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김영권,이기형,박태원,정인성 全北大學校 1995 論文集 Vol.39 No.-
This study discusses the finite element approximation and the choice of elements is dictated by the need to perform accuate for both thin and thick shells and by the complexity of the sensitivity calculations. A number of very accurate plate and shell elements exist for which the sensitivity computation become hopelessly complex. On the other hand, most very simple elements, which would lend themselves to compact and efficient sensitivity computation, do not posses sufficient accuracy for routine use.
김형기,권준택,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1
The bioequivalence of generic cefixime(Pofixim^(®), Kwangmyung Pharmaceutical Co.) capsule to the cefixime capsule(Suprax^(®), Dong-A Pharmaceutical Co.) as a reference drug. Single dose of 100 mg cefixime was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 14 hours and plasma concentration of cefixime was measured by well validated reverse phase high-performance liquid chromatography. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of cefixime can be declared bioequivalent with the reference, both formulations in 100 mg capsule.
김형기,권준택,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1
The bioequivalence of generic simvastatin tablet(Dongsung Pharmaceutical Co.) to the simvastatin tablet(Zocor^(®), MSD Korea Co.) as a reference drug. Single dose of 20 mg simvastatin was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 12 hours and plasma concentration of simvastatin was measured by well validated LC-MS/MS. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of simvastatin is bioequivalent with the reference, both formulations in 20 mg tablet.
肝吸蟲症 治療前後에 있어서 血淸 및 尿의 抗體價變動에 관한 比較硏究
金亨東,嚴基善,林漢鍾 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.3
The changes of IgG levels of sera and urine were observed with the enzyme-linked immunosorbent assay (ELISA) at before and after medication in human clonorchiasis. Sera and urine from 68 cases of confirmed clonorchiasis were tested at before and at 9 and 18 month after treatment with Distocide® (praziquantel). Group I (n=22) was cured after first medication and then followed up for 18 months. And Group Ⅲ (n=24) of patients with eggs in their feces after first medication showed egg reduction rate of 90%. Thirteen normal controls were parasite free healthy persons for clonorchiasis in non-endemic area. The antigen used was saline extract of crude Clonorchis sinensis adult worm with the protein concentration of 14.3㎍/㎖ and the results obtained were as follows: 1. When a serum dilution of 1:400 was used, the absorbance values (488 nm) were 1.122, 1.373 and 1.632 in groups Ⅰ,Ⅱ,Ⅲ respectively before medication. Antibody level decreased significantly at 9 months after medication showed 0.572, 0.749 and 1.155 in the respective group. Then the levels decreased slightly to 0.464, 0.516 and 1.107 at 18 months after medication. But the control group showed relatively constant absorbance values of 0.291 at before 0.301 and 0.286 respecively at 6 and 18 months. 2. Urine showed absorbance values of 0.484, 0.629 and 0.849 in groups Ⅰ, Ⅱ, Ⅲ respectively before medication. Then the values decreased about a half level revealed 0.261, 0.226 and 0.467 in the respective group at 18 months after medication. Control group showed relatively constant absorbance values 0.232 at before and 0.252 at 18 months. 3. The diameter of wheal size (mm) by intradermal test did not show substantial changes, i.e. 11.7, 13.3 and 12.7 in groups Ⅰ, Ⅱ, Ⅲ respectively before medication; 11.7, 12.9, and 11.4 in the respective group at 18 months after medication. 4. The relation of the absorbance values between sera (y) and urine (x) made the regression equation: y=0.707X+0.908, and showed relatively high correlation (r=0.619, n=68, p<0.001) before medication; y=0.760X+0.387 with some correlation (r=0.582, n=68, p<0.001) at 18 months after medication. 5. The relation between the absorbance values of urine and log EPG (eggs per gram of feces)/100 revealed more or less irregular correlations, i.e.r=0.566(p<0.01), 0.661(p<0.001)and 0.384(p<0.10)in groups Ⅰ, Ⅱ, Ⅲ respectively before medication. 6. The relation between the absorbance values of urine and the wheal size (mm) by intradermal test showed low correlation, i,e, r=0.416(p<0.10), 0.416(p<0.10)and 0.421(p<0.05)in groups Ⅰ, Ⅱ, Ⅲ respectively before medication.
S-mephenytoin 산화다형성의 검색 지표약물로서 omeprazole의 유용성
김형기,권준택 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1
Racemic mixture of mephenytoin has been used to measure the CYP2C19. However, mephenytoin is not available in Korea, and its sedative effect limits its use in Oriental population. The purpose of this study was to evaluate the usefulness of omeprazole as a probe drug for S-mephenytoin polymorphism. Single oral doses of mephenytoin or omeprazole were administered at lest 2 weeks apart to 123 and 93 healthy volunteers, respectively. The capacity of S-mephenytoin hydroxylation was measured using the amount of hydroxymephenytoin excreted in 8-hr urine after taking 100 mg of mephenytoin, and omeprazole hydroxylation activity was defined as log10 [omeprazole/hydroxyomeprazole] determined in plasma collected 2 hr after taking a 20 mg of omeprazole. Both methods separated poor metabolizer (PM) or extensive metabolizer (EM) phenotypes of polymorphism with complete concordance. But, omeprazole hydroxylation index does not correlated well (r²=0.108) with the log10 % hydroxymephenytoin excreted in EMs. The PMs identified by the log10 hydroxymephenytoin excreted were also assigned as PMs of omprazole with the antimode of 1.0. The results suggest that omeprazole appears to be a safe and convenient tool to identify the capacity of S-mephenytoin hydroxylation.