Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

다발성 말초신경병증의 조기진단 : 적외선 체열촬영검사와 전류지각역치검사의 조합진단 Combination Diagnosis Using by Digital Infrared Thermogram and Current Perception Threshold

이삼규,김재형,최인성,이소영,한재영,조성렬,김재휴,노성만,정민영,정동진,김현성 全南大醫大 2001 전남의대학술지 Vol.37 No.3

Trichophyton verrucosum infection in Korea: Analysis on 224 patients from 1976 to 2015

( Dong Hyuk Eun ),( Jun Hong Park ),( Sun Young Moon ),( Yong Hyun Jang ),( Seok-jong Lee ),( Do Won Kim ),( Yong Jun Bang ),( Jae Bok Jun ),( Weon Ju Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Trichophyton (T.) verrucosum is a dermatophyte causing ringworm in cattle, distributed worldwide. It can be responsible for various inflammatory lesions of skin and scalp. In Korea, kerion celsi caused by T. verrucosum was first reported at 1986 in the southeast province of Korea. Since then, many patients infected with T. verrucosum have been reported in Young-nam province. There are few long-term studies about epidemiological characteristics of T. verrucosum. Objectives: To investigate the clinical and epidemiological characteristics of T. verrucosum infections in Korea. Methods: A total of 224 patients were diagnosed as T. verrucosum infection by fungal culture from 1976 to 2015. The data were based on a retrospective survey of medical records. Results: The annual incidence of patients with T. verrucosum infection had been increasing since the report in 1986. The number of patients showed a peak in 1988. After 2000, the number of patients had been decreasing. Female to male ratio showed a 1.2-fold predominance of female infection. And more than 15-year-old group was 59.4% of total patients. T. verrucosum infection was most commonly seen in spring and was found predominantly in patients living in rural areas. Face was most frequently involved, followed by arms. Conclusion: These findings provide useful information for understanding of T. verrucosum infection and future dermatophytosis prospects.

플라즈마 표지소자의 제작

이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.

심산 차영배의 삼위일체론에 대한 연구

이동영 ( Dong Young Lee ) 한국복음주의조직신학회 2021 조직신학연구 Vol.38 No.-

본 논문의 목적은 한국 교회 안에서 삼위일체론에 대한 올바른 이해와 전수를 위하여 평생을 노력했던 개혁주의 조직신학자 심산 차영배의 삼위일체론을 분석하고 평가해 보는데 있다. 차영배는 삼위일체론을 기독교 신론의 일부가 아니라 신론 그 자체이며, 단지 신론이 아니라 ‘신학의 본질적 원리’(principium essendi )라고 천명했다. 차영배는 자신의 저서 『개혁교의학. 삼위일체론』에서 교리사적이고 신조학적인 연구를 통하여 삼위일체교리에 대한 자신의 견해를 개진하였다. 특히 『웨스트민스터 신앙고백서』 2장 3절에 대한 자신의 해석에서 우리는 삼위일체론에 대한 차영배의 이해의 정수와 만나게 된다. 차영배에 따르면 『웨스트민스터 신앙고백서』(1648)의 삼위일체론이 삼위를 먼저 구분하고 삼위가 소유한 동일한 본질을 일체로 파악하고 있다고 해석한다. 그렇게 함으로써 그는 장로교회의 표준문서 가운데 하나인 『웨스트민스터 신앙고백서』의 삼위일체론이 「니케아-콘스탄티노플신경」(381)을 통하여 동방교회와 서방교회가 공동으로 고백하는 공교회의 삼위일체론에 정확하게 부합됨을 논증함으로써, 『웨스트민스터 신앙고백서』의 삼위일체론의 공교회적인 성격을 잘 규명해 주었다는 것은 실로 그의 신학적 기여가 아닐 수 없다. 그러나 그에게도 아쉬운 점은 있다. 차영배가 삼위일체론을 기독교 신론의 일부가 아니라 신론 그 자체이며, 단지 신론이 아니라 신학의 본질적 원리라고 천명했음에도 불구하고 그가 삼위일체론을 신학의 원리로 삼아 교의 각론을 해명하고 해설하는 조직신학을 저술하지 못했다는 것, 그리고 그가 삼위일체론의 올바른 해석과 이해에만 집중한 나머지 우리의 신앙 및 삶과 관련하여 이 교리가 함의하고 있는 실천적인 의미를 규명해 주지 못했다는 것은 실로 아쉬운 일이 아닐 수 없다. 그러므로 이러한 조직신학 책의 저술은 차영배의 어깨 위에서서 계속해서 발전해 나가야만 하는 후학들의 몫으로 남아 있다. The purpose of this paper is to analyze and evaluate a Reformed Systematic Theologian Young-Bae Cha’s understanding of the Trinity, which has worked for its correct understanding and transfer within the Korean Church. He declares that the doctrine of Trinity is not part of the Christian doctrine of God, but the doctrine itself, and that this doctrine is not just the doctrine of God but the essential principle (principium essendi) of theology. In his book, “Reformed Dogmatics: doctrine of the Trinity ,” he developed his own view of doctrine of the Trinity through doctrine-historical and creed-historical studies. In particular, in his own interpretation of “the Westminster Confession of Faith 2, 3,” we encounter the essence of his deep understanding of the Trinity. According to him, the doctrine of Trinity in “The Westminster Confession of Faith”(1648) distinguishes tree Persons first and then regards the same essence(ομοουσιος. consubstantia) possessed by three persons, namely the Father, the Son and the Holy Spirit as unity (unitas). By doing so, he demonstrates that the Trinity of “The Westminster Confession of Faith,” one of the standard documents of the Presbyterian Church, is in accord with the doctrine of Trinity of the catholic church jointly confessed by the Eastern and Western Churches through “The Nicaeno-Constantinopolitanum”(381). It is indeed his theological contribution that he well identified the ecumenical character of the Trinity of “The Westminster Confession of Faith.” However, there is the following disappointment to him. 1) First, he failed to write a systematic theology that uses the doctrine of Trinity as a principle of theology to explain and explain another doctrines. 2) Second, he failed to elucidate the practical implications of this doctrine in relation to our faith and life, because he focuses only on its correct interpretation and understanding. Therefore his successors must continue to develop on his shoulders, that they may overcome speculation of the doctrine of Trinity.

