림프종 환자에서의 갈륨, TI-201 그리고 Tc-99m MIBI 섭취의 비교

천경아,조인호,원규장,이경희,이형우,현명수,이재태,이규보 영남대학교 의과대학 2002 Yeungnam University Journal of Medicine Vol.19 No.2

Purpose; Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. Materials and Methods: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. Results: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. Conclusion: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.

국소적으로 진행된 위암의 수술후 방사선 치료성적

이명자(Myung Za Lee0, 전하정(Ha Chung Chun),김인순(Insoon Kim),정태준(Tejune Chung) 대한방사선종양학회 1997 Radiation Oncology Journal Vol.15 No.2

목 적 : 국소적으로 진행된 위암치료는 수술이 주 치료로 5년 생존율은 그리높지 않아 좀더 완치율을 높이기 위하여 화학요법이나 화학요법과 병용하여 방사선치료 등이 시행되고 있다. 저자들은 위암환자에서 수술후 방사선치료를 받은 환자의 치료성적을 후향적으로 분석하였다 방 법 : 1985년 3월부터 1993년 6월까지 한양대학병원 치료방사선과에서 위절제수술후 방사선치료를 3500cGy 이상 받고 병기 3및 4기인 68명을 대상으로 후향적인 분석을 하였다. 연령분포는 28세부터 66세였고 중앙연령은 50세였다. 추적기간은 3개월에서 133개월(3명이 36개월 미만)로 중앙값은 50개월이었다. 조직병리상 37명이 non signet ring adenocarcinoma였고 29명이 signet r ing cell이었다. 병기로 ⅢA가 19명, ⅢB가 25명, Ⅳ가 24명이었다. 항암화학요법은 65명의 환자에게 투여되었으며 FAM계통의 치료가 28예 cisplatin, 5FU계통이 26예이었다. 결 과 : 5년생존율은 36.6% 5년무병생존율은 33.6%였다. 예후인자로 병소침입 임파선개수, 조직세포 종류 등이 생존율에 통계적으로 유의하게 영향을 주었고 잔존세포의 유무, 병기, 나이, 세포분화도 및, 방사선치료 총 기간 등도 생존율에 영향을 주었으나 통계적인 유의성은 없었고 항암화학제의 종류에따른 생존율의 차이는 없었다. 37명환자에서 재발이 있었고 위치로는 장망(omentum) 및 복막에 23.5%로 가장 재발율이 높았으며 남은 위나 봉합부위에 13.2%의 재발율을 보였다. 전체 국소재발은 20.7% 전체 원격전이는 39.7%였다. 방사선치료로 인한 부작용은 22.1%에서 grade 3의 백혈구감소가 있었고 1.5%에서 grade 4 부작용이 있었다. 치료중 10% 이상의 체중감소는 8.8%였다. 결 론 : 본 연구결과 수술후 화학요법과 방사선치료요법은 큰 부작용이 없었으며 실패양상은 주로 장망 및 복막이었고 치료부위내 국소재발율이 다음으로 많았다. 국소재발은 원격전이에 비해 많이 낮아지는 추세를 보였다. 방사선역할에 평가를 조금 더 명확하게 규명하기위해 향후 재발 위험이 큰 환자에서 수술후 화학요법만 한 군과 화학요법 및 방사선치료를 병용한 군과의 재발 양상 및 생존율 등의 전향적 비교 연구가 필요할 것으로 생각되며 더 나아가 수술후 항암화학요법 및 방사선 병용요법에 복강내 약물치료도 고려되어야 하겠다. Purpose : Radical gastrectomy is main treatment of gastric cancer. But the result is not satisfactory with surgery alone. Most of pattern of failure remain locoregional recurrence. To improve 5 year survival postoperative chemotherapy with or without radiotherapy has been used. We analyzed patients with stage Ⅲ and Ⅳ stomach cancer who had radical operation and received postoperative radiation therapy combined with or without chemotherapy retrospectively. Material and Method : From March 1985 to June 1993, 68 patients treated with curative resection and received postoperative adjuvant radiotherapy with 36Gy or more were evaluated. Median age was 60 years(range 28-66 yrs). Patients were followed from 3 to 133 months with median follow up of 48 months. Thirty seven patients had non signet ring adenocarcinoma, 29 signet ring cell, 2 other cell. Patients with stage ⅢA, ⅢB, Ⅳ disease were 19, 25 and 24 respectively. Chemotherapy was given to all patients except two. Results : Five-year overall survival and disease-free survival rate were 36.6% and 33.6%, respectively. Prognostic factor affecting survival were assessed. High ratio of involved/dissected lymph node, signet ring histology showed poor prognosis with statistical significance. Presence of residual tumor after surgery, stageⅣ, split course of radiation therapy, age, number of involved lymph node, number of lymph node dissection and grade of tumor affected survival without statistical significance. Type of chemotherapy did not affect survival. Recurrence was documented in 34 patients. High recurrence was seen in omentum and peritoneum with 23.5%, and remnant stomach, anastomosis site, A-loop and E- loop had also high recurrence with 13.2%. In field locoregional recurrence was 20.7% and total distant metastases were 39.7%. Total intraabdominal failure was 47.1% and extraabdominal failure was 13.2%. Treatment toxicity was considered to be acceptable. 22.1% of patients had grade 3 and only 1 patient had grade 4 leukopenia. Six patients(8.8%) had weigh loss more than 10%. Conclusion : Treatment toxicity was acceptable with combined treatment with chemotherapy and radiotherapy. Locoregional recurrence was relatively low compared to distant failure with addition of irradiation. Peritoneal and omental seeding was high. Five-year surival was increased with combined modality. Radiation may eradicate minimal residual disease and improve survival. To evaluate role of radiation prospective randomized study employing chemotherapy alone and chemotherapy plus radiation is necessary. Futhermore to reduce intraabdominal failure, role of intraabdominal chemotherapy in addition to combined chemotherapy plus radiation has to be explored.

Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

Gene pyramiding effect of two major bakanae disease resistance gene using qBK1 and qBKWD

Sais-Beul Lee,Tae-Heon Kim,Su-Min Jo,Jun-Hyun Cho,Ji-Yoon Lee,Jong-Hee Lee2,Dongjin Shin,You-Chun Song,Myung-Kyu Oh,Dong-Soo Park 한국작물학회 2017 한국작물학회 학술발표대회 논문집 Vol.2017 No.-

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

佛像을 通해 본 統一新羅時代 佛衣에 關한 硏究 : 着衣 및 衣褶을 中心으로 focused on the wearing method and clothes fold

李春桂,安明淑 東國大學校 1988 論文集 Vol.27 No.-

The purpose of this study is to investigate Unified Silla's distinctive style and process of change in Buddga's costumes as well as clothes and wearing method of Buddga's costumes. This study lays emphasis on Unified Silla's Age, which is comparatively definite in the periodical classification of Buddhist art and eminent in the style of a Buddhist image. While Buddhist art of Unified Silla handled in this study mainly had close relation to the art style of Tang(唐) in the ancient China, it received the foreign cultures from the western countries and India by direct or indirect contacts. Therefore, the international inclination of Buddhist art in Korea, China and Japan, from the end of the seventh century to the mid-eighth century, had been shown more remarkably than in any other times. Here I divide this period into three parts in order to observe on the Buddga's costumes of Unified Silla Age. The features of each period is that : 1> the first period The first period ranges from immediately after Silla's unification to the end of the seventh century. The features of Buddha's costumes in this period were little removed from those of the period of the three Kingdoms such as thick Kasa, thick folds of "U" shape, symmetrical folds in a costume. But we can also find the new style in which clothes have drooped fold of manifold semicircle in shape. So, the first period was characterized in the mixture of the traditional style and the foreign style in the appearance of clothes. 2> the second period The second period is during about one century of the eighth century. During this period Silla's way of art was influenced by that of Tang(唐) in china and come to maturity in the art of sculpture with deep faith, Finally Silla had enjoyed the golden age of the art of sculpture. The method of expression in Buddha's costumes also broke from the ancient conventional style and got realistic and refined features of Silla's art. We can also find that the front skirt of Kasa in dress bottom included the new style in which it was cut as a "V" shape besides the horizontally cut style as shown till now. 3> the third period It is the end of Unified Silla ranged from the ninth century to the beginning of the tenth century. In this period the art of Buddhist statue was about to decline gradually from the mid-eighth century, the acme of Buddhist art's prosperity. This degeneration also had great influence on the style of Buddha's costumes, so that the style became formal and schematized. Now, we can summarize the characteristics of the popular style of Buddha's costumes in the times of Unified Silla. First, the styles of Buddhist statue's clothes were more in dress method of put on right and left shoulder than in dress