The Role of Skeletal Muscle Mass in Development of Metabolic Syndrome

( Byung Sam Park ),( Jun Sung Moon ),( Ji Sung Yoon ),( Kyu Chang Won ),( Hyoung Woo Lee ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1

Introduction: It has been well known that abdominal adiposity is related with insulin resistance and greater risk of metabolic disorder. Skeletal muscle plays central role in insulin mediated glucose disposal of whole body, but we only know a little about the association between skeletal muscle mass and MetS (MetS). The aim of this study is to clarify the clinical role of skeletal muscle mass in developing MetS through using skeletal muscle parameters by body impedance analysis (BIA). Methods: 1,042 healthy adults aged from 20 to 75 years who visited Yeungnam university health promotion center from Jun. 2008 to Jun. 2010 were enrolled. 204 subjects who had prior MetS or chronic disease that can affect to skeletal muscle mass were excluded. After 24 months from baseline, the metabolic parameters were assessed and the development of MetS was diagnosed using modified NCEP-ATP III criteria. From the BIA (Inbody 720), we obtained skeletal muscle mass (SMM, Kg), body fat mass (BFM, Kg), and visceral fat area (VFA, cm2). Then, we had defined as follows; percent of skeletal muscle mass (SMM%, %): SMM (kg)/weight (Kg), skeletal muscle index (SMI, Kg/m2): SMM (Kg)/height (m)2, skeletal muscle to body fat ratio (MFR): SMM (kg)/BFM (Kg) and skeletal muscle to visceral fat ratio (SVR, Kg/cm2): SMM (Kg)/VFA (cm2) Results: Mean follow up periods were 28.7±5.4 months. Among total 838 subjects (46.9±9.9 years, M:F=477:361), 88 (10.5%) were newly diagnosed MetS. 5th quintile of the SMM%, MFR and SVR was associated with decreased risk of development of MetS after adjusting for confounding factors. Conclusion: Decreased skeletal muscle mass may play critical role in development of the MetS and not absolute amount of skeletal muscle mass but relative ratio to body composition may be more important.

개에서 이중 결찰법을 통한 동맥관 개존증의 완치 예

윤헌영,정순욱,박희명,박철,정만복,김준영,한현정,황민,노병국,박상혁,장하영,박정윤 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.1

A ten months old, female Yorkshire terrier weighing 2.88 kg referred to veterinary teaching hospital of college of veterinary medicine, Konkuk University because of syncope, cough and dyspnea. First hematological and serum chemical test revealed thrombocytopenia, mild anemia, and increase of concentration of ALP (195 U/L). On 57 days later, second hematological and serum chemical test revealed polycythemia, increase of concentration of ALP (211 U/L), and Tchol (387 mg/dl). Right atrium enlargement, main pulmonary artery bulge and cardiomegaly (VHS = 11.5) were observed in radiographic findings. Ultrasonographic images showed both right and left ventricular dilation and turbulent flow between the descending aorta and the main pulmonary artery in color Doppler imaging. ECG showed left ventricular enlargement, SA block, and electrical alternant. Thoracotomy was performed through left fourth intercostal incision under isoflurane anesthesia. Patent ductus arteriosus was double ligated with 1-0 silk. Cough and dyspnea disappeared on 5 days after operation. Turbulent flow was not found in color doppler imaging of ultrasonography on 10 days after operation. Ten months later after the operation, syncope could not exist any more.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

대장내시경검사에서 비특이적 염증형태로 나타난 대장선암 1예

박재현,장병익,이호찬,김성준,박준석 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.2

Colon cancer is the second most common malignancy in Korea. It is classified as superficial type, the mass type, the ulcerative type, the ulceroinfiltrative type, the diffuse infiltrative type and the unclassified type according to the colonoscopic findings. We report here on a case of colon cancer that was initially misdiagnosed as acute infectious colitis at the initial presentation. A 64-year-old man visited to Yeungnam University Hospital for watery diarrhea and lower abdominal pain. Colonoscopy revealed long segmental edematous mucosa and hyperemic mucosa with stenosis in the transverse colon. He was diagnosed as having acute infectious colitis according to the colonoscopic finding. However, two days later after colonoscopy, he visited the emergency room for hematochezia. We performed computerized tomography (CT) and obtained blood samples to find the origin of the bleeding. We found thickening of the transverse colon lumen and ascites on the CT finding and an elevated level of tumor markers; we also obtained the results of the colonoscopic biopsy that was done via colonoscopy. He was finally diagnosed as having colon cancer with carcinomatosis, a poorly differentiated adenocarcinoma.

