의식수준 감시의 최신경향

노규정,No, Gyu-Jeong 대한치과마취과학회 2004 Journal of Dental Anesthesia and Pain Medicine Vol.4 No.1

약동학 수식유도

노규정 대한마취통증의학회 2018 Anesthesia and pain medicine Vol.13 No.4

A variety of drugs are continuously or intermittently administered to patients during general or regional anesthesia. Pharmacotherapy should also receive priority compared with several treatment modalities including nerve blocks for chronic pain control. Therefore, pharmacology may be fundamental to anesthesia as well as pain medicine. Pharmacokinetic equations quantitatively evaluating drug transfer in the body are essential to understanding pharmacological principles. In mammillary compartmental models, pharmacokinetic equations are easily derived from a few simple principles. The kinetics of drug transfer between compartments is determined initially. Ordinary, linear differential equations are constructed based on the kinetics. The Laplace transforms of these differential equations are used to derive functions for the calculation of drug amounts in the central or effect compartments in the Laplace domain. The inverse Laplace transforms of these functions are used to obtain pharmacokinetic equations in time domain. In this review, a two-compartment mammillary pharmacokinetic model is used to derive pharmacokinetic equations using the aforementioned principles.

The Reliability and Validity of the Rhodes Index of Nausea, Vomiting and Retching in Postoperative Nausea and Vomiting

노규정,김태희,김동희,진지현,최병문,이무송 대한마취통증의학회 2007 Korean Journal of Anesthesiology Vol.52 No.6

Background: The Rhodes index of nausea, vomiting and retching (RINVR) is a patient self-report instrument to assess the objective and subjective factors of nausea and vomiting. The aim of this study is to evaluate the reliability and validity of the RINVR in postoperative nausea and vomiting (PONV). Methods: The RINVR, VAS for nausea and incidence of emetic episodes were administered to 150 patients approximately 30 minutes apart at 6 hours and 24 hours after surgery. The validity was evaluated by Spearman's correlation and internal consistency of reliability was determined using Cronbach's alpha. To determine test-retest reliability, second administration of the RINVR was done 2 hours after the first. The test-retest reliability was evaluated by Spearman's correlation and agreement. Results: Cronbach's alpha of nausea, vomiting, retching and total experience scores of the RINVR ranged from 0.912 to 0.968. Test-retest scores of all items were strongly correlated (Spearman's coefficients: 0.962-1.000, P < 0.0001) and highly agreed (weighted kappa: 0.932-1.000). Coefficients of construct validity for nausea components (vs VAS for nausea) and emetic components (vs incidence of emetic episodes) of the RINVR were 0.860-0.928 and 0.724-0.811, respectively (P < 0.0001). The overall weighted kappa between the incidences of PONV assessed by the RINVR and by patient self-assessment of VAS for nausea and incidence of emetic episodes was 0.917-0.945. The number of patients in “great” total experience category was 1.33% or less. There was no significant difference of VAS for nausea between “severe” and “great” nausea experience categories. Conclusions: The RINVR was a reliable and valid instrument to assess PONV.

Anesthesia

노규정 대한종양외과학회 2013 대한임상종양학회 학술대회지 Vol.2013 No.10

진정척도의 임상 적용

노규정,No, Gyu-Jeong 대한치과마취과학회 2003 Journal of Dental Anesthesia and Pain Medicine Vol.3 No.1

An Introduction to Bispectral Analysis for the Electroencephalogram and Bispectral Index

노규정 대한정맥마취학회 2003 정맥마취 Vol.7 No.3

노인마취

노규정(Gyu-Jeong Noh) 대한종양외과학회 2013 Korean Journal of Clinical Oncology Vol.9 No.2

As a result of improvements in health care, nutrition, and general living standards, the average life expectancy and elderly population is increased worldwide. Aging is associated with a universal and progressive loss of functional reserve and degenerative changes in all organ systems. Although physiologic compensation for age-related changes may be adequate in most geriatric patients, the functional reserve of organ systems is reduced, and susceptibilities to stress- and disease-induced organ system decompensation can occur. Anticipating the interactions between underlying diseases, limited end-organ reserve, and perioperative stress should aid physicians in providing the best perioperative care possible. We review the age-related physiologic changes in organ systems and pharmacokinetic and pharmacodynamic changes of anesthetics in elderly surgical patients.

