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The Beneficial Effect of Avocado on Skin Inflammation in a Mouse Model of AD-like Skin Lesions
명노일,김수진 한국자원식물학회 2019 한국자원식물학회지 Vol.32 No.6
Avocado, superfood, contains a variety of essential nutrients and phytochemicals. The purpose of this study was to explore whether avocado could modulate skin inflammation in vivo. We elucidated the pharmacological effects of avocado on compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in mice. Additionally, we investigated the anti-inflammatory activity of avocado and its underlying mechanism including its effect on the expression levels of inflammatory-related genes and nuclear factor -κB (NF-κB) in DNCB-induced AD-like skin lesions. The findings of this study demonstrate that avocado attenuated AD clinical symptoms including itching, eczematous, erythema and dryness and histamine levels in mice. Moreover, avocado suppressed both inflammatory cytokines expression as well as NF-κB and caspase-1 activation in AD-like skin lesions in mice. Taken together, these results demonstrate that avocado may be a potential candidate for treating skin inflammatory diseases like AD.
Dextran Sulfate Sodium으로 유도된 궤양성 대장염에 대한 작약의 개선 효과
명노일 한국자원식물학회 2018 한국자원식물학회지 Vol.31 No.4
Paeoniae Radix has been used as a traditional medicine for various diseases including hepatic disease. However, the inhibitory effect of Paeoniae Radix on intestinal inflammation has not been fully understood yet. The aim of this study was to evaluate the effect of Paeoniae Radix on colitis induced by dextran sulfate sodium in mice. To investigate the protective effects of Paeoniae Radix, the colitis mice were induced by drinking water containing 5% dextran sulfate sodium for 7 days. Mice were randomized into groups receiving Paeoniae Radix (100 ㎎/㎏), sulfasalazine (150 ㎎/㎏) as a positive control, or water as a negative control. We evaluated the effects of Paeoniae Radix on clinical signs induced by dextran sulfate sodium, measuring weight loss, colon length, and disease activity index. Additionally, to find a possible explanation for the anti-inflammatory effects of Paeoniae Radix, we evaluated the effects of Paeoniae Radix on the interleukin-6 and cyclooxygenase-2 levels in colitis tissue. The results indicated that mice treated with dextran sulfate sodium showed measurable clinical signs, including weight loss and reduced colon length. However, Paeoniae Radix treatment significantly improved the weight loss and disease activity index as clinical symptoms. Moreover, Paeoniae Radix inhibited the interleukin-6 and cyclooxygenase-2 expression levels in colon tissues treated with dextran sulfate sodium. Taken together, the findings of this study suggest that Paeoniae Radix may be useful for treating intestinal inflammation, including ulcerative colitis. Key words - Cyclooxygenase-2, Dextran sulfate sodium, Interleukin-6, Paeoniae Radix, Ulcerative colitis 염증성 대장질환에 대한 작약의 효능 연구가 미비하여 본연구에서는 dextran sulfate sodium로 유도된 궤양성 대장염의 임상증상인 체중감소, 결장단축, 질병활성화 정도에 대한 작약의 효과를 관찰하였다. 또한 대장 조직 내 염증매개인자인interleukin-6및 cyclooxygenase-2의 생성에 대한 작약의 효과를 측정하여 다음과 같은 결과를 얻었다. 첫째 dextran sulfate sodium로 유도된 궤양성 대장염에서 체중 감소에 대한 작약의효과를 관찰한 결과 유의적으로 억제함을 확인하였다. 둘째DSS로 유도된 궤양성 대장염에서 결장 단축에 대하여 작약의 억제 효과가 유의성 있게 나타났다. 셋째 dextran sulfate sodium 로 유도된 궤양성 대장염에서 임상증상인 설사, 잠혈 및 출혈 등의 질병활성화 정도에 대한 작약의 효과를 관찰한 결과 유의적으로 질병활성화 정도를 억제하였다. 넷째 대장 조직내 염증매개인자인 interleukin-6및 cyclooxygenase-2의 생성증가에대한 작약의 억제효과를 확인 하였다. 본 연구는 작약의 효능을과학적으로 입증한 결과로, 작약의 궤양성 대장염의 치료제 개발의 소재로서의 가능성을 시사한다.
이원자 기체 유동 해석을 위한 일반유체역학 계산모델 개발
명노신(Rho-Shin Myong),조수용(Soo-Yong Cho) 한국전산유체공학회 2001 한국전산유체공학회 학술대회논문집 Vol.2001 No.-
The study of nonlinear gas transport in rarefied condition or associated with the microscale length of the geometry has emerged as an interesting topic in recent years. Along with the DSMC method, several fluid dynamic models that come under the genera1 category of the moment method or the Chapman-Enskog method have been used for this type of problem. In the present study, on the basis of Eu's generalized hydrodynamics, a computational model for diatomic gases is proposed. The preliminary result indicates that the bulk viscosity plays a considerable role in fundamental flow problems such as the shock structure and shear flow. The general properties of the constitutive equations are obtained through a simple mathematical analysis. With an iterative computational algorithm of the constitutive equations, numerical solutions for the multi-dimensional problem can be obtained.