기능적 창조도시에서 창조적 학습도시로 : 창조도시논의에 대한 교육학적 접근의 유용성

이병준,박지연,박응희 한국문화교육학회 2010 문화예술교육연구 Vol.5 No.3

After the discussion for cultural city and learning city, the discussion for creative city is spreaded recently. It shows that the discussion for city is spreaded to all over the society & science and emerged as the studying subject among the school systems. But if examining the discussion for recent creative city, several studies lead that discussion so the possibility of studying among the school systems for the creative city is still narrowed. The viewpoint of Charles Landry, quoted by a lot of researchers is reduced in the discussion process. This study discusses which usefulness educational discussion has in the discussion for creative city. It say that the discussion for creative city under the educational viewpoint can be unfolded by connecting city culture, city space, creative competency, creative development of human resources, creative organizational culture, practical community, etc. variously. Especially, education focuses on human and social subjects which form the creative city. Extensive set-up for subject can make the discussion for creative city more affluent under the educational viewpoint. 문화도시와 학습도시 담론에 이어 최근에는 창조도시 논의가 확산되고 있다. 이는 도시에 대한 담론이 이제 사회과학전반으로 확산되고 있으며 학제간 연구주제로 떠오르고 있음을 보여주는 것이다. 그러나 최근의 창조도시 논의를 살펴보면 몇 개의 학문들이 담론을 주도하고 있어 여전히 창조도시에 대한 학제간연구의 가능성을 좁히고 있다. 많은 연구자들이 인용하고 있는 찰스 랜드리의 입장 또한 논의과정 속에 축소되고 있다. 본 연구에서는 교육학적 담론이 창조도시 논의에서 어떠한 유용성을 가지는지가 이야기된다. 교육학적 관점에서의 창조도시논의는 도시 문화와 도시 공간, 창조역량과 창조적 인력개발, 창조적 조직문화와 실천공동체 등 다양하게 연계되어 전개될 수 있음을 밝힌다. 특히 교육학은 창조도시를 형성해가는 인간과 사회적 주체에 초점을 둔다. 이러한 교육학적 측면에서의 광범위한 주제설정은 창조도시 논의를 좀 더 풍요롭게 만들 수 있다.

중금속오염을 고려한 온산만 조간대 및 아조대의 무척추동물 군집분석

박중기,이인숙,박경숙,송준임,최병래,노분조 이화여자대학교 환경문제연구소 1997 이화환경연구 Vol.1 No.-

한국 동해연안의 하나인 온산만 지역의 해양오염 실태를 파악하기 위해 저서동물 군집구조에 대한 정성, 정량적 분석을 실시하였다. 분석결과 조사지역별 습중량-개체수의 누적 κ-dominance curve 변화양상을 근거로 판단해 분석한 결과, 온산만의 내만에 위치한 춘도는 여름, 겨울 오후에 ()어서 오염지역으로, 대조군인 당사는 비오염지역,()각각 판정되었다. 이외에도 조사지역별 출현() () 있어서 대조구인 당사지역에 비해 춘도의 생물상이 ()대적으로 빈약하였으며 연체류중 패각만 채집된 ()에 있어서도 각각 춘도에서 16종, 당사에서는 (0로 커다란 차이를 나타내었다. 온산만에 대한 이러한 저서동물 군집결과는 이 주변의 비철금속 및 석유화학 공업단지로부터 ()입된 중금속으로 인하여 해수 및 생물농축량이 누적됨으로써 나타나는 중금속의 높은 농도와 관련이 있을 것으로 추측된다. The qualitative and quantitative analyses of macrozoobenthic communities sampled from Onsan bay of the eastern coast of Korea were conducted, in this study, to investigate the status of marine pollution. In each survey site, judging from the results of the combined κ-dominance curve for species biomass and individual numbers, it may be assessed that Chundo island, located in innerside of Onsan bay, was in the state of polluted condition both in the summar and winter seasons; on the other hand, Tangsa, the control site of this study, was in the state of unpolluted condition. The species composition of the Chundo island, in addition, was rather lower than that of the Tangsa in richness and showed critical differences with the control site in the number of molluscan species collected as dead shell(16 spp. from Chundo island; 2spp. from Tangsa respectively) It is inferred that the resultant macrozoobenthic community structure of the Onsan bay was related to the high concentration of heavy metals in seawater and bioaccumulation, attributed to the influx of the heavy metals from the surroundings, the nonferrous and the petrochemical industrial complex.

