Characterization of the European type of maternal lineage evident in extant Jeju native pigs

Byeong‐Woo Kim,In‐Cheol Cho,Moon‐Sung Park,Tao Zhong,임현태,Sung‐Soo Lee,Hee‐Bok Park,Moon‐Suck Ko,Jun‐Heon Lee,Jin‐Tae Jeon 한국유전학회 2011 Genes & Genomics Vol.33 No.2

Using a partial D‐loop sequence of mtDNA, an intensive analysis was conducted of the maternal lineages of Jeju native pigs (JNPs) from Korea. In total, 100 mtDNA sequences were obtained from Asian wild boars (AWBs), European wild boars (EWBs), Asian domestic pigs (ADPs), European domestic pigs (EDPs), and JNPs and were used for phylogeny and network analyses. Two distinct JNP groups - one (JNPA) in the Asian cluster and the other (JNPE) in the European cluster - were identified in the estimated phylogenetic tree and network. The maternal lineage of JNPE was the closest to that of EWB and a clear haplogroup was identified that shared an identical haplotype (hap04) among 15 individuals of JNPE and 2 individuals of EWB. A Landrace and an EWB shared hap03with a JNPE. EWB, Landrace, Large White, and Duroc formed two clear haplogroups with JNPE in a parsimonious medianjoining network analysis, suggesting that an obvious maternal contribution of EDP has occurred in JNPE in recent years. A pair‐wise mismatch analysis also indicated that JNPE may have experienced a sudden population expansion, suggesting a more recent establishment compared with the gradual population expansion of JNPA. The JNPE group therefore should be further evaluated in order to decide whether this group should be culled or accepted into further programs for maintenance of the JNP population as a pure breed.

전기적화상에 의한 구순결손의 재건 -증례보고-

박진규,김경원,김병린,민병일 大韓顎顔面成形再建外科學會 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.3

Electrical burns of the lips are most frequently seen in small children, who are apt to chew on electrical cord or plug, the ends of extension cords in their mouth, saliva creates a short circuit across the terminals within the plug, causing an electrical burn. Tissue destruction with electrical burns is sudden and extensive. Extensive, deep coagulation necrosis is instaneously produced by the extreme temparatures of electrical arc. If the child is well grounded, the circuit flow through his body may cause cardiac arrest. The purpose of this report is to document two cases of electrical lip burn and reconstruction of the lip defect with some local flap techniques. For case 1, Z plasty & V - Y plasty and lengthening of the commissure and in case 2, Abbe flap technique was used and scar was revised later. Z - plasty and V- Y plastry were used for scar release and Abbe flap was designed on lower lip to meet the need of upper lip. For short of right lip width, lengthening of the commissure was done. We are to report the improvement with forementioned operation on the patient of electrical burn upon the lip.

Ti-3Al-2.5V 합금의 피로특성 : 온도, 미세조직의 영향을 중심으로 The Effects of Temperature and Microstructure

박동준,김현철,임병수 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.2

Ti alloys, with the advantageous tensile strength/density ratio and the chemical stability, have been used widely in the aerospace and chemical engineering industries and their usages are still expanding in various industrial areas. In the automotive industry, because of their superior merits of weight reduction and fuel saving, Ti alloys are expected to be used as various part materials including connecting rods, engine valves, springs and retainers, which are all subjected to the fatigue loads. In this study, using Ti-3A1-2.5V alloy, the effects of temperature and microstructure change on fatigue crack propagation have been investigated.

