http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 이재태 (검색결과 272 건)
- 무료
- 기관 내 무료
- 유료
-
-
이재태 한국데이터전략학회 1994 Journal of information technology applications & m Vol.1 No.2
서로 관련있는 다수의 정보를 체계적으로 수집. 처리하여 컴퓨터등 전자계산조직에 의하여 축적.검색할 수 있도록 한 정보의 집합체가 데이터베이스(DB)이며, 또한 데이터베이스를 제작하는 데이터베이스제작업, 이 데이터베이스를 컴퓨터에 수록하여 이용자에게 제공하는 데이터전송업, 온라인단말기를 설치하고 이용자가 요구하는 정보를 검색.제공하는 정보검색 대행업등으로 구성된 것이 데이터베이스 산업이다.
-
-
-
-
-
-
-
K^+통로개방제 Pinacidil이 종양이식 생쥐에서 Tl-201의 체내분포에 미치는 영향
이재태,천경아,이상우,강도영,안병철,전수한,이규보,하정희 경북대학교 의학연구소 1999 경북대학교병원의학연구소논문집 Vol.3 No.1
Purpose: Thallium behaves similarly to potassium in vivo. Potassium channel opener (K-opener) opens ATP-sensitive K+ -channel located at cell membrane, resulting in potassium efflux from cytosol. We have previously reported that K-opener can alter biokinetics of T1-201 in cultured cells and in vivo. Malignant tumor cells have high Na-K ATPase activity due to increased metabolic activities and dedifferentiation, and differential delineation of malignant tumor can be possible with T1-201 imaging K-opener may affect tumoral uptake of T1-201 in vivo. To investigate the effects of pinacidil (one of the potent K-openers) on the localization of the tumor with T1-201 chloride, we evaluated the changes in biodistribution of T1-201 with pinacidil treatment in tumor-bearing mice. Materials and Methods: Balb/c mice received subcuta-neous implantation of murine breast cancer cells in the thigh and were used for biodistribution study 3 weeks later. 100㎍ of pinacidil dissolved in 200 □ DMSO/PBS solution was injected intravenously via tail vein at 10 min after 185 KBq (5 □Ci) T1-201 injection, Percentage organ uptake and whole body retention ratio of T1-201 were measured at various periods after injection, and values were compared between control and pinacidil-treated mice. Results: Pinacidil treatment resulted in mild decrease in blood levels of T1-201, but renal uptakes were markedly decreased at 30-min, 1- and 2-hour, compared to control group. Hepatic, intestinal and muscular uptake were not different. Absolute percentage uptake and tumor to blood ratios of T1-201 were lower in pinacidil treated mice than in the control group at all time points measured. Whole body retention ratio of T1-201 was lower in pinacidil treated mice (58±4%), than in the control group (67±3%) at 24 hours after with injection of 100 □g pinacidil. Conclusion: K-opener did not enhance, but rather decreased absolute tumoral uptake and tumor-to-blood ratios of T1-201 Decreased whole body retention ratio and renal uptake were observed with pinacidil treatment in tumor-bearing mice. (Korean J Nucl Med 2000;34:303-11)
-
ScienceON
DBpia연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
