이 형성되고 있다. 인터넷은 다양한 정보제공자에 의해 광범위한 분야의 정보를 멀티미디어 형태로 전달한다는 점에서 매우 각광을 받고 있지만 이용자의 증가로 무수한 정보들이 걸러지지 못한 채로 Web상에 존재하게 되었다. 따라서, 이러한 정보들을 체계적으로 정리하고, 이용자들의 구미에 맞게 가공된 정보의 필요성이 대두되게 되었다. 이러한 문제를 해결하기 위해서 이용자가 원하는 것을 스스로 인지하고 판단하여 요구사항을 해결해주는 "지능적 대리인" 또는 "지능을 가진 도우미"라고 일컫는 지능형 에이전트(Intelligent Agent)의 필요성이 대두되었다. 지능형 에이전트는 그 다양한 기능으로 인하여 인터넷에서 매우 중요한 요소로 자리잡게 되었다. 우리나라를 비롯해서 선진 해운국에서는 선박매매사이트를 개설하여 사이버 공간상에서 거래를 수행하고 있지만, 사이트별 등록된 선박의 수가 많지 않을 뿐 아니라 거래대상 선박의 표현 방식도 사이트별 국가별로 매우 달라, 선박 매매 시 충분한 매매 대상 선박정보를 획득하기 어려운 실정이다. 본 연구는 선박매매 시 고객에게 매매 선박정보를 제공해주는 선박매매용 에이전트 설계를 목표로 하고 있다. Bargainfinder, Bargainboat, Shopboat, Price watch 등 쇼핑몰을 대상으로하는 비교쇼핑에이전트는 상용화되어 운영되고 있지만 선박매매용 에이전트에 관한 연구는 시도되지 않고 있다. 본 연구는 선박매매용 에이전트를 개발하기 위한 설계연구로서 다음 사항에 대한 연구가 시도되었다. (a) 구매 선박에 대한 요구? 표현 방법 (b) 관련 선박의 표현, 등록 및 색인방법 (c) 공급 선박의 분류와 표현 방법 (d) 에이전트의 정보 수집을 위한 메시지 표현방법 (e) 수집된 선박정보의 데이터베이스 (f) 요구 선박을 찾아주는 정보제공 서비스가 요구된다. The IT for e-Business performance is composed of the financial performance of a corporation, the effectiveness of IT itself, the suitability of processes and so forth. For the last 30 years many studies about IT evaluation have been conducted, most cases have been measured inclusively in terms of technology level, information level, functional level and management level. However these management oriented evaluation models are too narrow to evaluate IT for 3-Business. The IT in a corporation needs to be measured broadly. Corporate performance of IT needs to use models in the past and concentrate on environmental characteristics. This study intends to find more practical IT evaluation models for e-Business. We found two standardized IT process evaluation models, CMM and SPICE which are analyzed in terms of process in an organization. Afterwards this study will suggest an appropriate conceptual model for evaluating IT for e-Business.