Siriraj Stroke Score 따른 뇌졸중 환자 감별의 적합성

유병대,이명갑,서영조,조준,박찬상,이동필 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: The differentiation between hemorrhagic(HS) and norhemorrhagic(NHS) stroke is the most important first step in the management of acute stroke because clinical management of the two disorders differs substantially. Neuroimaging studies are useful in diagnosing and distinctioning between HS and NHS. The use of clinical variables, such as Siriraj stroke scores(SSS), has led to good sensitivity, specificity and predictive values. The aim of our study was to evaluate the use of the SSS in the Korean population and assess whether it could aid to expedite treatment decisions. Methods: We reviewed 111 cases of stroke patients admitted to our hospital via the emergency department over a 6 months period from July to December 1998. Levels of consciousness, vomiting, headache, and atheroma markers used in the SSS were applied to these patients who met the criteria for a stroke. Results: Of the 111 patients, the SSS classified 83 with sensitivities of 81.1%(NHS) and 73.3%(HS) and positive predictive values of 84.3% and 68.8%, respectively. The overall accuracy rate was 78.3%. Conclusion: Our results suggest that the SSS is not reliable in distinguishing stroke types in the Korean population. Definite neuroimaging studies are needed prior to thrombolytic therapy.

팍스벡터패턴의 왜곡률 분석을 이용한 유도전동기 고정자 권선 상태진단 모듈 개발

김준영(Jun-Young Kim),박규남(Kyu-Nam Park),송명현(Myung-Hyun Song),양철오(Chul-Oh Yang),이대성(Dae-Seong Lee),강병철(Byeong-Cheol Kang) 대한전기학회 2017 대한전기학회 학술대회 논문집 Vol.2017 No.7

해외마케팅 지원체계 효율화 방안에 관한 연구

문병준,김한원,박원규 경희대학교 사회과학대학 2001 社會 科學 論叢 Vol.19 No.-

최근 국내 경제는 미국경기 침체에 따른 세계경기의 위축, IT경기의 부진, 경쟁의 격화, 환율의 불안 등의 거시환경의 변화로 인하여 수출부진에 직면하고 있으며 이러한 수출부진 여파로 인하여 국내기업의 수출채산성 악화, 설비 투자 및 산업생산감소, 제조업 가동률 하락 등의 문제로 이어지고 있다. 이러한 수출부진을 타개하기 위해서는 근본적으로 국내 기업의 대외경쟁력이 강화되어야 하지만, 아울러 정부의 해외마케팅 지원체계의 효율화가 강구될 필요가 있다. 수출기업의 애로점으로 해외시장의 동향과 바이어리스트 등의 시장정보의 부족을 가장 큰 문제점으로 지적되고 있고, 정부에서는 해외마케팅 지원을 위하여 그간 무역전시회, 시장개척단, 수출구매상담회 등을 추진해오고 있다. 그러나 각 부처의 해외마케팅지원활동이 중복되거나 표적고객을 대상으로 하여 지속적으로 이루어지지 못하는 문제점이 노정되고 있다. 최근 마케팅분야 연구에서 잠재고객을 대상으로 하여 여러 형태의 설득 커뮤니케이션 프로그램을 효율적으로 개발하고 실행하기 위해서는 다양한 커뮤니케이션 요소를 통합적으로 계획하고 조정하는 통합적 마케팅 커뮤니케이션의 중요성이 강조되고 있다. 본 연구에서는 정부의 해외마케팅 지원체계의 현황과 문제점을 분석하고 통합적 마케팅 커뮤니케이션 이론을 적용하여 해외마케팅 지원체계의 효율화방안을 제시하고자 한다.

