디스플레이용 이방전도성 필름(ACF) 기술 소개

서경원,강상용,정은기 대한용접·접합학회 2021 대한용접학회 특별강연 및 학술발표대회 개요집 Vol.2021 No.5

이방성전기전도 필름(ACF)은 전자부품을 구성하는 이종의 회로를 단시간에 전기적, 물리적으로 접속시키는 본딩 공정에 사용되는 전도성 접착 필름이다. ACF는 절연성을 가지는 경화성 접착제와 전기 전도성 입자로 구성되어 박막의 필름 형태로 제조된다. 본딩 공정에서 열과 압력을 가해 전극과 전극을 수직 방향으로는 전기 전도성, 면방향으로는 절연성, 그리고 접착성이라는 세가지 기능을 가진다. ACF는 스마트기기의 디스플레이(LCD, OLED) 및 터치 모듈 패키징의 미세 피치 전극 접속 공정에 범용적으로 사용된다. 모듈의 종류는 Chip on Board, Chip on Flex, Chip on Glass, Flex on Board, Flex on Flex 및 Flex on Glass로 분류된다. 디스플레이의 고화질화/고집적화로 인한 전극 면적의 감소 및 Wearable 기기의 발전으로 인한 열악한 사용 환경에 적합한 높은 접속 신뢰성 특성이 요구되고 있다. 이러한 다양한 형태와 기재 특성과 전극의 미세화를 대응하기 위한 고신뢰성의 접착제 배합 기술과 전도성 입자의 개발을 통한 고성능 ACF 개발이 진행되고 있으며, 이러한 한계점을 넘기 위한 다양한 제품이 개발되고 있다. ACF 시장의 현황 및 향후 개발 방향에 대해 소개하고자 한다.

중부지역 소나무 임분의 산림시업에 따른 생장 특성 및 지상부 탄소저장량

서경원,이상태,정준모,김석권 한국산림휴양복지학회 2013 한국산림휴양학회 학술발표회 자료집 Vol.2013 No.4

Dust Disks Around Young Stellar Objects

서경원 한국우주과학회 2016 Journal of Astronomy and Space Sciences Vol.33 No.2

To reproduce the spectral energy distributions (SEDs) of young stellar objects (YSOs), we perform radiative transfer model calculations for the circumstellar dust disks with various shapes and many dust species. For eight sample objects of T Tauri and Herbig Ae/Be stars, we compare the theoretical model SEDs with the observed SEDs described by the infrared space observatory and Spitzer space telescope spectral data. We use the model, CGPLUS, for a passive irradiated circumstellar dust disk with an inner hole and an inner rim for the eight sample YSOs. We present model parameters for the dust disk, which reproduce the observed SEDs. We find that the model requires a higher mass, luminosity, and temperature for the central star for the Herbig Ae/Be stars than those for the T Tauri stars. Generally, the outer radius, total mass, thickness, and rim height of the theoretical dust disk for the Herbig Ae/Be stars are larger than those for the T Tauri stars.

학술연구논문 구두발표 2 : 중부지역 소나무 임분의 산림시업에 따른 생장 특성 및 지상부 탄소저장량

서경원,이상태,정준모,김석권 한국임학회 2013 산림과학 공동학술대회 논문집 Vol.2013 No.-

Epidemiologic Study of Human Epidermal Growth Factor Receptor 2 Expression in Advanced/Metastatic Gastric Cancer: an Assessment of Human Epidermal Growth Factor Receptor 2 Status in Tumor Tissue Samples of Gastric and Gastro- Esophageal Junction Cancer

서경원,전태용,김세원,김성수,김광희,서병조,황선휘,최성희,류승완,민재석,이영준,지예섭,채현동,양두현,이상호 대한위암학회 2017 Journal of gastric cancer Vol.17 No.1

Purpose: The Trastuzumab for gastric cancer (GC) trial identified human epidermal growth factor receptor 2 (HER2) as a predictor of successful treatment with trastuzumab (HER2 receptor targeting agent) among patients with advanced/metastatic GC. To date, the prevalence of HER2 overexpression in the Korean population is unknown. The present study aimed to assess the incidence of HER2 positivity among GC and gastroesophageal (GE) junction cancer samples and the relationship between HER2 overexpression and clinicopathological characteristics in Korean patients. Materials and Methods: Tumor samples collected from 1,695 patients with histologically proven GC or GE junction enrolled at 14 different hospitals in Korea were examined. After gathering clinicopathological data of all patients, HER2 status was assessed by immunohistochemistry (IHC) at each hospital, and IHC 2+ cases were subjected to silver-enhanced in situ hybridization at 3 central laboratories. Results: A total of 182 specimens tested positive for HER2, whereas 1,505 tested negative. Therefore, the overall HER2-positive rate in this study was 10.8% (95% confidence interval=9.3%–12.3%). The HER2-positive rate was higher among intestinal-type cases (17.6%) than among other types, and was higher among patients older than 70 years and 50 years of age, compared to other age groups. Conclusions: Our evaluation of the HER2 positivity rate (10.8%) among Korean patients with GC and GE junction indicated the necessity of epidemiological data when conducting studies related to HER2 expression in GC and GE junction.

