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관상동맥질환 위험 인자인 심장외막 지방량의 예측시 심초음파 각 단면도의 유용성
황정원,최운정,안성균,임홍석,강수진,최병주,최소연,윤명호,황교승,탁승제,신준한,강두경 한국심초음파학회 2008 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.16 No.1
Background: Several studies suggested that epicardial adipose tissue (EAT) might be associated with metabolic syndrome and coronary atherosclerosis. But, little had been studied whether the thickness of EAT on echocardiography could represent the whole amount of EAT. The purpose of this study was to identify the best echocardiographic methods reflecting total amount of EAT. Methods: Sixty subjects (32 women, mean: 58±12 years-old) who underwent 64-slice multidetector computed tomography (MDCT) were consecutively enrolled. All CT scanning was performed one Brilliance CT-64-channel configuration scanner (Philips, Cleveland, USA) and axially contiguous 10-mm-thickeness sections were obtained from aortic valve to diaphragm level. EAT area was manually traced in each slice and summed up. The EAT thickness was measured as the echo-lucent or echo-dense space between epicardium and pericardium at parasternal long-axis, modified 4-chamber, and apical 4-chamber view. Results: The EAT thickness at parasternal long-axis and modified 4-chamber view and the sum of EAT thickness from each views (median thickness: 1.0, 2.8, 1.1 and 5.0 mm, respectively) were all correlated with total EAT area on MDCT. Among echo parameters, the EAT thickness measured on parasternal long-axis view during diastole correlated best with total EAT area on MDCT (r=0.572, p<0.001). Conclusion: The echocardiographic EAT measurement might be easily accessible and less harmful method representing whole amount of EAT. The measurement of the thickness of EAT on parasternal long-axis view during diastole by echocardiography might be feasible and reliable in the studying field of EAT. Background: Several studies suggested that epicardial adipose tissue (EAT) might be associated with metabolic syndrome and coronary atherosclerosis. But, little had been studied whether the thickness of EAT on echocardiography could represent the whole amount of EAT. The purpose of this study was to identify the best echocardiographic methods reflecting total amount of EAT. Methods: Sixty subjects (32 women, mean: 58±12 years-old) who underwent 64-slice multidetector computed tomography (MDCT) were consecutively enrolled. All CT scanning was performed one Brilliance CT-64-channel configuration scanner (Philips, Cleveland, USA) and axially contiguous 10-mm-thickeness sections were obtained from aortic valve to diaphragm level. EAT area was manually traced in each slice and summed up. The EAT thickness was measured as the echo-lucent or echo-dense space between epicardium and pericardium at parasternal long-axis, modified 4-chamber, and apical 4-chamber view. Results: The EAT thickness at parasternal long-axis and modified 4-chamber view and the sum of EAT thickness from each views (median thickness: 1.0, 2.8, 1.1 and 5.0 mm, respectively) were all correlated with total EAT area on MDCT. Among echo parameters, the EAT thickness measured on parasternal long-axis view during diastole correlated best with total EAT area on MDCT (r=0.572, p<0.001). Conclusion: The echocardiographic EAT measurement might be easily accessible and less harmful method representing whole amount of EAT. The measurement of the thickness of EAT on parasternal long-axis view during diastole by echocardiography might be feasible and reliable in the studying field of EAT.
수핵 탈출증 수술 후 복부 동정맥루 형성 -1례 보고-
황정원 대한영상의학회 1988 대한영상의학회지 Vol.24 No.3
A case of iatrogenic aortocaval fistula is presented. the fistula arose from lumbar disc surgery. its presence was immediately suspected on ultrasound and computed tomogram and was promptly confirmed by angiography. Ultrasound and computed tomogram also precisely define the anatomy between the aorta or its branches and the IVC or its tributaries. Sudden deterioration of the patient's condition necessitated surgical correction of the fistula before the elected date. The successful corrective operation is described.
황정원 대한영상의학회 1988 대한영상의학회지 Vol.24 No.5
Authors analysed the CT findings of the congenital ear anomalies of twenty-nine patients for 2 years and 3 moths. The results were as follows: 1.Most of the patients were under the age of 20 (82.7%) and prevalent in male (72,4%) 2. Clinically congenital ear anomalies were detected in 20 patients (68.9%) conductive hearing loss in 4 sensorineural hearing loss in 1 and the remained 4 patients were detected incidentally without clinical symptom. 3. In the cases of unilateral involvement of 20 patients right ear was more common (12/20), Eight of 9 bilateral involvement showed similar degree. 4. The middle ear malformations were found in 22 patients(75.9%) and bilateral in 4 patients. 26 cases of middle ear malformations had been classified by Frey into 4 groups; Group in 5 Group II in 9 Group III in 9 and Group IV in 3. 5. Incidentally found ear anomaly was lateral semicircular canal formed a single cavity with the vestibule in aoo patients(5 pts) 6. Inner ear malformations accompanying sensorineural hearing loss were found in 3 patients with bilateral involvement and middle ear malformations were accompanied in 2 patients, The degree of involvement of labyrinth was variable.
Formyl Peptide에 의하여 유도된 중성 백혈구의 화학주성에 미치는 칼슘이온의 영향
황정원,정노팔 大韓免疫學會 1993 大韓免疫學會誌 Vol.15 No.-
Chemotaxis of neutrophils stimulated by fMLP(N-formyl-methionylleucylphenyl-alanine) is not fully understood process. Present study mainly deals with the role of Ca" as a second messenger in chemotaxis. The chemotaxis of neutrophils which were treated with calcium antagonist and calcium channel blocker was decreased significantly. To investigate the effect of extracellular and intraceI-lular calcium, EGTA or EGTA +A23187 were treated. Both treatments decreased the chemotaxis of neutrophils. Intracellular Ca' level change was checked using fluorescent dye Quin-2/Am. When treated with fMLP, intractellular Cap+ level was found to be dependent on both extracellular Cal+ uptake and release from internal Cat+ storages. On the other hand, the treatment of callmodulin antagonists did not have any significant effect on chemotaxis. When treated with varying concentration of PK-C inhibitor, chemotaxis was decreased dependent manner on concentration. In addition to Ca'', PK-C is also supposed to be related to the signal transdution process of chemotaxis induced by fMLP.