나노테크놀로지 - 최정우 , 유 / 무기 복합박막의 나노성형 동향 - 안동준 , Nanobiotechnology - 정봉현 , 유 / 무기 나노복합재료 - 이희우 , 이재욱 , 나노전사법 ( nanolithography ) - 이해원 , 이해성.

최정우,안동준,정봉현,이희우,이재욱,이해원,이해성 한국화학공학회 2001 화학공업과 기술 Vol.19 No.1

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Whole-Genome Resequencing Analysis of Hanwoo and Yanbian Cattle to Identify Genome-Wide SNPs and Signatures of Selection

최정우,이승환,최봉환,이승수,김형철,유대영,정원형,최한하,이경태,임다정,조영민 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.5

Over the last 30 years, Hanwoo has been selectively bred to improve economically important traits. Hanwoo is currently the representative Korean native beef cattle breed, and it is believed that it shared an ancestor with a Chinese breed, Yanbian cattle, until the last century. However, these two breeds have experienced different selection pressures during recent decades. Here, we whole-genome sequenced 10 animals each of Hanwoo and Yanbian cattle (20 total) using the Illumina HiSeq 2000 sequencer. A total of approximately 3.12 and 3.07 billion sequence reads were mapped to the bovine reference sequence assembly (UMD 3.1) at an average of approximately 10.71- and 10.53- fold coverage for Hanwoo and Yanbian cattle, respectively. A total of 17,936,399 single nucleotide polymorphisms (SNPs) were yielded, of which 22.3% were found to be novel. By annotating the SNPs, we further retrieved numerous nonsynonymous SNPs that may be associated with traits of interest in cattle. Furthermore, we performed whole-genome screening to detect signatures of selection throughout the genome. We located several promising selective sweeps that are potentially responsible for economically important traits in cattle; the PPP1R12A gene is an example of a gene that potentially affects intramuscular fat content. These discoveries provide valuable genomic information regarding potential genomic markers that could predict traits of interest for breeding programs of these cattle breeds.

「아이디어」와 계획

최정우 한국사법행정학회 1962 사법행정 Vol.3 No.8

딥러닝 기반 반도체 물류 반송 시스템 다중 시점 처리 능력 예측 연구

최정우,강형원,김정섭,강필성 한국경영과학회 2022 한국경영과학회 학술대회논문집 Vol.2022 No.6

Fabrication of functional biomolecular layer using recombinant technique for the bioelectronic device

최정우,김상욱,Young Jun Kim,Cheol-Heon Yea,민준홍 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.5

A novel immobilization method of blue copper protein azurin on a gold surface was developed without a chemical linker using recombinant technique. Azurin was recombined with a cysteine anchors by site-directed mutagenesis (SDM) and used to effect the mutations, changing the codon for Leu39Cys (L39C) from CTG to TGC. The immobilization of the functionalized protein is confirmed by surface plasmon resonance (SPR) and its surface morphology is analyzed by scanning tunneling microscopy (STM). The immobilization efficiency has been increased about 76.3%, as compared to that of wild type azurin. The electrochemical property of the fabricated thin film was investigated by cyclic voltammetry (CV). As a result, cysteine-modified azurin can be used for making high quality protein film, and applied to the fabrication of nano-scale bioelectronics.

모든 것은 부재했다, 하여 순간 속에서 영원했다(2회) - 정지돈 『모든 것은 영원했다』의 소설적 불가능, 그리고 사라지지 않는 망각으로서의 비평

최정우 심미안 2021 문학들 Vol.- No.66

나노바이오칩 기반 무선 임플란트형 시스템

최정우,오병근,오수민 에스케이텔레콤 (주) 2007 Telecommunications Review Vol.17 No.2

최근 NT, BT, IT가 급속도로 발달하면서, 나노바이오칩기술을 정보통신 기술과 융합하여 신경회로의 활성을 기록하고, 질병 진단할 수 있는 무선 임플란트형 마이크로시스템을 개발하기 위한 연구가 시도되고 있다. 실리콘 마이크로 머신 형태의 전극 어레이는 세포수준에서 신경네트워크에 이르기까지 전기적 신호를 삽입하고, 생체 내에서 장시간 동안 신경 활동을 모니터링할 수 있다. 나노바이오칩 기반 무선 임플란트형 마이크로시스템 연구분야에서 전극배열은 칩 회로, 신호과정, 마이크로 유체, 무선 인터페이스 분야를 중심으로 연구되고 있으며, 기술발전과 더불어 신경시스템을 이해하는데 매우 중요한 역할을 하게 될 것으로 예견되고 있다. 본 논문에서는 나노바이오칩 기술을 기반으로 한 무선 임플란트 마이크로시스템 구현을 위한 핵심기술로서 전자 어레이 기술, 임플란트 기술, 전극 어레이의 무선통신기술을 소개하고, 새로운 시스템 모델을 제안하였다.

