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이병돈,박재홍,이용만,김동원 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.3
Eosinophilic otitis media is characterized by thickened, bulging and pale tympanic membrane with viscous or gelatinous secretion in the middle ear cavity. Gelatin-like fluid contains many eosinophils and this disease may occur in patients with adult onsetbronchial asthma. It is intractable otitis media which resists all therapy including myringostomy and tympanomastoidectomy due to abnormal mucosa until the allergic factor is controlled. In these patients, oral steroid is very effective in controlling the disease. Major complication of eosinophilic otitis media is sensorineural hearing loss which may occur despite steroid therapy. We report two cases of patients with bilateral otitis media with bronchial asthma, which were treated with oral and topical steroid therapies. (Korean J Otolaryngol 2006;49:334-8)
백색 기니픽 와우에서 Protein Kinase C 아형의 발현
이병돈,최제환,김희중,유명상,김재욱,이재형,김동욱,장혁순 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.9
Background and Objectives:Protein kinase plays an important role in transmembrane signalling, which is modulated by cellular transduction by second messengers such as inositol- 1,4,5- triphosphate (IP3), Diacylglycerol (DG), cAMP, to expres biological activity by stimulation of hormones, neurotransmitters, antigens, growth factors. Protein kinase Cs participate in signal transduction of cell, secretion of neurotransmitter, regulation of ion conduction, exocytosis, gene expresion and cellular proliferation. Also, it raises slow motility by Na+- H+ exchange (NHE) and Ca2+ channel in the outer hair cells. It may also be involved in mechanical transduction, cellular proliferation and reproduction in supporting cells, and in producing endolymphs using the KCNE1 and Na+/K+- ATPase in the lateral wall of cochlea. Materials and method:We investigated the imuno-reactivities of the PKC (α,β,γ,δ) via paraffin section and surface preparation of the cochlea of albino guinea pigs. Results:PKCαimmunoreactivities were shown in the outer and inner hair cell cytoplasm andδwas revealed in the type Ⅱ fibrocytes and suprastrial cells in the basal turn of the spiral ligament. Butβ,γwere not shown. Conclusion:We suggest that PKCαmay induce the slow motility and depolarization to mediate the ion conductance in the hair cells. Also, PKCδmay participate in the production of endolymph. We thus conclude that PKCαandδplay an important role in the cochlear signal transduction. (Korean J Otolaryngol 2003 ;46 :733-6)
이병돈 한국통합생물학회 1958 동물학회지 Vol.1 No.1
Studying on the shirpms produced out of the freshwater in Nam-hae Island , the four kinds of them were found as follows : 1. Paratya compressa (De Haan) 2. Neocaridina denticulata (De Haan) 3. Neocaridina denticulata koreana Kubo 4. Caridina leucostica Stimposon Among the said kinds of them, Paratya compressa and Caridina leucostica are to be listed for the first time in Korean shrimps fauna, and at the same time, Neocaridina denticulata and Neocaridina denticulata koreana were found distributed mostly in whole the rivers, lakes and ponds of this area.