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흰쥐의 일과성 전뇌허혈모델에서 허혈성 신경세포손상에 대한 저체온과 고혈당의 동반효과
오종배 대한뇌졸중학회 2000 Journal of stroke Vol.2 No.1
Background & Objectives : Hypothermia is used in patients undergoing cardiac surgery to protect the brain. Hyperglycemia aggravates neuronal damage in global and focal cerebral ischemia. However, it is not clear whether it is beneficial or harmful if both hypothermia and hyperglycemia coexist in transient global ischemia. Methods : We used forty male Sprague- Dawley rats. Rats were divided into four groups; 1) normoglycemic, normal temperature (NGNT), 2) normoglycemic, low temperature (NGLT), 3) hyperglycemic, normal temperature (HGNT), and 4) hyperglycemic, low temperature (HGLT). Hyperglycemia was induced by intraperitoneal injection of streptozotocin 3 days before ischemia or intraperitoneal injection of glucose solution 30 minutes before ischemia. Intraischemic body temperature was regulated as 32˚C for hypothermia and 37˚C for normothermia group. Transient global cerebral ischemia was induced by clipping both common carotid arteries and blood exsanguination. Pre- and postischemic blood pressure and preischemic physiologic parameters were measured. The numbers of viable neuron were counted at CA1 sector of hippocampus, 5 or 7 days after ischemia. Results : Mean glucose levels were significantly higher in HGNT and HGLT groups than in NGNT and NGLT groups. The number of viable neurons in NGLT group was significantly higher than that in NGNT group (p = 0.04). No significant differences were recognized between HGLT group and HGNT group (p = 0.71) and between NGNT group and HGLT group (p = 0.55). Conclusions : Hypothermia had protective effect against ischemia in case of normoglycemia, not in hyperglycemia. Our results suggest that avoidance of hyperglycemia is mandatory for the effective neuroprotection by hypothermia and that the harmful effect of hyperglycemia possibly overrides the protective effect of hypothermia in transient global ischemia. Korean Journal of Stroke 2000;2(1): 62~69
임태규,한승기,남현우,이상건,오종배 한국뇌학회 2001 한국뇌학회지 Vol.1 No.1
본 연구에서는 내측두엽 간질(medial Temporal Lobe Epilepsy, m-TLE) 환자의 발작기 뇌파(ictal electroencephalogram; ictal EEG)를 ICA(independent component analysis)로 처리하여, 근육잡파(muscle artifact)를 비롯한 여러 잡파들의 영향이 제거된 원래의 두뇌신경계에 의한 뇌파를 재구성할 수 있음을 보였다. 또한, ICA로 추출된 4∼6Hz의 발작리듬(ictal rhythm)에 해당하는 독립성분들이 환자군에 따라서 좌우 측두엽으로 편측화된 결과를 얻었다. 이 결과를 이용하여, 좌우 측두엽에서 θ파의 파워를 편측화의 지표로서 사용할 수 있음을 보였다. In this paper, we show that various artifacts due to muscle activity or eye movement could be removed from the ictal electro-encephalogram(EEG) of medial temporal lobe epilepsy(TLE) patients using the independent component analysis(ICA). The ictal rhythms in the 4°≠6Hz are obtained, with the topographic maps localized to the left or right side temporal lobe according to the patient group. Using the power spectral density of the ictal rhythms, we show that the lateralization of m TLE is possible.