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장기택,Jang, Gi-Taek 한국도서관협회 1972 圖協月報 Vol.13 No.7
이 글은 지난 5월 29일 본 협회에서 주최한 세계도서의해 기념 강연회에서 “도서관학과 정보과학의 최근연양”이란 주제로 강연한 내용을 간추려 정리한 것이다. 연사 장기택 선생은 1962년에 도미하여 교육심리학 및 Documentation and Information Science를 전공하였다. 1968년에는 Appalachia 교육정보센터의 소장을 역임하였으며 현재는 미국심리학회(APA)의 National Information System for Psychology (NISP)개발 Project의 선임 정보전문가로 활약주이다. 따라서 금번 KIST의 초청으로 일시 귀국하여 약 2개월간 체한하는동안 선생의 바쁜 일정의 틈을 내어 고국의 도서관과 동지들을 위해 강연회를 갖었든 것이다.
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장기택 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.1
To study the antimicrobial effect of fluoride-releasing removable orthodontic appliances, 0 wt%(Group 1), 5 wt%(Group 2) and 10 wt%(Group 3) of CaF₂were added to orthodontic resin. The specimens were then put in media in which S. mutans and Lactobacillus, known cariogenic bacteria, were cultured. Inhibiting zones wer measured 24, 48 and 72 hours later. The following conclusions were reached: 1. In the Lactobacillus media, no zone of inhibition was observed regardless of the time passed. 2. In the S.mutans media, zones of inhibition were observed sfter 48 hours. 3. S.mutans showed greater inhibition in Group 3 compared to Group 2, after 72 hours rather than 48 hours(p<0.01).
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췌장 악성 관내 유두모양 점액성 종양의 성장 양상에 따른 임상 및 병리학적 분석 - 드문 누공성 침범 성장 양식 -
장기택,권기영,안긍환 대한병리학회 2007 Journal of Pathology and Translational Medicine Vol.41 No.1
Background : Usually, a malignant intraductal papillary mucinous tumor (IPMT) of the pancreas shows invasive carcinoma. Recently, IPMT with an unusual growth pattern of a fistulous extension was reported. However, little is known about malignant IPMTs with a different growth pattern of invasion and fistulous extension. Methods : Malignant IPMTs were classified into invasive (colloid or tubular type) carcinomas and the fistulous extension type according to their growth patterns. Their clinicopathological characteristics were compared. Results : Among a total of 68 cases of IPMT, there were 16 cases with malignant IPMT; eight, six and two of the colloid, tubular, and fistulous extension types, respectively. The immunohistochemical (IHC) expression of MUC1 was found in seven out of eight colloid and five out of six tubular types, but there was no IHC expression of MUC1 in the fistulous extension type. The IHC expression of MUC2 was noted in one of the eight colloid, one of the six tubular and in both cases with the fistulous extension type. There was no difference in the tumor recurrence rates between the different growth patterns. Conclusions : IPMT with the fistulous extension type has a peculiar extension pattern consisting of multiple fistulous tracts without a mass. Although most of the epithelium in the fistulous tract show moderate to severe dysplasia, only the fistulous extension should be considered to be an unusual growth pattern of malignant IPMT. The clinical significance of this unusual type of IPMT remains to be determined.
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장기택 대한췌장담도학회(구 대한췌담도학회) 2019 대한췌담도학회지 Vol.24 No.4
췌장낭성종양의 병리진단에서 분자병리 검사의 활용은 통상적인 세포 또는 조직 진단이 어려운 경우 점진적으로 확대될 것으로 예상된다. 세포 또는 낭액에서 검사 결과에 필요한 충분한 디오시리보핵산(DNA)이 확보된다면 특정 유전자 변이를 확인해서 췌장낭성종양의 감별 진단이 가능하며 대표적인 유전자 변이에는 KRAS, GNAS, CTNNB1, VHL 변이 등이 있다. 하지만 분자병리 검사를 활용하는 경우에도 임상-영상의학적 소견을 참고하여 기본적인 병리진단을 한 후에, 이를 뒷받침하는 자료로 활용되는 것이 바람직하다. 차세대염기순서분석 검사는 소량의 세포 또는 조직으로 다수의 유전자 변이를 동시에 확인할 수 있는 장점이 있어 사용되는 범위가 확대될 것으로 기대되지만 적절한 정도 관리를 거치지 않으면 위음성의 결과로 보고될 위험성이 있으며 병리의사의 정도 관리를 거친다고 하더라도 30% 내외의 실패율을 보일 수 있다고 보고되어 있다. Pancreas cystic neoplasm is a relatively common disease. However, its’ pathologic diagnosis is not easy. The most frequent problem is low cellularity when compared to another organ cytology or biopsy material. Considering the procedure and anatomic difficulty, it is not uncommon to observe a low cellular smear or scanty volume of cells in the biopsy specimen. In this case, the molecular pathology test, including nextgeneration sequencing, may be helpful. If pathologist can identify some mutation in cells or cystic fluid, differential diagnosis of cystic neoplasm may be possible. These are KRAS and GNAS, VHL, and CTNNB1 mutation in mucinous cystic neoplasm, intraductal papillary-mucinous neoplasm, serous cystic neoplasm, and solid pseudopapillary neoplasm, respectively. The next-generation sequencing is an emerging molecular test that can detect multiple biomarkers for diagnosis, including pancreas cystic neoplasm. It has been reported that next-generation sequencing test can be applied for differential diagnosis of pancreas cystic neoplasm. However, these molecular pathology tests were not all-around; it needs to be properly managed with pathologist’s quality control. It should be remembered that even if it goes through quality control, it may show a failure rate of around 30%. Despite the advances in molecular methods of high techniques, it should be remembered that the most important thing in pathologic diagnosis of pancreas cystic neoplasm is an endoscopist’s skill and pathologist’s expertise those provide adequate specimen and accurate diagnosis.
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