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Eventhough there are many known and unknown micro-organisms in the atmosphere,. many disputable problems of the relationship between these and human beings still remain. According to the reports of aerial fungi being c10sely related with asthma, eczema and dermatitis, the dermatitis showing allergens and seasonal recurrence, ‘ aerial fungi began to be applied in the therapeutic field inc1uding skin tests. Therefore, aerial fungi formerly thought to be non-pathogenic were found to be possibly pathogenic. And also opportunisic infection of fungi is increasing after the popular use of various recently developed antibiotics, steroids and anticancerous agents. Before understanding the relationship between aerial fungi and various diseases, the flora and seasonal variations of all species of aerial fungi of each country should be investigated first. In countries where mycology -has been highly developed, many workers have already reported their own flora of aerial fungi annually, and it became known that . the commo-nest colonies were hormodendrum, penicillium, aspergillus and altemaria with slight differences. However investigation of the flora of aerial fungi in Korea has not been reported yet. For the purposes of determining the aerial fungi and seasonal variation of all species in various situations, the author has investigated Taegu city and some selected areas in Korea from February 1963 through July 1964 by the sampling method ' of gravity sedi-mentation by 5 and 10 minutes' exposure of Sabouraud’s dextrose agar plate and identified the fungi macroscopically and microscopically with the following results. 1. From 6 sites of Taegu city, 19 genera from 8, 536 total colonies -were sampled and the commonest fungi in the air were hormodendrum (25.08%), penicillium(13.6&%), alternaria (10.68%), aspergillus (7.08%) in order of frequency. 2. The highest frequency of the commonest genus was different each month. 3. The most suitable exposure time for sampling was 5 to 10 minutes. 4. The total number of colonies . began to increase from March through May with the peak in June, decreased in July, increased again from August through September,. and then decreased again from September. 5. The total number of colonies was colonies related to weather temperature, and with temperatures above 20˚C and below 5˚C, the number of colonies decrease markedly. 6. The relationship between the total number of colonies to humidity and windspeed was obscure. 7. The total number of colonies outdoors was twice as high as indoors. 8. Each month the total number of colonies of the commonest genera was a1most pararelled indoors and outdoors, except April through June and October through November. 9. The genera and tota1 number of colonies showed diurnal periodicity indoors and outdoors, increasing in the day-time and deα'easing in the night-time; concurrently. 10. of various situations, exposure in crowded 1ocations showed the highest number of colonies. 11. on a rainy day and a day after snowing the tota1 number of co10nies was increased, whilst on a severely cold day and an excessive1y hot day the total number of co1onies decreased. 12. Month1y. variations of each of the commonest genera including the effect of wea-ther were: 1) Hormodendrum: increased from March through June, decreased from July through August and then increased from September through October again, 50 that this genus was closely related -to the effect of weather. 2) Penicillium: incresed in April and May and seemed unrelated to the effect of weather. 3) Altelllelria: increased from Fe through June and was re1ated to the effect of weather. 4) Aspergillus: increased from June through September and was related to the effect of weather. 13. Except for penicillium and aspergillus, the number the commonest colories was higher outdoors than indoors. 14. The flora of aerial fungi at 1, 000 Ft. interva1s up to 6, 000 Ft. altitude were: 1) The total number of co10nies decreased with increase in a1titude and at a level of 5, 000 Ft. number of co10nies was marked1y decreased. 2) The commonest isolated genera were hormodendrum alternaria, penicillium, in that order, and compared with that of the ground, generally. hormodendrum and alternaria were increased whi1st penicillium and aspergillus co1onies were decreased. 3) Hormodendrum and alternaria colonies were isolated from each interval up to 6, 000Ft. a1titude but aspergillus and penicillium were isolated from each interva1 up to 5, 000 Ft. a1titude only.
In 1973 Gajl-peczalska and Dwyer have found significant increase in B-cells and a decrease in T-cells of peripheral blood among a group of Lepro-matous leprosy patient and suggested a measure of improvement of lepratous lesions by correcting this abnormal lymphocyte picture. While many researchers have attempted to treat cancers of both men and animals by stimulating Retuulo-Endotherial-System throcgh inoculations of BCG and its extracts. This study shows an encouraging clinical improvement on two severe cases of lepromatous le-prosy with an application of tubercin-3, tuber-culoprotein-complex, extracted from tubercule bacilli by Chung in 1973, believed to stimulate reticulo-endotherial-system without side effects.