산업보건관리자를 위한 소음성 난청 예방지침서의 개발

이원철,유경혜,장성실,이세훈,구정완,김현욱,노영만,이경재,김형아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1996 韓國의 産業醫學 Vol.35 No.1

Occupational hearing loss became the leading occupational disease by constioution 56% of all work-related diseases in Korea. However, the prevalance rates showed wide variations among the specific medical examination providers and were very low(0.8-1.4%) compared with those 8.4% in Japan. The sources of these variations was regarded in the preview study as 1) Employee audometric estings were primarily conducted by nurses and nurse-aids who had no formal training for audiometry; 2) althought audiometric testing equipment used by the spedific medical examination providers, it should be periodically calibrated, a significant number of them were not properly calibrated : 3) Initial audiometric testings were conducted at any available spaces in workplace or at the testing room without considering bachground noise level. One of solutions that can be done for sloving surrent noise related problems is to provide a noise related manual for the occupational health managers including doctors, nurses and hyginests. This study was done to provide such a manual. The main core of the manual was hearing conservation program. And the contents of the manual was the same as the main frame of hearing conservation program such as noise survey, provided of the diagram showing the core contents of each factor of the hearing conservation program. Hopefully, this manual will be the references of the standardized performances of the specific medical examination providers.

저체중 또는 과체중 청소년에서 캠프 프로그램을 이용한 영양 교육효과에 관한 연구

성미경,승정자,류화춘,박재년,박동연,최미경,조경옥,최선혜,이윤신,김유경,이은주 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.4

This study was performed to evaluate the effectiveness of a nutrition education program developed for nutritionally imbalanced adolescents. A summer nutrition camp was held for 23 overweight and 16 underweight subjects. Its effectiveness with regard to was evaluated at the end of the camp and 6 months later. Nutrition knowledge, nutritional attitude, food behavior, nutrient intake, exercise habit and ideal body figures desired by the subjects. The results showed significantly higher nutrition knowledge scores at the end of the camp as compared to those obtained prior to the camp program, and these scores were maintained for at least six months. Nutrition attitude scores also improved after the education program, and these improved scores also lasted for 6 months. However, the food behavior scores measured 6 months after the education program were not significantly different from those obtained prior to the camp. Also, the exercise habit, the ideal body figures and the body figures desired by the subjects remained unchanged. When nutrient intakes of subjects were assessed before the program and 6 months later, the mean daily vitamin C intake was significantly increased after the education program. Also, the intake of iron from plant food sources increased in the overweight subjects, while less iron from animal source were consumed by the underweight subjects. Both groups tended to consume more vegetables and fruits 6 months after the education program which may have contribute to the higher vitamin C and plant-based iron intakes. These results indicate that a 4-day nutrition education camp program sustained changes in nutrition knowledge and nutrition attitude for 6 months. The increased intake of vegetables and fruits was also achieved through this education program. However, changes in dietary behavior in adolescents may require repeated education.

Kartagener 증후군을 동반한 일차성 섬모 이상운동증 1례

변은경,조유경,송현주,이현경,이진화,성순희,김유경,장중현 梨花女子大學校 醫科大學 醫科學硏究所 2002 EMJ (Ewha medical journal) Vol.25 No.1

Primary ciliary dyskinesia is a genetic disorder of abnormal ciliary structure and function that leads to defective mucociliary clearance, resulting in sinopulmonary infection and infertility. Kartagener's syndrome is a subclass of primary ciliary dyskinesia and which is clinically distinguishable by the presence of situs inversus. Electron microscopy of cilia reveals ultrastructural defects in the ciliary axoneme. In the respiratory tract, this inability presumably causes impaired clearance of mucus and inhaled particles and results in the chronic infections of sinuses and bronchial trees that are characterized of the disease. Early diagnosis of the disease may be important for prevention of bronchiectasis and pulmonary insufficiency. We report one case of primary ciliary dyskinesia associated with Kartagener's syndrome in a 14 year-old young man who was presented as bronchiectasis, chronic and situs inversus, with review of literature.

Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

계류 유산 후 한방치료 위해 내원한 환자의 Heart Rate Variability(HRV) 특성 연구

유은실 ( Eun Sil Yoo ),김민영 ( Min Young Kim ),황덕상 ( Deok Sang Hwang ),이진무 ( Jin Moo Lee ),장준복 ( Jun Bok Jang ),이경섭 ( Kyung Sub Lee ),이창훈 ( Chang Hoon Lee ) 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.3

Objectives: This study aims to analyze Heart Rate Variability (HRV) in women after missed abortion compared with healthy women Methods: We studied 35 women who visited Kang-Nam Kyung-Hee Korean Hospital after missed abortion from 01 January 2012 to 28 February 2015 (missed abortion group) and 35 normal women visiting medical examination center from 1 January 2014 to 31 December 2014 (Normal Group). We measured HRV of each women and investigated the difference of HRV between two groups. Results: The standard deviation of NN intervals (SDNN) in Missed abortion group is lower than normal group. The square root of the mean square difference of successive NNs (RMSSD) in Missed abortion group is lower than normal group. However there was no significant difference. Total Power (TP) and Low frequency power (LF) is significantly lower in Missed abortion group compared with normal group. High frequency power (HF), Very low frequency power (VLF) and LF/HF ratio in missed abortion group is lower than normal group. but There was no significant difference. Conclusions: Missed abortion group is lower in function of overall autonomic nervous system, especially sympathetic nerve.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

