서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

The expression patterns of RANKL and OPG in murine tooth eruption

Hwang, Kyung-Mun,Kim, Eun-Jung,Kim, Hyun-Jung,,Kim, Young-Jin,Nam, Soon-Hyeun 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.2

치아의 맹출은 치아기 (dental organ)와 치조골의 세포와 연관된 매우 복잡한 과정이다. 우선 치아 맹출이 일어나기 전에 파골세포가 치낭으로 집결하게 된다. 이러한 치낭의 역할은 파골세포와 조골세포의 상호작용으로 이루어 지는 골개조와 밀접한 관련이 있는데, 이는 치아 맹출과 연관된 많은 유전자들이 치낭에서 발현되기 때문이다. RANKL는 TNF ligand family로써 조골세포에 존재하며 파골세포의 형성 및 전구세포로 부터의 활성화를 유도한다. 이러한 RANKL은 OPG에 의해 그 작용이 억제되며 RANKL와 OPG의 상대적인 비율이 파골세포의 형성에 영향을 미친다. 또한 Runx2유전자의 변이는 조골세포의 분화와 활성에 차질을 가져오고 결국 RANKL/OPG pathway를 통해 파골세포 형성에 영향을 줄 수 있다. 치아의 발육 및 맹출에 미치는 RANKL 및 OPG의 영향을 알아보고 Runx2와의 연관성을 알아보기 위해 in situ hybridization 방법으로 태생 1, 3, 5, 7, 9, 11일된 쥐의 하악 및 제1대구치를 사용하여 실험을 실시한 결과 RANKL, OPG, Runx2의 mRNA가 태생 1일부터 11일까지 치낭 및 치아주위조직에 특성있게 나타났다. 이중 태생 5일에서 9일 사이에 RANKL 및 Runx2는 치아의 교합면측과 하방 치조골 부위의 발현이 강하게 나타난 반면 OPG는 약한 발현을 보였다. 이는 또한 파골세포의 활성부위를 알아보기 위해 TRAP염색을 실시하여 태생 5일에서 9일 사이에 최대의 활성화를 나타낸 결과와 연광성 있게 나타났다. RANKL, OPG, Runx2의 특성있는 발현양상들을 종합해 볼 때, 치아 맹출은 치낭, 치아기, 치조골 사이의 상호 작용을 통해 이루어 지며, 이는 치낭이 치아 맹출에 있어서 매우 중요하다는 것을 의미한다. 또한, 이러한 유전자들 (RANKL, OPG, Runx2) 이 치아의 맹출에 중요한 역할을 하는 것으로 사료된다. Tooth eruption is a complex and tightly regulated process that involves cells of the tooth organ and the surrounding alveolus. Osteoclast precursors must be recruited into the dental follicle prior to the onset of eruption. This function of dental follicle may be regarded as the ability of bone remodeling characterized by the interaction of osteoclasts and osteoblasts. This is because tooth eruption is a localized event in which many of the genes required for eruption are expressed in the dental follicle. RANKL is a membrane-bound protein that is a member of the TNF ligand family, which is present on bone marrow stromal cells and osteoblasts, and induces osteoclast formation and activation from precursor cell. The biologic effect of RANKL is inhibited by OPG and, in bone, the relative ratio of RANKL and OPG modulates osteoclastogenesis. To evaluate the roles of RANKL and OPG in tooth eruption and the relations with the expression pattern of Runx2, in situ hybridization was performed with mandibles of mice at postnatal stage 1, 3, 5, 7, 9 and 11. mRNA of RANKL, OPG, and Runx2 are expressed in dental follicle and surrounding tissue from P1 to 11. To determine the sites of osteoclastic activity duing tooth eruption, mandibles were dissected. Peak osteoclastic activity in alveolar bone along the occlusal and basal regions was observed from P5 to 9, with osteoclasts in these regions being large and strongly TRAP-positive. The specific spatic-temporal expression patterns of RANKL, OPG and Runx2 in our study suggest that tooth eruption could be progressed through the interactions of molecular signaling among dental follicle, dental organ and alveolar bone, furthermore it means that dental follicle is quite important in tooth eruption. In addition, it indicates that these genes (RANKL, OPG, and Runx2) play critical roles in tooth eruption.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

