서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

최근 5년간 급성 A형 간염으로 입원한 환자들에 대한 입원 내용 분석

장재영,유병욱,조용진,오정은,홍성호,조주연 순천향대학교 의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.15 No.1

Abstract Background : Due to improvements in Korea's sanitary conditions, antibody rates to the hepatitis A virus is decreasing rapidly and admission due to the disease is increasing, Patients who were admitted for hepatitis A during the last 5 years were selected and yearly differences in admission, clinical picture, medical fees, and differences according to age and gender were analyzed. Methods : Patients who were admitted to the Seoul Soonchunhyang University Hospital during the 5 year period between May of 2003 and April of 2008 and tested positive for IgM anti-HAV were selected and their medical records retrospectively analyzed. Results : 156 subjects [91 male (58%), 65 female (42%) were selected. The average age was 29.2 years (range; 21.4-37), average admission period 12.6 days (range; 12.5-1 7.7) days, and average medical fees 2,295,151 (range; 932,097-3,658,205) KRW(Korean Won), Yearly incidence rates were as follows : 10 for May, 2003 to April, 2004, 14 for May, 2004 to April, 2005, 23 for May, 2005 to April, 2006, 69 for May, 2006 to April, 2007, and 41 for May, 2007 to April, 2008, The maximum value median of AST, ALT, and bilirubin during admission was 989 IU/L, 1999 IU/L, and 5.6 mg/dL each, Each factors were all positively correlated with the patient's age. Conclusions : Recent decrease in antibody positivity of the hepatitis A virus and subsequent surge of acute hepatitis A is a cause of rising socioeconomic costs. A large scale epidemiologic research on whether HAV vaccination should be made mandatory and health insurance applied seems to be needed. Key words : Hepatitis A, Age, Medical fees, Vaccination

Blind Interference Suppression for DS-CDMA Systems Based on Widely Linear Kalman Filtering

JaeㅡJin Jeon,Jun-Seok Lim,Sang-Wook Lee,Koeng-Mo Sung 대한전자공학회 2005 ITC-CSCC :International Technical Conference on Ci Vol.2005 No.4

강릉시 의료기관 수요공급 분석

김상아,곽연희,박웅섭,송재석,이상욱,강명근 關東大學校 醫科大學 醫科學硏究所 2002 關東醫大學術誌 Vol.6 No.1

This study was conducted to use for the Community Health Care Plan through the demand-supply analysis of medical institution in Gangneung. The study data were obtained from the Korean National Health Insurance Corporation and the government of Gangneung. The major findings is follows; First, the hospital beds in Gangneung was 793 beds, but supply was 2,187 beds. Second, the demand of clinic in rural area was 43, and supply was 21. But demand of clinic in urban area was 115, and supply was 144. Third, the pubic medical institution in rural covered 4.7% of outpatient demand, and that in urban covered 0.9% of outpatient demand.