가토 외고정 모델을 이용한 치밀체형 세라믹스의 골결합능 평가

이재협,이동호,이재학,공현식,안영준,류현승,서준혁,홍국선,김환,장봉순,이춘기 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

동씨침을 시술한 안면경련의 치험 3례

김태우,김효은,조명제,강영화,이재동,Kim, Tae-woo,Kim, Hyo-eun,Cho, Myung-je,Kang, Young-hwa,Lee, Jae-dong 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

Objective : Hemifacial spasm is painless uncommon disorder characterized by involuntary paroxysmal movement of one side of face, In this study, the effect of Dong-Si acupuncture therapy for three patients with hemifacial spasm were evaluated. Methods : We have treated them with acupuncture treatment of Dong-Si acupuncture points(Cheuk-Samni and Cheuk-ha-Samni) and evaluated the effect by Scott's scale, For the first two weeks, it was dine once a day, and after two weeks, the other day. Results : Before therapy, the grades of spasm intensity classified by Scott's description in three cases were 3. And after Dong-Si acupuncture therapy, the grade of one case was 0, and two cases were 1. Conclusion : The Dong-Si acupuncture therapy for hemifacial spasm was effective and will be attempted to the patients with it.

NGS_SNPAnalyzer: a desktop software supporting genome projects by identifying and visualizing sequence variations from next-generation sequencing data

Dong‑Jun Lee,Taesoo Kwon,Chang‑Kug Kim,Young‑Joo Seol,Dong‑Suk Park,Tae‑Ho Lee,Byung‑Ohg Ahn 한국유전학회 2020 Genes & Genomics Vol.42 No.11

Background Sequence variations such as single nucleotide polymorphisms are markers for genetic diseases and breeding. Therefore, identifying sequence variations is one of the main objectives of several genome projects. Although most genomeproject consortiums provide standard operation procedures for sequence variation detection methods, there may be differencesin the results because of human selection or error. Objective To standardize the procedure for sequence variation detection and help researchers who are not formally trainedin bioinformatics, we developed the NGS_SNPAnalyzer, a desktop software and fully automated graphical pipeline. Methods The NGS_SNPAnalyzer is implemented using JavaFX (version 1.8); therefore, it is not limited to any operatingsystem (OS). The tools employed in the NGS_SNPAnalyzer were compiled on Microsoft Windows (version 7, 10) andUbuntu Linux (version 16.04, 17.0.4). Results The NGS_SNPAnalyzer not only includes the functionalities for variant calling and annotation but also providesquality control, mapping, and filtering details to support all procedures from next-generation sequencing (NGS) data to variantvisualization. It can be executed using pre-set pipelines and options and customized via user-specified options. Additionally,the NGS_SNPAnalyzer provides a user-friendly graphical interface and can be installed on any OS that supports JAVA. Conclusions Although there are several pipelines and visualization tools available for NGS data analysis, we developedthe NGS_SNPAnalyzer to provide the user with an easy-to-use interface. The benchmark test results indicate that theNGS_SNPAnayzer achieves better performance than other open source tools.

S-525 : Correlations between skin prick test and specific IgE measured by CAP system of inhalant allergens

( Young Hee Nam ),( Soo Keol Lee ),( Dong Sub Jeon ),( Hye Won Lee ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Background/Aims: It appears that much of the discordance between skin prick test (SPT) and ImmunoCAP in clinical practice. We investigated the correlation between SPT and ImmunoCAP for inhalant allergens. Methods: A total of 523 patients who were tested SPT and ImmunoCAP were from July 2012 to June 2013 in Dong-A university hospital, and the results of two tests were compared. For SPT, wheal 3x3 mm or greater at 15min, and the result of ImmunoCAP of >0.35 kU/L was considered positive, respectively. Results: Of the study subjects, bronchial asthma was 22.2% (n=116), rhinitis 28.9% (n=151), allergic conjuctivitis 12.2% (n=64), and atopic dermatitis 0.8% (n=4). SPT were positive in 52% (n=272) of the subjects. The positive responses and agreements of SPT with ImmunoCAP for each allergens were Dermatophagoides pteronyssinus (32.1% for SPT and 36.1% for ImmunoCAP; aggrement 79.2%), Dermatophagoides farina (13.6% and 47.8%; 75.2%), birch (12.8% and 47.6%; 42.9%), beech (10.3% and 44.6%; 44.6%), ragweed (3.6% and 25%; 84.6%) and mugwort (9.4% and 43.8%; 82.9%). Conclusions: The aggrement between SPT and ImmunoCAP was various according to allergens. We should determine the clinical relevance of the allergen sensitization using both SPT and ImmunoCAP not alone with combination of clinical symptoms.