method of put on left shoulder. Second, the style of King Asoka's statues and King Udyana's statues in the folds of clothes were so popular that they became the main current during the eighth century. However, from the beginning of the ninth century, the appearances of folds were formal and schematized with compact and parallel folds which are formally expressed. It is true that the scientists who study dress and its ornaments have left Buddha's costumes out of account due to the peculiarity of Buddha's costumes, whereas there have been more studies on Buddha's costumes on the historical point of art. I hope that with this study as a momentum, new studies on Buddha's costumes will be continued on the historical point of dress and its ornaments as well as that of art.

T1급 고속 암호 시스템에 관한 연구

이훈재,류명춘,오주환 경운대학교 산업기술연구소 1998 産業技術硏究論文誌 Vol.1 No.1(A)

In this paper we propose a secure T1-rate digital image conference system which consists a stream cipher of 7-bit real adder with 2 bit carrys and a fast and stable 2-step full-duplex synchronization. And we analyze the cipher algorithm and the synchronization performance of the system.

항암항생제 Mitomycin C와 DNA의 상호작용

명평근,김춘성,유병태,이천배 충남대학교 암연구소 1991 癌共同硏究所 硏究誌 Vol.1 No.1

Mitomycin C is a clinically used antitumor antibiotic that binds covalently to deoxyribonucleic under reductive or acidic catalysis. We have investigated the confirmation, the determination of thermal melting point(Tm), the inhibition of S1 nuclease and exonuclease I and the transformation of supercoiled closed circular(SCC) PBR 322 DNA on the Mitomycin C-DNA complex. It was identified that Mitomycin C was reduced by 0.001M HC1 (pH<4), 0.01M NaBH_(4) and ascorbic acid. The alkylation of DNA by Mitomycin C was increased Tm; The Tm of control λDNA was 77.25℃ whereas Tm of Mitomycin C-DNA complex was 80℃. It was founded that Mitomycin C-DNA complex inhibited the activity of the S1 nuclease and exonuclease III. The SCC pBR 322 DNA was transformed into more open circular (OC) form by increasing concentration of the Mitomycin C. It is suggested that the interaction of Mitomycin C with DNA effects the conformation of DNA.

소아 확장성 심근증의 임상적 고찰

이성환,김준식,박근수,김명성,권태찬,김천수,이상락 啓明大學校 醫科大學 1996 계명의대학술지 Vol.15 No.1

A Clinical assessment of the 25 patients with dilated cardiomyopathy who were admitted to the Department of Pediatrics, Keimyung University Dong San Hospital from January, 1982 to June, 1993 was performed. The result were as follows: 1) Among 25 patients with dilated cardiomyopathy. 8(32%) were younger than 1 year of age at the time of admission. 2) Adriamycin toxicity was the only encountered etiologic factor in 1 patient. 3) On admission, hepatomegaly and tachycardia were noted in almost all patients. 4) The Chest X-rays showed cardiomegalies in all 25 patients, pulmonary vein congestions in 15(60%) and pleural effusion in 2(8%). 5) The electrocardiography showed left ventricular hypertrophy in 72% and supraventricular tachycardia in 32%. 6) The echocardiographic examination showed left ventricular dilatations in all patients and left atrial dilatations in 20(80%). 7) Of 18 patients who had followed mean period of 2.9 years, 10 patients died within 9 months after the diagnosis.