Abnormal Sleep Delta Rhythm and Interregional Phase Synchrony in Patients with Restless Legs Syndrome and Their Reversal by Dopamine Agonist Treatment

최정우,정민희,허성진,이병욱,차광수,정기영,김경환 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.4

Background and Purpose The purpose of this study was to characterize abnormal cortical activity during sleep in restless legs syndrome (RLS) patients and to determine the effects of treatment with a dopamine agonist. Based on whole-brain electroencephalograms, we attempted to verify alterations in the functional network as well as the spectral power of neural activities during sleep in RLS patients and to determine whether the changes are reversed by treatment with pramipexole. Methods Twelve drug-naïve RLS patients participated in the study. Overnight polysomnography was performed before and after treatment: the first recording was made immediately prior to administering the first dose of pramipexole, and the second recording was made 12–16 weeks after commencing pramipexole administration. Sixteen age-matched healthy participants served as a control group. The spectral power and interregional phase synchrony were analyzed in 30-s epochs. The functional characteristics of the cortical network were quantified using graph-theory measures. Results The delta-band power was significantly increased and the small-world network characteristics in the delta band were disrupted in RLS patients compared to the healthy controls. These abnormalities were successfully treated by dopaminergic medication. The delta-band power was significantly correlated with the RLS severity score in the RLS patients prior to treatment. Conclusions Our findings suggest that the spectral and functional network characteristics of neural activities during sleep become abnormal in RLS patients, and these abnormalities can be successfully treated by a dopamine agonist.

국립중앙박물관 내·외부 유휴공간의 활용성 개선에 관한 연구

최정우,문서현,윤철재 한국문화공간건축학회 2019 한국문화공간건축학회논문집 Vol.- No.67

This study proposed the direction of basic plan for space usability improvement of the National Museum of Korea as follows. First, to seek for a maximization method of linking and using the internal and external spaces, this study aimed to modify the visitor routes and provide various viewing methods so that the museum would be completed by visitor experiences, as a space of “interacting with visitors” and an “open city museum” for taking a walk. In addition, this study proposed ways of maximizing the space usability of museum: improve the accessibility by increasing the points of contact between the external space and the city (e.g., linking the external space with relevant facilities nearby) as a part of “connecting the places”; and “modifying other unused spaces” internally. Based on this, a master plan was proposed. First, the external space of vast size, which had a long and boring traffic line that had been neglected, was divided into four areas of A-pavilion, B-floor pattern, C-memorial hall, and D-wall observation platform, and the internal space was divided into three areas of E-floating ceiling, F-cultural heritage street, and G-observatory type rest space for a design that can be reflected to improve the main hall and solve the problem of low visibility of information facilities and amenities such as lounges. Based on these, respective programs and perspective drawings were proposed. In addition, plans for linking with the changed surrounding urban environment and adjacent relevant facilities were reviewed in order to propose a plan for the National Museum of Korea to increase the convenience of visitors and improve the satisfaction, as a space that has identity and philosophy corresponding to the consciousness level improvement of citizens.

아급성 림프절염의 임상·병리학적 분석

최정우,이지혜,이주한,채양석,김인선 대한병리학회 2004 Journal of Pathology and Translational Medicine Vol.38 No.5

Background : Kikuchi's disease has been known as a self-limiting lymphadenitis mostly affecting the cervical lymph nodes of young women. Methods : We retrospectively reviewed the clinical data of 77 cases of Kikuchi's lymphadenitis from 1996 to 2003 at Korea University Medical Center. Results : Histologically, 69 available cases were classified into three types: proliferative (60.8%), necrotizing (33.3%), and xanthomatous type (5.7%). These three types differed in terms of their clinical features, showing tenderness most predominantly in the necrotizing type. In spite of the insufficient numbers of cases, the data on the duration of the disease well correlated with the possible progression of the three histologic types (Kikuch's disease begins as proliferative type, then progress into necrotizing type and finally resolves into xanthomatous type). During the ten-month period of the mean follow-up, the recurrence rate was 7.0%. Three and two patients developed into pulmonary tuberculosis and systemic lupus erythematosus, respectively, but there were no prognostic differences among the three types. Conclusions : Our results confirmed that Kikuchi's lymphadenitis is a self-limiting necrotizing lymphadenitis with a low rate of recurrence. Here, we suggest that the classification of histologic types have some meanings because of their differences in certain clinical aspects and possible sequential disease progression.