정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

뇌실내출혈로 인한 급성 수두증에서 관찰된 해리증후군

김광기,이경민,이정주,오종배,안태범,정상욱,남현우,박성호 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

MANET 라우팅 프로토콜 QoS 지원서비스의 성능평가에 관한 연구

鄭燦赫,金鉉郁,李光培,姜景仁,朴京培,劉忠烈,吳世德,裵振勝,趙榮泰 明知大學校 産業技術硏究所 2004 産業技術硏究所論文集 Vol.23 No.-

In this paper, we evaluated two main QoS supporting routing protocol on wireless ad hoc network. At presence, wireless mobile communication focuses on how to efficiently support mobility of users more than QoS guarantee. However, in order to satisfy requirement of various applications which have been or will be served, QoS support service between source and destination becoming a very important issue. Of all routing protocols, DSR and AODV are very important routing protocol in MANET. So we simulated DSR and AODV QoS Routing Protocol Through simulation evaluation tool NS(Network Simulation) based on various environments.

임대아파트 장기수선 대체안 검토를 위한 CAFM 시스템 개발

정영한,박태근,김광우,김창덕,김옥규,황영삼,박홍석 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

In the case of rental apartment. the special Quality continuously preservation administration business consist and saves up Long-term Maintenance expense voluntarily. Because business surrounding that this can control preservation administration business whole is possible. administration of repair work is easy. Do system development that introduce technique for long-term strategy establishment in CAFM by purpose. Estimation of system to develop is as following: Can reduce time that take in LCC calculation because approach automatically to information of necessary facility in LCC calculation and know repair time as is easy. It is possible that execute selection of item that is examined in long-term maintenance plan as efficient and correct. Priority injection of budget by facility deteriorated degree is consisted preferentially using FCI.

공공부문 조직과 민간기업 조직의 직무만족도 비교분석 : 한국노동패널연구(KLIPS)자료를 중심으로

정광호,김태일 한국정책학회 2003 韓國政策學會報 Vol.12 No.3

그동안 국내에서 직무만족도에 관한 연구는 사회과학 여러 분야에서 이루어져 왔지만 공공부문과 민간부문사이의 직무만족도가 다를 것이라는 가설은 체계적으로 연구되지 못했다. 특히 대부분의 연구들은 횡단면 자료(cross-sectional data)를 가지고 분석했기 때문에 지난 1997년 경제위기 이후 직무만족도의 종단면적 추이를 분석하는데 한계가 있었다. 이에 본 연구는 기존의 연구와 달리 지난 1998년 이후 매년 조사되고 있는 한국노동패털자료(Korea Labor and Income Panel Study)를 이용하여 공공 및 민간부문간의 직무만족도의 차이에 대한 패널분석을 시도하고 있다. 본 연구의 분석결과 지난 1998년부터 2001년까지 정부기관에 종사자들의 직무만족도가 민간기업종사다들보다 높음을 보여준다. 특히 취업안정성 만족도에서 가장 큰 차이가 발견되었다. 한편 보수만족도의 경우 지난 1998년부터 2000년까지는 양 부문에서 유의미한 차이가 없었지만 2001년의 경우 민간부문에 비하여 공공부문의 보수만족도가 높아지고 있다. 추가로 본 연구는 교육변수와 성별변수에 따라 양 부문간의 직무만족도의 차이를 분석하고 있다. 특히 보수만족도와 복지후생만족도의 경우 공공부문의 고졸집단 만족도가 공공부문 및 민간부문의 대졸집단 만족도보다 높았다. 또한 직업 안정성, 직무내용, 그리고 복지후생 만족도의 경우 공공부문의 남성집단 만족도가 민간부문 여성집단의 만족도보다 높았다. 이 연구결과는 일반적으로 대졸집단이 고졸집단보다 그리고 여성이 남성보다 높은 직무만족도를 보인다는 사실과 상반된 것이다. 이것은 아마도 민간조직과 달리 공공조직이 가진 독특한 특성과 관련이 있어 보인다. Pervious studies have tended to neglect a hypothesis of differences in job satisfaction between public and private organization. Because they examined the hypothesis with a cross-sectional data, they have not showed a trend of job satisfaction since the 1997 economic crisis in South Korea. Unlike prior research, this study explores the longitudinal differences in job satisfaction between these two types of organizations with the Korean Labor & Income Study dat. This study shows that the level of job satisfaction in public organizations was higher difference in the level of satisfaction of job stability in the same period. While there was little difference of wage satisfaction between them between 1998 and 2000, the level of wage satisfaction in public organizations was higher than that in private organizations in 2001. In addition, this study examines differences in job satisfaction in terms of education and gender. In public organization, those with high school degree have a higher level of satisfaction in wage and welfare than those with college degree. In the case of job stability, job contents and occupational welfare, male group in public organizations has a higher level of satisfaction than female group in private organizations These results contrast with the following two facts: (1) in general, the level of job satisfaction for those with college degree is higher than that for those with high school degree or no high school degree; and (2) the level of job satisfaction for female group is higher than that for male group. It appears to be related to the unique characteristics of public organizations.

