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연 노출 근로자들의 ALAD genotype에 따른 연 노출지표 및 증상과의 관련성
안규동,이종천,조광성,김진호,이성수,이병국 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.2
A cross-sectional study was performed to evaluate associations between lead biomarkers, lead-related symptoms, and δ-aminolevuinic acid dethydratase (ALAD) genotype among 598 lead workers and 144 control office workers in storage battery industries, secondary smelting and litharge making industries. Lead inhibits the second enzymes, AlAD, in the heme synthesis pathway. ALAD gene, which codes for one of three isozymic proteins (termed ALAD1-1, ALAD1-2, and ALAD2-2), seems to modify the toxicokinetics of lead. The result as follows; The percents of total workers whose genotype of ALAD1-1 and ALAD1-2 were 88.4% and 11.6%, respectively. The zinprotoporphyrin in blood (ZPP) and δ-aminolevulinic acid in urine (ALAU) of lead workers with ALAD1-2 were signi-ficantly lower than those of lead workers with ALAD1-1, but there were no significant difference between two genotype for blood lead, age, and work duration. The proportion of ALAD1-2 genotype in control office workers was 13.2% . The proportions of ALAD1-2 genotype of lead workers were 14.0%(their mean air lead level below 0.024㎎/㎥), 10.4%(0.025-0.049㎎/㎥), 11.8%(0.050-0.099㎎/㎥), and 9.4%(above 0.100㎎/㎥), respectively. In the logistic analysis of 15 lead related symptoms, 'arthralgia'(S7) symptom of ALAD1-2 was significantly lower(Or=0.481; 95% CI=0.248-0.932) than that of ALAD1-1, but 'feeling of irritation'(S11) of ALAD1-2 was significantly higher(OR=1.636; 95% CI=1.035-2.586) than that of ALAD1-1 after controlling possible confounder (blood lead, work duration, smoking and drinking habit).
휴대용 X-Ray 형광기기(XRF)를 이용한 공기중 납농도 평가
안규동,이종천,조광성,김남수,김진호,이성수,이병국 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.3
This study was performed to compare the lead levels of 20 quality control standard samples(KOSHA:18-2000) and 72 field samples in lead-acid battery manufacturing plant between ICP and portable-XRF methods. 1. While the proficiencies of 20 quality control standard samples by ICP were 100%, those analytic result values by XRF were 75%. 2. The correlation coefficient(r) between the reference values for quality control (REF) and the analytic result values by ICP (ICP) was 1.0(p<0.05), and simple linear regression equation and the coefficient(R2) were REF = -0.0009 + 1.016 ICP and 0.9997, respectively. 3. The correlation coefficient(r) between the analytic result values of quality control standard samples by ICP(ICP and by XRF(XRF) was 0.975(p<0,005), and simple linear regression equation and the coefficient(R2) were ICP = -0.0003 + 1.0002 XRF and 0.950, respectively. 4. The correlation coefficient(r) between the analytic result of personal protection. values for lead samples of a lead-acid battery manufacturing plant by ICP (ICP) and by XRF (XRF) was 0.993(p<0.005). and simple linear regression equation and the coefficient(R2) were ICP=-2.058 + 0.996 XRF and 0.987, respectively. 5. While the frequency distributions of XRF /ICP(Ratio) for each ICP concentration levels in a lead-acid battery manufacturing plant revealed high proportion in ratio rage of 0.876-1.125 than in ration rang of 1.126-1.375. Also, ICP concentration level in ration range of 0.786-1.125 was increased with increase of frequency distribution of XRF/ ICP. 6. The limit of detection of XRF on lead was determined to be 6.11㎍/filter The data presented in this study indicated that relationship for lead level of quality control samples and field samples in a lead -acid battery manufacturing plant by ICP and portable-RF methods was proved. The practicing industrial hygienist can use portable-XRF to produce a rapid on-site determination of lead exposure that can immediately be communicated to workers and help identify appropriate levels of personal protection.
안규동 가톨릭대학 산업의학 쎈타 산업의학연구소 1989 韓國의 産業醫學 Vol.28 No.4
To evaluate the effect of group health service on the improvement of working conditon over the individual company providing health service, environmintal measurements of work-pace were done in each group of industries. 72 industries in Masan Industrial Complex which belonged to group health service scheme provided by Masan Industrial Health Center, KIHA were selected and 40 industries which were located in Masan and mearby area were selected as a group of company providing health service. The hazardous agents selscted for this study were noise, illumination,dust, organic solvent, acid & alkali, lead & heavy metal. The exposure rate to those hazardous agents were 21.3% in the group of company prov-iding health sevice and 15.6% in group health service respectively. The over rate (no. of measurement above permissible level/total no. of measurement) of those hazardous agents as a whole were significantly lower in group health service(16.3%) than the control group(30.3%) and overall rate of manufacturing industry in Korea(25.5%). Furthermore the over rate of group health service was lower than rate of each type of industries which each industries of group health service were belonged to. With above results we confirmed that group health service was more effective to improvement of working condition than individual company providing health service.