BRS 생체정보 분석방법(分析方法)의 정확도(正確度) 확인 연구

유상구,임무열,오상문,유경배,신연호,박병운,이완희 한국정신과학학회 1998 韓國精神科學學會誌 Vol.2 No.2

BRS는 인간의 잠재능력을 적극적으로 계발 · 활용하여 임의의 시료에 대한 미지 (未知)의 생체정보 (Bio-Information)를 편리하게 분석할 수 있는 효과적이고 경제적인 분석장비이다. 그러나 BRS와 관련된 분석방법 자체의 정확도에 대한 연구는 충분하게 이루어지지 않고 있다. 그래서 BRS 분석방법의 정확도를 과학적으로 확인해보기 위해서 본 연구를 진행했다 실험결과, BRS에 의한 생체정보 분석방법 의 정확도는 측정자의 숙련정도에 따라 다르지만 고급 측정자의 경우에는 95% 이상의 높은 확률로 표준시료의 생체정보를 정확하게 분석할 수 있으며, 측정자의 분석능력이 떨어지는 경우에는 여러 명의 측 정자를 대상으로 비교검토(Cross-Check) 방식으로 실험을 보완하면 90% 이상의 정확도를 확보할 수 있었다. BRS is a sort of analysis-instrument which help to estimate some Bio-Information for a sample conveniently and effectively But, for lack of the study to verify the confidence-degree of the Bio-Information analysis method related to BRS, the availability of the method is not known clearly yet, It was the reason that made authors perform this study And It was possible to arrive at the following two conclusions I though the confidence-degree of the Bio-Information analysis method ny BRS was different according to the degree of the expertness of a person using the instrument in the case of the very skillful expert, the confidence-degree for the standard sample used in this study was reached to 95% up 2 In the general case, to improve of the confidence-degree of the Bio-Information analysis method by BRS, the cross-check method by the several measuring person can be introduced.

꿀벌부채명나방의 종령유충-번데기 발생 단계별 유충호르몬 에스테라제(JHE) 활성도와 c-AMP농도의 변화

이경로,김유경,류진수 建國大學校基礎科學硏究所 1993 理學論集 Vol.18 No.-

꿀벌부채명나방(Galleria mellonella) 균질물의 유충호르몬 에스테라제(JHE)활성도와 c-AMP 농도를 종령유충과 번데기에서 Liquid scintillation counter와 HPLC를 이용하여 측정하였다. JHE level은 JHI를 기질로 하여 검사하였다. JHE의 활성도는 종령유충과 번데기 4일에서 peak를 나타냈다. JHE의 가장 높은 함량은 번데기 4일에서 6.28n mol/min/ml이었다. c-AMP 농도는 종령유충에서부터 증가하기 시작하여 번데기 4일에 최대에 도달하였다. c-AMP 농도는 번데기 4일에 1.07㎍/g이고, 종령유충에서 0.21㎍/g 이었다. JHE의 활성도와 c-AMP 농도는 번데기 4일에서 모두 최대치를 나타내어 JHE 활성도와 c-AMP 농도는 유사한 경향을 보였다. The juvenile hormone esterase(JHE) activity and adenosine 3', 5'-monophosphate(c-AMP) concentration of homogenates of the great wax moth, Galleria mellonella, were measured at the last instar larvae and pupal stages by liquid scintillation counter and HPLC. The juvenile hormone esterase levels were monitored using JH I as a substrate. The activity of the juvenile hormone esterase in homogenates peaked at the last instar larvae and the 4-day pupal stages. The highest activity of JHE was demonstrated at the 4-day pupal stages(6.28 n mol/min/ml). The c-AMP concentration started to increase from the last larvae and reached the maximum at the 4-day pupal stage. The concentration of c-AMP were 1.07㎍/g at the 4-day pupae and 0.21㎍/g at the last instar larval stage. JHE activity and c-AMP concentration were reached to the maximum at the 4-day pupae. There-fore, JHE activity and c-AMP concentration were shown to be similar aspect.

소세포 폐암의 갑상선전이 1예

장리라,최영식,박요한,문대성,김자경,김성은,최인수,유찬희,남성진 고신대학교 의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Metastasis to the thyroid gland is usually considered uncommon. The most frequent sites of the primary tumor include the kidney, breast and lung. Its presence often indicates poor prognosis. Metastases represent the advanced stage of the tumors and fine needle aspiration cytology is and important way of diagnosis in thyroid metastasis. we experienced a case of Metastatic Small cell Lung Carcinoma to the Thyroid Gland. A 58-year-old man with Graves' disease diagnosed pulmonary nodule in the left upper lung field on his chest X-ray film. The patient's thyroid gland was diffusely swollen, and elastic to hard. A thyroid ultrasonography showed 1cm sized hypodense nodule on the left thyroid gland. The patient underwent a ultrasonography guided fine needle aspiration cytology of the mass. Cytological diagnosis was a metastatic small cell carcinoma. Then Chemotherapy was administered to the patient. The authors report this rare case of metastatic small cell lung carcinoma to the thyroid with literature review.

Cervical headgear에 의한 상악의 후방 견인시 하악의 위치변화에 대한 임상적 고찰

유영재,이철민,차경석 단국대학교 치의학연구소 1994 논문집 Vol.6 No.1

The debate over the change in the Mandibular position during the cervical headgear traction has continued for decades. The purpose of this report is to assess the generalized rotation of the Mandibule occured due to the cervical traction by a graphic method that Isaacson proposed, and illustrate the mechanism by which the vertical independent variables affect the sagittal position of the mandible. The consequences is in accordance with the Baumrind's report that the use of cervical traction is associated with condyle growth, and its effect is to keep the Mandibular plane angle relatively constant.