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김광원,이문규,이명식,고은미,민용기,정재훈,안규정,김경아,김연선,기현균 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.1
Down's syndrome(trisomy 21) has been frequently associated with thyroid disease, mainly subclinical hypothyroidism(12.5-32.5%). The occurrence of Downs syndrome in conjunction with hyperthyroidism is rare(0.6-2.5%). The mechanism that Down's syndrome was frequently associated with autoimmune thyroid disease is not clear, but T cell maturation defects and overexpression of chromosome 21 products in Down's syndrome have been suggested. A 19-year-old female was transferred because of generalized weakness. She was born to a 42- year-old mother, She had been suffered from heat intolerance, weight loss, palpitation, dyspnea on exertion and neck swelling and had intermittently taken some medication since her age 9. She had mental retardation(IQ 41) and underdeveloprnent. Exophthalmos, upward-outward slant of palpabral fissures, epicanthal folds, lowset ears, and large, protruding, fissured tongue were identified. Short fifth middle phalanges, clinodactyly and small-sized interventricular septal defect were also detected. Thyroid gland was diffusely enlarged four times the normal size, firm in consistency and had a bruit. Serum T concentration was 7.8ug/dL, T2 306ng/dL, and TSH 0.01ulU/mL. She was positive for thyroid autoantibodies(antimicosomal antibody 1,867 IU/mL, antithyroglobulin antibody 106 IU/mL, and TBII 79.6%). Twenty-four hours radioactive iodine uptake was 64%. Chromosomal analysis with T cell culture stimulated by phytohemagglutinin revealed 47XX, 21 trisomy. Pituitary hormones except TSH were fully stimulated by combined pituitary stimulation. She was finally diagnosed as Down's syndrome with Graves' disease and controlled with use of methimazole. (J Kor Soc Endocrinol 12:61-67, 1997)
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불현성 갑상선기능 저하증에서 혈청 LP(a) 및 지질 농도의 양상
김광원,이문규,이명식,고은미,민용기,정재훈,안규정,김경아,김연선,이종헌 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.1
Background: Overt hypothyroidism is well-known cause of secondary hyperlipidemia and atherosclerosis. However, there have been dissenting reports of abnormalities in serum lipid concentrations in patients with subclinical hypothyroidism (SH). Recently, it has been reported that serum Lp(a) concentration, an independent risk factor of atherosclerosis, was increased in patients with SH. Therefore, we analyzed serum Lp(a) and other lipid concentrations to investigate whether they are increased in patients with SH and the correlation between serum Lp(a) and TSH concentrations. Methods: We undertook this study in 53 patients with SH (TSH $gt; 6 uiU/ml) and 197 age-and sex-matched healthy control subjects, They had no abnormalities in liver function, BUN, creatinine, fasting blood glucose, urinalysis, and past medical histories. Serum T3, T4, and TSH concentrations were measured by RIA using commercial kits. Serum concentrations of Lp(a), total cholesterol, triglyceride (TG), and HDL cholesterol (HDL-C) were measured by rate nephelometry and enzyme assay, respectively. Results: There were no significant differences of serum Lp(a), total cholesterol, LDL cholesterol, TG, and HDL-C concentrations in 53 patients with SH and 197 control subjects(25.6+-3.8mg/dL vs. 25.4+-1.5mg/dL ; 204.0+-4.2mg/dL vs. 204.0+-2.4mg/dL ; 127.0+-3.9mg/dL vs. 125.0+-2.3 mg/dL ; 133.0+-8.5mg/dL vs. 130.0+-6.0mg/dL ; 50.0+-1.5mg/dL vs. 53.0+-0.9mg/dL). There was no correlation between Lp(a) and TSH concentrations in SH(r=0.12, p$gt;0.05). Conelusion: Serum Lp(a) concentration as well as total cholesterol, LDL cholesterol, and TG was not increased in patients with SH. There was no correlation between serum Lp(a) and TSH levels in subclinical hypothyroidism. (J Kor Soc Endocrinol 12:11-17, 1997)
