한국형 혁신클러스터(연구개발특구)의 발전방안에 관한 연구 : 미국 Research Triangle Park 사례를 중심으로

손수창 혁신클러스터학회 2016 혁신클러스터연구 Vol.9 No.1

마취중 체온변화에 관한 연구

손수창,이정은,김익수,최세진 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

To study the temperature change and the degree of heat loss during general anesthesia, skin temperature, tympanic temperature and rectal temperature were measured in 21 patients. Mean skin temperature was calculated from four probes situated on the lateral aspect of the mid-calf, the ventral surface of the mid-thigh, the nipple and the lateral aspect of the upper arm, using the formula of Ramanathan, and the heat loss can be calculated by Burton's formula. the result are as follows. 1. Mean skin temperature increased higher than control value at 20 minute, not significantly. thereafter remained high. 2. Tympanic temperature decreased significantly at 20 minute (p<0.005), esophageal temperature decreased at 60minute, and rectal temperature decreased at 90 minute significantly (p<0.05). 3. There was continuous loss of total body heat during general anesthesia. 4. In the recovery room, the aural temperature increased progressively.

소아에서 전신마취 유도시 기관내 튜브와 후두 마스크 사용에 따른 호흡역학의 비교

손수창,고영권,이승진 대한마취과학회 2004 Korean Journal of Anesthesiology Vol.47 No.6

분만과 진통중 지속적 경막외마취와 간헐적 경막외마취의 비교연구

손수창,최세진,최희자 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1

Thirty one healthy women, ASA physical status 1-2 with an uncomplicated pregnancy and single fetus in vertex position were given lumbar epidural analgesia. After the initial injection of 0.25% bupivacaine(with 1:400,000 epinephrine) 8-10ml and fentanyl 50-75㎍, the parturients were divided randomly assigned to either continuous infusion group or intermittent infusion group. Intermittent infusion group received 0.125% bupivacaine (with or without 1 : 800,000 epinephrine) 10-12ml and fentanyl 50-75㎍. Continuous infusion group received 0.125% bupivacaine and fentanyl 2 ㎍/ml at a rate of 8-10ml/hr. There was no significant difference between two groups in duration of epidural infusion, duration of the second stage of labor, duration of pushing, motor block at delivery, mode of delivery and Apgar scores. 15 of 16(94%)women in the intermittent group, and 11 of 12(92%)women in the continuous group had analgesia of excellent or good quality. The number of refill-doses was 1.8±1.5 in intermittent group and 1.6±1.5 in continuous group, nonsignificantl different. The total dose of bupivacaine administered during epidural analgesia was more in continuous group than in intermittent group significantly. However mean hourly dose of bupivacaine and fentanyl were similar in both groups. It is concluded that the maintenance of epidural anangesia by continuous infusion is a safe and reliable method and may be advantageous and less labor intensive than the traditional intermittent technique.

Morphine에 의한 진통에 대한 calcium-channel blocker의 효과

손수창 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

Several previous studies have indicated that intrathecally administered calcium channel blockers potentiate the analgesic effects of intrathecally administered opioids. Furthermore, it has been reported that the systemically administered verapamil potentiate the antinociceptive effects of systemically administered morphine. The present study examined the analgesic effect of intravenously coadministered verapamil and morphine in humans. After informed consent, we have studied 52 ASA class 1 or 2 pationts scheduled for cesarean section under general anesthesia. Patients were randomized into two groups as follows. Group 1 patients(n=22) received only morphine 0.5mg/h as a background infusion with a lmg bolus and a lockout interval of 10min during the first 24 hour by intravenous PCA. Group 2 patients(n=30) used the same PCA mode with group 1, received solution added 0.2% verapamil(0.2mg/h) to group 1 solution (morphine 0.5mg/ml). Systolic and diastolic blood pressure, heart rate, morphine requirement and pain score(1-5) were recorded in lhr, 4hr and 24hr after surgery. The mean dose of morphine requirement for 24 hour was significant decrease in group 2(35.3±10.1 in group 1, and 26.5±10.4mg in group 2). There was no difference in pain score between the two groups and patient satisfaction was similar. Coadministration of intravenous morphine and verapamil allowed significant reduction in morphine requirement and showed decreases in systolic and diastolic blood pressure. Our data suggest, that, by adjusting the dose of morphine and varapamil used in these combinations, the incidence of postoperative myocardial ischemia or infartion may be decreased with increasing the anaigesic effect of these drugs.