급속냉동된 쥐 치아의 in vivo MTT 검색법을 이용한 치주인대세포 활성도 평가

김재욱,김의성,김진,이승종 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.3

본 연구의 목적은 흰쥐 상악 대구치를 발거 한 후 급속 냉동보존을 통해 치아를 보관하였을 때 in vivo MTT 검색법을 이용하여 치주인대세포의 활성도를 측정하고자 하였다. 실험 방법은 74마리 4주령의 암컷 Sprague-Dawley계의 흰쥐를 사용하여 각군당 10마리의 쥐에서 상악 좌우 제1, 2대구치를 발거하여 모두 40개의 치아를 사용하였다. 대조군은 즉시 발치군이며 냉동군은 F medium에 5% Dimethylsulfoxide (DMSO) 6% Hydroxyethyl starch (HES)를 포함한 군 (1군), 10% DMSO를 포함한 군 (2군) 그리고 Viaspan에 5% DMSO 6% HES (3군). 10% DMSO를 포함한 군 (4군)으로 나누어 1주일간 액체질소에 냉동한 뒤 해동하였다. 냉장군은 F medium (5군)와 Viaspan(6군)에 넣어 1주간 4℃ 냉장고에서 보관하였다. 냉동 및 냉장보존한 후에는 in vivo MTT 검색법을 시행하였다. 개개 치아의 치근면 단위면적으로 표준화하기 위해 치근을 1% eosin Y 용액에 12시간 담근 후 1% acid alcohol로 용해시켜 530 ㎚에서 측정한 흡광도 값을 in vivo MTT 측정값으로 나누었다. 통계 분석을 위해 Two way ANOVA와 Duncan's Multiple Range Test를 95% 신뢰 구간에서 시행하였다. 그리고 각 군당 2개의 치아를 같은 방법으로 처리한 후 10㎛ 두께로 냉동 절단하여 광학 현미경과 편광 현미경하에서 관찰하였다. 1, 2군은 3, 4군보다 높은 흡광도를 나타내었으며 6군은 5군보다 높은 흡광도를 나타내었다 (p < 0.05). 광학 현미경 관찰에서 MTT 결정은 파란색을, 편광현미경에서는 밝은 오렌지색을 나타내었고 전체적으로 in vivo MTT 검색법의 결과와 같은 양상을 나타내었다. 본 연굴의 결과 5%, 10% DMSO를사용한 F medium 배지로 냉동보존한 경우가 Viaspan을 배지로 냉동하였을 때나 냉장보존 하였을 때보다 통계적으로 유의차 있게 높은 세포 활성도를 나타내었다 (p < 0.05). The purpose of this study was to examine the viability of PDL cells in rat molars by using in vivo MTT assay, which was used to compare fast cryopreservation group by liquid nitrogen (-196℃) with 4℃ cold preservation group. A total of 74 Sprague-Dawley white female rats of 4 week-old with a body weight of 100 grams were used. The maxillary left and right, first and second molars were extracted as atraumatically as possible under ketamine anesthesia. Ten teeth of each group were divided as six experimental groups depending upon the preservation. Cryopreservation groups were Group 1 (5% DMSO 6% HES in F medium). Group 2 (10% DMSO in F medium). Group 3 (5% DMSO 6% HES in Viaspan). Group 4 (10% DMSO in Viaspan) which were cryopreserved for 1 week and cold preservation groups were Group 5 (F medium), Group 6 (Viaspan) at 4℃ for 1 week. Immediate extraction group was used as a control After preservation and thawing, the in vivo MTT assay was processed. Two way ANOVA and Duncan's Multiple Range Test was performed at the 95% level of confidence. Another 2 teeth of each group were treated as the same manner and frozen sections 10 ㎛ thick for microscopic observation. The value of optical density obtained after in vivo MTT analysis was divided by the value of eosin staining for tissue volume standardization. Group 1, 2 had significantly higher optical density than Group 3 and 4 which had the lowest OD value. Group 6 had higher OD value than in Group 5 (P < 0.05). Histological findings of periodontal ligament cell. after being stained with MTT solution were consistent with the in vivo MTT assay results. In this study, the groups which were frozen with DMSO as a cryoprotectant and the groups with F medium showed the best results.

Small Cell Lung Cancer Cell Line을 이용한 Xenoplanted nude mice에서 방서선 치료후 종양의 변화 관찰에 관한 연구

김동욱,유명상,김재욱,이병돈,장혁순 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Recently, combination of ionizing radiation with inhibitors of angiogenesis has been reported to improve tumor eradication compared to treatment with irradiation alone. However, the mechanism of this effect have not been defined. For this pupose we established a non-small cell lung cancer model in nude mice. Tumor vascularization was visualized in vivo by MRI using gadolinium-DTPA as contrast agent. Further, cryosections were produced exactly in the MRI slice positions. Since we were interested to examine formation of recurrent tumor irradiation was performed with a single fraction of 6 Gy. This dose caused a partial remission followed by recurrent tumor growth 25 to 35 days after therapy. The process of partial remission as well as formation of the recurrent tumor was examined in 35 nude mice analysing the following parameters: (1) contrast agent enhancement using high-resolution MRI, (2) proliferation of tumor cells and fibroblast using Ki-67 immunohistochemistry, (3) formation of microvessels using CD31 immunohistochemistry. The latter analyses lead to differentiation of three stages. Stage 1(day 1 to 15 after irradiation) was characterized by increasing area of dead cell mass in hematoxylin-eosin stained slides that corresponded to a decrease in tumor cellproliferation as well as contrast agent enhancement. The percentage of Ki-67 positive tumor cells decreased from initially 45.1 ±6.0 to 1.4 %±1.2 % on day 15. Stage 2(days 6 to 20 after irradiation; overlapping with stage 1) was characterized by proliferation of fibroblast leading to formation of fibrotic septae with abundant microvessels. Already during late stage 2 MRI identified new contrast agent enhancing areas. Stage 3(day 20 to 40 after irradiation) was characterized by new tumor cell proliferation. Interestingly, tumor cells almost exclusively proliferated in the direct neighbourhood of the fibroblasts and blood vessels was a condition prior to foramtion of recurrent tumor tissue. Thus our results are in contrast with the view that tumors or recurrent tumors begin as avascular masses that later induce neovascularization. With respect to clinical practice our results suggest that (1) adjuvant anti-angiogenic therapy should not be limited to the day of irradiation but should cover a critical period until day 5 to day 20 after radiotherapy, (2) adjuvant therapy should also include inhibition of fibroblast proliferation, (3) MRI can identify a recurrent tumor 10 to 15 days before occurrence of new tumor growth.