모래의 입도분포가 모르터의 물성에 미치는 영향에 관한 연구

김경원,김문희,김유진,안흥난,허태경,현철 경성대학교 공학기술연구소 2010 공학기술연구지 Vol.16 No.-

Fineness Modulus is a term used as an index to the fineness of sand. It is well - known that the modulus distribution of sand plays an important role in achieving the desired properties of mortar. The maximum size of sand is also important parameter in mortar. These parameters affect workability, strength and unitweight of mortar. In tills study, different sand gradings were used to investigate effects of fineness moduli of sand for examination about the workability, strength and unit weight characteristics of cement mortar. Two kinds of sands with various size distribution and three kinds of fine aggregates with the similar particle size distribution (Sieve No.16~30, No.30~50, No.50~100) were used. Water-cement ratio (W/C) of mortar mix was kept constant for all the trial mixes with sand of different fineness modulus. Major findings of tills study are: (a) Fine sand with the similar size distribution reduces the workability and unit weight of cement mortar. (b) The compressive strength of mortar is not sensitive to sand grading variations. (c) The compressive strengths at the age of 28 days range from 32.1 to 54.1 MPa. (d) The sand with standard modulus distribution has better positive effects on the properties of the mortar.

중추성 요붕증이 동반된 랑게르한스 세포 조직구증 1예

김진호,문준성,문선중,이지은,최재원,은미정,천경아,조인호,윤지성,원규장,이경희 신덕섭,이형우 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased form 109mOsmol/Kg to 327mOsmol/Kg (300%). Brain MRI showed a thickened pituitary stalk and at hot bone CT.CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes, The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.

스포츠센터 회원의 생활양식, 참여종목과 참여 촉진 요인의 관계

김경호,주석범,박순문 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6

This study is to investigate the relations with the factors like life style, participation event, and participation promotion of the members at the sports center. For investigating that, as an object for research, this study is to select the adults above 20 years old who make use of the sports center in Ilsan area in 2003 as a population. Then it is to write the sampling frame work by using the stratified cluster random sampling. After that, it is to utilize the 360 persons except for the 40 sheets of questionnaire with double entry and insincerity and without the reliability in the real analysis after the distribution of the questionnaire. As survey instruments, it is to utilize the questionnaire that the Plumer(1974) developed and that Sim Jae Seung(1998) reconstructed in order to measure the life style. As for the factor of participation promotion, this study is to utilize the desire of leisure that Kim Young Ho(1995) adapted and developed the physical desire and efficiency variable in the development model for Korean-styled leisure diagnosis instruments, and utilize the reconstructed items as Kim Hong Sik(2002)'s factor of participation promotion that used after the Ryu Byeong Ryeol(1997) adapted the scale of recognized leisure capacity and the physical activity attitudes that produced by British Columbia Ministry of Health(1991). For the data analysis, the statistical analysis was executed as one-way analysis of variance, ANOVA, multiple regression analysis and ANCOVA. The conclusions from the data analysis according to the methods and procedures like above are as follows. First, there arose differences partly in the factors like the life style, participation event, and participation promotion according to the demographical characteristics. Second, as for the life style of the members at the sports center, it made affect on the factor of participation promotion partly. Third, there arose differences in the factor of participation promotion partly according to the participation event of the members at the sports center.

시각적 전(前) 펄스 억제 패러다임을 이용한 정신분열증 치료약물의 효과 검사 : 도파민 D₄수용기 차단제 L-745,870의 효과 부재 The lack of effects of a dopamine D₄receptor blocker L-745,870

