한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

당뇨병 백서의 간세포에서 Glucokinase 활성도 및 유전자 발현에 대한 인슐린의 영향

강성이,팽정령,서광식,안규정,우정택,김성운,양인명,김진우,김영설,김광원,최영길 경희대학교 유전공학연구소 1993 遺傳工學論文集 Vol.5 No.-

목적 당대사의 조절 상태에 따른 생체 변화를 분자 수준에서 이해하고자 식이 조건을 달리한 정상 백서와 화학적으로 유도된 당뇨병 백서의 간조직에서 혈당수준과 인슐린치료 정도에 따라 나타나는 글루코키나제 활성도 및 유전자 발현을 분석하였다. 방법 스트렙토조토신 정맥투여 후 당뇨병의 유발을 확인하고, 인슐린을 1일 3회 3일간 복강내로 투여하여 상태를 안정시킨 후, 인슐린 투여군은 인슐린 투여 6시간이내에 그리고 인슐린 비투여군은 24시간 후 단두하여 채혈하고 복강을 열어 간조직을 채취하였다. 채취한 간조직에서 글루코키나제 활성도는 인산화된 포도당에서 NADH의 형성을 형광분광계로 측정하였으며, 글루코키나제 유전자 mRNA발현은 Northern 분석법을 이용하였다. 성적 정상 백서에서 공복상태와 식이를 섭취한 경우에 간조직의 글루코키나제 효소의 활성은 차이가 없었으나, 글루코키나제 유전자 mRNA 발현은 증가되었다. 당뇨병이 유발된 백서의 간조직에서 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA 발현은 정상 백서에 비하여 낮았다. 인슐린 투쳐 후 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA 발현이 증가되었고, 특히 혈당이 정상화된 경우에서 글루코키나제 유전자의 mRNA 발현이 증가도었다. 결론 인슐린에 의한 간조직에서 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA을 증가를 볼수 있었다. 당뇨병 백서에서 인슐린 투여 후에 혈당조절이 안된 경우 간조직의 글루코키나제 유전자의 mRNA 발현이 증가가 없는 것으로 보아 글루코키나제 mRNA의 발현에는 인슐린 이외의 다른 요소가 관여할 것으로 생각된다. The liver-specific hexokinase isoenzyme, referred to as glucokinase, is thought to play a key reglulatory role in hepatic glucose metabolism. The glucokinase gene is, therefore, of interest both because of its tissue-specific expression and because of the several regulatory processes that can be analyzed. The level of hepatic glucokinase activity appears to be determined essentially by regulation of the rate of enzyme synthesis, with insulin playing a leading role as an inducer. We investigated the role of insulin for the induction of glucokinase in the liver of diabetic rats. Experimental diabetes was induced by injection of streptozotocin 7 days before the experiment. Regular insulin was given by three days intraperitoneal injection at 8-h interval. The glucokinase mRNA in the liver was estimated by Nothern blot assay, as well as by fluorometric enzyme activity assay. Glucokinase activity was not reduced in the liver of normal fasting rats as compared to normal fed rats. And glucokinase activity was reduced in the liver of diabetic rats as compared to normal rats. In diabetic rats treated with insulin, glucokinase enzyme activity were increased. But glucokinase mRNA expression was only increased in normoglycemic diabetic rat with treated with insulin as compared to hyperglycemic rat. These data indicate that insulin stimulates hepatic glucokinase enzyme activity and mRNA expression. But other hormonal or metabolic factors may be contribute to regulation of glucokinase mRNA expression.

혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

적외선열화상장치를 이용한 Buchanan plugger 표면의 온도상승 분석

최성아,김선호,황윤찬,윤창,오병주,최보영,정우남,정선와,황인남,오원만 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.4

This study was performed to evaluate the temperature rise on various position of the Buchanan plugger, the peak temperature of plugger's type and the temperature change by its touching time of heat control spring. The heat carrier system 'System B' (Model 1005. Analytic Technologies, USA) and the Buchanan's pluggers of F, FM, M and ML sizes are used for this study. The temperature was set to 200℃ which Dr. Buchanan's "continuous wave of condensation" technique recommended on digital display and the power level on it was set to 10. In order to apply heat on the Buchanan's pluggers, the heat control spring was touched for 1, 2, 3, 4 and 5 seconds respectively. The temperature rise on the surface of the pluggers were measured at 0.5 mm intervals from tip to 20 mm length of shank using the infraed thermography (Radiation Thermometer-IR temper, NEC San-ei Instruments, Ltd, Japan) and TH31-702 Data capture software program (NEC San-ei Instruments, Ltd, Japan). Data were analyzed using a one way ANOVA followed by Duncan's multiple range test and linear regression test. The results as follows. 1. The position at which temperature peaked was approximately at 0.5 mm to 1.5 mm far from the tip of Buchanan's pluggers (p<0.001). The temperature was constantly decreased toward the shank from the tip of it(p<0.001). 2. When the pluggers were heated over 5 seconds, the peak temperature by time of measurement revealed from 253.3±10.5℃ to 192.1±3.3℃ in a touch for 1 sec, from 218.6±5.0℃ to 179.5±4.2℃ in a touch for 2 sec, from 197.5±3.0℃ to 167.6±3.7℃ in a touch for 3 sec, from 183.7±2.5℃ to 159.8±3.6℃ in a touch for 4 sec and from 164.9±2.0℃ to 158.4±1.8℃ in a touch for 5 sec. A touch for 1 sec showed the highest peak temperature, followed by, in descending order, 2 sec, 3 sec, 4 sec. A touch for 5 sec showed the lowest peak temperature (p<0.001). 3. A each type of pluggers showed different peak temperatures. The peak temperature was the highest in F type and followed by, in descending order, M type, ML type. FM type revealed the lowest peak temerature (p<0.001). The results of this study indicated that pluggers are designed to concentrate heat at around its tip, its actual temperature dose not correlate well with the temperature which Buchanan's "continuous wave of condensation" technique recommended, and finally a quick touch of heat control spring for 1 sec reveals the highest temperature rise.

개에서 발생한 이혈종의 임상적 관리

이우철,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

A 14-year-old male pomeranian was present with swollen left ear. The swelling occurred from base to apex of pinna. Otitis externa persisted for two years. Hematological and serum biochemistry values were not remarkable. The surgery treatment was the most appropriate method among indwelling drain, surgical, and steroid treatment in the aural hematoma because the dog was very sensitive to touching pinna and the size of aural hematoma. Longitudinal incision was applied after general anesthesia. Cefovecin was injected to prevent secondary infection. The outcome of surgery was good. There was no evidence of recurrence for one year.