Enflurane 마취시 유도저혈압을 위한 Sodium Nitroprusside 의 용량 및 심혈관계 변화

김광우,노규정,이병용,문선학,임승운,석세일 대한마취과학회 1989 Korean Journal of Anesthesiology Vol.22 No.5

Sodium nitroprusside given by intravenous drip has been used to control hypertensive crises since 1929. Its evanescent action makes it suitable for controlled hypotension during general anesthesia with enflurane. The patients (n=10) were all undergoing Cotrel-Dubousset instrumentation for the operative treatment of scoliosis or spinal stenosis. Hemodynamic variables were obtained during administration of sodium nitroprusside. Mean arterial pressure was decreased to 50-60mmHg, while cardiac output, central venous pressure, systemic vascular resistance showed only minor changes. The average dosage of sodium nitroprusside (ug/kg/ min), plotted against age, showed a significant correlation (p$lt;0.05, r= -0.63). The amonut of whole blood transfused during operation was 5.7±2.2 units (mean±SD) and postoperative hemoglobin and hematocrit (11.19±1.21g/dl, 33.49±3.79%, respectively, mean±SD) were singificantly lowered than preoperative hemoglobin and hematocrit (12.94±1.78g/dl, 37.22±4.88%, respectively, mean±SDlobin: p$lt;0.004, hematoorit: p$lt;0.006)

반복측정된 실험자료 분석에 관한 고찰

하일도,노규정,고정환,Ha, Il-Do,No, Gyu-Jeong,Go, Jeong-Hwan 한국데이터정보과학회 1996 한국데이터정보과학회지 Vol.7 No.1

본 논문은 의뢰인의 Pilot Study를 상담한 것으로서 당뇨병 및 암 환자에게 효능이 있는 약으로 밝혀진 Steroid계통의 Methyl Prednisolone이 척수손상 환자에게 효능이 있는지를 알아보기 위해, 토끼를 실험대상으로 하여 얻은 반복측정자료를 분석하였다.

자가조절진통 주입펌프 AccumateⓇ 1100의 정확도와 유효성에 대한 비교임상연구

김계민,노규정 대한마취통증의학회 2016 Anesthesia and pain medicine Vol.11 No.1

Background: The accuracy and efficacy of patient-controlled analgesia (PCA) devices are crucial because malfunction of the devices may lead to fatal outcomes. The aim of this study is to evaluate the accuracy and efficacy of AccumateⓇ 1100, an electronic PCA pump, in comparison with GemStarⓇ infusion system. Methods: Fifty patients scheduled for gastrectomy or colon resection were assigned to the Accumate or GemStar group (n = 25 in each group). Intraoperatively, backflow, siphonage, autoclamp function, and lockout time were tested. Postoperatively, PCA using either AccumateⓇ 1100 or GemStarⓇ infusion system according to the assigned group was maintained for 48 hours. For PCA, fentanyl 1,500 ug and ketorolac 180 mg in 100 ml were used (demand bolus 1 ml, background infusion 1 ml/h, lockout time 15 minutes). The accuracy of the total infused dose and the level of satisfaction of the patients and users were assessed. The results were compared between the two groups. Results: Although backflow and auto-clamp backflow were less with GemStarⓇ infusion system, their extent was negligible in both groups. Siphonage was not different between both pumps. Autoclamp and lockout time worked without abnormalities. The relative error of total infused volume over 48 hours was −0.26 ± 1.20% and −0.34 ± 0.48% in the Accumate group and GemStar group, respectively. The Accumate group showed a higher level of satisfaction in terms of the ease of priming (P < 0.05). Conclusions: The accuracy and clinical efficacy of AccumateⓇ 1100 were comparable to those of GemStarⓇ infusion system.