임대아파트 유지관리를 위한 성장형 데이터베이스 모델에 관한 연구

정영한,박태근,김광우,김창덕,김옥규,황영삼,박홍석 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

In making social sympathy about the drafting of a mid-long term of maintenance plan and the development of building maintenance database for technique support, the target of this study is rental apartments admitting a variety of objects to data model in maintenance. For the development of database in maintenance, it shows that the database model is possible for the references of AS-IS modeling and function model and continuous work analysis by function and process analysis. Also, the structure of model at this study will be applied in maintenance as well as construction needed the development of database. To get continuous growth in maintenance information, it has been necessary to take a standard of information in plan, design, construction, and management. After this, it would be required to develop the South Korea-type FMS(Facilities Management Classes) based on IFC(Industry Foundation Classes)

일제의 반인륜적 조선인 강제노무동원과 임금 탈취

정태헌,기광서 한국역사연구회 2003 역사와 현실 Vol.- No.50

The purpose of this article is to investigate the background and process of the forced mobilizalion of Koreans by Japanese imperialist, labour environment and the Japanese nation and enterprise's organized exploiting wages. In Korea, Japanese imperialist totally consumed manpower, materials and funds for the war which was provoked by Japan itself and contrary to morality. The number of labour compulsorily moved to Japan was at least seventy hundreds thousand. The forced mobilization of Koreans were used for the support of Japanese enterprises which relied on the Government-Genera! of Korea(Chosun Chongdokboo 朝鮮總督府) to carry out the drafting of the mobilization. Most wages of Korean were saved by compulsion or contributed. They were used for the war expenses and revolving funds of enterprises, being paid only small amount of wages. After all, Koreans forcedly mobilized by the Japanese imperialist were the victim of double exploitation structure. In other words to say, the Japanese imperialist horribly trampled on the value of private labour and the fundamental personal rights.

캐릭터 지다인을 위한 다변량분석의 적용방안

정광태,송복희 한국기술교육대학교 2006 論文集 Vol.13 No.1

Character is one of the most important high value-added industries in 21 century. Various analyses on character are required to raise customer's satisfaction on character products. In this study, we proposed application method of factor analysis, cluster analysis, multi-dimensional scaling and application cases. From the factor analysis, aesthetic factors on character could be decided and image maps with aesthetic factors could be obtained. From the cluster analysis, characters could be grouped by its aesthetic characteristics. From the multi-dimensional scaling, a direction of character design could be decided. Finally, it is concluded that multi-variate analysis should be effectively applied to character design.

센서 융합을 이용한 자율이동로봇의 위치추정

정석윤,진광식,윤태성 國立 昌原大學校 產業技術硏究院 2004 産技硏論文集 Vol.18 No.-

Accurate position estimation is required for mobile robot navigation. To estimate current position, mobile robot uses sensors. As one sensor or two sensors system is insufficient to estimate accurately, it is necessary to use sensor fusion method. Mobile robot can obtain redundant and complementary information by using sensor fusion method. It is possible to estimate current position more accurately than one sensor or two sensors system. Sensor fusion system is composed of vision sensor, ultrasonic sensors and encoder sensor. Personal computer and interface board control three different sensors. Extended Kalman Filter(EKF) method using three different sensors is proposed for sensor fusion. The validity of the proposed sensor fusion method is proved by experimental results in indoor environment.

CROSS 공법을 이용한 폐수의 생물학적 처리에 관한 연구

박광하,심재도,권영두,강동수,김인호,정태명,황갑성 7개 국립대학교 환경연구 논문집 공동발행 위원회 2003 공업기술연구 Vol.3 No.-

This study aims to develop using a continuous removal of organic and settling solid(CROSS) to increase the efficiency of aeration system for wastewater treatment. To solve many problems of the conventional activated-sludge process, authors suggested a new CROSS model in conjunction with aeration systems in 1996. This system is characterized by utilizing an intensive aeration pipe with inlets at the lower portion and outlets at the higher portion in an aeration tank. Through the experiments on CROSS process, the average removal efficiences of BOD, COD_(Mn), SS, T-N and T-P were showed 98.8%, 93.9%, 98.0%, 71.3% and 49.8%. The average DO (Dissolved-Oxygen) concentration was constantly maintained at 8.0 mg/L by the intensive aeration which was accompanied by rapid reduction of BOD. Degradation of the organic matters in sewage then continued for the whole aeration period. The process demonstrated that it was very adaptive without seeding and returning the sludge. Compared to the activated sludge system, the system was very flexible for the continuous flow treatment. This preliminary assessment showed that the porous media in CROSS reactor is viable for the sewage treatment, since the porous media under the intensive aeration achieves acceptable effluent quality.