사염화탄소의 친환경적 처리 기술

배종욱,이재성,이경희,김영걸 전남대학교 촉매연구소 2001 觸媒硏究 論文集 Vol.22 No.-

휘발성 유기화합물의 일종인 사염화탄소는 성층권에서 클로린 라디칼에 의한 오존층 파괴에 촉매작용을 하는 것으로 알려져 있다. 일반적인 사염화탄소의 처리 기술은 크게 다음의 세가지 기술로서, (1)직접 열분해 방법, (2) 촉매를 이용한 열분해 방법, (3)촉매를 이용한 탈염소수소화 반응이 있으며, hydrodechlorination반응은 수소화 반응에 보편적으로 사용되는 백금계 촉매를 사용하여 100~200oC의 낮은 반응 온도에서 이루어지므로 에너지 소비가 적으며 2차 오염원이 발생하지 않는 장점이 있다.

한국인 소아의 성장 발육 평가 자료 제작에 관한 연구

김영재,이신재,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.2

성장기 환자를 다루는 소아치과 분야에서 환아의 성장과 발육에 대한 지식이 필수적이다. 하지만, 현재 사용되고 있는 소아 성장 측정 도표는 현 시대성을 반영하지 못하는 오래된 것이거나 혹은 의과적 용도에 맞추어져 있어서 소아치과 분야에 적용하기에는 연령이 극히 제한적이었다. 이에 따라 본 연구는 2004년 산업자원부 기술표준원에서 시행하고 대한인간공학회에서 주관한 2004년 제5차 한국인 인체치수조사사업보고서를 토대로 현실성있고 유용한 성장 곡선 및 성장 속도 곡선을 제작하는 과정을 소개할 목적으로 시행되었다. 자료를 처리하고 재배열하는 과정을 통하여 자료의 변이를 사분위수를 기본 골격으로 하고 1, 5, 95, 99 백분위수를 추가하여 남·여별 키·몸무게 성장 곡선을 제작하였고 이와 아울러 기하 평균에 기초한 성장 속도 곡선도 제작하여 체성 성장 관찰 도표를 완성하였다. 본 연구 결과 생성된 성장 발육 평가 자료는 성장 발육의 지표로 이용될 수 있으며, 성장 발육과 관련, 소아치과 환자·보호자와의 의사소통에 도움이 될 수 있을 것으로 생각되었다. Knowledge of growth and development is essential for pediatric dentistry treating growing patients. The data from the pediatric growth curve being used today does not reflect the growth transition of modern times, nor does it match the age range required for dental purposes. The present study, therefore, aims to introduce the process of producing a growth curve and growth rate curve based on data which represents a more accurate description of the present situation. The original data used in this study were from 5th nationwide survey. SIZE KOREA 2004 study carried out by the Technology and Standards Policy Division. Department of Technology and Standards Planning. Ministry of Commerce, Industry, and Energy. Processing and rearranging the produced data with variations divided into the three quartiles and the 1st, 5th 95th and 99th percentiles were included to produce a growth observation chart according to sex, height and weight differences. In the same way, a growth rate curve based on the geometric mean value was produced. The resulting growth charts can be used as an index for growth and development, and used for better communication between the pediatric dentist, patients or their parents.

Transarticualr portal를 이용한 주관절의 관절경술

김성재,박인섭,김주영,정재훈,류상욱,천용민 대한견.주관절학회 2003 大韓肩.주關節學會誌 Vol.6 No.2

구진상괴사성 결핵진 3례

손보성,송준영,정재봉,김병천,이상숙,류영욱,이규석 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Papulonecrotic tuberculid is an eruption of necrotizing papules, particularly affecting the extremities and occurring in more or less symmetrical crops, and responding to antituberculosis therapy. Individual lesions heal with scarring. Histologically, vascular involvement is seen in early lesions. Late lesions are divided into two forms. In superficial forms, wedge shaped area of necrosis forms in epidermis and upper dermis. Epithelial and lymphoid cells gather around its periphery. In deep forms, with no epidermal change, granulomatous changes surrounded by well defined palisading histiocyte and lymphoid, epithelioid cells are seen. In mid-dermis and perivascular area, vessel shows vasculitis. In the first case, leukocytoclastic vasculitis and early granuloma formation were seen. In the second case, palisading granuloma formation was seen. In the third case, tuberculoid granuloma formation was seen. We report three cases of papulonecrotic tuberculid showing three different stages of histological finding, in individual cases.