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최선주 대한건축학회 1996 建築 Vol.40 No.7
일본의 역사환경 보존재생과 관련된 주요법률로는 [문화재보호법], [고도의 역사적 풍토 보존에 관한 특별조치법(통칭 고도보존법)], [도시계획법]과 [건축기준법]이 있다. 문화재보호법은 1950년 담징의 변화로 유명한 법륭사 금당의 화재를 계기로 제정되었다. 그후 문화재적인 가치가 높은 건축물은 문화재보호법에 의하여 보존되어 왔으나, 역사지구와 같은 면적인 역사환경을 보존하기 위한 제도는 [전통적건조물군보존지구제도]가 도입될 때까지 마련되지 못했다.
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Preparation and characterization of fractionized chitosan and its application for green tide
최선주,김태훈,정경원,이현수,김원석,최창용,최수경,김성초,나재운 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
The purpose of this study is to investigate the characterization and application of fractionated chitosan by ultrafiltration method. The distribution of molecular weight was measured by GPC and the physicochemical properties of fractionized chitosan were investigated by 1H NMR, FT-IR, DSC, and TGA. This study, we take advantage of fractionized chitosan to remove harmful algae. We harvested chitosan with accurate molecular weights, narrow molecular weight distribution and high purity. These results introduced that the chitosan can be applied to the various field such as treatment of fresh water and biomedical fields. **This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, ICT & Future Planning. (NRF-2014R1A2A1A10053027).
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최선주,홍웅길,김원석,최창용,나재운 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
Pluronic F127(poloxamer) is well known thermosensitive material, and it has a property of sol-gel phase transition in specific temperature. We synthesized thermo-sensitive chitosan-b-F127-b-chitosan tri-block copolymer by radical polymerization. The characterization of tri-block copolymer was analyzed by <sup>1</sup>H NMR, DSC, TGA, and rheological study. The value of a solid-like behavior (elastic modulus (G`)) and a liquidlike behavior(viscous modulus (G“)) was recorded according to changing temperature with parallel plate. Moreover, its sol-gel phase transition was confirmed by vial inversion method. These results suggest that tri-block copolymer can apply to biomaterial field for cell delivery. <sup>**</sup>This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Ministry of Science, ICT & Future Planning. (NRF-2014R1A2A1A10053027)
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코카시안과 한국인의 Phenytoin임상 약동학적 변수 비교
최선주,신완균,이명걸,이민화,이상복,Cloyd, James 한국병원약사회 1992 병원약사회지 Vol.9 No.3
The effective and safe use of phenytoin in epileptic patients is complicated by its nonlinear pharmacokinetic characteristic, Michaelis-Menten type which is reported by numerous investigator. Currently, Bayesian method which estimates the most probable parameters of V max and Km of the drug for each patient from population parameters data is very useful approach for adjusting phenytoin dosage. The pharmacokinetic parameters of phenytoin are affected by physiological factor, disease state, compliance, bioavailability and ethnic origin. To increase the accuracy of Bayesian method, it is desirable to use population parameters of Korean. Therefore, in the present study, pharmacokinetic parameters of phenytoin have been compared between Caucasian and Korean. Data from 20 adult neurology outpatients having normal liver and renal function from Seoul National University Hospital and University of Minnesota Hospital respectively were evaluated. Phenytoin pharmacokinetic parameters, Vmax & Km, were obtained from these two dose-concentration data at each steady-state by using Michaelis-Menten equation. Estimated mean values of Vmax and Km were 6.72㎎/㎏/day(SD 1.34 : CV 20%) and 4.77mcg/㎖(SD 2.39 : CV 50%), respectively in Korean. The corresponding values were 8.39㎎/㎏/day(SD 2.29 : CV 27%) and 6.67mcg/㎖(SD 6.04 : CV 90%) from Caucasian. Vmax were significantly different between two groups(p<0.05)
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추간공 경유 경막외 차단술 환자의 합병증에 대한 조사 연구
최선주,배성열,서성화,김상대,김세훈,박정율 대한척추신경외과학회 2004 Neurospine Vol.1 No.1
Objective: To study on the incidence of complications from C-arm guided lumbar transforarninal epidural injections in patients with radiculopathy caused by either lumbar spinal stenosis or herniated intervertebral disc. Materials & Methods: A total of 1200 patients with back/leg pain for more 3 months and received therapeutic injections in recent 1-year period was evaluated. All procedures were performed by one neurosurgeon with careful monitoring by nursing staffs during and after the procedures. Two party observers reviewed medical charts including immediate postprocedure complications using standardized questionnaire. Results: Average 1.9 injections per patient were done. Complications per injection seen included 12 transient headaches (0.9%), 5 increased back pain(0.4%), 4 increased leg pain(0.3%), 4 facial flushing(0.3%), 2 increased blood sugar in an insulin-dependent diabetic(0.2%), I vasovagal reaction(0.08%), and I hypertension(0.08%). All of these complications resolved within several hours to 2 weeks and there were no need for further specific management. There were no major or permanent complications. The incidence of minor complications was 2.3% per injection. All reactions resolved without morbidity. Conclusion: Although effectiveness varies with different pathologies, the C-arm guided lumbar transforaminal epidural injection seems to be a safe and effective procedure for these patients when carefully performed and closely observed with appropriate nursing care.
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On Relative Clause Attachment Preferences in the L2 LSTM LM
최선주 현대문법학회 2024 현대문법연구 Vol.122 No.-
A well-known evaluation technique of neural language models (NLMs) is how models correctly assign probabilities to valid versus invalid syntactic constructions. This methodology suggests a grammatical sentence is more probable than an ungrammatical sentence. In this study, we use ambiguous relative clause attachment to extend such evaluation to cases of multiple simultaneous valid interpretations except for grammaticality differences. We compare model performance in English and Korean L2 learners of English to probe the biases of the L2 LM for ambiguous relative clause attachments. As an initial research step, we implement the L2 Long-Short Term Memory (LSTM) model using the K-English Textbook corpus. We then test the attachment preferences of the L2 LM using the stimuli from Davis (2022). In so doing, we confirm that the L2 LSTM LM prefers a LOW attachment in all test sentences, as shown by the L1 LMs. In addition, the L2 LM’s knowledge of implicit causality is not as robust as that of humans. We find a mismatch between human attachment preferences and NLMs. Through several experiments, we provide additional compelling evidence that there is a broader gap between NLMs and humans during comprehension tasks.
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