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          • 전통 음료의 한의학적고찰(韓醫學的考察)

            이태경 ( Tae Kyong Lee ),김경신 ( Kyoung Shin Kim ),김병수 ( Byoung Soo Kim ) 대전대학교 한의학연구소 2013 한의학연구소 논문집 Vol.21 No.2

            The review of the literature had been done to investigate the mechanism of the herbal medicines contained in traditional Korean medical books. We had thought the results could provide the theoretical basis of adding herbal medicies to functional drink. This study is a document research in cluding a historical review of traditional beverages from after the period of the Joseon Dynasty, analysis of the characteristics of tradition the herbal medicine of the Joseon entered the new stage at the era of King Sejong. In the reign of Sejong, there had been a noticeable increase in kinds of herbs. Besides understanding the quality of herbs by provinces, the Joseon government also had pushed ahead with increase policy of herbs. The more the standard of living and incomes have increased, the more the concern of our health has been raised. This social phenomenon has affected on the food& beverage industry. The food& beverage industry of Korea has been already reorganized like the ones in developed countries in the early 21st century. Consumers are particular choosing their beverages; they concern their health, convenience, and taste more than ever. We had selected several herbal medicines contained in functional drink, and investigated the mechanism in field of oriental medicine and pharmacology.

          • 인삼의 항암작용에 대한 한의학 관련 논문 분석

            장성일 ( Sung Il Jang ),유화승 ( Hwa Seung Yoo ) 대전대학교 한의학연구소 2011 한의학연구소 논문집 Vol.19 No.2

            Backgrounds: Multidisciplinary approaches including surgery, chemotherapy, and radiation therapy are currently being performed to target various cancers in Western Medicine. However, some cancers still remain difficult to battle, which has long attracted many scientists for the discovery of new agents to fight cancers. Ginseng is one of the herbs used in Oriental Medicine including Korea, China and Japan. We have further investigated ginseng for its anticancer effect. Objective: This is a comprehensive review summary of anticancer effect of ginseng and ginsenoids as a possible agent for future cancer treatment. Methods: Data were retrieved from two web sites; www.pubmed.com and www.riss.kr, and authorized texts concerning anticancer effects of ginseng. From collected data, information on anticancer effect of ginseng was thoroughly sorted, restructured, then assessed. Results: Panax Ginseng C.A. Meyer belongs to Araliaceae Panax family, a perennial prairie plant with its root known as Ginseng Radix. Ginseng induces anticancer effect through cell cycle arrest, acceleration of apoptosis, anti-angiogenesis, and suppression of metastasis. Anticancer effect of ginseng may he due to single compound or multi-compound actions. Many studies report involvement of immune mechanisms of cytokines, Natural Killer (NK) cells, macrophages and some antibodies in enhancing anticancer effect of ginseng. In near future, possibility of applying these mechanisms into clinical trials is convinced. There were some important findings on saponin in ginsenoids in reviewing for this article; First, eradication of metastatic tumors were influenced by macrophage activation. Second, suppression of malignant melanoma cell metastasis to lung were induced by macrophage and NK cell activation in spleen with red ginseng acidic polysaccharide (RGAP). Third, final metabolites of M1, M4 had exerted anticancer effect of ginseng. Conclusion: Unknown anticancer mechanisms of ginseng have been studied for many years up until now. Ginseng is comprised of multiple bio-chemical compounds that create complex pharmaceutical interactions. Therefore, for its proper usage and safe prescription, studies on different types of ginseng and patients` susceptibility to ginseng according to their constitution and stages of the disease should be further pursued. More efforts are needed to understand the anticancer mechanisms of ginseng as well.

          • 생쥐의 심리적 스트레스에 대한 호초(胡椒)의 효과

            이소영 ( So Young Lee ),최재홍 ( Jae Hong Choi ),정향숙 ( Hyang Sook Jeong ),김영균 ( Young Gyun Kim ),조수인 ( Su In Cho ) 대전대학교 한의학연구소 2013 한의학연구소 논문집 Vol.21 No.2

            스트레스로 인한 인체의 반응은 중추신경계, 시상하부, 변연계 및 기타 표적기관으로부터 시작되는데, 자율신경계 반응, 내분비계 반응, 면역계 반응 등을 통하여 복합적인 신체 증상으로 발현되며, 스트레스 상황에서는 시상하부-뇌하수체-부신 축 (HPA axis)과 교감신경계의 작용으로 여러 신경전달물질 방출에 변화가 생기며 이러한 변화는 면역기전에 중요한 역할을 하고 일부는 면역세포의 활성에 직접적으로 영향을 미쳐 신체 각종 질병의 원인이 될 것으로 추정된다. 한의학에서는 天人相應의 관점에서 六氣를 생체자극의 외적 요인으로 간주하고, 생체내적 현상인 정신이 외적 자극을 통하여 나타나는 생체반응을 七情으로 보았으며, 이러한 관점에서 스트레스는 신체에 五臟의 虛實, 血虛, 精損, 氣逆, 氣의 순환장애, 痰涎, 火등의 병적인 요인을 만들어 준다 본 연구에서 재료로 사용된 호초 (Piper nigrum Linne)는 후추나무의 과실을 말린 것으로서 세계적으로 널리 사용되는 향신료이며, 한의학에서는 溫中除寒下氣, 快膈消痰, 解毒등의 효능으로 寒痰食積脘腹冷通?亂吐瀉등의 치료에 활용되어 왔다 특히 快膈消痰하는 작용은 정신적 스트레스에 유효할 것으로 생각되므로 본 연구에 이용하게 되었다. 실험동물은 ICR계 생쥐를 이용하였으며, 심리적 스트레스는 옆쪽 cage에서 다른 마우스의 신체에 가해지는 전기 충격을 하루 1시간 동안 지켜보게 하는 것으로 유발하였으며, 이 상태에서 약물을 투여한 그룹을 실험군, 그렇지 않은 그룹을 대조군으로 하였다. 정상군은 아무런 자극 없이 하루 1시간 동안 일정 공간에 가두어 두는 것으로 하였다. 실험 결과, 胡椒추출물을 100㎎/㎏/day 용량으로 5일간 투여한 실험군은 아무런 처치를 하지 않은 대조군에 비해 혈장 중 corticosterone 함량이 유의하게 감소되었고, 뇌에서의 noradrenalin 분비량이 유의하게 증가되었으며, plus maze test에서의 머무름 시간이 연장되는 것으로 나타나 胡椒가 심리적 스트레스를 효과적으로 억제하고 진정작용이 있는 것으로 사료되나 구체적인 작용기전 및 인체에서의 효과에 대해서는 향후의 보다 자세한 연구가 필요할 것으로 생각된다.

