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돼지 무릎뼈 용출액 중의 칼슘, 인, 조단백질 및 아미노산의 함유 변화
조경옥 숙명여자대학교 대학원원우회 1991 원우논총 Vol.9 No.-
This study designed to elucidate contents of amino acids, crude protein, Calcium(Ca), and phosphorus(P) contents in extractive cooking broth of pigs' kneecap. Quantitative changes of nutrients in pigs' kneecap broth were investigated according to various boiling times(1, 3, 6, 9, and 12 hours). The results are summerized as follow; 1. In case of quantitative changes of amino acids, crude protein, Ca and P in Pigs' kneecap broth according to boiling time, amino acids, crude protein, Ca and P were increased as boiling time and marked maximum of 12 hours. 2. The major components of essential amino acids were shown to be Leucine, Valine, Phenylalanine, Threonine and minor components of essential amino acids was His-tidine, which all of them were in sequence of amounts, respectively. In nonessential amino acids, the major components were Glycine, Glutamic acid, Proline, Alanine and minor components was Cystine, which all of them were in sequence of amounts, respectively. This above mentioned results suggest that it needs 9-12 hours over boiling time and that the pigs' kneecap broth is a good source as crude protein and phosphorus.
기관 배기형의 머플러에서 압력맥동에 기대된 방사음에 관한 실험적 연구
조경옥 한국마린엔지니어링학회 1998 한국마린엔지니어링학회지 Vol.22 No.5
In automobile exhaust system. Internal pressure pulsation and shell vibration greatly affect the surface sound radiation. This noise is emitted from the muffler outer shell due to the pulsation of the exhaust gas pressure. This paper describes an analytical study of these characteristics as influenced by exhaust system structure. An exhaust simulator was used for generating the pressure pulsation. The relationship between shell vibration and radiated noise was used for generating the pressure pulsation. The relationship between shell vibration and radiated noise was identified by finding FRF.
조경옥,한승조,Cho, Kyoung-Ok,Han, Seung-Jo 한국정보통신학회 2010 한국정보통신학회논문지 Vol.14 No.9
현대 사회에서는 정보 시스템을 이용한 업무의 편의성과 효율성은 높아지고 있지만, 네트워크의 발달로 인한 악성코드, 시스템 해킹, 내부자 정보유출 등의 역기능이 날로 대두되고 있다. 이로 인하여 시스템의 복구와 관리에 막대한 인력과 비용이 소요되고 있다. 기존의 시스템은 두 가지 측면에서 바이러스, 악성코드를 감시하고 치료하는 보안 솔루션과 컴퓨터의 시스템감시, 관리, 복구, 백업 등 유지보수를 하는 네트워크 관리 솔루션으로 나눌 수 있다. 본 논문에서는 Active Write Filter 메커니즘, NFS기반의 기술을 응용하여 기존 시스템의 사용자 데이터 등의 보전문제점을 보완하여 정보보호 및 불법 저작물 등 지적재산권의 문제 해결이 가능한 시스템을 설계하였다. In contemporary society, though convenience and efficiency of work using information system is growing high, adverse effect problems of malignant code, system hacking, information leak by insiders due to the development of the network are raising their head daily. Because of this, enormous work forces and expenses for the recovery and management of system is needed. The existing system can be divided into two aspects: security solution which surveils and treats virus and malignant codes, and network management solution which observes the system of computer, and practices maintenance and repair such as management, recovery, backup. This treatise applied Active Write Filter mechanism and the technology based on NFS and complemented the maintenance problems of user data of the existing system and designed the system which enables solving problems of intellectual property right such as information protection and illegal work.
