신경 인지검사를 이용한 최소증상 간성뇌증 진단

양동원,손영민,김범생,한준열,정규원,선희식 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.1

표적분할 신뢰도 값 기반의 형태특징과 지역특징을 이용한 차량표적 분류기법 연구

양동원,이용헌,곽동민,Yang, DongWon,Lee, Yonghun,Kwak, Dongmin 한국군사과학기술학회 2017 한국군사과학기술학회지 Vol.20 No.1

To classify the vehicle targets automatically using thermal images, there are usually two main categories of feature extraction method, local and shape feature extraction methods. Since thermal images have less texture information than color images, the shape feature extraction method is useful when the segmentation results are correct. However, if there are some errors in target segmentation, the shape feature may contain some errors, then the classification accuracy can be decreased. To overcome these problems, in this paper, we propose the segmentation reliability estimation method for target classification. The segmentation reliability can be estimated by using the difference information of average intensities and edge energies between the target and the background area. The estimated segmentation reliability is applied in the decision level fusion method of classification results using both shape and local features. Experiment results using the thermal images of the vehicle targets (main battle tank, armored personnel carrier, military truck, and an estate car) show that the proposed classification method and the segmentation reliability estimation method have a good performance in classification accuracy.

알쯔하이머병 환자의 뇌혈류 장애 : Statistical Parametric Mapping을 이용한 Tc-99m ECD SPECT 분석 Statistical Parametric Mapping analysis of Tc-99m ECD SPECT

양동원,김범생,손영민,박정욱,정용안,손형선,김상윤 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.2

Background and Objectives . Alzheimer's disease (AD) is the most common cause of the dementia Pathologic and functional changes of AD are known to be unevenly distributed in the brain. This study investigates changes of cerebral blood flow (CBF) in patients with AD to determine brain regions with hypoperfusion that reflects progression of disease. Methods. Tc-99m-ECD single photon emission computed tomography (SPECT) was performed to measure regional CBF and statistical parametric mapping (SPM) 99 soft ware was used for the automated and objective approach to analyze SPECT image data. Twenty-five patients with mild to moderate dementia who met NINCDS-ADRDA critena for AD (male 11 female 14) and 17 age-matched normal control subjects were studied. The severity of AD was measured by clinical dementia rating (CDR) scale Results. SPM analysis of SPECT images revealed that CBF in the anterior cingulate gyrus left superior panetal cortex left medial frontal cortex left infenor temporal cortex. right thalamus and left hippocampus was significantly decreased in AD patients compared with normal controls (corrected p<0.05). The reduction of CBF according to CDR was localized in the left hippocampus and infenor temporal cortex right antenor and postenor ciagulate cortex and right superior panetal cortex (uncorrected p<0.01). Conclusions : Our data suggest that the cognitive dysfunction of AD is strongly related with functional abnormality in discrete brain areas 99m-Tc ECD SPECT with SPM analysis could be used as a useful functional imaging tool in AD study.

가미속풍활형탕이 human fibroblast-like synoviocytes 내 염증 유발 cytokine과 전사인자에 미치는 영향

양동원,오민석,김동희 대한한의학회 2003 대한한의학회지 Vol.24 No.3

Objective : This study was carried out to investigate the effects of Kamisopunghwalhyeol-tang (Jiaweishujenghuoxie-tang; Kami-SPHHT) on the immunity responses of the Synoviocytes isolated from the patients on rheumatoid arthritis. Methods : Cells were stimulated by $Interleukin-1{\beta}$ and Tumor Necrosis $Factor-{\alpha}$ in the presence or absence of Kami-SPHHT, and then induced cytokine mRNA levels were determined by RT-PCR and real-time quantitative RT-PCR. Results : Levels of $IL-1{\beta},{\;}IL-6,{\;}TNF-{\alpha}$, COX-2, and NOS II mRNA expressions significantly decreased in Kami-SPHHT treated cells compared to non-treated control cells. Also, DNA-binding activity of $NF-{\kappa}B$ and AP-l decreased in Kami- SPHHT treated hFLSs. Conclusion : These results suggest that Kami-SPHHT may be involved in anti-inflammatory reactions by inducing cytokine gene expression in synoviocytes, and further in vivo examination on its efficacy can provide potential application for the treatment of rheumatoid arthritis.

레이저 다이오드를 이용한 이진 신호누적 방식의 거리측정기 기술

양동원,Yang, Dong-Won 한국군사과학기술학회 2007 한국군사과학기술학회지 Vol.10 No.4

In this paper, a new design technique on the LRF which is useful for low power laser and a CBDA(Cummulative Binary Detection Algorithm) is proposed. The LD(Laser Diode) and Si-APD(Silicon Avalanche Photo Diode) are used for saving a power. In order to prove the detection range, the Si-APD binary data are accumulated before the range computation and the range finding algorithm. A prototype of the proposed DLRF(Diode Laser Range Finder) system was made and tested. An experimental result shows that the DLRF system have the same detection range using a less power(almost 1/32) than an usual military LRF. The proposed DLRF can be applied to the Unmanned Vehicles, Robot and Future Combat System of a tiny size and a low power LRF.