MCM-41의 표면 특성이 Cr(III)과 Cr(VI)의 흡착거동에 미치는 영향

박수진,전병렬,Kawasaki, Junjiro 한국공업화학회 2004 공업화학 Vol.15 No.1

본 연구에서는 실리카 원으로 colloidal silica를 이용하고, template로 cetyltrimethylammonium chloride (CTMACI)를 사용하여 MCM-41을 수열 합성하였다. MCM-41의 표면 성질과 구조는 pH, 산/염기도, FT-IR, XRD, 그리고 TEM을 이용하여 살펴보았다. 비표면적(S_(BET)), 전체 기공부피(V_(T)), 그리고 평균 기공지름(D_(BJH))을 포함하는 N_(2) 등온 흡착 특성은 BET식과 de Boer의 t-plot을 이용하여 확인하였다. 또한, MCM-41의 Cr(Ⅲ)와 Cr(Ⅵ) 흡착량은 ICP와 UV 분광기를 이용하여 측정하였다. 그 결과, MCM-41의 산도가 염기도 보다 더 높았으며, -OH, Si-OH, Si-O-Si와 같은 표면 작용기들을 IR로 확인할 수 있었다. N_(2) 등온 흡착 결과 S_(BET)는 803 ㎡/g이었으며, 평균 기공 크기는 29 Å이었고, 벽 두께는 기공 크기와 a_(0)의 차이로부터 22.5 Å임을 알 수 있었다. MCM-41의 Cr 이온 흡착은 용액의 pH 변화에 의존하였고, Cr(Ⅵ)보다 Cr(Ⅲ)가 더 좋은 흡착 거동을 보였다. In this work, MCM-41 mesoporous materials were prepared from hydrothermal synthesis using gel mixture of colloidal silica solution as silica source and cetyltrimethylammonium chloride (CTMACI) as a template. The surface and structure properties of MCM-41 were determined by pH, acid/base value, FT-IR. XRD, and TEM, N2adsorption isotherm characteristics. including the specific surface area (SBET), total pore volume (V_(T)), and average pore diameter (DBJH), were determined by BET and de Boer's t-plot methods, Also, the adsorption amounts of Cr(III) and Cr (VI) ion on MCM-41 were measured using ICP and UV spectrometer. As a result, the acidity of MCM-41 had higher than the basicity of one and surface functional groups. such as, -OH, Si-OH. Si--O-Si were observed by IR measurement. A S_(BET) of 803 m^(2)/g was determined from the N_(2)adsorption isotherm. Also, the average pore diameter of 29 A was obtained and the wall thickness of the MCM-41, given by the difference of a_(0) amount of Cr(III) on MCM-41 had higher than that of Cr(VI).