Effects of Brain Insults and Pharmacological Manipulations on the Adult Hippocampal Neurogenesis
조경옥,김성윤 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.10
During the last two decades, neurogenesis in the adult mammalian brain has been extensively investigated. Studies have indicated that two brain regions, the subgranular zone of the hippocampal dentate gyrus and the subventricular zone of the lateral ventricle, possess the most active progenitor cells that are capable of generating neurons throughout the lifespan of human beings. Adult hippocampal neurogenesis is the focus of this review. We intend to discuss the changes in the hippocampal neurogenesis caused by pathologic brain insults such as brain ischemia, traumatic brain injury, epileptic seizures, neurodegenerative disorder, and psychiatric diseases. Further, we discuss the stimulatory and inhibitory actions on adult hippocampal neurogenesis by biochemicals and pharmacological agents, including antidepressants,antipsychotics, agonists and antagonists of glutamate and GABA, adrenal corticoids, gonadal hormones, growth factors such as insulin-like growth factor I, erythropoietin, and drugs of abuse, including nicotine, alcohol, opiates, cocaine, methamphetamine, and 3,4-methylenedioxymethamphetamine (“ecstasy”).
조경옥,김주연,정경훈,이문용,김성윤 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.4
Vascular endothelial growth factor (VEGF)-C and its receptor, vascular endothelial growth factor receptor (VEGFR)-3, are responsible for lymphangiogenesis in both embryos and adults. In epilepsy, the expression of VEGF-C and VEGFR-3 was significantly upregulated in the human brains affected with temporal lobe epilepsy. Moreover, pharmacologic inhibition of VEGF receptors after acute seizures could suppress the generation of spontaneous recurrent seizures, suggesting a critical role of VEGF-related signaling in epilepsy. Therefore, in the present study, the spatiotemporal expression of VEGF-C and VEGFR-3 against pilocarpine-induced status epilepticus (SE) was investigated in C57BL/6N mice using immunohistochemistry. At 1 day after SE, hippocampal astrocytes and microglia were activated. Pyramidal neuronal death was observed at 4 days after SE. In the subpyramidal zone, VEGF-C expression gradually increased and peaked at 7 days after SE, while VEGFR-3 was significantly upregulated at 4 days after SE and began to decrease at 7 days after SE. Most VEGFC/ VEGFR-3-expressing cells were pyramidal neurons, but VEGF-C was also observed in some astrocytes in sham-manipulated animals. However, at 4 days and 7 days after SE, both VEGFR-3 and VEGF-C immunoreactivities were observed mainly in astrocytes and in some microglia of the stratum radiatum and lacunosum-moleculare of the hippocampus, respectively. These data indicate that VEGF-C and VEGFR-3 can be upregulated in hippocampal astrocytes and microglia after pilocarpine-induced SE, providing basic information about VEGF-C and VEGFR-3 expression patterns following acute seizures.
조경옥,김슬기,김성윤 대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.6
Vascular dementia (VaD) is a group of heterogeneous diseases with the common feature of cerebral hypoperfusion. To identify key factors contributing to VaD pathophysiology, we performed a detailed comparison of Wistar and Sprague– Dawley (SD) rats subjected to permanent bilateral common carotid artery occlusion (BCCAo). Eight-week old male Wistar and SD rats underwent BCCAo, followed by a reference memory test using a five-radial arm maze with tactile cues. Continuous monitoring of cerebral blood flow (CBF) was performed with a laser Doppler perfusion imaging (LDPI) system. A separate cohort of animals was sacrificed for evaluation of the brain vasculature and white matter damage after BCCAo. We found reference memory impairment in Wistar rats, but not in SD rats. Moreover, our LDPI system revealed that Wistar rats had significant hypoperfusion in the brain region supplied by the posterior cerebral artery (PCA). Furthermore, Wistar rats showed more profound CBF reduction in the forebrain region than did SD rats. Post-mortem analysis of brain vasculature demonstrated greater PCA plasticity at all time points after BCCAo in Wistar rats. Finally, we confirmed white matter rarefaction that was only observed in Wistar rats. Our studies show a comprehensive and dynamic CBF status after BCCAo in Wistar rats in addition to severe PCA dolichoectasia, which correlated well with white matter lesion and memory decline.