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RISS 인기검색어
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- 저자 : 이규보 (검색결과 267 건)
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이규보,황기석,조동규 慶北大學校 醫科大學 1988 慶北醫大誌 Vol.29 No.4
저자들은 1987년 8월부터 1988년 8월까지 정상 성인 6례와 각종의 신장질환 32례를 대상으로 ^99mTc-DTPA를 정주한 후에 2분에서 3분 사이에 신장부위의 방사능을 체외계측하여 얻은 신장섭취율에서 GFR를 계산하는 Gates의 방법을 채택하였다. 정상 성인에서 GFR은 111.4±10.24㎖/min.였고, 급성신부전증에서는 66.8±18.55㎖/min.였고, 만성신부전증에서는 51.3±24.38㎖/min.였으며, 신증후군에서는 98.3±33.02㎖/min.였다. 이 방법으로 계산된 GFR과 CCR과의 상관성(r=0.8235)은 매우 좋았는데, GFR이 50㎖/min. 이상의 군에서는 상관성이 좋았으나 그 미만의 군에서는 상관성이 저조하였다. 신장의 깊이를 계측하는 방법에는 초음파도로 실측하는 경우보다도 Tonnesen의 공식을 적용하는 경우에 더 좋은 경향이 있었다. The authors evaluated the glomerular filtration rate(GFR) derived from using Tc-99m DTPA on the 38 people, which consisted of 6 normal persons and 32 patients with the various renal diseases. The GFR was calculated from fractional renal uptake of Tc-99m DTPA 2 to 3 minutes after intravenous injection. The GFR was 111.4±10.24/㎖/min. in the normal persons and 66.8±18.55㎖/min. in patients with acute renal failure. The patients with chronic renal failure reveal a GFR of 51.3±24.38㎖/min. and those with nephrotic syndrome show a GFR of 93.8±33.03㎖/min. The relationship of GFR to the creatinine clearance rate(CCR) was a significant correlation coefficient of 0.8235 in 34 cases and it was relatively remarkable in the groups with a GFR of above 50㎖/min.
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만성 골수성 백형병에 있어서 Busulfan 과 Hydroxyurea 의 치료 효과의 비교
이규보,황기석,류만준,구본환 대한내과학회 1986 대한내과학회지 Vol.31 No.4
A retrospective analysis of 27 patients with chronic myelogenous leukemia treated with busulfan(20 patients) and hydroxyurea(7 patients) was done in order to compare .the effectiveness of each therapeutic modality. In the busulfan-treated group the white blood cell count decreased to normal in all the patients, anemia improved in 88.9%, and splenomegaly decreased or disappeared in 85.0%. In the hydroxyurea-treated group, the decrease of white blood cell count to normal, correction of anemia, and disappearance of splenomegaly were observed in all the patients treated. The order of recovery in the busulfan-treated group was the normalization of the white blood cell count, correction of anemia, and disappearance of splenomegaly, while the hydroxyureatreated group showed the normalization of white blood cell count, disappearance of splenomegaly, and correction of anemia. The treatment with hydroxyurea demonstrated a more rapid decreasing effect on the white blood cell count than did busulfan. On the other hand, the fluctuations of the white blood cell count in the hydroxyurea-treated group were so remarkable that frequent adjustments to dosage were necessary to maintain the sustained control of the cell count. The adverse effects of busulfan were skin pigmentation(100%) and pancytopenia(10%), whereas in the hydroxyurea-treated group mild nausea. and vomiting were noted in only 3cases(43%).
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