外來語の省略表現に関する考察

徐慶元,金鎔均 대한일어일문학회 2017 대한일어일문학회 학술대회 발표논문 요지집 Vol.2017 No.4

Autosomal-dominant Polycystic Kidney Disease in a Family of Scottish Fold Cats

서경원,김새움,안진옥,고예린,한성영,윤화영 한국임상수의학회 2010 한국임상수의학회지 Vol.27 No.6

Autosomal-dominant polycystic kidney disease (AD-PKD) is common in Persian and Persian-related breeds,and is sporadically reported in Scottish Fold cats. A 5-year-old male Scottish Fold cat was diagnosed with polycystic kidney disease based on screening tests and abdominal ultrasonography and died 3.5 months after diagnosis. The cat had 14 kittens with three queens, including his female sibling, with an age range of 3 months to 8 years. Genetic testing to confirm the genetic transmission of AD-PKD which detects the mutated PKD1 gene was performed. Abdominal ultrasonography confirmed the presence of renal cysts. Nineteen cats were screened in the present study (13 males and 6 females), with an age range of 3 months to 8 years. The results of renal ultrasonography agreed with the genetic test results in the 19 cats in which both tests were performed and 8 cats were diagnosed as ADPKD based on these tests. AD-PKD has not been investigated in cats in South Korea. Moreover, this is the first report of AD-PKD in a family unit of Scottish Fold cats.

Correlation between Claudins Expression and Prognostic Factors in Prostate Cancer

서경원,권영기,김병훈,김천일,장혁수,최미선,박철희 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.4

Purpose: The purpose of this study was to evaluate the correlation between the expression of claudins and prognostic factors in patients with prostate cancer. Materials and Methods: The subjects of this study were 48 patients who had undergone surgery for prostate cancer. The Gleason score (6 or lower, 7 or higher), prostate-specific antigen (PSA) level, T stage, biochemical recurrence, local recurrence, and distant metastasis were compared according to the expression of claudin-1 and claudin-5 in prostate cancer. Results: In the group with a low expression of claudin-1, the Gleason score was 7 points or higher in 18 cases (82%) and 6 points or lower in 4 cases (18%). In the group with a high expression of claudin-1, the Gleason score was 7 points or higher in 13 cases (50%) and 6 points or lower in 13 cases (50%). Thus, the low-expression group had more cases with a Gleason score of 7 or higher (p=0.022). The group with a low expression of claudin- 5 also had more cases with a Gleason score of 7 or higher (p=0.011). The mean PSA values in the groups with a low and high expression of claudin-1 were 9.6 ng/ml and 5.6 ng/ml, respectively (p=0.007). A low expression of claudin-5 was also associated with a high PSA value (p=0.002). There was no statistical difference in the expression of claudin-1 and claudin-5 by T stage, biochemical recurrence, local recurrence, or distant metastasis. Conclusions: The low expression of claudin-1, claudin-5 was associated with a Gleason score of 7 or higher and a high PSA value in prostate cancer. Purpose: The purpose of this study was to evaluate the correlation between the expression of claudins and prognostic factors in patients with prostate cancer. Materials and Methods: The subjects of this study were 48 patients who had undergone surgery for prostate cancer. The Gleason score (6 or lower, 7 or higher), prostate-specific antigen (PSA) level, T stage, biochemical recurrence, local recurrence, and distant metastasis were compared according to the expression of claudin-1 and claudin-5 in prostate cancer. Results: In the group with a low expression of claudin-1, the Gleason score was 7 points or higher in 18 cases (82%) and 6 points or lower in 4 cases (18%). In the group with a high expression of claudin-1, the Gleason score was 7 points or higher in 13 cases (50%) and 6 points or lower in 13 cases (50%). Thus, the low-expression group had more cases with a Gleason score of 7 or higher (p=0.022). The group with a low expression of claudin- 5 also had more cases with a Gleason score of 7 or higher (p=0.011). The mean PSA values in the groups with a low and high expression of claudin-1 were 9.6 ng/ml and 5.6 ng/ml, respectively (p=0.007). A low expression of claudin-5 was also associated with a high PSA value (p=0.002). There was no statistical difference in the expression of claudin-1 and claudin-5 by T stage, biochemical recurrence, local recurrence, or distant metastasis. Conclusions: The low expression of claudin-1, claudin-5 was associated with a Gleason score of 7 or higher and a high PSA value in prostate cancer.

