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皮膚腫瘍에서 single-stand conformation polymorphisms法에의한 p53 遺傳子 突然變異 檢索
孫輔晟,宋俊榮 계명대학교 의과대학 1999 仁耕 宋俊榮 敎授 定年紀念 論文集 Vol.S No.-
The tumor suppressor gene p53, located on the short arm of chromosome 17, encodes for a nuclear protein which regulates cell proliferation by inhibiting cells entering S-phase. Mutations in p53gene are . the most frequent genetic alterations founded human cancers to date. This study was exammied mutant p53 gene mutation using PCRSSCP method and mutant p53 oncoprotein expression using avidin biotin peroxidase complex method immunohistochemically, in 2 seborrheic keratosis, 3 BCC , 3 SCC andl metaststic SCC cases. With PCR-SSCP methods in exon 5 and 7, no genetic mutation of p53 gene was observed in 2 seborrheic keratosis, 3 BCC , 3 SCC and 1 metaststic SCC cases. With immunohistochemical staining with ABC method, A case of SCC developed on lower lip was positive but another were all negative. This result means that p53 gene mutation on skin tumor may develope in SCC developed on sun exposed area and this mutation on SCC can develope other exonal site except exon 5 and 7.
皮膚腫瘍에서 single-stand conformation polymorphisms法에의한 p53 遺傳子 突然變異 檢索
孫輔晟,宋俊榮 계명대학교 醫科大學 皮膚科學 1999 논문집 Vol.S No.-
The tumor suppressor gene p53, located on the short arm of chromosome 17, encodes for a nuclear protein which regulates cell proliferation by inhibiting cells entering S-phase. Mutations in p53gene are . the most frequent genetic alterations founded human cancers to date. This study was exammied mutant p53 gene mutation using PCRSSCP method and mutant p53 oncoprotein expression using avidin biotin peroxidase complex method immunohistochemically, in 2 seborrheic keratosis, 3 BCC , 3 SCC andl metaststic SCC cases. With PCR-SSCP methods in exon 5 and 7, no genetic mutation of p53 gene was observed in 2 seborrheic keratosis, 3 BCC , 3 SCC and 1 metaststic SCC cases. With immunohistochemical staining with ABC method, A case of SCC developed on lower lip was positive but another were all negative. This result means that p53 gene mutation on skin tumor may develope in SCC developed on sun exposed area and this mutation on SCC can develope other exonal site except exon 5 and 7.
병렬 플라즈마 소스를 이용한 마이크로 LED 소자 제작용 GaN 식각 공정 시스템 개발
손보성,공대영,이영웅,김희진,박시현,Son, Boseong,Kong, Dae-Young,Lee, Young-Woong,Kim, Huijin,Park, Si-Hyun 한국반도체디스플레이기술학회 2021 반도체디스플레이기술학회지 Vol.20 No.3
We developed an inductively coupled plasma (ICP) etcher for GaN etching using a parallel plasma electrode source with a multifunctional chuck matched to it in order for the low power consumption and low process cost in comparison with the conventional ICP system with a helical-type plasma electrode source. The optimization process condition using it for the micro light-emitting diode (µ-LED) chip fabrication was established, which is an ICP RF power of 300 W, a chuck power of 200 W, a BCl<sub>3</sub>/Cl<sub>2</sub> gas ratio of 3:2. Under this condition, the mesa structure with the etch depth over 1 ㎛ and the etch angle over 75° and also with no etching residue was obtained for the µ-LED chip. The developed ICP showed the improved values on the process pressure, the etch selectivity, the etch depth uniformity, the etch angle profile and the substrate temperature uniformity in comparison with the commercial ICP. The µ-LED chip fabricated using the developed ICP showed the similar or improved characteristics in the L-I-V measurements compared with the one fabricated using the conventional ICP method
최근 10년간 피부 질환으로 응급실에 내원한 환자에 대한 통계학적 고찰 ( 1986 - 1995 )
손보성,신문석,권호준,김병천,이규석,송준영 ( Bo Sung Son,Moon Seok Sihn,Ho June Kwon,Byung Chun Kim,Kyu Suk Lee,Joon Young Song ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.2
Background: Dermatologic emergency patients who visit the emergency room increase in number every year. But there is no report about the statistical analysis of such visits. Objectives & Method: We reviewed 326 new dermatologic emergency patients who uisited the emergency room of Dongsan Medical Center in Taegu from 1986 to 1995 to study the age, sex, monthly and yearly distributior, arrival time, length of visit, prevalence of common dermatoses, admission rate and death rate. Results : The results are summarized as follows: 1. Of 326 patients, there were 151 males and 175 females. The sex ratio of male to female was 1: 1.15. The number of patients increased with each year. 2. In age distribution, there were 23(7%) under 10;46(14%) between 11-20,55(17%) between 21-30;49(15% ) between 31-40;33(10%) between 41 50; 62(19% ) between 51-60 years,39(12% ) between 61-70 and 19(6%) between 71-80 years. 3. In monthly and arrival time distribution, the peak month incidence occurred in August(24 %), and the lowest incidence in December(1%). The peak incidence of arrival time occurred PM 6-12 hours and the lowest incidence AM 0-6 hour. 4. In the distribution about length nf visit, 73% of patients stayed more than 10 hours, 23% 5-10 hours and 4% less than 5 hours. 5. Of the most common derrnatoses, acute urticaria was seen in 124 cases(38%), and herpes zoster. in 94 cases (29%). In age distribution, acute urticaria was most preualent between the age of 0-30 and herpes zoster between 50-70. 6. The admission rate was 43%(140 cases). The death rate was 1.2%(3 cases). Conclusion : Our study of e nergency patients revealed that dermatologic emergency patients who visited the emergency room had increased in number every year and the distribution of patients is quite different from that of outpatients. (Kor J Dermatol 1997;35(2): 223-227)
Composite Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ampulla of Vater
손보성,남유희,이진아,한남익,이희정,박일영 한국간담췌외과학회 2009 한국간담췌외과학회지 Vol.13 No.2
Large Cell Neuroendocrine Tumors (LCNEC) in the ampulla of Vater are extremely rare. This report addresses a case of concurrent LCNEC and adenocarcinoma in the ampulla of Vater. A 60-year-old male patient experienced fever, body chills and jaundice. He had a periampullary ulcerative lesion and underwent radical pancreaticoduodenectomy. Histopathologically, the tumor consisted of an LCNEC component and an adenocarcinoma component. Simultaneous LCNEC and adenocarcinoma has been reported in a few cases. Our patient had a coexisting LCNEC and an adenocarcinoma of the ampulla of Vater. We also present a review of the literature.
급성 괴사성 췌장염에서 발생한 결장 합병증 -1 예 보고-
손보성,정재희,송영택,Sohn, Bo-Sung,Jung, Jae-Hee,Song, Young-Tack 대한소아외과학회 2003 소아외과 Vol.9 No.2
We present a case of a colonic involvement associated with necrotizing pancreatitis, with a review of the literature. A 10 year old boy had an appendectomy at the local clinic ten days ago. On admission, he complained nausea, vomiting and severe constipation. His abdomen was distended and he had tenderness on the left abdomen. Laboratory and radiologic studies revealed findings consistent with acute pancreatitis with colonic complication. He was treated conservatively for 30 days but did not improve. On hospital 30th day, abdominal pain developed and his vital sign changed. Abdominal CT suggested ischemic change of the transverse colon. At laparotomy, the left colon showed stenosis. The greatly distended transverse colon was resected and a transverse end colostomy was done. He was discharged at postoperative 45th day with improvement and colostomy closure was performed 8 months later.