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백승운,강은영,허윤,박천권,한동근 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Biodegradable poly(L-lactic acid) (PLLA) has attracted a great deal of attention as biomedical materials. However, it has some drawbacks such as lower hydrophilicity, slow degradation rate, and acidic degradation product that causes inflammatory response. In this study, the PLLA composites with two surface-modified nanoparticle magnesium hydroxide (nMH) with totally different topological structure were prepared to enhance the physico-mechanical and biological properties. The incorporation of surface-modified nMH not only enhanced mechanical properties but also improved homogeneity of magnesium hydroxide particles in the PLLA matrix. Additionally, the PLLA composites with surface-modified nMH reduced cytotoxicity and immunogenicity, and increased hemocompatibility. This study suggests a new platform in designing a biodegradable cardiovascular implant including stents with improved thermal and mechanical properties and reduced inflammatory response.
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우리나라 간암 환자에서의 Cytochrome p450 2E1유전자의 다형성에 관한 연구
백승운,이효석,김정룡,윤정환,장유현,황유진 대한소화기학회 1998 대한소화기학회지 Vol.30 No.4
Background/Airns: Cytochrome P450 2E1(CYP2EI) is the only enzyme that rnetabolizes very low doses of N-nitrosodimethylamine(NDMA) and is characterized by its ethanol inducibility. Recently, it has been shown in an animal-experimental study that NDMAinduced hepatocarcinogenes was facilitated by chronic alcohol ingestion. CYP2E1 expression in human beings was reported to be about 10 times higher in genotype c2/c2 than in genotype c1/c1. Bacause CYP2El gene expression is the highest in the liver, we hypothesized that the polymorphism of CYP2E1 may affect the risk of hepatocellular carcinoma(HCC), especially in patients with chronic alcohol consumption. Methods: We enrolled 46 HCC patients and 32 age-sex-matcied healthy controls without liver disease or cancer in any other organ. The genotypes in the 5-flanking region of CYP2E1 gene were determined by restriction fragment length polymorphisms using two endonucleases: PstI and RsaI. Results: The frequencies of genotype A(c1/c1), B(c1/c2) and C(c2/c2) were 56.5%, 39.1%, 4.4% in HCC patients, and 62.5%, 28.1%, 4.4% in controls, regiectively. The frequency of allele c2 was 23.9% in HCC patients and 23.4% in control, re.;pectively. The difference in the frequencies of both CYP2E1 genotyps and alleles was not statistically significant between the HCC patients and controls. The HCC patients with a history of ckonic alcohol ingestion were more like]y to carry genotype B and C than in patients without such history, even though the differences are not statistically significant(p=0.077). Conclusions: Although polymorphisms of CYP2E1 gene is not a major genetic risk factor for the development of HCC, it might increase the risk of HCC in patients with chronic HBV or HCV infection and chronic alcohol consumption. Further study to test this bypothesis on a large number of patients and on patients of different ethnic groups is warranted.
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