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김광원 한국기독교사회윤리학회 2000 기독교사회윤리 Vol.3 No.-
최근 들어 남북의 정치적 상황이 고무적으로 급진전되면서 이른바 20세기를 현란하게 장식했던 정치적 이데올로기 대립의 시대가 완전히 종식되었다는 사실을 한반도에서도 피부로 느끼게 하고 있다. 이미 세계 질서는 완전히 새로운 패러다임으로 재편되고 있다. 즉 21세기에 있어서의 평화 문제는 더 이상 정치적 이데올로기의 갈등이 아니라, 문화와 종교의 갈등에서 비롯될 것이라는 데서 오늘 우리에게 새로운 과제로 다가오고 있는 것이다. 바로 이 점 때문에 필자는 본고를 통하여 종교와 평화의 문제를 신학적으로 접목시키는 작업에 주력하였으며, 더 나아가서 평화로운 하나의 지구촌 시대를 묶어 나아갈 21세기 지구촌 윤리의 형성에 미력하나마 공헌해 보려는데 목적을 두고 있다. 다문화 내지 다원화 시대로 특징지어지고 있는 21세기 시대의 평화 문제는 종교와 사회윤리의 문제와 함께 묶어내어 풀어가지 않으면 안 된다. 따라서 필자는 최근 지구촌의 정치적 화약고의 역할을 해 온 유고 사태에 대하여 이른바 종교적 시각으로 사례를 분석으로써 본고의 논지를 뒷받침하였으며, 평화를 향한 종교의 순기능(평화의 영성)과 역기능(평화를 깨는 마성)을 상세히 분석함으로써 평화 종교신학의 가능성을 타진해 보았다. 그리고 무엇보다도 본고의 주요 관심사인 21세기의 지구촌 평화를 위한 윤리적 실천을 거칠게나마 제안해 보고자 하였다.
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Orthopantomograph에 依한 混合齒列象의 解析에 關한 硏究
金光垣 대한치과교정학회 1982 대한치과교정학회지 Vol.12 No.2
Plaster models were constructed and orthopantomographs were taken for 86 male and 70 female primary school pupils, whose upper and lower permanent 4 incisors and 1st molars were completely crupted without crowding, whose deciduous canines and molars were found almost uniformly even without any visible tooth fractures, dental caries or restorations on proximal surfaces of the teeth. Certain reference points on the orthophantormograph were set up and measured and the values were compared with actual or predicted values from the models. The following results were obtained; 1. In regards to available space, the values from the orthopantmograph were greater than the values from the models by a mean of 3.24% on the upper and 10.06% on the lower for males; 3.05% on the upper and 10.01% on the lower for females. 2. In regards to total mesiodistal widths of permanent canine, 1st and 2nd premolars, the values from the orthopantomograph were greater than the presumed values based on the size of lower permanent 4 incisors from the models by a mean of 18.50% on the upper and 24.09% on the lower for males; 14.54 on the upper and 20.51% on the lower for females. 3. Comparing the magnified values of total mesiodistal widths of permanent canine, 1st and 2nd premolars with those of available space, the regression constants of regression equation (Y=a+bX) between them were a=3.2336, b=0.6533 on the upper and a=5.0138,b=0.3290 on the lower for males; a=2.5994, b=0.6521 on the upper and a=3.0113, b=0.6586 on the lower for females. 4. The correlation coefficients between the magnified values of space and permanent canine, 1st and 2nd premolars were moderately positive as 0.6474 on the upper and 0.5050 on the lower for males; 0.6493 on the upper and 0.6183 on the lower for females. 5. In regards to magnified values of the available space from the orthopantomographs, there were no significant difference between sexes, (P>0.05) but of the total mesiodistal widths of permanent canine, 1st and 2nd premolars, a significant difference between sexes was found. (P<0.01)
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