          • 韓醫學의 疾病分類에 關한 小考

            金聖勳 대전대학교 韓醫學연구소 1999 한의학연구소 논문집 Vol.8 No.1

            By studying disease classifications of oriental medicine from Nei-Ching, Chao's-Bing-Yuan, Dong-Yi-Bao-Jian and Korea-standard classification of causes of disease & death. The results were obtained as follows 1. In Nei-Ching 181 kinds, Chao's-Bing-Yuan 1729 kinds, Dong-Yi-Bao-Jian 966 kinds, and Korea-standard classification of causes of disease & death 2519 kinds of diseases, which suggested more diseases as time flew. 2. In classical books such as Nei-Ching, Chaos--Bing-Yuan, and Dong-Yi-Bao--Jian most of diseases and their names were originated from six kinds of pathogenic factors, Zang-Fu, Jung-Qi-Blood-Fluid, soul, and outer-body-signs, while Korea-standard classification of causes of disease & death classified diseases according to oriental medical departments. 3. Symptoms of Cold-Heat-Excess-Deficiency and pathogenic factors, body parts, Zang-Fu were applied to names of diseases in oriental medicine. 4. In oriental medicine, some symtoms, many intermal diseases were used as disease name, but it is necessary for us to select exact name of diseases in modem clinical treatment. 5. We should consider disease names in Korea-standard classification of causes of disease & death in relations with western medical terms of diseases.

          • 몸에서 이루어지는 組織纖維化 病變의 病理機轉에 關한 考察

            劉源昇,孫彰奎 대전대학교 한의학연구소 2000 한의학연구소 논문집 Vol.9 No.1

            關於組織纖維化病變的病機進行文獻考察之後, 得到了如下結論: 1. 正常纖維化是指在人體正常組織和損傷部位之間, 根據收復機轉産生再生或代置過程, 再由此形成較强 的癒着. 2. 這樣的生理性纖維化經過肉芽祖織形成期和瘢痕組織形成期之後, 形成纖維性瘢痕萎縮及壓縮. 而在這 樣的形成過程中未形成纖維性瘢痕的萎縮及壓縮約, 視爲病理性纖維化. 3. 病理性纖維化的代表性疾病有乳腺增生症,纖維腺腫,纖維性異形成症, 纖雄索性炎症, 纖維性組織求腫, 纖維腫和纖維肉腫,纖維素性心??炎, 漿液纖維素性心??端, 炭鑛夫塵肺症, 肝硬變症, 纖維筋性異形成症等. 4. 韓醫學的觀點上與織纖維化有關的疾病有乳岩, 징하, 積聚, 현癖, 脇痛, 肝陰虛等. 綜上所述, 組織纖維化對了解組織間經過相互協調性機轉的生理現象和未經過相互協調的病理現象, 幷發 揮與纖維化有關疾病的基礎作用方面具有意義. 這將對進一步硏究韓方中的하, 積聚, 현癖, 乳岩等疾病作 出更多貢獻.

          • 삼차신경통의 한의학적 치료에 대한 국내 임상 연구 고찰

            차현지,이예지,김효빈,김범석,성기정,이영록,최강민,김진엽,전주현,김은석,김영일,Cha, Hyun Ji,Lee, Ye Ji,Kim, Hyo Bin,Kim, Beom Seok,Sung, Ki Jung,Lee, Young Rok,Choi, Kang Min,Kim, Jin Youp,Jeon, Ju Hyun,Kim, Eun Seok,Kim, Young Il 대전대학교 한의학연구소 2020 한의학연구소 논문집 Vol.29 No.2

            Objectives : The aim of this study is to review clinical studies on trigeminal neuralgia treatment through Korean Medicine. Methods : We used search engines such as KISS, RISS, KOREAMED and NDSL. We limited cases as idiopathic trigeminal neuralgia without comorbidities. We excluded dissertation. We considered papers published after year 2000. Results : Fourteen studies were searched for this study. Various treatments such as acupuncture therapy, herbal medicine, moxibustion therapy, manipulation, pharmocopuncture, vomiting therapy were practiced for trigeminal neuralgia. Conclusions : All study were case report and evidence level of the searched studies was not high. They reported meaningful improvement through Korean Medicine treatment and these studies implied effectiveness and safety of Korean Medicine for Trigeminal neuralgia.

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