안모의 수직고경에 영향을 미치는 교정적 요인에 관한 연구

최우정,김상철 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.2

전통적 교정술식인 edgewise technique으로 치료한 경우 잔여성장, 안모 유형과 발치 여부가 안모고경에 미치는 영향과 요소를 알아보고자 165명을 대상으로 조사하였다. 이 대상군들은 SN-GoGn angle, Frankfort mandibular plane angle, Occluso-mandibular plane angle을 이용하여 수직 비발치군, 수직 발치군, 수평 비발치군,수평 발치군으로 구분하였다. 치료 전후에 두부계측방사선사진을 계측하고 통계처리하여 다음과 같은 결론을 얻었다. 1.모든 군에서 치료 후의 전하안모고경, 전안모고경, 후안모고경이 유의하게 증가하였으며 상하악 구치고경이 유의하게 증가하였다. 2.치료 전후의 안모고경 변화에서 수직, 수평 안모 유형 간에 유의한 차이는 인정되지 않았다. 3.발치군과 비발치군 간의 안모고경 변화는 유의한 차가 없었다. 4.전하안모고경의 변화량이 성장군에서 상악 구치고경의 변화와,성인군에서 하악 구치고경의 변화와 유의한 상관성을 보였다. 5.전하안모고경의 변화량에 영향을 미치는 요소는 뚜렷하지 않았다. The change of the vertical dimension is of fundamental importance to the orthodontist. However, the choice between the two methods of treatment, extraction versus nonextraction, is not clear. It is not verified that the extraction method decreases vertical dimension, or nonextraction methods result in an increase in vertical dimension. The purpose of this study was to evaluate the changes of vertical dimension of face after the orthodontic treatment with standard edgewise technique, and to compare them in relation to facial types and bicuspid extraction. The subjects consisted of 165 orthodontic patients (77 of adolescents, 88 of adults), and was divided into vertical nonextraction (VN) group, vertical extraction (VE) group, horizontal nonextraction (HN) group, horizontal extraction (HE) group. Pre-and Post-treatment cephalograms were taken with standard method, traced, and digitized for each subject. The comparison of the measurements were statistically executed with Student's t-test. The results were as follows : 1.The facial height and molar height were increased after orthodontic treatment in the all groups. 2.No significant difference was found in the facial height chance between the vertical and horizontal 3.No significant difference was found In the facial height change between the extraction and nonextraction groups. 4.As the upper molars were extruded in adolescents group and lower molars were extruded in adults group, lower anterior facial height (LAFH) was increased. 5.None of the pretreatment variables correlates to the change of lower anterior facial height (LAFH).

지난 6년간(1997~2002) 양산리 소주리 지하수의 수질 조사

최우성,정기호 부산대학교 환경문제연구소 2003 環境硏究報 Vol.21 No.-

In this research, we investigated the KMnOc, consumption rate, pH, and the contents of major anions of the ground water fron Soju-ri, Yangsan(during the last 6 years 1997~2002). In this area, average rainfall during the last 6 years was 1,618.3 mm and a monthly average 134.85 mm. The KMnO₄ consumption rate was 0~3.7 ppm NO₃-N concentration was 1.3~6.5 ppm SO₄ concentration was 10~83 ppm, CI concentration was 4~60 ppm and NH₃-N corcentration was 0~0.05 ppm. Zn, Al, and Ou concentration were 0~0.999, 0~0.17, and 0~0.043 ppm respectively. As Pb, Cd, and Hg were not detected

중요도-성취도 분석을 이용한 도시공원 관리운영방안 : Case Study in the Han Riverside Civic Park 한강시민공원의 사례를 통하여

최정우 牧園大學校 建築·都市硏究센터 1999 建築·都市環境硏究 Vol.7 No.-

This study aims to apply and examine that Importance-Performance Analysis can be an efficient methods for citizen park management. The Importance-Performance Analysis developed in marking field to measure attribute importance and performance is an easily-applied technique for the management of urban public park. Ratings used mean values from a seven-point scale. Results were then graphically displayed on an easily interpreted two-dimensional 'Action Grid'. The Han Riverside Civic Park was selected as a study area. Twenty main function attributes for urban public park was selected. Public Facilities, dust treatment, and management facility are perceived high in importance but low in performance. Taking a walk, resting place and sports field get high ratings in performance. Compared among five areas in Han Riverside Civic Park, Tuksum area is high, but Yuido and Jamsil low in performance.

巴戟天의 實驗的 硏究(第1報)

최정화,홍석,정현우 대한본초학회 1996 大韓本草學會誌 Vol.11 No.1

These studies were carried out to investigate the effect of Radix Morindae water extract on the inhibitory contractile action of histamine in guinea pig. The results of these studies were as follows; 1. Contractile force of histamine from trachea smooth muscle in guinea pig was inhibited by Radix Morindae. 2. Radix Morindae did not changed the contractile force of histamine pretreated propranolol, indomethacin, and methylene blue. 3. Contractile force of uterus in rat was inhibited by Radix Morindae. 4. Contractile frequence of uterus in rat was inhibited by Radix Morindae.