김문수,김경만 한국심리학회 한국심리학회지 생물 및 생리 Vol.12 No.1

전형적인 정신분열증 치료약물의 문제는 운동장애를 일으키는 부작용이 심각하다는 것이다. 따라서 그러한 부작용이 없는 약물을 개발하려는 노력이 집중적으로 이루어지고 있는데, 이를 위해서는 정신분열증 치료약물의 효과를 탐지하는 도구의 유용성이 중요성을 가진다. 그런 도구 중 하나로 정신분열증의 주의집중장애에 대한 중요한 동물모델의 하나인 전펄스 억제(prepulse inhibition; PPI) 패러다임이 있는데, 지금까지는 주로 청각적 전펄스가 사용되어 왔다. 따라서 이 패러다임의 일반성을 확증하기 위하여 본 연구에서는 시각자극을 전펄스로 사용하였다. 그 결과, 정신분열증 환자들이 나타내는 것과 같은 PPI의 결손을 도파민 효능제인 apomorphine이 유발할 수 있었고, 이러한 PPI의 결손 효과는 전형적인 정신분열증 치료약물인 haloperidol에 의해 방지될 수 있었다. 도파민 D_(4) 수용기만을 차단하는 약물이 운동장애란 부작용을 일으키지 않으면서 정신분열증 치료효과가 있을 것이라는 주장이 많이 제기되었는데, 본 연구에서는 apomorphine으로 인한 PPI의 결손이 도파민 D_(4) 수용기 차단제인 L-745,870에 의해서는 방지되지 않음이 발견되었다. 이는 도파민 D_(4) 수용기만을 차단하는 약물은 정신분열증 치료효과가 없을 가능성을 지지한다. The problem with typical antipsychotics have been that they induce motor side effects. Therefore, efforts have been focused on developing drugs without such side effects. The prepulse inhibition (PPI) of startle reflex is one of the paradigms used for screening antipsychotics, since PPI is reduced in schizophrenia patients and this PPI deficits can be induced in rats by injecting dopamine agonists. Until now, most studies with this paradigm have used only auditory prepulse stimuli. To ensure the generality of this paradigm, this study used a visual prepulse stimulus and showed that a dopamine agonist, apomorphine, dose-dependently blocks the PPI in rats (Experiment 1). This PPI deficits induced by apomorphine was blocked by typical antipsychotic, haloperidol (Experiment 2). Finally, the hypothesis that dopamine D_(4) receptor is preferentially involved in mediating the antipsychotic effects of drugs was examined by using a selective D_(4) receptor blocker, L-745,870. The results showed that L-745,870 did not block the effects of apomorphine (Experiment 3).

프렌치 후드 제작에 관한 고찰Ⅰ

김경희,문윤경 服飾文化學會 2003 服飾文化硏究 Vol.11 No.2

The study was designed to review the changes in designs and the manufacturing methods of french hood, one of the headdresses which play an important role in showing the appearance of costume, to understand design expression techniques through manufacturion of the head dress of the western costumes, and to provide materials to exert creativity for new designs. Based on literature review and portrait study, I manufactured a frenchhood. I set the study cope as from the late 15 century when frenchhood was used for the first time, to the mid 16 century. For the frenchhood selected, I examined the hair style, the characteristics of the french hood, and the pattern first, and proceeded to manufacturing. I used velvet and silk for the textile as explained in the literature. And, I purchased such similar ornaments as shown in the pictures, making the color so similar to the original to the most. Dimensions in manufacturing were those in the literature, since the study is focusing on the reproduction of the features of the portraits. Dimensions of detailed decoration were measured using the ratio of the headdress in the portraits.

부식산의 광촉매 산화 공정에 도입된 여러 종류이 상용 TiO₂비교연구

문경숙,김다희,이동석 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

In this study, the effects of crystalinity, composition and particle size of TiO2 catalysts on the degradations of humic acid in aqueous solution was assessed using the commercially avaliable TiO2 particles. Photocatalytic oxidations of humid acid (HA, Aldrich Co.) solution were carried out in case of adding different types of TiO2 catalysts and their decomposition efficiencies were analyzed with respect to pH, DOC and UV absorbances values for the HA solutions and compared one another. The experimental results showed that TiO2 particles(Degussa P-25) mixed with anataze and rutile gave the highest degradation efficiencies, respectively and much lower degradation efficiency in TiO2 paticles of rutile only type. In comparing among ST series of anataze types, it was observed that the degradation efficiencies generally were increased with increasing TiO2 contents and surface area of the particles. Higher degradation efficiency of HA was also found in zeolite type(D-TZ) of TiO2 paticles compared with hydroxyapatite type (D-TH) of TiO2 particles.

스키상해에 관한 실태 조사 연구

김정주,민경두,이재문 경희대학교 체육과학연구소 2001 體育學論文集 Vol.29 No.-

As the number of people who enjoy skiing are increasing, it has become more important to work out a countermeasure for prevention of injuries. To prevent accidents, finding out the causes and analyzing them is more meaningful than post-accidental treatment. This study is based on records of 494 injured people at H ski resorts. From December, 2000 to March, 2001 this research and analysis was undertaken in detail by classifying the situation and causes at the accidents, into personal, material and environmental factors. The results from which following conclusion were made. First of all, after analyzing the situation of the injured people, the facts that most of the accidents occurred on weekends and holidays, when most students and salarymen went skiing and that the injures were usually in the form of a slight contusion were found out. The major cause was that people ignored the safety rules and descended immoderately. But skiers that used a certain ski resort regularly showed lower occurrence of injuries. For these reasons in order to reduce the rate of accidents happening skiers should be tested by a ski instructor and then should be taught at a right level. Ski-related organizations should inform skiers with facts that are commonly misunderstood through seminars and training courses. The lack of facilities for beginners should be improved and resorts for group training courses should be built separately so that beginners can prevent ahead of time, form getting hurt in a disorderly situation .