Benoist씨 장치를 이용한 소아의 하악 과두 골절의 치험례 : A CASE REPORT

박상욱,최형준,차인호,김성오,최병재 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.3

소아에서의 하악 골절은 성인에서보다 드물다. 그러나, 어릴수록 강직과 성장장애의 가능성이 크며 성인만큼 악간고정을 잘 견뎌내지 못한다. 반면에, 골절은 소아에 있어 더 빨리 치유되고 합병증도 적다. 소아에서 하악 골절은 종종 하악의 acrylic splint therapy 단독 또는 eyelet wire 와 악간 고정을 같이 사용하여 성공적으로 치료될 수 있다. 발생할 수 있는 심각한 합병증으로는 유착과 성장장애가 있다. 이러한 합병증의 빈도와 심 각성은 좀더 짧은 기간의 악간고정과 긴밀한 술 후 관리에 의해 감소될 수 있다. 특히 소아 환자가 악간고정을 잘 견디지 못하는 경우, 악간고정의 기간이 길어지는 경우, 환자의 자발적인 운동요법이 어려운 경우, 악간고정이 불필요하고 개구장애 만을 일으킨 미약한 증상의 경우에는 동기부여에 의한 물리적 하악 운동요법이 사용될 수 있다. 본 증례에서는 하악 정중부의 외상으로 인하여 양측성 과두 골절이 일어난6세 여자 환아를 대상으로 상,하악에 elastic을 이용하여 하악의 개구, 측방 전방운동에 대해 훈련을 가능하게 하는 Benoist씨 장치를 이용한 능동적 하악 운동 요법으로 7개월 간의 정기 검진을 통하여 하악 운동량의 증진, 과두 유착의 방지, 골개조의 치료효과를 보였다. Mandibular fracture is less common in children than in adults. However children are more susceptible to ankylosis and developmental disorders, and don't respond as well to intermaxillary fixation compared to adults. On the other hand, bone fracture is healed more quickly in children and complications are scarce. Mandibular fracture in children is usually treated successfully with acrylic splint therapy with or without the use of eyelet wires and intermaxillary fixation. Severe complications that include ankylosis and developmental disorders may occur. The frequency and severity of such complications can be mitigated with a shorter duration of intermaxillary fixation and good post-operative care. Encouraging mandibular physical therapy by increasing patient motivation may be necessary in such cases where the patient's response is poor and the duration of intermaxillary fixation increases; when the patient is unable to undergo physical therapy, or when intermaxillary fixation is not necessary with the patient showing only minor symptoms such as trismus. In this case report, a 6 year-old girl with bilateral condylar fracture was treated with elastic in both the upper and lower jaws to allow mandibular physical therapy using a Benoist's appliance, which allows opening, lateral, and protrusive retrusive movements of the mandible. A 7-month follow-up showed beneficial therapeutic effects such as increased mandibular movement and prevention of condylar ankylosis.

소재 관련업체 및 기관과 신소재연구소의 상호 정보교환 시스템 구축

박재윤,안영철,전병세 경남대학교 신소재연구소 2002 신소재연구 Vol.14 No.-

현재 국내 부품소재 산업은 제조업 총 생산액의 약 30%를 차지하는 주요산업이며, 향후 그 규모가 확대될 전망이다. 그러나, 산학간의 관계에 있어서는 상대방에 대한 정보가 제한되어 있기 때문에 중소기업의 애로기술을 해결하기 위한 산학협동이 어려운 실정이다. 따라서 경남대학교 신소재연구소에서는 산학간의 정보교환을 원활하게 하고 중소기업의 애로기술을 해결하고자 부품소재관련 전문 홈페이지를 구축하였다. 본 연구에서는 중소기업 및 경남대학교의 구성원이 신소재연구소의 홈페이지를 쉽게 사용할 수 있도록 홈페이지의 내용을 설명하고자 한다. Currently, parts and materials industry is the major part of the domestic manufacturing industry occupying 30% of the market and the share is expected to increasingly grow. However, as far as the relationship between the industry and the university is concerned, it is very difficult to develop an industry-university cooperation to solve a technological difficulties of the medium and small sized enterprises because of the limited amount of informations between them. Therefore, a homepage for parts and materials has been constructed in the Institute for Advanced Materials in Kyungnam University to facilitate free exchange of informations between industry and university and to solve technological difficulties of the industry. In this study, the contents of the homepage are introduced in detail for the users in the medium and small sized enterprises and Kyungnam University.

脇痛의 鍼灸治療穴에 對한 文獻的 考察

朴基榮,李浚龜,金永一,朴泰均,辛泳一,黃載然,李賢,李秉烈 대전대학교 한의학연구소 2002 한의학연구소 논문집 Vol.10 No.2

As mentioned above, I have acquired some valuable results about medical treatment with acupuncture and Moxibustion of " Flank pain" after studying oriental medical books . The results Were like below: 1. Medical treatment with acupunctures of Flank pain belonged to the Urinary Bladder Meridian of Foot Taiyang, the Liver Meridian of Foot Jueyin, the Gall Bladder Meridian of Foot Shaoyang. 2. Medical treatmcnt with acupunctures of Flank pain used to Yang-laung-chan(陽陵泉), Gi-gu(支溝), Gi-mun(期門), Kan-su(肝兪) in turn. 3. Medical treatment with Ear acupunctures of Flank pain used to Dam(膽), Sin-Mun(神門), Gan(肝)in turn 4. Acupuncture point of Flank pain were lowrer limb part. chest and abdominal part, back part in turn. 5. Medical treatment with Moxibustion of Flank pain was the most Jang-mun(章門)