정상 면역 성인에서 발생한 거대세포바이러스 위염 1예

김갑현,박병배,백현정,이준행,백승운,백경란,장기택 대한내과학회 2004 대한내과학회지 Vol.66 No.3

거대세포바이러스 감염은 주로 면역기능이 저하된 환자에서 치명적인 기회감염으로 잘 나타나는 질환이다. 한편 면역 상태가 정상인 사람에서 발생되는 경우는 매우 드물다. 저자들은 심와부 동통과 구토를 주소로 내원한 정상면역의 27세 남자 1예를 보고한다. 상부위내시경상위 점막 결절상과 궤양소견을 보였고, 위 점막 결절과 궤양부위 조직검사상 거대세포바이러스 봉입체의 관찰로 거대세포바이러스 위염을 진단하였다. 최근 감염과 일차감염을 나타내는 거대세포바이러스 Ig M 항체는 양성이었다. Ganciclovir와 proton pump 억제제를 병용하여 치료하였고 증상 호전과 거대세포바이러스 seroconversion을 확인하였다. 저자들은 거대세포바이러스가 정상면역 성인에서 위 궤양을 일으킬 수 있는 경우를 경험하여 보고하는 바이다. Cytomegalovirus (CMV) infections are usually reported in immunocompromised patients. However, it occurs rarely in immunocompetent individuals. A case of CMV associated with stomach ulcers and mucosal nodules is reported in a immunocompetent host. A previously healthy 27-year-old man visited our hospital with a thirty-day history of epigastric pain and a nine-day history of vomiting. The demonstration of intranuclear inclusion bodies in a few gastric glandular epithelial cells contributed to the diagnosis of CMV gastritis. Treatment with a proton pump inhibitor and ganciclovir was successful to mitigate the epigastric pain and vomiting.

계방산과 오대산 일대 분비나무 자생지 군집 구조 및 하층식생 특성

천광일,변준기,김정인,박병주,Cheon, KwangIl,Byeon, Jun-Gi,Kim, Jung-In,Park, Byeong-Joo 한국환경복원기술학회 2022 한국환경복원기술학회지 Vol.25 No.5

This study was conducted to investigated woody species community classification and understory vegetation characteristics of Abies nephrolepis forest in Mt. Gyebang and Mt. Odae designated as Protected Area for Forest Genetic Resource Conservation and National Park. Vascular plants were surveyed as following; 55 family, 148 species, 3 sub species, 14 variety, 2 form 167 taxa. As an analysis of the species estimator of Jackknife 1, 29 survey plots could be representative of vegetation in study site. Results of the woody species, 3 communities were divided by cluster analysis(A=Abies nephrolepis-Tilia amurensis, B=Betula ermanii-Abies nephrolepis, C=Quercus mongolica-Abies nephrolepis). Using MRPP-test, there were significant differences between the communities indicating analysis of the appropriate group classification(p<0.01). The basal area and altitude were analyzed by negative relationship for NMS ordination. By analyzing plexus diagram of woody species, Acer pseudosieboldianum is strong associated with Quercus mongolica and Rhododendron schlippenbachii. Magnolia sieboldii is strong associated with Acer pictum subsp. mono etc.

Possible Involvement of Photoperiodic Regulation in Reproductive Endocrine System of Female Olive Flounder Paralichthys olivaceus

Hyun Chul Kim,Chi Hoon Lee,Sung Pyu Hur,Byeong Hoon Kim,Jun Young Park,Young Don Lee 한국발생생물학회 2015 발생과 생식 Vol.19 No.1

This study investigated possible involvement of photoperiodic regulation in reproductive endocrine system of female olive flounder. To investigate the influence on brain-pituitary axis in endocrine system by regulating photoperiod, compared expression level of Kisspeptin and sbGnRH mRNA in brain and FSH-β, LH-β and GH mRNA in pituitary before and after spawning. Photoperiod was treated natural photoperiod and long photoperiod (15L:9D) conditions from Aug. 2013 to Jun. 2014. Continuous long photoperiod treatment from Aug. (post-spawning phase) was inhibited gonadal development of female olive flounder. In natural photoperiod group, the Kiss2 expression level a significant declined in Mar. (spawning period). And also, FSH-β, LH-β and GH mRNA expression levels were increasing at this period. However, in long photoperiod group, hypothalamic Kiss2, FSH-β, LH-β and GH mRNA expression levels did not show any significant fluctuation. These results suggest that expression of hypothalamic Kiss2, GtH and GH in the pituitary would change in response to photoperiod and their possible involvement of photoperiodic regulation in reproductive endocrine system of the BPG axis.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.