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김경원,윤정구 대한미생물학회 1988 大韓微生物學會誌 Vol.23 No.1
Non-specific cellular immunity may play an important role in the immune defense mechanism against tumors and has recently become of great interest to many researchers. Among the effector cells involved in non-specific cellular immune reactions, natural killer(NK) cells and antibody dependent cell-mediated cytotoxicity(ADCC) effector cells are the principal targets in many of the investigations studying the hosts immune defense aginst tumors. In general most chemotherapeutic agents are known to depress host immune functions. However, such an effect in non-specific cellular immunity particulary on NK cell and ADCC activities has not been fully determined. In this report, the effects of 5-fluorouracil(5-FU) and adriamycin(ADM), which are widely used for the chemotherapy of human cancer, on mouse NK and ADCC activities were studied. Adult ICR mice were injected with either one of the drugs or a combination of them and then at given interval, splenocytes were collected. NK and ADCC activities were measured in vitro using a 4hr ^(51)Cr release assay employing YAC-1 and L1210 target cells respectively. The following results were obtained. 1, The administration of different doses of 5-FU or ADM either alone or in combination resulted in a dose-dependent inhibition of NK activity 48 hours post injection. In these experiments, the doses which showed the most significant inhibition were 12.0mg/ml and 1.2mg/ml or greater for 5-FU and ADM respectively. No difference in NK activity was observed between mice treated with the drugs in combination. In contrast, assays of AD- CC activity in splenocytes from the same mice showed no appreciable change in the level of cytotoxicity. 2. Kinetic studies revealed t4at splenocytes from mice treated with a single dose of 5-FU (12mg/kg) or ADM(1.2mg/kg) alone or in combination showed significantly decreased levels of NK activity 48 72 hours after treatment. Thereafter NK activity progressively increased and reacked the level of the controls at 7 days. Again, no significant changes in ADCC activity were observed in these experiments. 3. Splenocytes from mice treated 48 hours previously with the drugs significantly suppressed the NK activity of normal mice. 4. Futhermore, these splenacytes had an impaired in-vitro production of interleukin-2 as compared to those from normal controls. In conclusion, mice treated with 5-FU or ADM either alone or in combination, exhibited significantly depressed NK activities 2 3 days after treatment, but the level of ADCC activity was not effected. This suggest that NK-suppressing mechanisms which involve the appearance and activation of suppressor cells and which impair the production of interleukin-2, may de- velope following chemotherapy.
스마트홈 클라우드 서비스를 위한 디바이스 가상화 프레임워크
김경원,박종빈,금승우,정종진,양창모,임태범 에스케이텔레콤 (주) 2014 Telecommunications Review Vol.24 No.5
최근 네트워크와 연동된 스마트 단말들의 개발과 보급이 거세다. 이런 트렌드는 홈 가전 디바이스들에도 반영되어 스마트 기능을 탑재한 TV, 오디오, 전등, 냉장고, 세탁기 등이 속속 출시되고 있다. 이를 통해 미디어 콘텐츠들의 공유와 소비가 그 어느 때보다 편리하고 유연해지고 있다. 본 논문은 이러한 홈 내 스마트 디바이스들의 기능들이 상호 공유되고 협력적으로 제어됨으로써, 더욱 창의적이고 혁신적인 서비스 구성이 가능한 클라우드 기반 디바이스 가상화 프레임워크 기술을 제시한다. 본 논문에서는 홈 내에서 UPnP 통신 프로토콜을 사용하는 디바이스들의 서비스 정보 및 제공하는 기능 정보를 클라우드 서버에서 자동으로 분석 및 처리하여 동적으로 어플리케이션 프로그래밍 인터페이스를 제공할 수 있도록 한다. 이를 위한 디바이스 서비스 및 제공 기능 정보를 분류하고, 정의된 규칙에 의해 홈 내 스마트 디바이스들을 가상화된 자원으로 등록하고 검색 가능한 형태로 변환하는 기술을 제안한다. 디바이스 가상화 처리를 통해 독립적으로 제공되었던 스마트 디바이스들의 기능들이 상호 협업이 가능한 단위 기능들로 분해되고, 이를 조합하여 클라우드 기반 신규 서비스 개발이 가능하게 된다. 본 논문에서는 이러한 디바이스 가상화 프레임워크와 이를 기반으로 하는 다양한 클라우드 서비스들을 제시하여 그 실효성을 검증한다.
Effect of excimer laser annealing on the properties of ZnO thin film prepared by sol-gel method
김경원,김상식,이상렬 한국물리학회 2012 Current Applied Physics Vol.12 No.2
Pristine ZnO thin films have been deposited with zinc acetate [Zn(CH3COO)2], mono-ethanolamine (stabilizer), and isopropanol solutions by sol-gel method. After deposition, pristine ZnO thin films have been irradiated by excimer laser (l ¼ 248, KrF) source with energy density of 50 mJ/cm2 for 30 sec. The effect of excimer laser annealing on the optical and structural properties of ZnO thin films are investigated by photoluminescence and field emission scanning electron microscope. As-grown ZnO thin films show a huge peak of visible region and a wide full width at half maximum (FWHM) of UV region due to low quality with amorphous ZnO thin films. After KrF excimer laser annealing, ZnO thin films show intense near-band-edge (NBE) emission and weak deep-level emission. The optically improved pristine ZnO thin films have demonstrated that excimer laser annealing is novel treatment process at room temperature.