한국어판 하세가와 치매척도 개정본의 신뢰도 및 타당도의 평가

양동원,김범생,심동석,정성우,이광수,한설희,김상윤,정슬기 대한신경과학회 2004 대한신경과학회지 Vol.22 No.4

Background: The revised version of the Hasegawa Dementia Scale (HDS-R) is a useful dementia screening tool with a test for frontal lobe function and is relatively less influenced by education level and linguistic ability. We developed a Korean version of HDS-R (K-HDS) by translating the HDS-R to screen dementia patients in the Korean elderly. Methods: The basic structure of the HDS-R was preserved but some questions were modified for lingual and cultural difference. It was administrated along with the Korean version of the MMSE, Korean Dementia Screening Questionnaire, Short form Samsung Dementia Questionnaire and Clinical Dementia Rating (CDR) scales, to 151 patients (55 Alzheimer's disease, 73 vascular dementia, 23 others) with mild to moderate dementia and to 225 elderly control subjects. To screen dementia, the optimal cut-off score was estimated by receiver operating characteristic (ROC) curve analysis. By comparing the Area Under the Curve, the diagnostic efficiency of K-HDS was compared with that of K-MMSE. Results: The K-HDS had good internal consistency (Crohnbach's alpha coefficient=0.66), inter-rater reliability (r=0.95), and test-retest reliability (r=0.92). K-HDS was well correlated with the K-MMSE (r=0.84) and CDR (r=-0.67), which confirms the validity of this test. The optimal cut-off score was different according to educational level. In patients with an educational level less than 10 years, the cut-off score was 20 with the sensitivity of 87.0% and the specificity of 83%. With an educational level of 10 years or more, the cut-off score was 22 with the sensitivity of 93.0% and the specificity of 89.6%. The overall diagnostic efficiency of K-HDS was superior to that of K-MMSE especially in patients with an educational level of less than 10 years. Conclusions: The K-HDS is a reliable, valid and useful tool to screen dementia in the Korean elderly. J Korean Neurol Assoc 22(4):315~321, 2004

수열합성을 이용한 ZnO 마이크로 구조의 성장 및 전사

양동원,이원우,박원일 한국마이크로전자및패키징학회 2017 마이크로전자 및 패키징학회지 Vol.24 No.4

Recently, there has been substantial interest in flexible and wearable devices whose properties and performances are close to conventional devices on hard substrates. Despite the advancement on flexible devices with organic semiconductors or carbon nanotube films, their performances are limited by the carrier scattering at the molecular to molecular or nanotube-to-nanotube junctions. Here in this study, we demonstrate on the vertical semiconductor crystal array embedded in flexible polymer matrix. Such structures can relieve the strain effectively, thereby accommodating large flexural deformation. To achieve such structure, we first established a low-temperature solution-phase synthesis of single crystalline 3D architectures consisting of epitaxially grown ZnO constituent crystals by position and growth direction controlled growth strategy. The ZnO vertical crystal array was integrated into a piece of polydimethylsiloxane (PDMS) substrate, which was then mechanically detached from the hard substrate to achieve the freestanding ZnO-polymer composite. In addition, the characteristics of transferred ZnO were confirmed by additional structural and photoluminescent measurements. The ZnO vertical crystal array embedded in PDMS was further employed as pressure sensor that exhibited an active response to the external pressure, by piezoelectric effect of ZnO crystal. 최근, 유연하며 몸에 부착 가능한 소자들에 대한 관심이 늘어나고 있다. 이런 관심을 뒷받침 하여 이와 관련된다양한 연구들이 진행되고 있는데, 기존 딱딱한 성질을 가진 소자에 사용되던 무기물 기반의 재료의 경우 유연 소자로 만들기에 여러 가지 제약이 있어 유연하게 제작할 수 있는 유기물 반도체나 탄소 나노튜브 필름 등을 이용한 소자들이 주로연구되고 개발되어 왔다. 하지만 이런 재료들을 이용한 소자의 경우 유기물 분자와 분자 사이 또는 탄소 나노튜브와 나노튜브 사이에서 전하들이 산란되는 등 재료 자체의 한계로 인해 기존의 재료를 사용한 소자들보다 전기적 성능이 떨어지는단점을 가지고 있다. 이런 단점들을 해결하기 위하여 이 연구에서는 수직 정렬된 반도체 결정 어레이를 투명 유연한 폴리머와 결합하는 방법을 이용, 고품질 나노/마이크로 반도체 결정을 유연한 기판으로 전사 시킬 수 있는 방법을 제시한다. 위와 같은 구조는 재료에 가해지는 힘을 완화 시켜줄 수 있으며, 이로 인해 큰 변형에도 재료의 손상이 없는 소자 제작이 가능하다. 이런 구조를 구현하기 위해 위치 및 크기가 정교하게 제어된 ZnO 나노막대 단결정을 저온에서 용액공정을 통하여합성시킨다. 이후 성장시킨 ZnO 단결정 어레이와 polydimethylsiloxane (PDMS) 폴리머를 결합시킨 후 단단한 기판에서기계적으로 박리시켜 ZnO/폴리머 복합체를 분리해 낸다. 추가적으로 전사된 ZnO의 결정성을 확인하기 위하여 photoluminescent 분석을 진행하였으며, ZnO/폴리머 복합체를 이용한 외부 힘에 반응하는 압력 센서를 제작하였다.

동적 객체 추적 및 제거 기능을 갖춘 라이다 기반 실내 지도 작성

양동원,임진호,홍성훈,박정홍 제어로봇시스템학회 2024 제어로봇시스템학회 국내학술대회 논문집 Vol.2024 No.7

N-Methyl-D-Aspartate 수용체 길항제 MK-801의 흰쥐 심혈관계에 대한 작용

양동원,이상복 가톨릭대학 (가톨릭신학대학) 대학원 1995 가톨릭大學醫學部 論文集 Vol.48 No.1

뇌혈관 장애 환자에 대한 Idebenone(CV-2619)의 임상 연구

양동원,정성우,이광수,김범생 최신의학사 1993 最新醫學 Vol.36 No.2