간호학생의 인성과 자아개념 및 대인지각간의 관계연구

이명신,홍춘실 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

The objects of this study are nursing students who will be engaged in professional nursing practice or will be connected with it, and this study is made in order to see what kind of students have a professional or desirable quality and an appropriate personality on the assumption that the science of nursing is a kind of human study. In order to study the difference or the relationship of each grade, I applied the test to all the students of the nursing department of university in chungnam province for 10 days (from December 1st to December 10th, in 1988), using "A personality test" made by Jeong Won-Sik and Kim, Ho-Gwon, "Self concept test" made by Jeong. Won-Sik and "The instrument for perceptual orientation test made by Choi, Jeong-Hoon. In terms of validity of the test, after excluding the data which have no answer and have too high grades misrepresentation, I calculated total 126 students marks. (freshman 34, sophomore 34, junior 40, senior 18). Finally, I came to reach the following conclusion, after computing the data with program of spss/PC. 1. In case of the personality test, I got the final scores to be 130.7 for senior, 116.5 for freshman, 104.4 for sophomore, and 104.3 for junior and this result means that freshman, sophomore and junior have more desirable and stable personality than senior. Also, senior got 14.0(72%) for sociality Ⅰ(family relationship), 12.6(75%) for conformity, 21.8(72%) for adjustment to reality, and 21.3(72%) for emotional stability and this result means lot of senior need consultation and advice. While there is significant difference in total score, sociality Ⅰ(family relationship), conformity, adjustment to reality, mood, and emotional stability(P<.05), then that there is not significant difference in sociality Ⅱ(social relations) and leadership. In terms of personality, therefore, senior students need more consultation and advice. 2. In the results of the self-concept test, total positive self score which represents this test and is the most important item, got the following distribution: 303.4(60%) for freshman, 312.2(70%) for sophomore, 317.0(75%) for junior, and 303.1(60%) for senior. And the result reveals that most students have positive self concept although it is not a desirable level. There is not significant difference among each grade, but there is significant difference in physical self score of subordinative area. 3. In the result of the perceptual orientation test, freshman, sophomore, junior and senior got 216.4(52%), 216.0(51.5%), 228.4(72%) and 216.6(52.5%) respectively and showing significant difference among grades, the result means that junior students have the most desirable perceptual orientation and other grades have neither positive nor negative view of job. 4. The relationship between personality and perceptual orientation, personality and self-concept reveals negative correlation.(the former r=-.40, P<.001, the latter r=-.66, P<.001). It means that the more desirable personality students have, the more perceptual orientation and self-concept they have. Perceptual orientation and self-concept have positive correlation(r=.47, P<.001) 5. There is significant difference in total marks of perceptual orientation between student's experience of clinical practice and have not.(P<.05) Junior and senior who have experienced it, have more perceptual orientation than freshman and sophomore who has never been experienced it. In case of subordinative area, we can see statistically significant difference only in the perceptual to the others. Through the result of this study, I will assert as following; 1. As the personality can be changed by environment and education, etc. in senior, scores are needed to be re-tested, Because we must know whether external factor affects their personality. 2. We can use this test for the improvement of the personality with the difference of scores which is calculated in the personality test, the perceptual orientation test and the self-concept test. 3. The results reveals that the more student has desirable personality the better student has self-concept and perceptual orientation with a view to carrying out the student's duty efficiently in the future or equipping him with the high quality of a practitioner, I think there is the necessity of an experimental study on desirable changes taking place by providing the student with trainings, education, or desirable circumstances. 4. Although the group which have experienced the clinical practice have more perceptual orientation the reason in unknown yet. So we need to make the reason clear and reinforce, them this process through generalized results of the continuous study. 5. This research includes the information of each students personality, his perceptual orientation, his self concept, and then these results are available data for student counselling and advice.