Nicardipine이 기관내 삽관에 의한 심혈관계 변동에 미치는 영향

손수창,고영권,한규철 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

Arterial blood pressure, heart rate and rate pressure product changes following tracheal intubation were studied in 49 patients undergoing elective surgical procedures who received a thiopental-succinylcholine anesthetic intubation sequences. Two treatment groups and a control group were observed. Intravenous nicardipine doses of 20 mcg/kg and 30 mcg/kg, injected prior to anesthesia, were compared with respect to effect on the cardiovascular sequences to direct larygoscopy followed by the passage of an endotracheal tube. The increase in heart rate and rat pressure product associated with tracheal intubation were insignificantly prevented in nicardipine treated patient. The increase in arterial pressure was prevented, insignificantly. However, it was dose-depending. From the above resulr, a pre-induction dose of nicardipine was effective in attenuating the pressure response to laryngoscopy and intubation.

당뇨병성 자율신경 장애 환자의 전신 마취시 심혈관계의 변화

손수창,정규돈 대한마취과학회 1999 Korean Journal of Anesthesiology Vol.37 No.6

Background : Autonomic reflex dysfunction in patients with diabetes is associated with unstable cardiovascular response in perioperative period. In this study we wanted to investigate the extent to which the intraoperative cardiovascular responses depend on the degree of autonomic dysfunction. Methods : The influence of diabetic autonomic neuropathy upon the behavior of the circulatory system was investigated in 35 patients who had undergone ophthalmological surgery. A standardized test combination was used to study the patient's cardiovascular refractory reactions. The patients were then divided into a control group, non-diabetics without autonomic neuropathy (n = 18), and an experimental group, diabetics with autonomic neuropathy (n = 17). The anesthetic and surgical procedures (vitrectomy) were standardized and always identical. Results : During the induction of anesthesia, patients in the experimental group didn't experience changes in mean arterial blood pressure and heart rate as compared to patients in control group. During the maintenance of anesthesia, there were significant decreases in mean arterial blood pressure and heart rate in the experimental group, but in the state of emergence of anesthesia, there were no significant differences in either group. Conclusions : Autonomic neuropathy represents a perioperative risk factor, especially during induction and maintenance of anesthesia. I therefore recommend an autonomic nervous function test for evaluation of diabetic autonomic neuropathy in preoperative anesthesiological examination. (Korean J Anesthesiol 1999; 37: 1034∼1040)

Lidocaine 및 Labetalol의 기관내 삽관에 의한 심혈관계에 미치는 영향

손수창 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

Arterial blood pressure, pulse rate and rate pressure product changes following tracheal intubation were studied in 44 patients undergoing elective surgical procedures who reduced a thiopentalsuccinylcholine anesthetic intubation sequence. Three treatment groups and a control group were observed. Intravenous lidocaine 1.5mg/kg, labetalol 0.5mg/kg and lidocaine 1.5mg/kg+ labetalol 0.5 mg/kg injected prior to anesthesia were compared with respect to their effect on the cardiovascular sequences to direct laryngoscopy followed by the passage of an endotracheal tube. The increase in heart rate, arterial pressure and RPP associated with tracheal intubation were not prevented in lidocaine treated patients. In labetalol treated patients, the increase in heart rate and RPP associated with tracheal intubation were prevented, significantly. but, the increase in arterial pressure was not prevented. only, it was dose-dependent. The lidocaine-labetalol treated patients were a similar tendency with labetalol treated patients in the change of arterial pressure, heart rate and RPP. From the above result, a preinduction dose of labetalol was effective in attenuating the pressure response to laryngoscopy and intubation.

Atracurium 투여에 의한 기관내 삽관의 임상적 고찰

손수창 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Succinylcholine is still recognized as the drug of choice in many circumstances because of its yet unequalled speed of onset and the profound relaxation it produces, but succinylcholine has many side effects. In order to accelerate the rate of onset of action, several techniques have been described. This study was undertaken to estimate a newer nondepolarizing muscle relaxants, atracurium, in divided doses to apply for rapid sequence endotracheal intubation. The results was as follows. 1. there was no significant difference between a small subclinical dose of atracurium and a single IV bolue in the ease of endotracheal intubation. 2. after the priming dose, 12 patients complainted of minor side effects. 3. there was no significant hemodynamic changes after atracurium administration.

제왕절개술 및 자궁절제술후 PCA에 의한 통증조절의 비교

손수창 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Thirty seven patients following cesarean section (n=22) and abdominal hysterectomy (n=15) were treated with intravenous patient-controlled analgesia (PCA) using morphine. The patient-controlled analgesia machine were set to allow a 1 mg bolus dose, a 10 min lockout interval with a 0.5mg/h background infusion. The degree of analgesia was subjectively evaluated by a visual analogue scale (VAS), and by an number of supplemental analgesic requests.and the 24-h morphine requirement by PCA was recorded. There was no significant differences in VAS and an number of analgesic requests between cesarean sections and abdominal hysterectomys, but there was significant difference in the 24-h morphine requirement by PCA between two operations (p<0.05).