Natural Toxin의 안전성 평가연구 : Ochratoxin A의 표적장기독성 Target organ toxicity of ochratoxin A

서경원,김효정,김준규,조대현,박창원,이윤숙,김태완,정세영,이인수,김정구,문화회 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-

곰팡이 독소인 ochratoxin A(OTA)는 신장독성, 최기형성, 발암성 및 면역독성을 나타내며, 식품, 곡류 및 정육등에 잔류한다고 알려져 있다. 최근 우리나라의 된장, 간장 등 발효식품에서도 OTA의 전반적인 위해성 평가의 일환으로 OTA의 독성 표적장기인 신장에 초점을 맞추어 신장독성 감소 방법을 제시하고자 한다. 신장독서을 감소시키기위한 대상물질로는 1) 기존에 독성 감소 물질로 알려진 phenylalanine(Phe)2) phenylalanine과 aspartic acid로 구성된 가미료인 아스파탐(Asp),3)녹차의 성분이며 free radical scavenger 및 antioxdant 작용이 있는 polyphenol 70ㄴ(PP),4)최근수명연장 효과가 있고 특히 신장질환에 대한 예방효과가 있다고 알려진 알로에 추출물(AE)을 선택하였다. 신장독성을 유발시키기 위하여 OTA를 2.0mg/kg의 용량으로 2주간 연속 경구추여하였다. Phe (40mg/kg,i.p.)과 Asp(25mg/kg,p.o)은 OTA(2.0mg/kg,p.o)와 병용투여하였으며, PP(200mg/kg,p.o.)는 OTA 투여 2주전부터 AE (501ng/kg, i.v.)은 3일전부터 전처리하여 OTA (2.Omg간9, f.a)와 2주간 병용투여하였다. 신장독성의 확안은.혈청중 BUN, creatinine치 및 뇨중 y-glutamyltranspeptidase와 』ㄴacetyl-,5-D-slucoaarninidase의 팔성을 측정하였고 신장에 대한 조직병리 검사를 실시하였다. 실험결과, OTA를 2주간 2.Omg/kg용량으로 투여한 결과 신장 독성이 유발되었으며,독성 감소물질로 사용한 4개의 화합물 모두 혈액 및 뇨 중 신장독성 지표를 유의성 있게 감소시켰다. 조직병리 검사 결과 OTA에 좌하여 신장의 근위세뇨관에 변성이 유발되었으며, 4개의 화합물 처리군에서는 변성이 관찰되지 않았다. 이러한 결과펄부터 Phe, Asp, PP 및 A료는 모두 OTA에 의한 신장독성을 감소션킬 수 있으며, OTA에 의한 신장독성 유발에는 Phe콘 대한 경쟁작용 및 free radical 생성치 관여되어 있음을 확글할 수 있었다. Oehratoxin A (OTA) is a mycotoxin produced by f3rergiffHa ocaraceHs as well ar molds. It is a natural contaminant of mouldy food and feed. OTA has a number of toxic effects,premiBant being nephrotoxicity. Futherraore, OTA is immubosuppressiue, genotoxic,impossible to avoid contamin,ation of foodstuffs by toBic fungi, detoxification and detoxication of OTA are needed. In this study we investigated the protective effects of aspartame (Asp), phenylalanine(Phe), polrphenoB 705(PP) and aloe estract (AE ) on the nephrotoxicity induced by subacute exrolurewere admiai'ftered to Spragu,e-Dawley rats simultaneously with 07,c, (2.Omg/kg, f.a) for 2 weeks. PP (200mg/kg, f,o.) and AE (SOmg/Etg, i. u.) were pretreated before adminfstration of OTA, for 2 weeks and3 days, respectivelf. Using e]Ixymuria, BUN level, creatfneinia and histophathologic examination as indices of renal damage, we observed that all of four compvnds preveBted the nephrotoxic effects inducedby OTA. It seems that stnlct,ural analogues of OTA such as Asp and Phe have better protective effecton the nephrotoxicity of OTf. than aBtioxidants. These results indicate that 1) formation of free radicaland lipid peroxidation are like?y to be involved in the nephrotoxicity of OTA in vivo,2) Asp, PP and AEare might be used for prevent,ion of renal lesions in cases of ochratoxicosis.

마우스에서 아세트아미노펜의 급성간독성과 독물동태학

서경원,류정상,김효정 한국독성학회 1997 Toxicological Research Vol.13 No.3

As the development of a pharmaceutical product is a dynamic process which involves continuousfeed-back between non-clinical and clinical studies, the integration of pharmacokinetics into toxicity testing became increasingly important in recent years. Toxicokinetic measurements in the toxicity studies is considered to be an important scientific approach in the interpretation of the toxicology findings and the promotion of rational study design development. Primarily this research project was conducted to determine the systemic exposure achieved in acute toxicity test and its relationship to dose level and the time course of the toxicity study. Acute hepatotoxicity study and its relevant toxicokinetic study in mice were performed using acetarninophen (AA) as a model compound. The correlation between acute hepatotoxicity indices and toxicokinetic parameters following intraperitoneally administration of various dosages of AA in mice was evaluated and discussed minutely in the text. Based on these studies, single-dose toxicity testing of AA including kinetic studies was evaluated in ICR mice for 7 days and interpreted in the text. Our results from the integration of toxicokinetic monitoring into single-dose toxicity study enable to elucidate the relation of the exposure achieved in toxicity study to toxicological findings and assist in the selection of appropriate dose levels for use in repeated-dose toxicity or later studies.